Use of anti-CD40 ligand monoclonal antibody as antirejection therapy in a murine peripheral nerve allograft model.


:Monoclonal antibody directed against CD40 ligand prevents acute allograft rejection in several models of solid-organ transplantation. This study describes the use of CD40 ligand as antirejection therapy in a mouse peripheral nerve allograft model. C3H mice received 8-mm nerve isografts (n = 2) or nerve allografts from C57BL donors. Treated animals (n = 11) received anti-CD40 ligand antibody applied to the graft and by intraperitoneal injections postoperatively. At 3 weeks, nerve histology from treated animals was comparable to isografts, whereas untreated allografts demonstrated virtually no signs of regeneration. Walking-track analysis demonstrated a trend toward improved functional recovery in treated animals. In conclusion, blockade of the CD40 pathway suppresses nerve allograft rejection in mice, and facilitates regeneration comparable to isografts.






Jensen JN,Tung TH,Mackinnon SE,Brenner MJ,Hunter DA




Has Abstract


2004-01-01 00:00:00












  • Single free anterolateral thigh flap for simultaneous reconstruction of composite hypopharyngeal and external neck skin defect after head and neck cancer ablation.

    abstract::Single flap for complex hypopharyngoesophageal and anterior neck skin defect reconstruction is still a challenge for reconstructive surgeons. Herein, we present five patients, with advanced hypopharyngeal cancer and anterior neck skin invasion, which received a single anterolateral thigh (ALT) fasciocutaneous flap for...


    pub_type: 杂志文章


    authors: Tan NC,Yeh MC,Shih HS,Nebres RP,Yang JC,Kuo YR

    更新日期:2011-10-01 00:00:00

  • Treatment of recurrent lingual nerve end-neuroma: A case report.

    abstract::A neuroma is a collection of disorganized nerve sprouts emanating from an interruption of axonal continuity, forming within a collagen scar as the nerve attempts to regenerate. Lingual neuroma formation secondary to iatrogenic trauma to the tongue is likely not uncommon; however, we could not find a report in the lite...


    pub_type: 杂志文章


    authors: Bellamy JL,Steinbacher DM,Debrux JC,Magarakis M,Rosson GD

    更新日期:2013-10-01 00:00:00

  • Free flap failure in an anticardiolipin antibody-positive patient with neoplasm--a case report.

    abstract::We present herein a case of massive arterial thrombosis of a free rectus abdominal musculocutaneous flap used for reconstructive surgery of gingival carcinoma that could not be rescued. A 54-year-old woman underwent the operation. She had experienced two miscarriages in her 20s, but medical history was otherwise uneve...


    pub_type: 杂志文章


    authors: Asai E,Okouchi M,Momiyama M,Kajikawa A,Ueda K

    更新日期:2010-01-01 00:00:00

  • Fascicular nerve graft using an empty perineurial tube: an experimental study in the rabbit.

    abstract::An experimental model of a free, empty perineurial tube for use as a nerve graft is presented as an alternative to existing methods. The technique is described and the model compared with conventional nerve graft in the sciatic nerve of a rabbit. Results are evaluated with EMG studies, angiography, and histology. The ...


    pub_type: 杂志文章


    authors: Restrepo Y,Merle M,Michon J,Folliguet B,Petry D

    更新日期:1983-01-01 00:00:00

  • A thinned forearm flap transfer to the nose.

    abstract::We employed a forearm flap that had been thinned through primary defatting for nasal covering in three cases to reduce the need for secondary revision. Partial flap loss did occur in one case due to subcutaneous vascular plexus injury, but acceptable results were obtained in the remaining two cases. Donor site concave...


    pub_type: 杂志文章


    authors: Kobayashi S,Akizuki T,Yoza S,Ohmori K

    更新日期:1996-01-01 00:00:00

  • Tendocutaneous free flap transfer from the dorsum of the foot.

    abstract::Tendocutaneous free flap transfer has been used to treat troublesome wounds involving skin and tendons, with the dorsum of the foot being the most frequent donor site. Free flaps consist of the dorsalis pedis artery, saphenous vein, branch of the superficial peroneal nerve, long extensor tendons, and overlying skin. W...


    pub_type: 杂志文章


    authors: Lee KS,Park SW,Kim HY

    更新日期:1994-01-01 00:00:00

  • Secondary ischemic tolerance improved by administration of L-NAME in rat flaps.

    abstract::Nitric oxide (NO) under basal conditions is an important regulator of vascular tone. Under ischemic conditions, however, NO can combine with superoxide anion to produce the damaging hydroxyl free radical. The current project observes the effect of inhibiting NO production (L-Nitro-amino-methyl-arginine, L-NAME) on fla...


    pub_type: 杂志文章


    authors: Knox LK,Angel MF,Gamper T,Amiss LR,Morgan RF

    更新日期:1996-01-01 00:00:00

  • Restoration of shoulder abduction function by direct muscular neurotization with the phrenic nerve fascicles and nerve grafts: a case report.

    abstract::In this report, we describe the first case of using the partial phrenic nerve transfer and direct muscular implantation into the deltoid muscle for restoration of the shoulder function and stability. A patient suffering from the partial brachial plexus injury with absent axillary nerve underwent reconstructive surgery...


    pub_type: 杂志文章


    authors: Sinis N,Boettcher M,Werdin F,Kraus A,Schaller HE

    更新日期:2009-01-01 00:00:00

  • Effect of heparinized irrigating solutions on patency of experimental microvascular anastomoses.

    abstract::The effect of five different irrigating solutions on patency of four different types of microvascular anastomoses was studied. The solutions used were lactated Ringer's without heparin and four lactated Ringer's solutions with varying concentrations of heparin ranging from 10,000 units/liter to 100,000 units/liter. Th...


    pub_type: 杂志文章


    authors: Zinberg EM,Choo DI,Zotter LA

    更新日期:1989-01-01 00:00:00

  • Cross-leg tibial posterior perforator flap.

    abstract:BACKGROUND:In the lower leg posttraumatic pathology, we are frequently confronted with tissue defects that are difficult to cover by local or distance means, because of either the poor tissue quality or the precarious local vessels. One of the still available methods for solving these cases remains the cross-leg flap. ...


    pub_type: 杂志文章


    authors: Georgescu AV,Irina C,Ileana M

    更新日期:2007-01-01 00:00:00

  • Optical requirements on magnification systems for intracranial video microsurgery.

    abstract:INTRODUCTION:The basic idea of video-microsurgery is the improvement of ergonomic conditions in microsurgical procedures by replacing the bulky operating microscope with a compact videosystem. OBJECTIVE:To specify optical requirements on a videosystem for microsurgical intracranial procedures in neurosurgery. METHODS...


    pub_type: 杂志文章


    authors: Ebner FH,Marquardt JS,Hirt B,Tatagiba M,Duffner F

    更新日期:2011-10-01 00:00:00

  • Microsurgical reconstruction: the weightbearing surface of the foot.

    abstract::Microsurgical reconstruction in the weightbearing surface of the foot is discussed. Thirty-eight patients treated at the Mayo Clinic are reviewed as well as a review of the current literature, leaving 122 patients for analysis. Minor complication rates in the skin grafted muscle flaps were 18.5% and major complication...


    pub_type: 杂志文章


    authors: Meland NB

    更新日期:1990-01-01 00:00:00

  • Noradrenaline levels rise significantly in rat arterial grafts at 6 hours postoperatively, and take 48 hours to come down.

    abstract::The aim of this study was to investigate the rate of disappearance of noradrenaline in arterial grafts after their transplanation. Arterial grafts were harvested from AO/Ks:OC strain rats. In each rat, a graft was harvested from the femoral artery and transplanted into the common carotid artery. A contralateral unoper...


    pub_type: 杂志文章


    authors: Penttilä H,Huttunen P,Von Smitten K,Waris T,Ashammakhi N

    更新日期:2004-01-01 00:00:00

  • A more versatile and reliable method for renal transplantation in the rat.

    abstract::This study describes the authors' experience with a new method of orthotopic renal transplantation in the rat. This technique combines previously described modifications with the use of the donor inferior vena cava as a conduit to perform an end-to-side venous anastomosis. Survival was 87% and 80% at 3 and 120 days, r...


    pub_type: 杂志文章


    authors: Blom D,Orloff MS

    更新日期:1998-01-01 00:00:00

  • Abdominoplasty as the patient impetus for selection of the deep inferior epigastric artery perforator free flap for knee coverage.

    abstract::Extensive wounds about the knee can rarely be covered with local or even regional flaps. Free flaps often then become obligatory. Many factors will determine the surgeon's selection of the best donor site. Yet the patients' concerns with donor site morbidity cannot be overlooked. Most would agree that a large, but rel...


    pub_type: 杂志文章


    authors: Hallock GG

    更新日期:2014-02-01 00:00:00

  • Protective effects of ligustrazine on ischemia-reperfusion injury in rat kidneys.

    abstract::To investigate the protective effects of ligustrazine on renal ischemia-reperfusion injury, the influence of ligustrazine injection on plasma superoxide dismutase (SOD), malondialdehyde (MDA), and endothelin-1 (ET-1), as well as changes of morphology of renal tubules, were studied in rat kidney models with ischemia-re...


    pub_type: 杂志文章


    authors: Sun L,Li Y,Shi J,Wang X,Wang X

    更新日期:2002-01-01 00:00:00

  • The treatment of composite defect of bone and soft tissues with a combined latissimus dorsi and serratus anterior and rib free flap.

    abstract:BACKGROUND:Composite defects of bone and soft tissues represent a reconstructive challenge. Several techniques have been described in the medical literature; however, extensive composite defects should be reconstructed with microvascular free tissue transfer. The purpose of this report is to present the use of a compos...


    pub_type: 杂志文章


    authors: Trignano E,Fallico N,Nitto A,Chen HC

    更新日期:2013-03-01 00:00:00

  • The potential roles for adipose tissue in peripheral nerve regeneration.

    abstract:INTRODUCTION:This review summarizes current understanding about the role of adipose-derived tissues in peripheral nerve regeneration and discusses potential advances that would translate this approach into the clinic. METHODS:We searched PubMed for in vivo, experimental studies on the regenerative effects of adipose-d...


    pub_type: 杂志文章,评审


    authors: Walocko FM,Khouri RK Jr,Urbanchek MG,Levi B,Cederna PS

    更新日期:2016-01-01 00:00:00

  • Relationship between lymphatic and venous pressure in normal and lymphedematous rabbit ears.

    abstract::Studies of lymphatic and venous pressures of normal and lymphedematous rabbit ears reveal the end pressure of lymphatics to be higher than the venous pressure. Massage of the related rabbit ear increases the lymphatic pressures and can markedly raise the side and end pressures within the lymphatic wall. The venous pre...


    pub_type: 杂志文章


    authors: Huang GK,Hsin YP

    更新日期:1984-01-01 00:00:00

  • Adenovirus-mediated angiopoietin-1 gene therapy enhances skin flap survival.

    abstract::This experimental study investigates the feasibility of pretreating the abdominal skin of a rat with subdermal injections of adenovirus encoding angiopoietin-1 in order to improve postoperative survival of the skin flap. An epigastric skin flap was used as the model in this study. Rats received subdermal injections of...


    pub_type: 杂志文章


    authors: Jung H,Gurunluoglu R,Scharpf J,Siemionow M

    更新日期:2003-01-01 00:00:00

  • Does the addition of a nerve wrap to a motor nerve repair affect motor outcomes?

    abstract::The purpose of this study was to evaluate the effect of wrapping bioabsorbable nerve conduit around primary suture repair on motor nerve regeneration in a rat model. Forty rats were randomly divided into two experimental groups according to the type of repair of the rat sciatic nerve: group I had primary suture repair...


    pub_type: 杂志文章


    authors: Lee JY,Parisi TJ,Friedrich PF,Bishop AT,Shin AY

    更新日期:2014-10-01 00:00:00

  • Free and island flap transfer for soft tissue defects in the hand and forearm.

    abstract::Two hundred twenty patients with soft tissue defects in the hand and forearm were treated with 226 free and island flap transfers. Reconstructed sites involved the thumb in 74 cases, the fingers in 117, the hand in 30, and the forearm in 5. Seventy-nine patients received 82 free flaps, and 141 patients received 144 is...


    pub_type: 杂志文章


    authors: Yajima H,Tamai S,Fukui A,Ono H,Inada Y

    更新日期:1996-01-01 00:00:00

  • Reduction of reperfusion injury edema with corticotropin-releasing factor (CRF): a pilot study.

    abstract::Regulation of capillary permeability with ischemic reperfusion injury is a complex interaction between vascular endothelium and circulating blood factors. Corticotropin-releasing factor (CRF), a 41 -amino acid peptide CNS neurotransmitter known to modulate the pituitary-adrenal axis during stress response, has been sh...


    pub_type: 杂志文章


    authors: Whitney TM,Bentz ML,Johnson PC

    更新日期:1998-01-01 00:00:00

  • Non-revascularized epigastric free flap: no all-or-none survival pattern.

    abstract::We have previously shown that the epigastric flap in Dark Agouty rats, measuring approximately 6 x 4 cm with borders related to well-defined anatomical structures, does not exhibit an all-or-none survival pattern. This study was designed to investigate the survival pattern of non-revascularized epigastric flaps in thr...


    pub_type: 杂志文章


    authors: Franken RJ,Werker PM,Overgoor ML,Kon M

    更新日期:1993-01-01 00:00:00

  • Muscle fiber diameter and muscle type distribution following free microvascular muscle transfers: a prospective study.

    abstract::The histology of free microvascular muscle flaps in 19 patients was studied prospectively. Biopsies were taken during operation, and after 2 and 6 weeks, as well as 3, 6, and 9 months, postoperatively, fixed and stained using the van Gieson method. Fiber diameters were analyzed morphometrically and fiber types defined...


    pub_type: 临床试验,杂志文章


    authors: Kauhanen MS,Salmi AM,von Boguslawsky EK,Leivo IV,Asko-Seljavaara SL

    更新日期:1998-01-01 00:00:00

  • Vascularized periosteal graft from the first metatarsal bone: a new technique to prevent collapse of osteonecrosis of the talus in children. A case report.

    abstract::Several microsurgical techniques have been described for the treatment of osteonecrosis of the talus (ONT). Recently reported in children, vascularized periosteal grafts showed promising revascularizing properties. We report a novel technique using a pedicled periosteal graft from the first metatarsal bone to treat st...


    pub_type: 杂志文章


    authors: Soldado F,Barrera-Ochoa S,Fontecha CG,Haddad S,Barastegui D,Barber I,Rego P

    更新日期:2013-01-01 00:00:00

  • Transfer of two motor branches of the anterior obturator nerve to the motor portion of the femoral nerve: an anatomical feasibility study.

    abstract::Femoral nerve lesions are uncommon, but very distressing at the functional level because of the absence of knee locking mechanism by the quadriceps muscle. We propose here a new neurotization procedure of obturator nerve motor branches to the motor portion of the femoral nerve in the thigh. This study was conducted on...


    pub_type: 杂志文章


    authors: Goubier JN,Teboul F,Yeo S

    更新日期:2012-09-01 00:00:00

  • Peripheral hemodynamic stability during prolonged anesthesia in the rat.

    abstract::The present study tests the hypothesis that peripheral hemodynamics in the rat femoral artery remain relatively stable during 3 hours of general anesthesia. Hemodynamic variables (pulse period, maximal centerline velocity, lumen diameter, and mean volumetric flow) were measured by the 20 MHz-pulsed ultrasonic Doppler ...


    pub_type: 杂志文章


    authors: Joos KM,Blair WF,Brown TD,Gabel RH

    更新日期:1986-01-01 00:00:00

  • Intraoperative flap design using ICG monitoring of a conjoined fabricated anterolateral thigh/tensor fasciae latae perforator flap in a case of extensive soft tissue reconstruction at the lower extremity.

    abstract::In this report, we present a case of the use of a conjoined fabricated free anterolateral thigh (ALT)/tensor fascia latae (TFL) perforator flap for reconstruction of the lower extremity with intraoperative flap design using intraoperative indocyanine green (ICG) monitoring. The flap was used for reconstruction of a 16...




    authors: Buehrer G,Taeger CD,Ludolph I,Horch RE,Beier JP

    更新日期:2016-11-01 00:00:00

  • Beneficial effect of hyperbaric oxygen on island flaps subjected to secondary venous ischemia.

    abstract::The potential for hyperbaric oxygen therapy (HBO) to decrease the untoward effects of a secondary ischemic event was studied in the rat superficial epigastric flap model. The secondary venous ischemic flap was created by cross-clamping the vascular pedicles for 2 h. Twenty-four hours later, the flap was reelevated and...


    pub_type: 杂志文章


    authors: Gampper TJ,Zhang F,Mofakhami NF,Morgan RF,Amiss R,Hoard MA,Angel MF

    更新日期:2002-01-01 00:00:00