Noradrenaline levels rise significantly in rat arterial grafts at 6 hours postoperatively, and take 48 hours to come down.

Abstract:

:The aim of this study was to investigate the rate of disappearance of noradrenaline in arterial grafts after their transplanation. Arterial grafts were harvested from AO/Ks:OC strain rats. In each rat, a graft was harvested from the femoral artery and transplanted into the common carotid artery. A contralateral unoperated femoral artery served as control. High-performance liquid chromatography (HPLC) with electrochemical detection was used to determine the noradrenaline content in grafts and controls. Immediately after grafting, the noradrenaline content was 76% of control value, at 6 h 130% of control value, and at 48 h 4% of control value. The drop in graft noradrenaline content (from 0-48 h) was statistically significant (P = 0.005). The difference between 0-h, 12-h, and 24-h groups was statistically insignificant. Compared to control specimens, grafts contained less noradrenaline after 12 h, and it disappeared almost completely from femoral arterial grafts in rats within 48 h.

journal_name

Microsurgery

journal_title

Microsurgery

authors

Penttilä H,Huttunen P,Von Smitten K,Waris T,Ashammakhi N

doi

10.1002/micr.20004

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

139-42

issue

2

eissn

0738-1085

issn

1098-2752

journal_volume

24

pub_type

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