Use of anti-CD40 ligand monoclonal antibody as antirejection therapy in a murine peripheral nerve allograft model.

Abstract:

:Monoclonal antibody directed against CD40 ligand prevents acute allograft rejection in several models of solid-organ transplantation. This study describes the use of CD40 ligand as antirejection therapy in a mouse peripheral nerve allograft model. C3H mice received 8-mm nerve isografts (n = 2) or nerve allografts from C57BL donors. Treated animals (n = 11) received anti-CD40 ligand antibody applied to the graft and by intraperitoneal injections postoperatively. At 3 weeks, nerve histology from treated animals was comparable to isografts, whereas untreated allografts demonstrated virtually no signs of regeneration. Walking-track analysis demonstrated a trend toward improved functional recovery in treated animals. In conclusion, blockade of the CD40 pathway suppresses nerve allograft rejection in mice, and facilitates regeneration comparable to isografts.

journal_name

Microsurgery

journal_title

Microsurgery

authors

Jensen JN,Tung TH,Mackinnon SE,Brenner MJ,Hunter DA

doi

10.1002/micr.20028

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

309-15

issue

4

eissn

0738-1085

issn

1098-2752

journal_volume

24

pub_type

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