Nimodipine does not affect the cerebral autoregulatory response in the anesthetized pig.


:The effect of the calcium blocker nimodipine on the cerebral blood flow (CBF) and cerebral autoregulatory responses was examined in seven fentanyl/N2O/anesthetized pigs. CBF was measured continuously from the sagittal sinus by a venous outlet flow technique. Cerebral autoregulation tests were performed before, after 30 min of nimodipine infusion (0.5, and at 30 min after the infusion. The autoregulatory response to a gradual blood pressure increase was tested by infusion of angiotensin, and to a gradual blood pressure decrease was tested by caval block. The slope of the relationship between the regional cerebral vascular resistance (rCVR) and mean arterial blood pressure (MABP) was used as a measure of the autoregulatory capacity. The lower limit of autoregulation was determined as the MABP at which rCVR did not further decrease. An i.v. bolus dose (10 of nimodipine resulted in a transient increase in rCBF during 3 min, together with an MABP reduction. After 1 h of nimodipine infusion, MABP was reduced (19%), while rCBF, rCVR, and cerebral metabolism were unaffected. In the control condition, a preserved cerebral autoregulatory response to the increase of MABP (+30 mm Hg) was indicated by an unaffected rCBF and determined by the slope of the rCVR/MABP regression line (0.053), not different from the slope during blood pressure decrease (0.063). The cerebral autoregulatory responses to increase or decrease in MABP were not attenuated by nimodipine infusion. The lower limit of autoregulation (48 +/- 6 mm Hg) was not altered by nimodipine.


Stånge K,Lagerkranser M,Sollevi A




Has Abstract


1994-04-01 00:00:00












  • A randomized, double-blinded comparison of ondansetron, granisetron, and placebo for prevention of postoperative nausea and vomiting after supratentorial craniotomy.

    abstract::Postoperative nausea and vomiting (PONV) are frequent and distressing complications after neurosurgical procedures. We evaluated the efficacy of ondansetron and granisetron to prevent PONV after supratentorial craniotomy. In a randomized double-blind, placebo controlled trial, 90 adult American Society of Anesthesiolo...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章,随机对照试验


    authors: Jain V,Mitra JK,Rath GP,Prabhakar H,Bithal PK,Dash HH

    更新日期:2009-07-01 00:00:00

  • Effect of isoflurane-induced hypotension on cerebral autoregulation in the anesthetized pig.

    abstract::The influence of isoflurane-induced hypotension on regional cerebral blood flow (rCBF) and cerebrovascular autoregulation was evaluated in 11 normocapnic pigs during anesthesia comprising fentanyl and nitrous oxide in oxygen. rCBF was determined as sagittal sinus outflow and recorded continuously by an electromagnetic...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章


    authors: Stånge K,Lagerkranser M,Sollevi A

    更新日期:1990-06-01 00:00:00

  • Seizures in the adult intensive care unit.

    abstract::Seizures are a common occurrence in the intensive care unit (ICU). The presentation of seizures is usually as focal or generalized motor convulsions, but other seizure types may occur. Etiologies of the seizures are typically secondary either to primary neurologic pathology or a consequence of critical illness and cli...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章,评审


    authors: Varelas PN,Mirski MA

    更新日期:2001-04-01 00:00:00

  • Unrecognized internal jugular vein obstruction: cause of fatal intracranial hypertension after tracheostomy?

    abstract::We report an unusual case of fatal intracranial hypertension following tracheostomy due to the obstruction of the internal jugular veins (left side: thrombosis after central venous cannulation, right side: hypoplastic vein) and their collaterals. Principal cerebral outflow through the internal jugular veins can be sub...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章


    authors: Schummer W,Schummer C,Niesen WD

    更新日期:2002-10-01 00:00:00

  • Influence of patient variables and sensor location on regional cerebral oxygen saturation measured by INVOS 4100 near-infrared spectrophotometers.

    abstract::Cerebral oximeter based on near-infrared spectroscopy has been used as a continuous, noninvasive monitoring of regional cerebral oxygen saturation (rSO2). Although the absolute rSO2 values have a wide range of variability, the factors affecting a variability of rSO2 values have not been extensively investigated. The a...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章


    authors: Kishi K,Kawaguchi M,Yoshitani K,Nagahata T,Furuya H

    更新日期:2003-10-01 00:00:00

  • Recurrent bradycardia and delayed recovery in a neonate following repair of nasofrontal encephalocoele with holoprosencephaly and single cerebral ventricle.

    abstract::Holoprosencephaly and single cerebral ventricle are uncommon congenital anomalies that are associated with a high rate of perinatal mortality. We describe a neonate who developed recurrent bradycardia along with delayed recovery following frontal craniotomy for the repair of a nasofrontal encephalocoele associated wit...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章


    authors: Bharti N,Dash HH,Mahapatra AK

    更新日期:2003-04-01 00:00:00

  • Comparison of the Effects of Propofol and Sevoflurane Combined With Remifentanil on Transcranial Electric Motor-evoked and Somatosensory-evoked Potential Monitoring During Brainstem Surgery.

    abstract:BACKGROUND:We compared the effect of propofol and sevoflurane combined with remifentanil under comparable bispectral index (BIS) levels on transcranial electric motor-evoked potentials (TceMEPs) and somatosensory-evoked potentials (SSEPs) during brainstem surgery. MATERIALS AND METHODS:A total of 40 consecutive patien...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章,随机对照试验


    authors: Hernández-Palazón J,Izura V,Fuentes-García D,Piqueras-Pérez C,Doménech-Asensi P,Falcón-Araña L

    更新日期:2015-10-01 00:00:00

  • A dose-response study of the influence of propofol on cerebral blood flow, metabolism and the electroencephalogram in the rabbit.

    abstract::This experiment was designed to study the effect of progressively increasing blood propofol concentrations on cerebral blood flow (CBF), cerebral metabolic rate for oxygen (CMRO2), and the electroencephalogram (EEG). Nine New Zealand White rabbits were anesthetized with morphine (10 mg kg bolus and 2 mg/kg/h infusion)...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章


    authors: Ramani R,Todd MM,Warner DS

    更新日期:1992-04-01 00:00:00

  • Brain tissue oxygen monitoring for assessment of autoregulation: preliminary results suggest a new hypothesis.

    abstract::Brain tissue oxygen monitoring (P(ti)O2 (Neurotrend, Codman, Germany) was employed in addition to standard intracranial pressure (ICP) and cerebral perfusion pressure (CPP) monitoring in seven patients with severe neuronal damage of heterogeneous etiology. The correlation between P(ti)O2 changes and CPP fluctuations d...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 临床试验,杂志文章


    authors: Menzel M,Soukup J,Henze D,Clausen T,Marx T,Hillman A,Miko I,Grond S,Rieger A

    更新日期:2003-01-01 00:00:00

  • Epidural hematoma after cervical spine surgery.

    abstract::The authors report an acute epidural hematoma after the surgical removal of a cervical C6-C7 disc herniation through an anterolateral approach of the cervical spine. Clinical history consisted of respiratory distress and flaccid tetraplegia that appeared 2.5 hours after surgery. Without any complementary radiologic in...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章


    authors: Hans P,Delleuze PP,Born JD,Bonhomme V

    更新日期:2003-07-01 00:00:00

  • Incidence and clinical significance of hemidiaphragmatic paresis in patients undergoing carotid endarterectomy during cervical plexus block anesthesia.

    abstract::This study was designed to investigate the incidence and clinical consequences of hemidiaphragmatic paresis in patients undergoing carotid endarterectomy using cervical plexus block anesthesia. In 28 patients, diaphragmatic motion was evaluated by fluoroscopy 20 min after cervical plexus block with 1% mepivacaine. In ...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章


    authors: Castresana MR,Masters RD,Castresana EJ,Stefansson S,Shaker IJ,Newman WH

    更新日期:1994-01-01 00:00:00

  • Manually controlled total intravenous anesthesia augmented by electrophysiologic monitoring for complex stereotactic neurosurgical procedures.

    abstract::Stereotactically guided procedures are performed for an ever extending range of conditions. They present a unique anesthetic challenge. In our institution, a standardized anesthetic protocol for total intravenous anesthesia (TIVA) augmented by electrophysiologic monitoring with BIS or AEP monitors was introduced. We c...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章


    authors: Dagtekin O,Berlet T,Delis A,Kampe S

    更新日期:2007-01-01 00:00:00

  • A comparison of auditory evoked potentials derived from a monitor integrated module versus standard technique.

    abstract:PURPOSE:Measurement of brain stem auditory evoked potentials (BAEP) and midlatency auditory evoked potentials (MLAEP) using a new monitor integrated module was compared with an established device. The aim of this study was to evaluate if the new system could replace the more inconvenient established technique. MATERIA...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章


    authors: Fudickar A,Kluzik A,Weiler N,Scholz J,Tonner PH,Bein B

    更新日期:2009-04-01 00:00:00

  • Neonatal Sevoflurane Exposure Induces Adulthood Fear-induced Learning Disability and Decreases Glutamatergic Neurons in the Basolateral Amygdala.

    abstract:BACKGROUND:Neonatal mice exposed to sevoflurane show certain cognitive and behavioral impairments in adulthood. However, the mechanisms underlying long-term cognitive deficits induced by sevoflurane exposure remain unknown. The present study was performed to investigate whether there is differential neuronal activation...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章


    authors: Satomoto M,Sun Z,Adachi YU,Makita K

    更新日期:2018-01-01 00:00:00

  • Sevoflurane versus halothane anesthesia after acute cryogenic brain injury in rabbits: relationship between arterial and intracranial pressure.

    abstract::The relationship between intracranial pressure and arterial blood pressure during sevoflurane or halothane anesthesia was evaluated in New Zealand white rabbits after cryogenic brain injury. Fourteen rabbits were randomized to be anesthetized with 1.5 MAC of sevoflurane or halothane in oxygen. All animals were paralyz...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章


    authors: Kim HK,Zornow MH,Illievich UM,Strnat MA,Scheller MS

    更新日期:1994-10-01 00:00:00

  • Assessing risk factors for postoperative nausea and vomiting: a retrospective study in patients undergoing retromastoid craniectomy with microvascular decompression of cranial nerves.

    abstract::We have observed that patients, after retromastoid craniectomy (RMC) with microvascular decompression (MVD) of cranial nerves, frequently experienced postoperative nausea and vomiting (PONV). The authors conducted this study to track the incidence of PONV and to identify potential factors for PONV after RMC with MVD. ...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章


    authors: Meng L,Quinlan JJ

    更新日期:2006-10-01 00:00:00

  • Rapacuronium administration to patients receiving phenytoin or carbamazepine.

    abstract::Patients receiving anticonvulsants such as phenytoin or carbamazepine may be resistant to neuromuscular blocking agents. The authors report the response to rapacuronium bromide (1.5 mg/kg) in two adult patients; one receiving phenytoin and the other receiving carbamazepine. In both patients, there was a delay in achie...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章


    authors: Tobias JD,Johnson JO

    更新日期:2001-07-01 00:00:00

  • Incidence and predictors of bulbar palsy after surgery for acoustic neuroma.

    abstract::We present a retrospective review of the perioperative management and complications of 102 cases of acoustic neuroma operated on at an English teaching hospital over the last 9 years. Nine patients had a bulbar palsy postoperatively; five of those patients developed pulmonary complications. A bulbar palsy was more lik...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 临床试验,杂志文章


    authors: Duane DT,Howard SJ,Kraayenbrink M

    更新日期:1997-07-01 00:00:00

  • Changes in oxygenation variables during progressive hypothermia in anesthetized patients.

    abstract::Because deliberate hypothermia is becoming commonly used during neurosurgery, this study was performed to investigate the effects of a progressive reduction of body core temperature (T) on whole body oxygenation variables in patients undergoing elective intracranial surgery. In 13 patients (Hypothermic Group), T was r...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 临床试验,杂志文章


    authors: Bacher A,Illievich UM,Fitzgerald R,Ihra G,Spiss CK

    更新日期:1997-07-01 00:00:00

  • Effects of Prone Position and Positive End-Expiratory Pressure on Noninvasive Estimators of ICP: A Pilot Study.

    abstract:BACKGROUND:Prone positioning and positive end-expiratory pressure can improve pulmonary gas exchange and respiratory mechanics. However, they may be associated with the development of intracranial hypertension. Intracranial pressure (ICP) can be noninvasively estimated from the sonographic measurement of the optic nerv...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章


    authors: Robba C,Bragazzi NL,Bertuccio A,Cardim D,Donnelly J,Sekhon M,Lavinio A,Duane D,Burnstein R,Matta B,Bacigaluppi S,Lattuada M,Czosnyka M

    更新日期:2017-07-01 00:00:00

  • Transesophageal echocardiography as a guide for patient positioning before neurosurgical procedures in semi-sitting position.

    abstract::With an incidence of a patent foramen ovale in nearly one fourth of the normal population, neurosurgical procedures in the semi-sitting position are associated with the risk of paradoxical air embolism. The present study was undertaken to evaluate an anesthetic concept to detect a patent foramen ovale with the help of...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 临床试验,杂志文章


    authors: Kwapisz MM,Deinsberger W,Müller M,Nopens H,Neuhäuser C,Klasen J,Hempelmann G

    更新日期:2004-10-01 00:00:00

  • Anesthesia for minimally invasive cranial and spinal surgery.

    abstract::The field of minimally invasive neurosurgery has evolved rapidly in its indications and applications over the last few years. New, less invasive techniques with low morbidity and virtually no mortality are replacing conventional neurosurgical procedures. Providing anesthesia for these procedures differs in many ways f...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章,评审


    authors: Schubert A,Deogaonkar A,Lotto M,Niezgoda J,Luciano M

    更新日期:2006-01-01 00:00:00

  • Neuroanesthesiology review-2007.

    abstract::The 2007 literature pertaining to perioperative care of neurosurgical patients contains a wealth of articles. In this review, we provide a synopsis of common themes and unique contributions that are relevant to the care of patients with neurologic disorders who require either neurosurgical intervention or care in a ne...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章,评审


    authors: Pasternak JJ,Lanier WL

    更新日期:2008-04-01 00:00:00

  • Repair of two unruptured intracranial aneurysms in the presence of coarctation of the aorta-anesthetic implications and management.

    abstract::A case of two incidental familial intracranial aneurysms associated with asymptomatic coarctation of the aorta is reported. Priority was assigned to aneurysm surgery, which was accomplished by means of two distinct procedures, both requiring moderate, deliberate hypotension. Invasive monitoring always included radial ...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章


    authors: Orsi P,Rosa G,Liberatori G,Lunardi PP,Ferrante L

    更新日期:1993-01-01 00:00:00

  • The influence of acute and chronic alcohol treatment on brain edema, cerebral infarct volume and neurological outcome following experimental head trauma in rats.

    abstract::The aim of this study was to determine the influence of acute and chronic ethanol treatment on neurological outcome following head trauma in rats. Eight-two Sprague-Dawley rats were divided into 10 groups. Four groups received sham head trauma (surgical incision of the scalp but no trauma) and were treated with (A) no...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章


    authors: Shapira Y,Lam AM,Paez A,Artru AA,Laohaprasit V,Donato T

    更新日期:1997-04-01 00:00:00

  • Assessment of the ECG T-Wave in Patients With Subarachnoid Hemorrhage.

    abstract:BACKGROUND:Prolongation of the interval from the peak to the end of the T wave (Tp-Te) on a 12-lead electrocardiogram (ECG) is associated with ventricular arrhythmias. The aim of this study was to clarify associations between Tp-Te, Tp-Te/QT, and Tp-Te/rate-corrected QT (QTc) with clinical severity of subarachnoid hemo...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章


    authors: Komatsuzaki M,Takasusuki T,Kimura Y,Yamaguchi S

    更新日期:2021-01-01 00:00:00

  • Prostaglandin E1 but not corticosteroid increases nerve root blood flow velocity after lumbar diskectomy in surgical patients.

    abstract::The purpose of this study was to clarify whether prostaglandin E1 (PGE(1)) or corticosteroid could increase blood flow in the nerve root because neurologic symptoms in spinal stenosis may be based on the vascular insufficiency in the nerve root. Fifty-seven patients undergoing lumbar diskectomy were randomly assigned ...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Fukusaki M,Miyako M,Miyoshi H,Takada M,Terao Y,Konishi H,Sumikawa K

    更新日期:2003-04-01 00:00:00

  • Inhibition of cyclooxygenase 2 by nimesulide decreases prostaglandin E2 formation but does not alter brain edema or clinical recovery after closed head injury in rats.

    abstract::Recently, the enzyme cyclooxygenase (COX) has been recognized to exist as constitutive (COX-1) and inducible isoforms (COX-2). In previous studies, drugs that were inhibitors of both COX-1 and COX-2 failed to decrease brain edema formation or improve Neurological Severity Score (NSS) after closed head trauma (CHT), al...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章


    authors: Koyfman L,Kaplanski J,Artru AA,Talmor D,Rubin M,Shapira Y

    更新日期:2000-01-01 00:00:00

  • Epidemiology and Resource Utilization of Simple Febrile Seizure-associated Hospitalizations in the United States, 2003-2012.

    abstract:BACKGROUND:Simple febrile seizure (SFS) affects 2% to 4% of children under 6 years of age. The purpose of this study is to examine the epidemiologic patterns and resource utilization of SFS-associated hospitalizations in children aged younger than 6 years of age in the United States. MATERIALS AND METHODS:This study i...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章


    authors: Huang YY,Li G,Sun LS

    更新日期:2019-01-01 00:00:00

  • Awareness during general anesthesia: analysis of contributing causes aided by automatic data capture.

    abstract::The cause of the awareness under general anesthesia often cannot be definitely determined from retrospective reviews of handwritten records, examinations of equipment, or interviews with clinicians. Failure to deliver the intended concentrations of anesthetic agents to the patient is one possible contributing cause fo...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章


    authors: Driscoll WD,Columbia MA,Peterfreund RA

    更新日期:2007-10-01 00:00:00