Abstract:
BACKGROUND:Some low-incidence antigens in the Rh blood group system (e.g., VS, Rh32, FPTT) are expressed by more than one Rh complex. We describe a new low-incidence antigen that is present on RBCs with the partial D phenotypes, DIIIa or DOL, on RN RBCs and on one example of STEM+S RBCs. STUDY DESIGN AND METHODS:Standard hemagglutination testing was performed with two sera that agglutinated DIIIa RBCs on our in-house antibody identification panel. DNA-based assays were performed on selected samples. RESULTS:RBCs with the DIIIa (n = 31), DOL (n = 5), or RN (n = 10) phenotype were agglutinated by both sera, as were RBCs from one STEM+S person. Reactivity with RBCs of either DIIIa or DOL phenotypes was stronger than with RN RBCs and could not be separated by adsorption and elution. CONCLUSION:An antibody, anti-DAK, which recognizes a novel low-incidence antigen that is more strongly expressed on DIIIa and DOL RBCs than on RN RBCs is described. The antibody agglutinated RBCs from 4 percent of D+ African American blood donors in New York. The antigen, DAK, has been assigned the ISBT number RH54 (004.054).
journal_name
Transfusionjournal_title
Transfusionauthors
Reid ME,Storry JR,Sausais L,Tossas E,Rios M,Hue-Roye K,Gloster ES,Miller ST,Wolf C,Lomas-Francis Cdoi
10.1046/j.1537-2995.2003.00517.xsubject
Has Abstractpub_date
2003-10-01 00:00:00pages
1394-7issue
10eissn
0041-1132issn
1537-2995pii
517journal_volume
43pub_type
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