Abstract:
:Tuberous sclerosis (TS) is caused by point mutations in the TSC1 or TSC2 genes on chromosomes 9q33-34 or 16p13, respectively. Clinical manifestations can be quite variable but are primarily limited to cutaneous, neurologic, and cardiovascular abnormalities. Phenotypes range from neurologically devastated to those with silent lesions. A 34-year-old patient with genetically documented TSC1 developed progressive ataxia over a decade, without TS lesions to correlate with this finding. After evaluation of common causes including long-term antiepileptic regimens, DNA testing for hereditary ataxias was performed and revealed the presence of an additional mutation on chromosome 9. The patient was homozygous for the Friedreich ataxia (FA) mutation, with 500 and 700 GAA repeats in the FRDA gene on chromosome 9q13. There is no established relationship between these two disorders and the occurrence of two mutations on the same chromosome is probably coincidental but emphasizes the importance of searching for additional genetic causes when the phenotype does not fit with an established genetic diagnosis.
journal_name
J Neurol Scijournal_title
Journal of the neurological sciencesauthors
Walker M,Samii A,Bird Tdoi
10.1016/j.jns.2004.02.009subject
Has Abstractpub_date
2004-06-15 00:00:00pages
91-3issue
1-2eissn
0022-510Xissn
1878-5883pii
S0022510X04000383journal_volume
221pub_type
杂志文章abstract::The present single center, double-blind, delayed start study was conducted to examine possible symptomatic and disease-modifying effects of GM1 ganglioside in Parkinson's disease (PD). Seventy-seven subjects with PD were randomly assigned to receive GM1 for 120 weeks (early-start group) or placebo for 24 weeks followe...
journal_title:Journal of the neurological sciences
pub_type: 杂志文章,随机对照试验
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更新日期:2013-01-15 00:00:00
abstract:UNLABELLED:Riluzole is currently the only drug that holds any hope of prolonging life in amyotrophic lateral sclerosis (ALS) by slowing the rate of disease progression. METHODS AND RESULTS:Between 1995 and 1997 a total of 7916 ALS patients in 39 countries, were given 100 mg riluzole per day for a mean of 7.2 months. T...
journal_title:Journal of the neurological sciences
pub_type: 临床试验,杂志文章,多中心研究
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pub_type: 杂志文章
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journal_title:Journal of the neurological sciences
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更新日期:2000-09-15 00:00:00
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更新日期:2015-04-15 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1980-03-01 00:00:00
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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更新日期:1989-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:1985-05-01 00:00:00