DAK, a new low-incidence antigen in the Rh blood group system.

Abstract:

BACKGROUND:Some low-incidence antigens in the Rh blood group system (e.g., VS, Rh32, FPTT) are expressed by more than one Rh complex. We describe a new low-incidence antigen that is present on RBCs with the partial D phenotypes, DIIIa or DOL, on RN RBCs and on one example of STEM+S RBCs. STUDY DESIGN AND METHODS:Standard hemagglutination testing was performed with two sera that agglutinated DIIIa RBCs on our in-house antibody identification panel. DNA-based assays were performed on selected samples. RESULTS:RBCs with the DIIIa (n = 31), DOL (n = 5), or RN (n = 10) phenotype were agglutinated by both sera, as were RBCs from one STEM+S person. Reactivity with RBCs of either DIIIa or DOL phenotypes was stronger than with RN RBCs and could not be separated by adsorption and elution. CONCLUSION:An antibody, anti-DAK, which recognizes a novel low-incidence antigen that is more strongly expressed on DIIIa and DOL RBCs than on RN RBCs is described. The antibody agglutinated RBCs from 4 percent of D+ African American blood donors in New York. The antigen, DAK, has been assigned the ISBT number RH54 (004.054).

journal_name

Transfusion

journal_title

Transfusion

authors

Reid ME,Storry JR,Sausais L,Tossas E,Rios M,Hue-Roye K,Gloster ES,Miller ST,Wolf C,Lomas-Francis C

doi

10.1046/j.1537-2995.2003.00517.x

subject

Has Abstract

pub_date

2003-10-01 00:00:00

pages

1394-7

issue

10

eissn

0041-1132

issn

1537-2995

pii

517

journal_volume

43

pub_type

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