Abstract:
:The Arg-Gly-Asp (RGD) peptide sequence was conjugated to poly (lactid acid), (PLA), microcapsules. These hollow, biodegradable PLGA microcapsules were developed in our laboratory for use as ultrasound contrast agents. By modifying the surface of the agent with a targeting ligand, it can be targeted to a specific address within the body. This application is ideal for both targeted imaging and/or targeted drug delivery. Integrins are membrane-spanning proteins in cells that play a vital role in cell attachment and many other processes. The RGD peptide sequence targets integrins expressed during angiogenesis, alphavbeta3 and alphavbeta5. The integrins specific to angiogenesis are more active during cancer and can be used as receptors for the RGD-conjugated contrast agents. Although the generic RGD sequence is not specific to only alphavbeta3 and alphavbeta5 integrins, it is an excellent candidate for proof of concepts studies such as described here. Preliminary in vitro results indicate that the modified capsules remain highly echogenic (maximum enhancement of 20 dB in vitro) and adhere specifically to a breast cancer cell line MDA-MB-231 in static experiments. However, no adherence is seen with either unmodified capsules (negative control), or when cells that have been pre-saturated with RGD ligand are contacted with modified capsules (positive control). Specific targeting of ultrasound contrast agents could lead the way to imaging as a method for discrimination of malignant from benign.
journal_name
Ultrasonicsjournal_title
Ultrasonicsauthors
Lathia JD,Leodore L,Wheatley MAdoi
10.1016/j.ultras.2003.12.018subject
Has Abstractpub_date
2004-04-01 00:00:00pages
763-8issue
1-9eissn
0041-624Xissn
1874-9968pii
S0041624X03002294journal_volume
42pub_type
杂志文章相关文献
ULTRASONICS文献大全abstract::Ultrasonic vibration has been observed to lower the flow stress necessary to initiate plastic deformation, a phenomenon known as "acoustic softening". This unique effect of ultrasound has been extensively applied in welding, machining, forming of metals, and ultrasonic additive manufacturing to lower the yield stress ...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2019.106005
更新日期:2020-03-01 00:00:00
abstract::Estimation of the attenuation is important in medical ultrasound not only for correct time-gain compensation but also for tissue characterization. In this paper, the feasibility of a new method for attenuation estimation is tested. The proposed method estimates the attenuation by repeatedly solving the forward wave pr...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2017.10.008
更新日期:2018-03-01 00:00:00
abstract::The microwave ablation has become an important manner for tumor treatment. In this paper, we proposed a new method for evaluation of microwave-induced thermal lesions using the wavelet analysis of the mean scatterer spacing (MSS). First, the ultrasonic radiofrequency (RF) data of normal and coagulated porcine liver ti...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2013.03.018
更新日期:2013-09-01 00:00:00
abstract::An eight-channel ultrasonic detecting device for microbiological quality evaluation of packed liquid foods is presented in this paper. This device makes possible a non-invasive detection of the microbial growth in liquid foods with no need to open the carton-based packages where they are contained. Thermal and humidit...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2006.07.011
更新日期:2006-12-01 00:00:00
abstract::Reflections of 4 MHz ultrasound pulses from 60 sites on 15 human aorta specimens were analysed using the plane-wave Born approximation (PWBA) inverse scattering method. The recovered high-resolution acoustic impedance profile for each site was correlated with an analysis (by microscope) of sections taken from that sit...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/0041-624x(95)00025-x
更新日期:1995-07-01 00:00:00
abstract::The electromagnetic acoustic transducers (EMATs) with a meander-line coil possess the capability of generating Lamb waves carrying multiple wavelengths, and the characteristics of multiple wavelengths is analyzed by developing a spatial transversal filter model for the EMAT. It is shown that the characteristics is due...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2013.09.003
更新日期:2014-02-01 00:00:00
abstract::To improve the integrated performance of a representative bimodal linear ultrasonic motor under continuous operation, this paper proposes a novel dual-frequency asymmetric excitation method for such motors which can operate under traditional single-phase asymmetric or two-phase symmetric excitation modes. In particula...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2020.106224
更新日期:2020-12-01 00:00:00
abstract::This paper presents a study on topology optimization of novel material microstructural configurations to achieve directional elastic wave propagation through maximization of partial band gaps. A waveguide incorporating a periodic-microstructure material may exhibit different propagation properties for the plane elasti...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2017.07.006
更新日期:2018-01-01 00:00:00
abstract::For coupled structures surrounded by heavy fluids, it is difficult to obtain dispersion curves from an eigenvalue analysis, because the external fluid term in the coupled equation includes transcendental functions for frequency and wavenumber. Thus, in this study, the acoustic mass of the external fluid was approximat...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2017.12.009
更新日期:2018-04-01 00:00:00
abstract::The acousto-optic interaction with leaky surface acoustic wave radiation into the bulk of YX-cut LiTaO(3) crystals has been investigated. The light incidence and diffraction angles corresponding to the strongest acousto-optic interaction were calculated and measured as functions of the acoustic wave frequency. The dep...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2011.12.004
更新日期:2012-07-01 00:00:00
abstract::This paper presents an original experimental and numerical investigation of acoustic streaming driven by an acoustic beam reflecting on a wall. The water experiment features a 2 MHz acoustic beam totally reflecting on one of the tank glass walls. The velocity field in the plane containing the incident and reflected be...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2016.02.003
更新日期:2016-05-01 00:00:00
abstract::This paper focuses on transmission characteristics of fundamental symmetric Lamb mode (So) at the junction of a main waveguide and sub-waveguides in composite laminates. Numerical simulations on transmission of So from the main to sub-waveguide revealed that transmission factors of the modes depend on stacking sequenc...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2015.08.003
更新日期:2016-01-01 00:00:00
abstract::The study is aimed to perform dynamic modeling of a part feeder powered by piezoelectric actuation. This part feeder consists mainly of a horizontal platform vibrated by a pair of parallel piezoelectric bimorph beams. Owing to intermittent impacts with the platform, the transported part on the platform is able to marc...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2007.02.002
更新日期:2007-06-01 00:00:00
abstract::Ultrasonic insertion technique (IT) is an ultrasonic technique which involves sample immersion in a solution to determine its acoustic properties. IT is normally used to determine the acoustic properties of a medical phantom. We proposed the use of IT as an alternative technique to the common contact ultrasonic techni...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2016.11.025
更新日期:2017-03-01 00:00:00
abstract::For medical high frequency acoustic imaging purposes the reduction in size of a single transducer element for one-dimensional and even more for two-dimensional arrays is more and more limited by fabrication and cabling technology. In the fields of industrial distance measurement and simple object recognition low cost ...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/s0041-624x(99)00085-2
更新日期:2000-03-01 00:00:00
abstract::In this paper a high intensity focused ultrasound (FUS) phantom model was developed, in order to be used in experiments for Blood Brain Barrier (BBB) disruption. The target was to create a phantom model that represents the disruption of the BBB during ultrasound application. An appropriate experimental setup was creat...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2020.106244
更新日期:2021-02-01 00:00:00
abstract::Sonic crystals are artificial structures consisting of a periodic array of acoustic scatterers embedded in a homogeneous matrix material, with a usually large impedance mismatch between the two materials. They exhibit strong sound attenuation at selective frequency bands due to the interference of multiply reflected w...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2004.01.014
更新日期:2004-04-01 00:00:00
abstract::Interference noising originating from the ultrasonic testing defect signal seriously influences the accuracy of the signal extraction and defect location. Time-frequency analysis methods are mainly used to improve the defects detection resolution. In fact, the S-transform, a hybrid of the Short time Fourier transform ...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2013.09.004
更新日期:2014-02-01 00:00:00
abstract::An ultrasonic method of acoustic parameter evaluation for porous materials saturated by air (or any other gas) is discussed. The method is based on the evolution of speed of sound and the attenuation inside the material when the static pressure of the gas saturating the material is changed. Asymptotic development of t...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/s0041-624x(00)00062-7
更新日期:2001-04-01 00:00:00
abstract::This paper presents the influence of ultrasonic beam ray refraction effect on the internal object structure imaging using the ultrasound transmission tomography method (UTT), in parallel ray projection geometry, for ultrasonic pulse run-time measurements. Simulation calculations carried out using specially elaborated ...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/s0041-624x(99)00137-7
更新日期:2000-03-01 00:00:00
abstract::We have developed an ultrasonic array sensor useable for locating air leaks in manned spacecraft and have found that this sensor locates leaks in a 1-m(2) plate to within 2 cm. The sensor consists of a 63-element multiplexed array plus a reference element, all constructed from a single PZT disc and a printed circuit b...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2006.07.020
更新日期:2006-12-01 00:00:00
abstract::The profiles of an acoustic field and electric potential of the forward and backward shear-horizontal (SH) acoustic waves of a higher order propagating in X-Y potassium niobate plate have been theoretically investigated. It has been shown that by changing electrical boundary conditions on a surface of piezoelectric pl...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2018.01.010
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND AND MOTIVATION:Previous works investigating the radiation force of diverging spherical progressive waves incident upon spherical particles have demonstrated the direction of reversal of the force when the particle is subjected to a curved wave-front. In this communication, the analysis is extended to the cas...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2010.12.004
更新日期:2011-07-01 00:00:00
abstract::Accurate characterization of the characteristic dimensions of a periodically corrugated surface using ultrasonic imaging technique is investigated both theoretically and experimentally. The possibility of accurately characterizing the characteristic dimensions is discussed. The condition for accurate characterization ...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2012.12.006
更新日期:2013-04-01 00:00:00
abstract::In the food industry, ultrasonic cutting is used to improve separation by a reduction of the cutting force. This reduction can be attributed to the modification of tool-workpiece interactions at the cutting edge and along the tool flanks because of the superposition of the cutting movement with ultrasonic vibration of...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2009.03.001
更新日期:2009-06-01 00:00:00
abstract::Arterial stiffness has been shown to be a good indicator of arterial wall disease. However, a single parameter is insufficient to describe the complex stress-strain relationship of a multi-component, non-linear tissue such as the aorta. We therefore propose a new approach to measure the stress-strain relationship loca...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2010.01.003
更新日期:2010-06-01 00:00:00
abstract::Ultrasonic modes guided along the surface of a concrete block covered by a composite plate are investigated. First of all, the propagation phenomenon is studied by predicting the dispersion curves for various modes supposed to exist in this structure. Then, focus is made on a specific mode expected to be sensitive to ...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2004.01.074
更新日期:2004-04-01 00:00:00
abstract::The propagation of thickness shear waves in a periodically corrugated quartz crystal plate is investigated in the present paper using a power series expansion technique. In the proposed simulation model, an equivalent continuity of shear stress moment is introduced as an approximation to handle sectional interfaces wi...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2017.02.004
更新日期:2017-05-01 00:00:00
abstract::As biotechnology develops, techniques for manipulating and separating small particles such as cells and DNA are required in the life sciences. This paper investigates on-chip manipulation of microparticles in small channels by using ultrasonic vibration. The chip consists of a rectangular glass substrate with a cross-...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2016.11.026
更新日期:2017-08-01 00:00:00
abstract::Most methods used to measure the thickness of thin liquid or solid surface films and coatings need access to the coated surface. In this work reflected ultrasonic pulses were used to measure a coating thickness from a solid back face. Piezoelectric transducers on the solid back face emitted ultrasound waves and receiv...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2020.106291
更新日期:2021-02-01 00:00:00