Light deprivation slows but does not prevent the loss of photoreceptors in taurine transporter knockout mice.

Abstract:

UNLABELLED:Taurine transporter knockout mice show severe retinal degeneration at an early age. The study was designed to determine whether degeneration also takes place in the absence of light. Mice were maintained up to 6 weeks of age in cyclic lighting or in total darkness. Degeneration took place in both groups, but was more rapid in animals exposed to standard cyclic illumination. At the ultrastructural level the retinas showed features characteristic of apoptosis but not of necrosis. CONCLUSIONS:Cell differentiation is not seriously affected by the lack of a functional taurine transporter but mature photoreceptor cells do not survive without an intact transporter, even in the dark.

journal_name

Vision Res

journal_title

Vision research

authors

Rascher K,Servos G,Berthold G,Hartwig HG,Warskulat U,Heller-Stilb B,Häussinger D

doi

10.1016/j.visres.2004.03.027

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

2091-100

issue

17

eissn

0042-6989

issn

1878-5646

pii

S0042698904001555

journal_volume

44

pub_type

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