Abstract:
:Gene therapy raised euphoric expectations in the past that have yet to be met and have even been lowered due to the absence of concrete clinical successes and the occurrence of some tragic incidents. In spite of the great future potential of gene therapy, numerous pilot studies in this field will probably be discontinued for a long time. However, despite these failures, diseases will continue to be the aim of gene transfer studies with experimental protocols using only temporary gene expression or those restricted to individual organs and thus requiring only a low dose of the vehicle (vector). The eye is exceptionally well suited as a potential target organ because of its good and selective accessibility, low volume and the resultant low number of gene ferries required as well as its special immunological status. The prognosis of corneal grafting can be improved and profit from the methods catalogue of gene transfer protocols. Moreover, the cornea can be used for ex vivo gene transfer before grafting. Ophthalmology could thus occupy a pioneer position in clinical gene transfer. A survey of the literature describes the current state of experimental improvement in corneal grafting, the effect on scarring, neovascularization, and herpetic corneal infection. The essential problem of gene therapy is the unsatisfactory gene transfer technique. Difficulties and current improvements are discussed.
journal_name
Klin Monbl Augenheilkdjournal_title
Klinische Monatsblatter fur Augenheilkundeauthors
Hoffmann F,Junghans Cdoi
10.1055/s-2003-44610subject
Has Abstractpub_date
2003-11-01 00:00:00pages
731-7issue
11eissn
0023-2165issn
1439-3999journal_volume
220pub_type
杂志文章,评审abstract::Among the 185 retinoblastoma patients seen at the Lausanne Retinoblastoma Clinic from 1963-1993, 24 (14%) first presented with another sign than classical leukocoria (60.5%) or strabismus (21.5%). Most of these atypical signs were related to inflammatory complications of unrecognized retinoblastoma; they consisted of ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1035546
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND:The present study investigates how often a simultaneous fluorescein and indocyanine green (ICG) angiography had therapeutic consequences and if it is useful as a clinical routine diagnostic tool. PATIENTS AND METHODS:502 consecutive simultaneous angiographies in eyes with exudative macular degeneration were...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2005-858011
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:The use of prisms and cover is the established clinical method to measure eye alignment, the accuracy of which may reach 0.5 degree (1 cm/m). By contrast, there are contradictory recommendations in the literature regarding the measurement with corneal reflections. The purpose of the study was to present a sy...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1034681
更新日期:1999-08-01 00:00:00
abstract:PATIENTS:Since Mai 1991 we performed a total of 17 endonasal dacryocystorhinostomies under transillumination of the lacrimal sac on 15 patients with lacrimal obstruction aged 11 to 88 years. 11 patients with 12 operations were followed up between 40 and 393 days (mean of 5.6 months). RESULTS:In all cases the connectio...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1994-05-01 00:00:00
abstract::These techniques are used in far-advanced cases of glaucoma when the campimetric method is not practicable due to a considerable loss of visual field. The patient takes a mixture of glycerol and ascorbic acid as a hypotensive agent, his visual field or visual acuity and intraocular pressure are checked every 30 minute...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1055143
更新日期:1982-06-01 00:00:00
abstract::In 20 cases of herpes simplex keratitis the efficacy of Vidarabin ointment has been tested, in 19 cases after corneal abrasion. The eyes were treated once a day and padded until the epithelial defects had closed. Thereafter the ointment was applied 4 times per day for about one week more. On the average epithelial clo...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 临床试验,杂志文章
doi:
更新日期:1978-02-01 00:00:00
abstract::A cases of Pyoderma vegetans attacking only the outer skin of the eyelid and leaving free the conjunctiva is reported. The diagnosis of this rare condition, belonging to the pemphigus diseases, depends on clinical course and especially on histological investigation. The aetiology of Pyoderma vegetans still remains unk...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1978-08-01 00:00:00
abstract::Biological, rather then purely technical approach seems to be very essential to ensure better results in alloplasty of the cornea. The diseased corneal tissue (especially, after corneal burns) usually fails to accept a keratoprosthesis permanently. The cornea must, therefore, be biologically reconstructed by transplan...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1976-05-01 00:00:00
abstract::Intraocular pressure (IOP) of 617 eyes was measured with both an AO non-contact tonometer (NCT) and a Goldmann applanation tonometer (GAT). - Statistical evaluation and the scattergram gave the following results: Correlation coefficient r = 0.74. Regression line y = 3.01 + 0.8x. Close agreement between mean GAT (17.8 ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1057700
更新日期:1980-11-01 00:00:00
abstract:BACKGROUND:The ongoing and fast evolution of foldable IOL designs established the necessity to evaluate the different abilities of each lens style. The large IOL database (over 16,500 specimens) acquired in our laboratory, has permitted us to perform a clinico-pathological analysis on pseudophakic autopsy globes provid...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2001-18386
更新日期:2001-10-01 00:00:00
abstract::Intravenously administered nitroglycerin lowers intraocular pressure both in glaucoma patients and healthy subjects. The effect is dose-related. The use of the drug in ocular hypotensive therapy before and after surgery is suggested. Nitrates administered orally (isosorbide dinitrate 2 x 40 mg daily, depot form) bring...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1057647
更新日期:1980-09-01 00:00:00
abstract:INTRODUCTION:Prevention of cardiovascular disease is an important goal in clinical medicine and public health. In the process, the diagnosis of early end-organ damage is a priority beside the treatment of classic cardiovascular risk factors. To achieve this, the ophthalmoscopic examination of the retinal vessels plays ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-0031-1273199
更新日期:2011-11-01 00:00:00
abstract::Applanation tonometry has been the gold standard in clinical ophthalmology for more than fifty years. The most popular factor is central corneal thickness that is now routinely considered in glaucoma management. However, other individual features of the cornea can also play a key role for the interpretation of the app...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章,评审
doi:10.1055/s-0029-1246037
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:A high corneal astigmatism limits the attainable visual acuity and the ability of correction with spectacles or contact lenses. The astigmatism can also be an impairment for visual rehabilitation, especially after penetrating keratoplasty. A pseudohakic toric intraocular lens (T-IOL) can correct high corneal...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章,评审
doi:10.1055/s-0029-1246046
更新日期:2011-08-01 00:00:00
abstract:PURPOSE:Today, for the preparation of donor and recipient cornea during keratoplasty either single-use or reusable metal trephines are commonly used although excimer and femtosecond laser systems are available. Due to the surgical techniques as well as the configuration of metal trephine's cutting edge irregular cornea...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2005-858661
更新日期:2005-09-01 00:00:00
abstract:INTRODUCTION:Advances in the area of information technology have opened up new possibilities for the use of interactive media in the training of medical students. Classical instructional technologies, such as video, slides, audio cassettes and computer programs with a textbook orientation, have been merged into one mul...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1996-05-01 00:00:00
abstract:INTRODUCTION:Numerous studies on the operative therapy for lagophthalmos exist. Reports about postoperative results, however, are rare and most studies include just a small number of patients. Additionally, since 1999a flexible platinum chains has been available as an alternative to the rigid gold implant. The authors ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2007-963790
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND:A major focus of our study was to determine the value of postoperative intraocular pressure (IOP) in predicting the outcome of trabeculectomy (TE). PATIENTS AND METHODS:The medical charts of 547 patients undergoing glaucoma filtering surgery at the Department of Ophthalmology of the University of Cologne fr...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2000-10376
更新日期:2000-07-01 00:00:00
abstract::A 52-year-old woman contracted a serious influenza; three weeks later a dropshaped patch, whitish-yellow in color and deeply vascularized, was seen on the posterior upper surface of the cornea of one eye. It was accompanied by an anterior uveitis. The Tyndall phenomenon was positive. The sensibility of the upper quadr...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1054449
更新日期:1984-03-01 00:00:00
abstract::On the basis of data collected over a period of 22 years from 376 patients enucleated at the Eye Clinic of Karl Marx University, Leipzig because of malignant choroidal melanoma, the prognostic significance and reliability of various histopathological characteristics was investigated. The most significant characteristi...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1050116
更新日期:1988-04-01 00:00:00
abstract::We report on the pathomorphological findings in the optical system, including the ocular muscles, of a girl who died at the age of 15 of subacute necrotizing encephalomyelopathy (Leigh). The first symptom of the disease, which was caused by respiratory insufficiency, was the alteration in visual function seven-and-a-h...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1057239
更新日期:1981-06-01 00:00:00
abstract::In 300 cases the effectiveness of the long-acting anesthetic Meaverin-ultra for retrobulbar anesthesia was systematically investigated. The duration of analgesis and immobilisation for the globe as well as for the eyelids runs over hours; they are considerabley more effective than with other common local anesthetics s...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1977-09-01 00:00:00
abstract:OBJECTIVE:Comparison of retinal neovascularizations of the disc (NVD) and elsewhere (NVE) in optical coherence tomography angiography (OCTA) and fluorescein angiography (FA) in patients with proliferative diabetic retinopathy. MATERIALS AND METHODS:15 consecutive patients were included in this study. All patients rece...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/a-0983-2271
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:The aim of this study is to report the feasibility of one to two weeks delayed reconstruction after eyelid tumor excision. PATIENTS AND METHODS:A retrospective case-series study was designed. Fourteen consecutive outpatients referred to a tertiary referral eye center for eyelid tumor management were enrolle...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-0031-1299208
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:The short-term impact of eye muscle surgery on the blood-aqueous barrier has been described by iris fluoresceinangiography and laser tyndallometry. The aim of this study was to investigate the long-term effects of eye muscle surgery on the oxygen supply of the anterior segment of the eye by determination of ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2007-962981
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND:Myelodysplastic syndrome is a clonal disease of the hematopoetic system characterized by insufficiency of affected bone marrow cell lines. After long-term course of myelodysplastic syndrome an acceleration towards acute myeloic leukemia is a frequent finding. Involvement of the eye is a well known phenomenon...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1034944
更新日期:1998-07-01 00:00:00
abstract::Background Until now, many studies have investigated the link between motor development and visual-spatial abilities in infancy and childhood. Most of these studies found evidence that there is such a link in typically developing children or children with locomotor delay. Only a few studies have tested the consequence...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-0043-118831
更新日期:2017-10-01 00:00:00
abstract::A study is presented of a case of serous detachment of the mucula secondary to congenital pit of the optic disc. We observed during fluorescein angiography a late leakage of dye at the temporal margin of the disc. A lasercoagulation of this lesion gave a favourable result. All these findings support Gass' explanation ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1977-12-01 00:00:00
abstract:BACKGROUND:Earlier studies in monkeys have shown that latanoprost 0.005% lowers the IOP by improving the uveoscleral Outflow. We wanted to know if this is also the case in the human eye. PATIENTS AND METHODS:We used our new aqueous humor outflow test with 2-nitrophenyl-acetate in 9 healthy human volunteers, mean age 3...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1034877
更新日期:1998-05-01 00:00:00
abstract::The conjunctivae of nine rabbits of the same breed were used to compare the local compatibility of the Endorfer Jod-Thermalsole with that of a physiological NaCl solution. The neuroleptanalgesics were administered using perfusion techniques. The reddening thus caused was used to measure the degree of inflammation. The...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1055295
更新日期:1981-01-01 00:00:00