Abstract:
:For the sub-chronic toxicity an aqueous preparation of Plantago major leaves was tested in 20 male NGP mice, with an average weight of 20.15 g and separated in two groups of ten individuals each. The dose used was 2000 mg/kg and the control group received 0.5 ml of distilled water. The extract administration was done daily during five days at week for a total period of 40 days. Signs of sub-chronic toxicity were observed in the days two and 12 of treatment. No significant change in corporal weight was observed. The ocular irritation was tested in five New Zeland male rabbits, with an average weight of 3.640 kg. The dose used was a 200 microliters the preparation (100 mg/ml) of Plantago major leaves, instill into the right eye and the control was used the left eye instill 200 microliters of distilled water. The administration was done daily during five days. The extract shows no significant irritation during the observation period.
journal_name
Rev Biol Tropjournal_title
Revista de biologia tropicalauthors
García González M,Coto Morales T,Soto Rodríguez GA,Pazos Lsubject
Has Abstractpub_date
2003-09-01 00:00:00pages
635-8issue
3-4eissn
0034-7744issn
2215-2075journal_volume
51pub_type
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journal_title:Revista de biologia tropical
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