Integration of gene maps: chromosome X.


:Omitting 1137 loci that are included in the location database but have only cytogenetic assignment, there are 605 loci in the integrated map that synthesizes physical and genetic data and subsumes a composite physical location, cytogenetic and regional assignments, mouse homology, rank, and references. With error filtration and allowance for interference the genetic length is 211 cM, to which the p arm contributes 100 cM. The physical length is 164 Mb, with 62 Mb in the p arm. Current problems in map integration are discussed and some solutions proposed.






Wang LH,Collins A,Lawrence S,Keats BJ,Morton NE




Has Abstract


1994-08-01 00:00:00
















  • Effects of genome architecture and epigenetic factors on susceptibility of promoter CpG islands to aberrant DNA methylation induction.

    abstract::Aberrant DNA methylation is induced at specific promoter CpG islands (CGIs) in contrast with mutations. The specificity is influenced by genome architecture and epigenetic factors, but their relationship is still unknown. In this study, we isolated promoter CGIs susceptible and resistant to aberrant methylation induct...


    pub_type: 杂志文章


    authors: Takeshima H,Yamashita S,Shimazu T,Ushijima T

    更新日期:2011-09-01 00:00:00

  • Organization and evolutionary relatedness of OR37 olfactory receptor genes in mouse and human.

    abstract::We report a comprehensive comparative analysis of human and mouse olfactory receptor (OR) genes encoding OR37 subtypes to determine the repertoire, chromosomal organization, and relatedness of these genes. Two OR37 clusters were found in both mouse (chromosome 4) and human (chromosome 9); with five genes in cluster I ...


    pub_type: 杂志文章


    authors: Hoppe R,Breer H,Strotmann J

    更新日期:2003-09-01 00:00:00

  • Human type I pituitary adenylate cyclase activating polypeptide receptor (ADCYAP1R): localization to chromosome band 7p14 and integration into the cytogenetic, physical, and genetic map of chromosome 7.

    abstract::The gene encoding the human type I pituitary adenylate cyclase activating polypeptide receptor (ADCYAP1R1) was mapped to chromosome 7 by PCR analysis of genomic DNA from a human/rodent somatic cell hybrid mapping panel. This assignment was confirmed and the gene localized to chromosome band 7p14 by fluorescence in sit...


    pub_type: 杂志文章


    authors: Stoffel M,Espinosa R 3rd,Trabb JB,Le Beau MM,Bell GI

    更新日期:1994-10-01 00:00:00

  • Polycystin-1L2 is a novel G-protein-binding protein.

    abstract::Mutations in genes encoding polycystin-1 (PC1) and polycystin-2 cause autosomal dominant polycystic kidney disease. The polycystin protein family is composed of Ca2+-permeable pore-forming subunits and receptor-like integral membrane proteins. Here we describe a novel member of the polycystin-1-like subfamily, polycys...


    pub_type: 杂志文章


    authors: Yuasa T,Takakura A,Denker BM,Venugopal B,Zhou J

    更新日期:2004-07-01 00:00:00

  • Identification and functional characterization of SOC1-like genes in Pyrus bretschneideri.

    abstract::Flowering is a prerequisite for pear fruit production. Therefore, the development of flower buds and the control of flowering time are important for pear trees. However, the molecular mechanism of pear flowering is unclear. SOC1, a member of MADS-box family, is known as a flowering signal integrator in Arabidopsis. We...


    pub_type: 杂志文章


    authors: Liu Z,Wu X,Cheng M,Xie Z,Xiong C,Zhang S,Wu J,Wang P

    更新日期:2020-03-01 00:00:00

  • A comparative transcriptional map of a region of 250 kb on the human and mouse X chromosome between the G6PD and the FLN1 genes.

    abstract::The transcriptional organization of the region of the mouse X chromosome between the G6pd and the Fln1 genes was studied in detail, and it was compared with the syntenic region of the human chromosome. A cosmid contig of 250 kb was constructed by screening mouse cosmid libraries with probes for human genes and with wh...


    pub_type: 杂志文章


    authors: Rivella S,Tamanini F,Bione S,Mancini M,Herman G,Chatterjee A,Maestrini E,Toniolo D

    更新日期:1995-08-10 00:00:00

  • The order and transcriptional orientation of the human COL13A1 and P4HA genes on chromosome 10 long arm determined by high-resolution FISH.

    abstract::The genes for type XIII collagen (COL13A1) and prolyl 4-hydroxylase (P4HA) were previously assigned to human chromosome 10q by radioactive in situ hybridization. Here we have applied fluorescence in situ hybridization combined with targets representing different levels of resolution to determine, first, the order of t...


    pub_type: 杂志文章


    authors: Horelli-Kuitunen N,Kvist AP,Helaakoski T,Kivirikko K,Pihlajaniemi T,Palotie A

    更新日期:1997-12-01 00:00:00

  • Molecular phenotype of the human oocyte by PCR-SAGE.

    abstract::Consecutive application of PCR and serial analysis of gene expression (SAGE) was used to generate a catalog of approximately 50, 000 SAGEtags from nine human oocytes. Matches for known genes were identified using the National Institutes of Health SAGEtag database. This database links directly to the UniGene database, ...


    pub_type: 杂志文章


    authors: Neilson L,Andalibi A,Kang D,Coutifaris C,Strauss JF 3rd,Stanton JA,Green DP

    更新日期:2000-01-01 00:00:00

  • Assignment of a novel protein tyrosine phosphatase gene (Hcph) to mouse chromosome 6.

    abstract::Hematopoietic cell phosphatase (Hcph) was identified by amplification of conserved protein tyrosine phosphatase sequences from a myeloid cell line and is predominantly expressed in hematopoietic cells. Hcph is unique in containing two, tandemly repeated, src-homology 2 domains in the amino terminal region of the phosp...


    pub_type: 杂志文章


    authors: Yi T,Gilbert DJ,Jenkins NA,Copeland NG,Ihle JN

    更新日期:1992-11-01 00:00:00

  • The mitochondrial genomes of three skippers: Insights into the evolution of the family Hesperiidae (Lepidoptera).

    abstract::We sequenced the mitogenomes of Astictopterus jama, Isoteinon lamprospilus and Notocrypta curvifascia to obtain further insight into the mitogenomic architecture evolution and performed phylogenetic reconstruction using 29 Hesperiidae mitogenome sequences. The complete mitogenome sequences of A. jama, I. lamprospilus ...


    pub_type: 杂志文章


    authors: Ma L,Liu F,Chiba H,Yuan X

    更新日期:2020-01-01 00:00:00

  • A single segment substitution line population for identifying traits relevant to drought tolerance and avoidance.

    abstract::A population of chromosome segment substitution lines was developed using KDML105 as the recurrent parent and one of DH212 (IR68586-F2-CA-143) or DH103 (IR68586-F2-CA-31) as the donor parent. The donor parents are part of a doubled haploid population from a cross between CT9993, an upland japonica accession, and IR622...


    pub_type: 杂志文章,评审


    authors: Shearman JR

    更新日期:2019-10-31 00:00:00

  • Regions of low single-nucleotide polymorphism incidence in human and orangutan xq: deserts and recent coalescences.

    abstract::While scanning for single-nucleotide polymorphisms (SNPs) in the human Xq25-q28 region of CEPH families, we found six long "deserts" of low SNP incidence representing 28% of the investigated genome. One was 1.66 Mb in length. To determine whether these SNP deserts were due to reduced input of mutations or to recent co...


    pub_type: 杂志文章


    authors: Miller RD,Taillon-Miller P,Kwok PY

    更新日期:2001-01-01 00:00:00

  • The MAS proto-oncogene is imprinted in human breast tissue.

    abstract::The human MAS proto-oncogene is situated at 6q25.3-q26, a region that is homologous to mouse chromosome 17 where two parentally imprinted genes (Mas and Igf2r) have previously been identified. We investigated the imprinting status of MAS in adult lesions to establish the imprinting status of this gene in humans, as ce...


    pub_type: 杂志文章


    authors: Miller N,McCann AH,O'Connell D,Pedersen IS,Spiers V,Gorey T,Dervan PA

    更新日期:1997-12-15 00:00:00

  • The gene for the human putative apoE receptor is on chromosome 12 in the segment q13-14.

    abstract::We have previously described the cDNA coding for a new lipoprotein receptor that contains domains closely related to the ligand-binding domain of the LDL receptor. We have now investigated the localization of the gene for this new receptor by hybridization of the cDNA to panels of rodent cells containing subsets of hu...


    pub_type: 杂志文章


    authors: Myklebost O,Arheden K,Rogne S,Geurts van Kessel A,Mandahl N,Herz J,Stanley K,Heim S,Mitelman F

    更新日期:1989-07-01 00:00:00

  • Functional consequences of naturally occurring DRY motif variants in the mammalian chemoattractant receptor GPR33.

    abstract::Most members of the large family of rhodopsin-like G-protein-coupled receptors possess an evolutionarily conserved Asp-Arg-Tyr (DRY) motif in the C-terminal region of the third transmembrane domain. Mutations of residues within this motif usually abolish receptor function and, when they occur naturally, can even cause...


    pub_type: 杂志文章


    authors: Römpler H,Yu HT,Arnold A,Orth A,Schöneberg T

    更新日期:2006-06-01 00:00:00

  • Physical mapping of the human neurotensin gene (NTS) between markers D12S1444 and D12S81 on chromosome 12q21.

    abstract::Neurotensin (NTS) is an endogenous tridecapeptide of the central nervous system and the gastrointestinal tract of different mammalian species including human. The human gene encoding neurotensin has previously been assigned to chromosome 12 but no regional localization was available. We now confirm this assignment and...


    pub_type: 杂志文章


    authors: Marondel I,Renault B,Lieman J,Ward D,Kucherlapati R

    更新日期:1996-12-01 00:00:00

  • Human-mouse homologies in the region of the polycystic kidney disease gene (PKD1).

    abstract::Autosomal dominant polycystic kidney disease (PKD1) is linked to the alpha-globin locus near the telomere of chromosome 16p. We established the existence of a conserved linkage group in mouse by mapping conserved sequences and cDNAs from the region surrounding the PKD1 gene in the mouse genome. Results obtained with t...


    pub_type: 杂志文章


    authors: Himmelbauer H,Pohlschmidt M,Snarey A,Germino GG,Weinstat-Saslow D,Somlo S,Reeders ST,Frischauf AM

    更新日期:1992-05-01 00:00:00

  • Comparative sequence analysis of the Gdf6 locus reveals a duplicon-mediated chromosomal rearrangement in rodents and rapidly diverging coding and regulatory sequences.

    abstract::Duplicated segments of genomic DNA can catalyze both gene evolution and chromosome evolution. Here we describe a rodent-specific duplication involving the Uqcrb gene, a cis-regulatory element for the Gdf6 gene, and a chromosomal rearrangement. Comparisons of Gdf6 sequences from several placental mammals and platypus r...


    pub_type: 杂志文章


    authors: Mortlock DP,Portnoy ME,Chandler RL,NISC Comparative Sequencing Program.,Green ED

    更新日期:2004-11-01 00:00:00

  • YAC mapping by FISH using Alu-PCR-generated probes.

    abstract::Human genomic mapping has been greatly advanced by the independent development of three new methods: large DNA fragment cloning in yeast artificial chromosomes, amplification from complex DNAs of human specific segments by Alu-PCR, and high-resolution localization of complex DNA probes by fluorescent in situ hybridiza...


    pub_type: 杂志文章


    authors: Breen M,Arveiler B,Murray I,Gosden JR,Porteous DJ

    更新日期:1992-07-01 00:00:00

  • Molecular cloning and chromosomal localization of the ADH7 gene encoding human class IV (sigma) ADH.

    abstract::The ADH7 gene encoding human Class IV (sigma) alcohol dehydrogenase (ADH) was cloned from a Caucasian genomic DNA library and characterized. It has nine exons and eight introns that span about 22 kb, and its intron insertion is identical to that of the other ADH genes (ADH1 to ADH5). The nucleotide sequences of the ex...


    pub_type: 杂志文章


    authors: Yokoyama H,Baraona E,Lieber CS

    更新日期:1996-01-15 00:00:00

  • Genomic organization, alternative splicing, and expression patterns of the DSCR1 (Down syndrome candidate region 1) gene.

    abstract::Down syndrome is a major cause of mental retardation and congenital heart defects and is due to the presence of three copies of human chromosome 21 in the affected individual. We have identified a gene, DSCR1 (HGMW-approved symbol), from the region 21q22.1-q22.2, which is highly expressed in human fetal brain and adul...


    pub_type: 杂志文章


    authors: Fuentes JJ,Pritchard MA,Estivill X

    更新日期:1997-09-15 00:00:00

  • A simple and highly efficient transgenesis method in mice with the Tol2 transposon system and cytoplasmic microinjection.

    abstract::Creating transgenic mice is an important technology for genetic studies and is currently performed by pronuclear microinjection of plasmid DNA into fertilized eggs. Since survival of injected embryos and integration of plasmid DNA are not efficient, total efficiency is only around 3% with a standard protocol. To circu...


    pub_type: 杂志文章


    authors: Sumiyama K,Kawakami K,Yagita K

    更新日期:2010-05-01 00:00:00

  • The human alpha 2(XI) collagen gene (COL11A2) maps to the centromeric border of the major histocompatibility complex on chromosome 6.

    abstract::Type XI collagen, a minor structural component of cartilage fibrils, is composed of three chains, alpha 1(XI), alpha 2(XI), and alpha 3(XI). Using a cloned fragment of the human alpha 2(XI) collagen gene (COL11A2) as a molecular probe for in situ hybridization and somatic cell hybrid mapping, we have localized the gen...


    pub_type: 杂志文章


    authors: Hanson IM,Gorman P,Lui VC,Cheah KS,Solomon E,Trowsdale J

    更新日期:1989-11-01 00:00:00

  • Expression analysis of a panel of long non-coding RNAs (lncRNAs) revealed their potential as diagnostic biomarkers in bladder cancer.

    abstract:INTRODUCTION:Long non-coding RNAs (lncRNAs) have fundamental roles in cell migration, proliferation, invasion and metastasis. METHODS:In the current study, we evaluated expression of a panel of lncRNAs in bladder cancer tissues, adjacent non-cancerous tissues (ANCTs) and normal bladder tissues to evaluate their diagno...


    pub_type: 杂志文章


    authors: Abdolmaleki F,Ghafoui-Fard S,Taheri M,Mordadi A,Afsharpad M,Varmazyar S,Nazparvar B,Oskooei VK,Omrani MD

    更新日期:2020-01-01 00:00:00

  • Complex genetic organization of junB: multiple blocks of flanking evolutionarily conserved sequence at the murine and human junB loci.

    abstract::A comparison of the murine and human junB loci reveals nine regions of distal 5'- and 3'-flanking DNA that exhibit greater than 72% sequence identity. A large fraction (over 50%) of the junB locus is contained in these flanking evolutionarily conserved sequences (FECS), which may be required for effecting the proper t...


    pub_type: 杂志文章


    authors: Phinney DG,Tseng SW,Ryder K

    更新日期:1995-07-20 00:00:00

  • Isolation and regional mapping of NotI and EagI clones from human chromosome 21.

    abstract::NotI and EagI boundary libraries were constructed for human chromosome 21. One hundred forty-seven clones were isolated from the somatic cell hybrid 72532X-6 and localized using a hybrid mapping panel. After identification of those clones, which were isolated more than once, as well as those probes derived from a prev...


    pub_type: 杂志文章


    authors: Gao JZ,Erickson P,Patterson D,Jones C,Drabkin H

    更新日期:1991-05-01 00:00:00

  • RNA-Seq profiling reveals the plant hormones and molecular mechanisms stimulating the early ripening in apple.

    abstract::Fruit development and ripening are essential components of human and animal diets. Fruit ripening is also a vital plant trait for plant shelf life at the commercial level. In the present study, two apple cultivars, Hanfu wild (HC) and Hanfu mutant (HM), were employed for RNA-Sequencing (RNA-Seq) to explore the genes i...


    pub_type: 杂志文章


    authors: Nawaz I,Tariq R,Nazir T,Khan I,Basit A,Gul H,Anwar T,Awan SA,Bacha SAS,Zhang L,Zhang C,Cong P

    更新日期:2020-09-20 00:00:00

  • Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia.

    abstract::The TLE genes are the human homologues of Drosophila groucho, a member of the Notch signaling pathway. This pathway controls a number of different cell-fate choices in invertebrates and vertebrates. We are interested in investigating the functions of the TLE gene family during epithelial determination and carcinogenes...


    pub_type: 杂志文章


    authors: Liu Y,Dehni G,Purcell KJ,Sokolow J,Carcangiu ML,Artavanis-Tsakonas S,Stifani S

    更新日期:1996-01-01 00:00:00

  • Genomic structure and chromosome location of the human mutT homologue gene MTH1 encoding 8-oxo-dGTPase for prevention of A:T to C:G transversion.

    abstract::8-Oxo-dGTP (8-oxo-7,8-dihydrodeoxyguanosine triphosphate) is produced by active oxygen species in the nucleotide pool of the cell and can be incorporated into cellular DNA. Human cells contain enzyme activity that hydrolyzes 8-oxo-dGTP to 8-oxo-dGMP, thereby preventing occurrence of mutations, caused by misincorporati...


    pub_type: 杂志文章


    authors: Furuichi M,Yoshida MC,Oda H,Tajiri T,Nakabeppu Y,Tsuzuki T,Sekiguchi M

    更新日期:1994-12-01 00:00:00

  • Isolation and characterization of a novel gene from the DiGeorge chromosomal region that encodes for a mediator subunit.

    abstract::Hemizygous deletions on chromosome 22q11.2 result in developmental disorders referred to as DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS). We report the isolation of a novel gene, PCQAP (PC2 glutamine/Q-rich-associated protein), that maps to the DiGeorge typically deleted region and encodes a protein identi...


    pub_type: 杂志文章


    authors: Berti L,Mittler G,Przemeck GK,Stelzer G,Günzler B,Amati F,Conti E,Dallapiccola B,Hrabé de Angelis M,Novelli G,Meisterernst M

    更新日期:2001-06-15 00:00:00