Clinical and subclinical ophthalmic findings with retinol deficiency.


BACKGROUND:Patients at risk for retinol deficiency in developed countries include those with hepatic dysfunction and malabsorption states. Symptoms of retinol deficiency may go unrecognized or unreported. METHODS:The authors describe 15 patients with hepatic dysfunction, two of whom had procedures that would predispose to malabsorption and were ophthalmologically symptomatic of retinol depletion. The other 13 patients were ophthalmologically asymptomatic liver transplant candidates examined prospectively for subclinical evidence of retinol deficiency. Combined laboratory analysis, Schirmer's testing, conjunctival impression cytology, and electroretinography were performed. RESULTS:Twelve of 15 patients had serum retinol levels below the lower limit of normal. Aqueous tear production was reduced in 7 of 14 patients. Abnormal conjunctival morphology was noted in 6 of 12 patients. Electroretinograms were abnormal in the two patients who were visually symptomatic and in seven of nine patients who were ophthalmologically asymptomatic. CONCLUSION:Subclinical, physiologically significant retinol deficiency may be a frequent and unrecognized problem among patients with hepatic dysfunction.






Newman NJ,Capone A,Leeper HF,O'Day DG,Mandell B,Lambert SR,Thoft RA




Has Abstract


1994-06-01 00:00:00














  • Linear array multiple transducer ultrasonic examination of the eye.

    abstract::Dynamic ultrasonic imaging adds a time dimension to the clinical diagnosis of ocular pathology. A recent development in this area of ophthalmic sonography has been the introduction of an electronically scanned, multiple transducer system that provides improved real-time imaging of ocular tissue motion. This paper disc...


    pub_type: 杂志文章


    authors: Susal AL,Gaynon MW,Walker JT

    更新日期:1983-03-01 00:00:00

  • Nasolacrimal duct probing in infants.

    abstract::Use of a fiberoptic endoscope to visualize the vault of the inferior turbinate during lacrimal duct probing and irrigation revealed a high incidence of false passages. This was confirmed on dacryocystofluoroscopy. The creation of false passages as documented by us can help explain clinical probing failure in apparentl...


    pub_type: 杂志文章


    authors: Cibis GW,Jazbi BU

    更新日期:1979-08-01 00:00:00

  • Macular pigment optical density in a midwestern sample.

    abstract:OBJECTIVE:To assess the distribution of the macular pigments (MPs) lutein (L) and zeaxanthin (Z) in a healthy sample more representative of the general population than past studies and to determine which dietary factors and personal characteristics might explain the large interindividual differences in the density of t...


    pub_type: 杂志文章


    authors: Ciulla TA,Curran-Celantano J,Cooper DA,Hammond BR Jr,Danis RP,Pratt LM,Riccardi KA,Filloon TG

    更新日期:2001-04-01 00:00:00

  • Microbial keratitis predisposing factors and morbidity.

    abstract:PURPOSE:To examine predisposing factors, treatment costs, and visual outcome of microbial keratitis in an ophthalmic casualty and inpatient population. DESIGN:Retrospective medical records review. PARTICIPANTS:Fifteen- to 64-year-olds with microbial keratitis treated at the Royal Victorian Eye and Ear Hospital betwee...


    pub_type: 杂志文章


    authors: Keay L,Edwards K,Naduvilath T,Taylor HR,Snibson GR,Forde K,Stapleton F

    更新日期:2006-01-01 00:00:00

  • Ganglion cell-inner plexiform layer thickness after epiretinal membrane surgery: a spectral-domain optical coherence tomography study.

    abstract:PURPOSE:To investigate postoperative macular ganglion cell-inner plexiform layer (GCIPL) thickness, determine the factors related to GCIPL thickness, and evaluate the association of GCIPL thickness with postoperative visual outcomes in patients with idiopathic epiretinal membrane (ERM). DESIGN:Retrospective, cohort st...


    pub_type: 杂志文章


    authors: Lee EK,Yu HG

    更新日期:2014-08-01 00:00:00

  • Vision-Related Quality of Life Associated with Unilateral and Bilateral Ocular Conditions.

    abstract:PURPOSE:To present ophthalmic patient time-tradeoff vision utilities for quantifying vision-related quality-of-life when the fellow eye still has good vision. These utilities are important for performing reliable cost-utility analyses. DESIGN:Consecutive time-tradeoff vision utilities were obtained from ophthalmic pat...


    pub_type: 杂志文章


    authors: Brown GC,Brown MM,Stein JD,Smiddy WE,Ophthalmic Utility Research Study Group.

    更新日期:2018-07-01 00:00:00

  • Effects of laser in situ keratomileusis on tear production, clearance, and the ocular surface.

    abstract:PURPOSE:To evaluate components of the integrated ocular surface/lacrimal gland unit in a series of patients before and after undergoing bilateral laser in situ keratomileusis (LASIK). DESIGN:Prospective, noncomparative case series. PARTICIPANTS:Forty-eight eyes of 14 men and 34 women (age range, 26-54; mean, 39.2 yea...


    pub_type: 杂志文章


    authors: Battat L,Macri A,Dursun D,Pflugfelder SC

    更新日期:2001-07-01 00:00:00

  • Retinal detachment in eyes undergoing pars plana vitrectomy for removal of retained lens fragments.

    abstract:PURPOSE:To investigate the incidence and outcomes of retinal detachment (RD) associated with retained lens fragments removed by pars plana vitrectomy (PPV). DESIGN:Retrospective, noncomparative, interventional consecutive case series. PARTICIPANTS:All patients who underwent PPV for retained lens material after catara...


    pub_type: 杂志文章


    authors: Moore JK,Scott IU,Flynn HW Jr,Smiddy WE,Murray TG,Kim JE,Vilar NF,Pereira MB,Jorge R

    更新日期:2003-04-01 00:00:00

  • Defining real change in measures of stereoacuity.

    abstract:PURPOSE:To establish the thresholds for "real change" in stereoacuity by defining long-term test-retest variability as 95% limits of agreement for 4 stereoacuity tests. DESIGN:Retrospective cohort study. PARTICIPANTS AND CONTROLS:We identified 36 patients (median, 17 years; range, 7-76) with any type of stable strabi...


    pub_type: 杂志文章


    authors: Adams WE,Leske DA,Hatt SR,Holmes JM

    更新日期:2009-02-01 00:00:00

  • Visual function in prolactinoma patients treated with bromocriptine.

    abstract::Ten patients with prolactin-secreting pituitary adenomas (prolactinoma) and visual dysfunction were treated primarily with bromocriptine. Nine patients had improvement of visual field or acuity associated with computed tomography (CT) evidence of a decrease in tumor size and reduction of serum prolactin level (SPL). V...


    pub_type: 杂志文章


    authors: Moster ML,Savino PJ,Schatz NJ,Snyder PJ,Sergott RC,Bosley TM

    更新日期:1985-10-01 00:00:00

  • Statistical evaluation of the diagnostic accuracy of methods used to determine the progression of visual field defects in glaucoma.

    abstract:OBJECTIVE:To evaluate trend-type analyses to judge the progression of visual field damage (VFD) of glaucoma in terms of ratios of making judgments of progression and specificity, and to report a new method. DESIGN:Retrospective analysis of visual field (VF) results of actual glaucoma cases and those simulated by compu...


    pub_type: 杂志文章,多中心研究


    authors: Mayama C,Araie M,Suzuki Y,Ishida K,Yamamoto T,Kitazawa Y,Shirakashi M,Abe H,Tsukamoto H,Mishima HK,Yoshimura K,Ohashi Y

    更新日期:2004-11-01 00:00:00

  • Functional improvement after one- and two-eye cataract surgery in the Salisbury Eye Evaluation.

    abstract:PURPOSE:To determine the impact that cataract and cataract surgery have on clinical measurements of vision, reading speed, objective mobility performance, and subjective visual functioning. DESIGN:Prospective, population-based study. PARTICIPANTS:A total of 1739 Salisbury Eye Evaluation (SEE) participants without pre...


    pub_type: 杂志文章


    authors: Lee BS,Munoz BE,West SK,Gower EW

    更新日期:2013-05-01 00:00:00

  • Primary intraocular lens implantation for penetrating lens trauma in Africa.

    abstract:OBJECTIVE:This study aimed to audit the surgical strategy of primary posterior chamber intraocular lens implantation for cases of recent penetrating trauma involving the lens in an African population. DESIGN:Retrospective, noncomparative case series. PARTICIPANTS:Seventy-two cases are reported, including all patients...


    pub_type: 杂志文章


    authors: Bowman RJ,Yorston D,Wood M,Gilbert C,Foster A

    更新日期:1998-09-01 00:00:00

  • Anterior optic nerve blood flow decreases in clinical neurogenic optic atrophy.

    abstract::Anterior optic nerve blood flow was studied in nine patients with unilateral neurogenic optic atrophy using noninvasive techniques. Disk reflectometry measurements from temporal sites demonstrated a significant reduction in the index of blood volume in atrophic optic nerves as compared with the contralateral optic ner...


    pub_type: 杂志文章


    authors: Sebag J,Delori FC,Feke GT,Goger D,Fitch K,Tagawa H,Deupree D,Weiter JJ,McMeel JW

    更新日期:1986-06-01 00:00:00

  • Proliferative vitreoretinopathy. Lymphocytes in epiretinal membranes.

    abstract:BACKGROUND:To investigate the potential contribution of inflammatory and immune-mediated processes contributing to the pathogenesis of proliferative vitreoretinopathy (PVR), an immunohistochemical study was undertaken to characterize the infiltrating inflammatory cells in epiretinal membranes surgically removed from th...


    pub_type: 杂志文章


    authors: Charteris DG,Hiscott P,Grierson I,Lightman SL

    更新日期:1992-09-01 00:00:00

  • Factors prompting sneezing in intravenously sedated patients receiving local anesthetic injections to the eyelids.

    abstract:PURPOSE:To investigate the frequency of sneezing among patients receiving intravenous sedation and periocular local anesthetic for oculoplastic procedures in a single center. To identify potential risk factors involved. DESIGN:Prospective, consecutive, interventional case series in a single tertiary-referral oculoplas...


    pub_type: 杂志文章


    authors: Morley AM,Jazayeri F,Ali S,Malhotra R

    更新日期:2010-05-01 00:00:00

  • Femtosecond Laser-Assisted Cataract Surgery Versus Phacoemulsification Cataract Surgery (FACT): A Randomized Noninferiority Trial.

    abstract:PURPOSE:To report the 3-month results of a randomized trial (Femtosecond Laser-Assisted Cataract Trial [FACT]) comparing femtosecond laser-assisted cataract surgery (FLACS) with standard phacoemulsification cataract surgery (PCS). DESIGN:Multicenter, randomized controlled trial funded by the UK National Institute of H...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Day AC,Burr JM,Bennett K,Bunce C,Doré CJ,Rubin GS,Nanavaty MA,Balaggan KS,Wilkins MR,FACT group.

    更新日期:2020-08-01 00:00:00

  • Agreement for detecting glaucoma progression with the GDx guided progression analysis, automated perimetry, and optic disc photography.

    abstract:PURPOSE:To evaluate the ability of the GDx Variable Corneal Compensation (VCC) Guided Progression Analysis (GPA) software for detecting glaucomatous progression. DESIGN:Observational cohort study. PARTICIPANTS:The study included 453 eyes from 252 individuals followed for an average of 46+/-14 months as part of the Di...


    pub_type: 杂志文章


    authors: Alencar LM,Zangwill LM,Weinreb RN,Bowd C,Vizzeri G,Sample PA,Susanna R Jr,Medeiros FA

    更新日期:2010-03-01 00:00:00

  • Prevalence of Oculo-auriculo-vertebral Spectrum in Dermolipoma.

    abstract:OBJECTIVE:To describe the observed frequency of oculo-auriculo-vertebral spectrum (OAVS) in patients with dermolipoma. DESIGN:Retrospective case series. PARTICIPANTS:Patients with primary presentation of ocular dermolipoma. METHODS:All patients with ocular dermolipoma or lipodermoid were identified from the authors'...


    pub_type: 杂志文章


    authors: Khong JJ,Hardy TG,McNab AA

    更新日期:2013-08-01 00:00:00

  • Relationship of macular microcirculation and retinal thickness with visual acuity in diabetic macular edema.

    abstract:PURPOSE:To assess perifoveal capillary blood flow velocity (BFV), capillary occlusion, and retinal thickness at the central fovea in diabetic patients with or without clinically significant macular edema; to examine the relationships of these variables with visual acuity (VA); and to identify their contributions to vis...


    pub_type: 杂志文章


    authors: Sakata K,Funatsu H,Harino S,Noma H,Hori S

    更新日期:2007-11-01 00:00:00

  • A randomized controlled trial of combined 5-fluorouracil and low-molecular-weight heparin in management of established proliferative vitreoretinopathy.

    abstract:OBJECTIVE:To determine the efficacy of a combination of 5-fluorouracil and low-molecular-weight heparin (LMWH) to improve the outcome of surgery for established proliferative vitreoretinopathy (PVR). DESIGN:Double-masked, prospective, randomized, placebo-controlled clinical trial. SETTING:Three tertiary-referral teac...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Charteris DG,Aylward GW,Wong D,Groenewald C,Asaria RH,Bunce C,PVR Study Group.

    更新日期:2004-12-01 00:00:00

  • Decision-making in the management of microbial keratitis.

    abstract::The successful management of suppurative microbial keratitis requires five steps: (1) make the clinical diagnosis, (2) perform the proper laboratory procedures, (3) initiate antimicrobial therapy, (4) modify the initial therapy, and (5) terminate therapy. The most helpful guidelines to decision-making in these steps a...


    pub_type: 杂志文章


    authors: Jones DB

    更新日期:1981-08-01 00:00:00

  • Blood dyscrasias in patients using methazolamide (neptazane) for glaucoma.

    abstract::Carbonic anhydrase inhibitors used in the treatment of glaucoma are rarely associated with blood dyscrasias. Several case reports of aplastic anemia with use of acetazolamide, and two cases with use of methazolamide, have appeared in the literature. This report documents two cases of aplastic anemia, at least one of w...


    pub_type: 杂志文章


    authors: Werblin TP,Pollack IP,Liss RA

    更新日期:1980-04-01 00:00:00

  • Topical beta-blockers and mortality.

    abstract:PURPOSE:To study the associations between long-term and short-term use of topical beta-blockers and mortality. DESIGN:Prospective population-based cohort study. PARTICIPANTS:To examine long-term effects, 3842 participants aged 55 years and older were recruited. To examine short-term effects, 484 incident beta-blocker...


    pub_type: 杂志文章


    authors: Müskens RP,Wolfs RC,Witteman JC,Hofman A,de Jong PT,Stricker BH,Jansonius NM

    更新日期:2008-11-01 00:00:00

  • Analysis of the acute ophthalmic manifestations of the erythema multiforme/Stevens-Johnson syndrome/toxic epidermal necrolysis disease spectrum.

    abstract:PURPOSE:To evaluate the epidemiology, possible etiologic factors, complications encountered, and treatment administered to a group of patients with ocular involvement in the erythema multiforme/Stevens-Johnson syndrome/toxic epidermal necrolysis disease spectrum who were seen at two large tertiary referral centers over...


    pub_type: 杂志文章,多中心研究


    authors: Power WJ,Ghoraishi M,Merayo-Lloves J,Neves RA,Foster CS

    更新日期:1995-11-01 00:00:00

  • Intermediate-term results of a randomized clinical trial of the 350- versus the 500-mm2 Baerveldt implant.

    abstract:BACKGROUND:The Baerveldt glaucoma implant is a large equatorial aqueous shunting device that is installed through a single-quadrant conjunctival incision. The intermediate-term results of a randomized study comparing the 350- and 500-mm2 Baerveldt implants are reported. METHODS:Seventy-three patients with medically un...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Lloyd MA,Baerveldt G,Fellenbaum PS,Sidoti PA,Minckler DS,Martone JF,LaBree L,Heuer DK

    更新日期:1994-08-01 00:00:00

  • Management of advanced retinopathy of prematurity in the older patient.

    abstract::The authors studied 11 eyes of 10 patients who complained of a recent decrease in vision and whose eyes had the clinical appearance of stage 5 retinopathy of prematurity (ROP) as diagnosed by the presence of a dense, opaque retrolenticular membrane. Patients ranged in age from 4 to 33 years, and birth weights ranged f...


    pub_type: 杂志文章


    authors: Bradford JD,Trese MT

    更新日期:1991-07-01 00:00:00

  • Evaluation of diagnostic capabilities of interactive test strategies in automated perimetry.

    abstract::Simple strategies for visual field screening with automated perimeters can detect abnormalities at acceptable rates. However, the information available from a screening field chart is often insufficient to assign the field into a diagnostic category, and further field testing is necessary. Automated perimeters can be ...


    pub_type: 杂志文章


    authors: Mills RP

    更新日期:1985-09-01 00:00:00

  • Role of Orbscan II in screening keratoconus suspects before refractive corneal surgery.

    abstract:OBJECTIVE:To evaluate the relationship between videokeratographic keratoconus screening programs and Orbscan II topography. DESIGN:Prospective, observational case series and instrument validation study. PARTICIPANTS:Sixty consecutive eyes with suspicious videokeratography (TMS-1, Tomey Technology, Waltham, MA) were e...


    pub_type: 杂志文章


    authors: Rao SN,Raviv T,Majmudar PA,Epstein RJ

    更新日期:2002-09-01 00:00:00

  • Rabbit ocular reactivity to bacterial endotoxin contained in aqueous solution and ophthalmic viscosurgical devices.

    abstract:OBJECTIVE:To describe the ocular reactivity of the rabbit to bacterial endotoxin contained in an aqueous medium and in a cohesive and a dispersive ophthalmic viscosurgical device (OVD). DESIGN:Experimental, randomized animal study. PARTICIPANTS:Seventy-five New Zealand white rabbits. METHODS:This study was performed...


    pub_type: 杂志文章


    authors: Buchen SY,Calogero D,Hilmantel G,Eydelman MB

    更新日期:2012-07-01 00:00:00