Inputs from regularly and irregularly discharging vestibular nerve afferents to secondary neurons in squirrel monkey vestibular nuclei. III. Correlation with vestibulospinal and vestibuloocular output pathways.

Abstract:

:1. A previous study measured the relative contributions made by regularly and irregularly discharging afferents to the monosynaptic vestibular nerve (Vi) input of individual secondary neurons located in and around the superior vestibular nucleus of barbiturate-anesthetized squirrel monkeys. Here, the analysis is extended to more caudal regions of the vestibular nuclei, which are a major source of both vestibuloocular and vestibulospinal pathways. As in the previous study, antidromic stimulation techniques are used to classify secondary neurons as oculomotor or spinal projecting. In addition, spinal-projecting neurons are distinguished by their descending pathways, their termination levels in the spinal cord, and their collateral projections to the IIIrd nucleus. 2. Monosynaptic excitatory postsynaptic potentials (EPSPs) were recorded intracellularly from secondary neurons as shocks of increasing strength were applied to Vi. Shocks were normalized in terms of the threshold (T) required to evoke field potentials in the vestibular nuclei. As shown previously, the relative contribution of irregular afferents to the total monosynaptic Vi input of each secondary neuron can be expressed as a %I index, the ratio (x100) of the relative sizes of the EPSPs evoked by shocks of 4 x T and 16 x T. 3. Antidromic stimulation was used to type secondary neurons as 1) medial vestibulospinal tract (MVST) cells projecting to spinal segments C1 or C6; 2) lateral vestibulospinal tract (LVST) cells projecting to C1, C6; or L1; 3) vestibulooculo-collic (VOC) cells projecting both to the IIIrd nucleus and by way of the MVST to C1 or C6; and 4) vestibuloocular (VOR) neurons projecting to the IIIrd nucleus but not to the spinal cord. Most of the neurons were located in the lateral vestibular nucleus (LV), including its dorsal (dLV) and ventral (vLV) divisions, and adjacent parts of the medial (MV) and descending nuclei (DV). Cells receiving quite different proportions of their direct inputs from regular and irregular afferents were intermingled in all regions explored. 4. LVST neurons are restricted to LV and DV and show a somatotopic organization. Those destined for the cervical and thoracic cord come from vLV, from a transition zone between vLV and DV, and to a lesser extent from dLV. Lumbar-projecting neurons are located more dorsally in dLV and more caudally in DV. MVST neurons reside in MV and in the vLV-DV transition zone.(ABSTRACT TRUNCATED AT 400 WORDS)

journal_name

J Neurophysiol

authors

Boyle R,Goldberg JM,Highstein SM

doi

10.1152/jn.1992.68.2.471

subject

Has Abstract

pub_date

1992-08-01 00:00:00

pages

471-84

issue

2

eissn

0022-3077

issn

1522-1598

journal_volume

68

pub_type

杂志文章
  • 5-HT modulation of hyperpolarization-activated inward current and calcium-dependent outward current in a crustacean motor neuron.

    abstract::1. Serotonergic modulation of a hyperpolarization-activated inward current, Ih, and a calcium-dependent outward current, Io(Ca), was examined in the dorsal gastric (DG) motor neuron, with the use of intracellular recording techniques in an isolated preparation of the crab stomatogastric ganglion (STG). 2. Hyperpolariz...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1992.68.2.496

    authors: Kiehn O,Harris-Warrick RM

    更新日期:1992-08-01 00:00:00

  • Thalamic and cortical contributions to neural plasticity after limb amputation.

    abstract::Little is known about the substrates for the large-scale shifts in the cortical representation produced by limb amputation. Subcortical changes likely contribute to the cortical remodeling, yet there is little data regarding the extent and pattern of reorganization in thalamus after such a massive deafferentation. Mor...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.83.5.3154

    authors: Florence SL,Hackett TA,Strata F

    更新日期:2000-05-01 00:00:00

  • Virtual vocalization stimuli for investigating neural representations of species-specific vocalizations.

    abstract::Most studies investigating neural representations of species-specific vocalizations in non-human primates and other species have involved studying neural responses to vocalization tokens. One limitation of such approaches is the difficulty in determining which acoustical features of vocalizations evoke neural response...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00818.2005

    authors: DiMattina C,Wang X

    更新日期:2006-02-01 00:00:00

  • Hour-long adaptation in the awake early visual system.

    abstract::Sensory adaptation serves to adjust awake brains to changing environments on different time scales. However, adaptation has been studied traditionally under anesthesia and for short time periods. Here, we demonstrate in awake rabbits a novel type of sensory adaptation that persists for >1 h and acts on visual thalamoc...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00116.2015

    authors: Stoelzel CR,Huff JM,Bereshpolova Y,Zhuang J,Hei X,Alonso JM,Swadlow HA

    更新日期:2015-08-01 00:00:00

  • Localized adenosine signaling provides fine-tuned negative feedback over a wide dynamic range of neocortical network activities.

    abstract::Although the patterns of activity produced by neocortical networks are now better understood, how these states are activated, sustained, and terminated still remains unclear. Negative feedback by the endogenous neuromodulator adenosine may potentially play an important role, as it can be released by activity and there...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00620.2014

    authors: Wall MJ,Richardson MJ

    更新日期:2015-02-01 00:00:00

  • Comparative transduction mechanisms of hair cells in the bullfrog utriculus. I. Responses to intracellular current.

    abstract::1. Hair cells in whole-mount in vitro preparations of the utricular macula of the bullfrog (Rana catesbeiana) were selected according to their macular location and hair bundle morphology. The voltage responses of selected hair cells to intracellular current steps and sinusoids in the frequency range of 0.5-200 Hz were...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1994.71.2.666

    authors: Baird RA

    更新日期:1994-02-01 00:00:00

  • Signs of functional maturation of peripheral auditory system in discharge patterns of neurons in anteroventral cochlear nucleus of kitten.

    abstract::1. Responses to pure tones were recorded from single neurons in the anteroventral cochlear nucleus (AVCN) in kittens ranging in age from 4 to 45 days. Different response properties mature at different times after birth. 2. The shapes of response areas of AVCN neurons after the 1st postnatal week resemble those recorde...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1978.41.6.1557

    authors: Brugge JF,Javel E,Kitzes LM

    更新日期:1978-11-01 00:00:00

  • Live imaging of bulk endocytosis in frog motor nerve terminals using FM dyes.

    abstract::We observed endocytosis in real time in stimulated frog motor nerve terminals by imaging the growth of large membrane infoldings labeled with a low concentration of FM dye. The spatial and temporal information made available by these experiments allowed us to image several new aspects of this synaptic vesicle recyclin...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00123.2011

    authors: Gaffield MA,Romberg CF,Betz WJ

    更新日期:2011-08-01 00:00:00

  • Intended arm use influences interhemispheric correlation of β-oscillations in primate medial motor areas.

    abstract::To investigate the role of interhemispheric β-synchronization in the selection of motor effectors, we trained two monkeys to memorize and perform multiple two-movement sequences that included unimanual repetition and bimanual switching. We recorded local field potentials simultaneously in the bilateral supplementary m...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00379.2016

    authors: Nakajima T,Arisawa H,Hosaka R,Mushiake H

    更新日期:2017-11-01 00:00:00

  • Neuronal gap junctions are required for NMDA receptor-mediated excitotoxicity: implications in ischemic stroke.

    abstract::N-methyl-D-aspartate receptors (NMDARs) play an important role in cell survival versus cell death decisions during neuronal development, ischemia, trauma, and epilepsy. Coupling of neurons by electrical synapses (gap junctions) is high or increases in neuronal networks during all these conditions. In the developing CN...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00656.2010

    authors: Wang Y,Denisova JV,Kang KS,Fontes JD,Zhu BT,Belousov AB

    更新日期:2010-12-01 00:00:00

  • Action potential in neurons of motor nerve net of Cyanea (Coelenterata).

    abstract::Neurons of the motor nerve net of the jellyfish Cyanea were impaled with microelectrodes for intracellular recordings. The cells have conventional, negative resting potentials and produce variable-amplitude action potentials with complex waveforms. The variability and complexity of these spikes is due to the superimpo...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1983.50.3.671

    authors: Anderson PA,Schwab WE

    更新日期:1983-09-01 00:00:00

  • Nicotinic receptors modulate olfactory bulb external tufted cells via an excitation-dependent inhibitory mechanism.

    abstract::Olfactory bulb (OB) glomeruli, the initial sites of synaptic processing of odor information, exhibit high levels of nicotinic acetylcholine receptor (nAChR) expression and receive strong cholinergic input from the basal forebrain. The role of glomerular nAChRs in olfactory processing, however, remains to be elucidated...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00865.2012

    authors: D'Souza RD,Parsa PV,Vijayaraghavan S

    更新日期:2013-10-01 00:00:00

  • Differential activation and classification of cutaneous afferents in the rat.

    abstract::1. A total of 312 cutaneous afferent units identified in the rat foot as belonging to one of nine major types of sensory receptors were included in the present study. A natural stimulus set was defined to differentiate optimally among those receptor types according to the distinguishing response patterns that it produ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1993.70.6.2411

    authors: Leem JW,Willis WD,Weller SC,Chung JM

    更新日期:1993-12-01 00:00:00

  • Anticipatory postural adjustments and spatial organization of motor cortex: evidence of adaptive compensations in healthy older adults.

    abstract::During anticipated postural perturbations induced by limb movement, the central nervous system generates anticipatory postural adjustments (APAs) in the trunk and hip musculature to minimize disturbances to equilibrium. Age-related changes in functional organization of the nervous system may contribute to changes in A...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00428.2018

    authors: Smith JA,Fisher BE

    更新日期:2018-12-01 00:00:00

  • On the importance of static nonlinearity in estimating spatiotemporal neural filters with natural stimuli.

    abstract::Understanding neural responses with natural stimuli has increasingly become an essential part of characterizing neural coding. Neural responses are commonly characterized by a linear-nonlinear (LN) model, in which the output of a linear filter applied to the stimulus is transformed by a static nonlinearity to determin...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01397.2007

    authors: Sharpee TO,Miller KD,Stryker MP

    更新日期:2008-05-01 00:00:00

  • Representation of the spatial relationship among object parts by neurons in macaque inferotemporal cortex.

    abstract::We investigated object representation in area TE, the anterior part of monkey inferotemporal (IT) cortex, with a combination of optical and extracellular recordings in anesthetized monkeys. We found neurons that respond to visual stimuli composed of naturally distinguishable parts. These neurons were sensitive to a pa...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01224.2005

    authors: Yamane Y,Tsunoda K,Matsumoto M,Phillips AN,Tanifuji M

    更新日期:2006-12-01 00:00:00

  • Physiological and behavioral reactivity to social exclusion: a functional infrared thermal imaging study in patients with psoriasis.

    abstract::Recent studies have shown that sympathetic nervous system (SNS) activity can be heavily impacted not only by basic threats to survival but also by threats to social bonds. In this study we explored the behavioral and physiological consequences of social exclusion/inclusion in patients with psoriasis, a disease frequen...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00555.2018

    authors: Ponsi G,Monachesi B,Panasiti V,Aglioti SM,Panasiti MS

    更新日期:2019-01-01 00:00:00

  • Symbolic cue-driven activity in superior colliculus neurons in a peripheral visual choice task.

    abstract::Recent evidence implicates the superior colliculus (SC) in cognitive processes, such as target selection and control of spatial attention, in addition to the execution of saccadic eye movements. We report here the presence of a cognitive response in some cells in the SC in a task that requires the long-term associatio...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01071.2005

    authors: Lee KM,Keller EL

    更新日期:2006-06-01 00:00:00

  • Synaptic transmission and hippocampal long-term potentiation in olfactory cyclic nucleotide-gated channel type 1 null mouse.

    abstract::Field potential recording was used to investigate properties of synaptic transmission and long-term potentiation (LTP) at Schaffer collateral-CA1 synapses in both hippocampal slices of mutant mice in which the alpha-subunit of the olfactory cyclic nucleotide-gated channel (alpha3/OCNC)1 was rendered null and also in s...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.79.6.3295

    authors: Parent A,Schrader K,Munger SD,Reed RR,Linden DJ,Ronnett GV

    更新日期:1998-06-01 00:00:00

  • Neurons in the human hippocampus and amygdala respond to both low- and high-level image properties.

    abstract::A large number of studies have demonstrated that structures within the medial temporal lobe, such as the hippocampus, are intimately involved in declarative memory for objects and people. Although these items are abstractions of the visual scene, specific visual details can change the speed and accuracy of their recal...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00977.2010

    authors: Steinmetz PN,Cabrales E,Wilson MS,Baker CP,Thorp CK,Smith KA,Treiman DM

    更新日期:2011-06-01 00:00:00

  • Effects of large excitatory and inhibitory inputs on motoneuron discharge rate and probability.

    abstract::We elicited repetitive discharge in hypoglossal motoneurons recorded in slices of rat brain stem using a combination of a suprathreshold injected current step with superimposed noise to mimic the synaptic drive likely to occur during physiological activation. The effects of repetitive en mass stimulation of afferent n...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1999.82.2.829

    authors: Türker KS,Powers RK

    更新日期:1999-08-01 00:00:00

  • Functional expression of α7-nicotinic acetylcholine receptors by muscle afferent neurons.

    abstract::The exercise pressor reflex (EPR) is generated by group III and IV muscle afferents during exercise to increase cardiovascular function. Muscle contraction is triggered by ACh, which is metabolized into choline that could serve as a signal of exercise-induced activity. We demonstrate that ACh can induce current in mus...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00035.2014

    authors: Baxter JC,Ramachandra R,Mayne DR,Elmslie KS

    更新日期:2014-09-15 00:00:00

  • Deficits of visual attention and saccadic eye movements after lesions of parietooccipital cortex in monkeys.

    abstract::1. Visual attention is often profoundly disturbed in humans after damage to the cortex of the posterior parietal lobe, particularly of the minor hemisphere, with some patients being totally unaware of visual stimuli in the hemifield of extrapersonal space contralateral to the cortical damage. This severe form of visua...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1989.61.1.74

    authors: Lynch JC,McLaren JW

    更新日期:1989-01-01 00:00:00

  • Properties of the nociceptive neurons of the leech segmental ganglion.

    abstract::1. The electrical responses of nociceptive (N) lateral and N medial neurons of the leech segmental ganglion to mechanical, chemical, and thermal stimulation of the skin were studied in a superfused ganglion-body wall preparation. 2. Mechanical indentation of the skin > 10 mN evoked in both types of cells a sustained d...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1996.75.6.2268

    authors: Pastor J,Soria B,Belmonte C

    更新日期:1996-06-01 00:00:00

  • Bimanual proprioception: are two hands better than one?

    abstract::Information about the position of an object that is held in both hands, such as a golf club or a tennis racquet, is transmitted to the human central nervous system from peripheral sensors in both left and right arms. How does the brain combine these two sources of information? Using a robot to move participant's passi...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00537.2013

    authors: Wong JD,Wilson ET,Kistemaker DA,Gribble PL

    更新日期:2014-03-01 00:00:00

  • Motion selectivity in macaque visual cortex. I. Mechanisms of direction and speed selectivity in extrastriate area MT.

    abstract::Mechanisms of direction selectivity and speed selectivity were studied in single neurons of the middle temporal visual area (MT) of behaving macaque monkeys. Visual stimuli were presented in both smooth and stroboscopic motion within a neuron's receptive field as the monkey fixated a stationary point of light. Directi...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1986.55.6.1308

    authors: Mikami A,Newsome WT,Wurtz RH

    更新日期:1986-06-01 00:00:00

  • Context-dependent modulation of interlimb cutaneous reflexes in arm muscles as a function of stability threat during walking.

    abstract::Cutaneous reflexes evoked in the muscles of the arms with electrical stimulation of nerves of the foot ("interlimb reflexes") are observed during walking. These reflexes have been suggested to coordinate the actions of the legs and arms when walking is disturbed. Recently, we showed that cutaneous reflexes evoked in t...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00746.2006

    authors: Haridas C,Zehr EP,Misiaszek JE

    更新日期:2006-12-01 00:00:00

  • Responses of medullary dorsal horn neurons to corneal stimulation by CO(2) pulses in the rat.

    abstract::Corneal-responsive neurons were recorded extracellularly in two regions of the spinal trigeminal nucleus, subnucleus interpolaris/caudalis (Vi/Vc) and subnucleus caudalis/upper cervical cord (Vc/C1) transition regions, from methohexital-anesthetized male rats. Thirty-nine Vi/Vc and 26 Vc/C1 neurons that responded to m...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1999.82.5.2092

    authors: Hirata H,Hu JW,Bereiter DA

    更新日期:1999-11-01 00:00:00

  • Slow brain potential and oscillatory EEG manifestations of impaired temporal preparation in Parkinson's disease.

    abstract::Performance in behavioral tasks is influenced by temporal expectations shaped by the temporal structure of the task. Such implicit temporal preparation is reflected in slow brain potentials and electroencephalographic oscillations and is attributed to interval timing mechanisms that probably depend on intact basal gan...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00224.2007

    authors: Praamstra P,Pope P

    更新日期:2007-11-01 00:00:00

  • Risky business: disambiguating ambiguity-related responses in the brain.

    abstract::Previous functional MRI studies reported neural correlates of risk and ambiguity based on behavioral economic theories. A recent study controlled for uncertainty by adding noise to information of an impending aversive event and demonstrated brain areas that did not track the degree of uncertainty: the activation peake...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章,评审

    doi:10.1152/jn.00406.2009

    authors: O'Neill M,Kobayashi S

    更新日期:2009-08-01 00:00:00