Antigen-mediated effects on epithelial function.

Abstract:

:In summary, immediate hypersensitivity reactions to luminal antigens occur in the intestine and result in pathophysiology including increased permeability and ion secretion. The mechanism involves activation of mast cells with neural amplification (FIG. 5). Released mediators/neurotransmitters may act independently or synergistically on the epithelium to elicit Cl ion secretion. In addition, a cyclooxygenase product of arachidonic acid metabolism, possibly of mesenchymal cell origin, may be a common mediator. However, additional effector cell(s) besides mast cells are undoubtedly involved. This system demonstrates undeniably the concept of neuro-immuno-physiology of gut mucosa.

journal_name

Ann N Y Acad Sci

authors

Perdue MH,Kosecka U,Crowe S

doi

10.1111/j.1749-6632.1992.tb39771.x

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

325-34

eissn

0077-8923

issn

1749-6632

journal_volume

664

pub_type

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