Abstract:
UNLABELLED:Taurine transporter knockout mice show severe retinal degeneration at an early age. The study was designed to determine whether degeneration also takes place in the absence of light. Mice were maintained up to 6 weeks of age in cyclic lighting or in total darkness. Degeneration took place in both groups, but was more rapid in animals exposed to standard cyclic illumination. At the ultrastructural level the retinas showed features characteristic of apoptosis but not of necrosis. CONCLUSIONS:Cell differentiation is not seriously affected by the lack of a functional taurine transporter but mature photoreceptor cells do not survive without an intact transporter, even in the dark.
journal_name
Vision Resjournal_title
Vision researchauthors
Rascher K,Servos G,Berthold G,Hartwig HG,Warskulat U,Heller-Stilb B,Häussinger Ddoi
10.1016/j.visres.2004.03.027subject
Has Abstractpub_date
2004-01-01 00:00:00pages
2091-100issue
17eissn
0042-6989issn
1878-5646pii
S0042698904001555journal_volume
44pub_type
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