p53 mutations in colorectal cancers in the patients of Metropolitan New York.

Abstract:

:An unselected series of 19 colorectal adenocarcinomas obtained from patients treated by surgery at Memorial Sloan-Kettering Cancer Center (MSKCC), New York, USA was investigated for mutations in exons 5, 6, 7 and 8 of the p53 gene. Ten of the tumors revealed at least one somatic mutation either in the exon 5 or 8. Two of them were found to carry two somatic mutations each. The DGGE pattern of one of these two tumors indicated that it contained two different clonal cell populations; a similar assessment was not possible in the other tumor. Sequence analysis of all the observed variants showed that eighty percent of the mutations were due to transitions and that half of them were at mutational hot spot codons, 175 and 273.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

van den Broek MH,Jhanwar SC,Fodde R,Chaganti RS,Meera Khan PM

subject

Has Abstract

pub_date

1993-09-01 00:00:00

pages

1769-72

issue

5C

eissn

0250-7005

issn

1791-7530

journal_volume

13

pub_type

杂志文章
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