Abstract:
:Monoclonal antibody directed against CD40 ligand prevents acute allograft rejection in several models of solid-organ transplantation. This study describes the use of CD40 ligand as antirejection therapy in a mouse peripheral nerve allograft model. C3H mice received 8-mm nerve isografts (n = 2) or nerve allografts from C57BL donors. Treated animals (n = 11) received anti-CD40 ligand antibody applied to the graft and by intraperitoneal injections postoperatively. At 3 weeks, nerve histology from treated animals was comparable to isografts, whereas untreated allografts demonstrated virtually no signs of regeneration. Walking-track analysis demonstrated a trend toward improved functional recovery in treated animals. In conclusion, blockade of the CD40 pathway suppresses nerve allograft rejection in mice, and facilitates regeneration comparable to isografts.
journal_name
Microsurgeryjournal_title
Microsurgeryauthors
Jensen JN,Tung TH,Mackinnon SE,Brenner MJ,Hunter DAdoi
10.1002/micr.20028subject
Has Abstractpub_date
2004-01-01 00:00:00pages
309-15issue
4eissn
0738-1085issn
1098-2752journal_volume
24pub_type
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