The changing spectrum of fungal keratitis in south Florida.


PURPOSE:To review the clinical experience with fungal keratitis in south Florida over a 10-year period. METHODS:One hundred twenty-five cases of fungal keratitis were identified in the microbiology laboratory records between January 1982 and January 1992. The medical record of each patient was reviewed. RESULTS:The most commonly associated risk factor was trauma (44%). Fungal keratitis developed in five patients using extended wear contact lenses and one patient wearing a therapeutic bandage contact lens. Clinical features included irregular, feathery margins (62%), a dry, rough texture (47%), and satellite lesions (41%). An initial positive culture was obtained in 90% of patients, with a majority of cultures becoming positive within 48 hours. The Fusarium sp accounted for 62% of the isolates, with Fusarium oxysporum being the most commonly isolated organism. New fungal isolates include Candida parapsilosis, Aspergillus terreus, Candida tropicalis, and Trichosporon beigellii. Natamycin 5% suspension was the initial antifungal agent used for 91% of the patients, with an average duration of treatment of 38 days. Twenty-five patients were treated with oral ketoconazole for a median duration of 2 weeks, in addition to topical antifungal therapy. Thirty-four patients (27%) required a penetrating keratoplasty. Six patients had recurrence of fungal keratitis after penetrating keratoplasty. CONCLUSIONS:Trauma, including contact lens wear, is the most commonly associated risk factor. The fungal organisms can be readily identified in culture. F. oxysporum is the most common organism, with new isolates identified. The mainstay of therapy is topical natamycin with the increasing use of imidazoles.






Rosa RH Jr,Miller D,Alfonso EC




Has Abstract


1994-06-01 00:00:00














  • Outer retinal ischemic infarction--a newly recognized complication of cataract extraction and closed vitrectomy. Part 1. A case report.

    abstract::This report describes a peculiar syndrome occurring as a complication of cataract extraction. The syndrome is characterized initially by (1) acute loss of central and paracentral vision discovered usually on the first postoperative day; (2) diffuse and patchy whitening of the outer retinal layers in the posterior fund...


    pub_type: 杂志文章


    authors: Gass JD,Parrish R

    更新日期:1982-12-01 00:00:00

  • Foldable Artiflex phakic intraocular lens for the correction of myopia: two-year follow-up results of a prospective European multicenter study.

    abstract:OBJECTIVE:To evaluate the safety, efficacy, predictability, stability, and complications of the foldable Artiflex iris-fixated intraocular lens (Ophtec BV, Groningen, The Netherlands) for the correction of myopia in phakic eyes. DESIGN:Prospective, nonrandomized, open-label, multicenter trial. PARTICIPANTS:Two hundre...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Dick HB,Budo C,Malecaze F,Güell JL,Marinho AA,Nuijts RM,Luyten GP,Menezo JL,Kohnen T

    更新日期:2009-04-01 00:00:00

  • Eyelid involvement in multicentric reticulohistiocytosis.

    abstract:CASE REPORT:The authors report the first biopsy-confirmed ocular adnexal involvement by multicentric reticulohistiocytosis. The patient was a 28-year-old black woman with a 15-year history of well-documented multicentric reticulohistiocytosis who had multiple dermal nodules and severe mutilating arthritis that had prod...


    pub_type: 杂志文章


    authors: Eagle RC Jr,Penne RA,Hneleski IS Jr

    更新日期:1995-03-01 00:00:00

  • Partial lacrimal carunculectomy: a simple procedure for epiphora.

    abstract:OBJECTIVE:To evaluate the effect of partial surgical excision of enlarged lacrimal caruncles, termed megalocaruncles, in patients with epiphora from functional lacrimal drainage obstruction. DESIGN:Retrospective, noncomparative, interventional case series. PARTICIPANTS:From May 1995 through December 1999, 88 patients...


    pub_type: 杂志文章


    authors: Mombaerts I,Colla B

    更新日期:2001-04-01 00:00:00

  • Glaucoma and associated visual acuity and field loss significantly affect glaucoma-specific psychosocial functioning.

    abstract:OBJECTIVE:To examine the impact of glaucoma and visual acuity (VA) and visual field (VF) losses on psychosocial functioning (PF). DESIGN:Cross-sectional study. PARTICIPANTS:We compared PF between 192 participants with bilateral glaucoma with VA or VF losses and 40 controls from a tertiary eye hospital clinic in Singa...


    pub_type: 杂志文章


    authors: Chan EW,Chiang PP,Liao J,Rees G,Wong TY,Lam JS,Aung T,Lamoureux E

    更新日期:2015-03-01 00:00:00

  • Advances in immunology and uveitis.

    abstract::*Subspecialty synopses are intended to present major clinical developments and innovations in diagnosis, treatment, surgical technique, and recent clinical research. Each synopsis, written by a recognized knowledgeable subspecialist, is co-sponsored by a major subspecialty society or organization. This subspecialty sy...


    pub_type: 杂志文章,评审


    authors: Fujikawa LS

    更新日期:1989-07-01 00:00:00

  • Acute promyelocytic infiltration of the optic nerve treated by oral trans-retinoic acid.

    abstract:BACKGROUND:Oral trans-retinoic acid has recently been shown to be an effective treatment modality for acute promyelocytic leukemia. This type of drug differs from traditional tumoricidal agents by promoting differentiation of the malignant, immature cells. METHODS:The authors describe a patient with optic nerve infilt...


    pub_type: 杂志文章


    authors: Brown DM,Kimura AE,Ossoinig KC,Weiner GJ

    更新日期:1992-09-01 00:00:00

  • IntraLase-enabled astigmatic keratotomy for post-keratoplasty astigmatism: on-axis vector analysis.

    abstract:PURPOSE:To determine the refractive predictability, stability, efficacy, and complication rate of femtosecond laser-enabled astigmatic keratotomy for post-keratoplasty astigmatism. DESIGN:A retrospective case series (pilot study). PARTICIPANTS:Thirty-seven eyes of 34 patients. METHODS:All eyes underwent IntraLase-en...


    pub_type: 杂志文章


    authors: Kumar NL,Kaiserman I,Shehadeh-Mashor R,Sansanayudh W,Ritenour R,Rootman DS

    更新日期:2010-06-01 00:00:00

  • Secondary hemorrhage in traumatic hyphema. Predictive factors for selective prophylaxis.

    abstract:BACKGROUND:Treatment to decrease the rebleeding rate in traumatic hyphema remains controversial. Although antifibrinolytics recently have been shown to reduce secondary hemorrhage rates, their routine use has not been widely applied because of adverse side effects and the relatively low frequency of severe hyphema comp...


    pub_type: 杂志文章


    authors: Fong LP

    更新日期:1994-09-01 00:00:00

  • Risk factors for microbial keratitis with contemporary contact lenses: a case-control study.

    abstract:OBJECTIVE:To assess the relative risks (RR) of microbial keratitis (MK) for contemporary contact lens (CL) types and wearing schedules. DESIGN:A 2-year prospective case-control study begun in December 2003. PARTICIPANTS:Cases were 367 CL wearers attending Moorfields Eye Hospital with proven or presumed MK. Controls w...


    pub_type: 杂志文章


    authors: Dart JK,Radford CF,Minassian D,Verma S,Stapleton F

    更新日期:2008-10-01 00:00:00

  • Twin and triple peaks papilledema.

    abstract:PURPOSE:To describe 2 adult patients who presented with papilledema after band atrophy (i.e., twin and triple peaks papilledema). DESIGN:Retrospective small case series. PARTICIPANTS:Two outpatients. METHODS:Observations made on 2 patients whose cases were reviewed in the neuro-ophthalmology clinic. RESULTS:The fir...


    pub_type: 杂志文章


    authors: Mehta JS,Plant GT,Acheson JF

    更新日期:2005-07-01 00:00:00

  • Correction of enophthalmos in the anophthalmic orbit.

    abstract::Enophthalmos with an associated superior sulcus syndrome is a common finding in the anophthalmic socket. Two common causes are: (1) progressive relaxation of the lower eyelid leading to downward migration of the prosthesis and associated ectropion formation; and (2) decreased volume of the orbit. Relaxation of the low...


    pub_type: 杂志文章


    authors: Paris GL,Spohn WG

    更新日期:1980-12-01 00:00:00

  • Acquired ptosis in the young and middle-aged adult population.

    abstract:PURPOSE:The authors studied the etiology of acquired ptosis in the young to middle-aged adult population with specific attention to the role of rigid contact lens use. METHODS:The study consisted of all patients between the ages of 15 and 50 years with acquired ptosis who presented between April 1986 and May 1994. Pot...


    pub_type: 杂志文章


    authors: Kersten RC,de Conciliis C,Kulwin DR

    更新日期:1995-06-01 00:00:00

  • Outcomes of changing immunosuppressive therapy after treatment failure in patients with noninfectious uveitis.

    abstract:PURPOSE:To evaluate the outcomes of changing immunosuppressive therapy for noninfectious uveitis after failure. DESIGN:Retrospective cohort study. PARTICIPANTS:Patients with noninfectious uveitis managed at 2 tertiary uveitis clinics in the United Kingdom and Australia. METHODS:Participants with a history of using i...


    pub_type: 杂志文章,多中心研究


    authors: Joshi L,Talat L,Yaganti S,Sandhu S,Taylor SR,Wakefield D,McCluskey P,Lightman S

    更新日期:2014-05-01 00:00:00

  • Intraocular Lens Implantation in the Absence of Zonular Support: An Outcomes and Safety Update: A Report by the American Academy of Ophthalmology.

    abstract:PURPOSE:To review the published literature on the visual acuity results and complications of different surgical techniques for intraocular lens (IOL) implantation in the absence of zonular support. METHODS:Peer-reviewed literature searches were conducted last in PubMed and the Cochrane Library in July 2019. The search...


    pub_type: 杂志文章,评审


    authors: Shen JF,Deng S,Hammersmith KM,Kuo AN,Li JY,Weikert MP,Shtein RM

    更新日期:2020-09-01 00:00:00

  • Risk factors for loss of visual acuity among patients with uveitis associated with juvenile idiopathic arthritis: the Systemic Immunosuppressive Therapy for Eye Diseases Study.

    abstract:PURPOSE:To describe the incidence of and risk factors for visual acuity (VA) loss and ocular complications in patients with juvenile idiopathic arthritis (JIA)-associated uveitis. DESIGN:Multicenter retrospective cohort study. PARTICIPANTS:A total of 327 patients (596 affected eyes) with JIA-associated uveitis manage...


    pub_type: 杂志文章,多中心研究


    authors: Gregory AC 2nd,Kempen JH,Daniel E,Kaçmaz RO,Foster CS,Jabs DA,Levy-Clarke GA,Nussenblatt RB,Rosenbaum JT,Suhler EB,Thorne JE,Systemic Immunosuppressive Therapy for Eye Diseases Cohort Study Research Group.

    更新日期:2013-01-01 00:00:00

  • Intravitreal aflibercept injection for neovascular age-related macular degeneration: ninety-six-week results of the VIEW studies.

    abstract:PURPOSE:To determine efficacy and safety of intravitreal aflibercept in patients with neovascular age-related macular degeneration (AMD) during a second year of variable dosing after a first-year fixed-dosing period. DESIGN:Two randomized, double-masked, active-controlled, phase 3 trials. PARTICIPANTS:Two thousand fo...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Schmidt-Erfurth U,Kaiser PK,Korobelnik JF,Brown DM,Chong V,Nguyen QD,Ho AC,Ogura Y,Simader C,Jaffe GJ,Slakter JS,Yancopoulos GD,Stahl N,Vitti R,Berliner AJ,Soo Y,Anderesi M,Sowade O,Zeitz O,Norenberg C,Sandbrink R

    更新日期:2014-01-01 00:00:00

  • Choroideremia: variability of clinical and electrophysiological characteristics and first report of a negative electroretinogram.

    abstract:PURPOSE:To analyze the variability of clinical and electrophysiological characteristics in X-linked choroideremia and provide the first report of a negative electroretinogram in choroideremia. DESIGN:Retrospective study. PARTICIPANTS:The records of 18 male patients with choroideremia and 8 female carriers were evalua...


    pub_type: 杂志文章


    authors: Renner AB,Kellner U,Cropp E,Preising MN,MacDonald IM,van den Hurk JA,Cremers FP,Foerster MH

    更新日期:2006-11-01 00:00:00

  • Monthly versus as-needed ranibizumab injections in patients with retinal vein occlusion: the SHORE study.

    abstract:OBJECTIVE:To compare pro re nata (PRN) and monthly injections of 0.5 mg ranibizumab in retinal vein occlusion (RVO) patients stabilized by monthly injections. DESIGN:Randomized, open-label, vision-examiner masked, 15-month study. PARTICIPANTS:Subjects with macular edema secondary to branch or central RVO. METHODS:Su...


    pub_type: 杂志文章,随机对照试验


    authors: Campochiaro PA,Wykoff CC,Singer M,Johnson R,Marcus D,Yau L,Sternberg G

    更新日期:2014-12-01 00:00:00

  • Proliferative vitreoretinopathy. Lymphocytes in epiretinal membranes.

    abstract:BACKGROUND:To investigate the potential contribution of inflammatory and immune-mediated processes contributing to the pathogenesis of proliferative vitreoretinopathy (PVR), an immunohistochemical study was undertaken to characterize the infiltrating inflammatory cells in epiretinal membranes surgically removed from th...


    pub_type: 杂志文章


    authors: Charteris DG,Hiscott P,Grierson I,Lightman SL

    更新日期:1992-09-01 00:00:00

  • Results of phototherapeutic keratectomy in the management of flap striae after LASIK before and after developing a standardized protocol: long-term follow-up of an expanded patient population.

    abstract:OBJECTIVE:To evaluate the efficacy and safety of phototherapeutic keratectomy (PTK) for treatment of striae in LASIK flaps. DESIGN:Retrospective consecutive series. PARTICIPANTS:Forty-seven eyes of 44 patients with flap striae after LASIK with reduced best-corrected visual acuity (VA) or visual symptoms with at least...


    pub_type: 杂志文章


    authors: Ashrafzadeh A,Steinert RF

    更新日期:2007-06-01 00:00:00

  • Astigmatism induced by spherical photorefractive keratectomy corrections.

    abstract:PURPOSE:The purpose of the study is to evaluate the induced astigmatism after spherical photorefractive keratectomy on the Summit Omnimed (Summit Instruments, Waltham, MA) and the Nidek EC-5000 (Nidek Co. Ltd, Aichi, Japan) excimer lasers. METHODS:A total of 4269 eyes of 3289 patients were treated with a 5-mm optical ...


    pub_type: 杂志文章


    authors: Shah S,Chatterjee A,Doyle SJ,Bessant DA

    更新日期:1997-08-01 00:00:00

  • 5-year follow-up of LASIK for hyperopia.

    abstract:PURPOSE:To assess the long-term efficacy and stability of LASIK for hyperopia (+0.75 to +7.00 diopters [D]). DESIGN:Retrospective follow-up study of a previous phase III multicenter clinical trial (unpublished data). PARTICIPANTS:Patients who had been treated for hyperopia (33 individuals, 47 eyes) attended follow-up...


    pub_type: 杂志文章


    authors: Jaycock PD,O'Brart DP,Rajan MS,Marshall J

    更新日期:2005-02-01 00:00:00

  • Ocular hypertensive response to topical dexamethasone in children: a dose-dependent phenomenon.

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    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ng JS,Fan DS,Young AL,Yip NK,Tam K,Kwok AK,Lam DS

    更新日期:2000-11-01 00:00:00

  • Surgical outcomes of medial rectus recession in esotropia with cerebral palsy.

    abstract:PURPOSE:To determine the outcome of a reduced amount of medial rectus (MR) muscle recession in esotropes with cerebral palsy (CP) and to compare the surgical response with that of normal controls. DESIGN:Retrospective cohort study. PARTICIPANTS:Thirty esotropes with CP and 60 age-matched esotropes without CP who unde...


    pub_type: 杂志文章


    authors: Ma DJ,Yang HK,Hwang JM

    更新日期:2013-04-01 00:00:00

  • Five years' follow-up in the surgical management of cataracts in high myopia treated with the Kelman phacoemulsification technique.

    abstract::With the advent of phacoemulsification, much interest has again been rekindled in extracapsular cataract surgery and its effects on the vitreoretinopathies associated in high myopia. Since 1972, 278 patients with high myopia greater than --7.50 D, as as determined by axial length echography, have been operated on by t...


    pub_type: 杂志文章


    authors: Praeger DL

    更新日期:1979-11-01 00:00:00

  • Long-term incidence of reopening of macular holes.

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    pub_type: 杂志文章


    authors: Paques M,Massin P,Blain P,Duquesnoy AS,Gaudric A

    更新日期:2000-04-01 00:00:00

  • Detection of choroidal calcium by computed tomography scan quantitative computerized tomography: a clinically useful diagnostic tool.

    abstract:OBJECTIVE:Quantitative computerized tomography (QCT), a scanning method routinely used to classify tissues based on their radio density, was used to detect choroidal calcification. DESIGN:Case reports. PARTICIPANTS:Two patients with known or suspected choroidal calcium-choroidal osteoma (CO) and pseudoxanthoma elasti...


    pub_type: 杂志文章


    authors: Jokl DH,Tsai N,Kreps S

    更新日期:1999-09-01 00:00:00

  • No forward shifting of posterior corneal surface in eyes undergoing LASIK.

    abstract:PURPOSE:To evaluate structural changes in the cornea and anterior chamber (AC) after LASIK for myopia. DESIGN:Retrospective nonrandomized study. PARTICIPANTS:One hundred sixty-one eyes of 83 patients (mean age, 34.5+/-8.3 years) who underwent uneventful LASIK for myopia and myopic astigmatism. The preoperative refrac...


    pub_type: 杂志文章


    authors: Nishimura R,Negishi K,Saiki M,Arai H,Shimizu S,Toda I,Tsubota K

    更新日期:2007-06-01 00:00:00

  • The sensitive period for strabismic amblyopia in humans.

    abstract:PURPOSE:In order to assess the sensitive period for strabismic amblyopia, the period of susceptibility to monocular occlusion was investigated in 407 children who ranged in age from 21 months to 12 years. METHODS:Patients were treated between 1975 and 1990 by occlusion of the best eye. The efficiency of the treatment ...


    pub_type: 杂志文章


    authors: Epelbaum M,Milleret C,Buisseret P,Dufier JL

    更新日期:1993-03-01 00:00:00