Sevoflurane versus halothane anesthesia after acute cryogenic brain injury in rabbits: relationship between arterial and intracranial pressure.


:The relationship between intracranial pressure and arterial blood pressure during sevoflurane or halothane anesthesia was evaluated in New Zealand white rabbits after cryogenic brain injury. Fourteen rabbits were randomized to be anesthetized with 1.5 MAC of sevoflurane or halothane in oxygen. All animals were paralyzed with pancuronium, and mechanically ventilated. A cryogenic lesion was created over the left hemisphere. Thirty minutes later, the intracranial pressure had risen to a mean value of 15 mm Hg. The inhaled concentration of anesthetic drugs was then increased to achieve a blood pressure of 35 mm Hg. Baseline measurements were made of monitored variables including mean arterial pressure, intracranial pressure, esophageal temperature, end-tidal CO2, and arterial blood gases. Neosynephrine was then infused to raise the blood pressure from 35 to 100 mm Hg during 20 min. The PaCO2 was maintained between 38 and 42 mm Hg. At baseline, there were no significant differences in mean arterial pressure, intracranial pressure, and blood gas values between the two groups. The intracranial pressure in the sevoflurane anesthesia group increased from 11 +/- 1 to 44 +/- 4 mm Hg as mean arterial pressure increased from 35 to 100 mm Hg. Intracranial pressure in the halothane anesthesia group increased from 9 +/- 1 to 32 +/- 3 mm Hg during the same range of blood pressure. Linear regressions of intracranial pressure on mean arterial pressure were performed for each of the two anesthetic groups. The slope of the regression line for the sevoflurane animals (0.491) was significantly greater than that for the halothane animals (0.323, p < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)


Kim HK,Zornow MH,Illievich UM,Strnat MA,Scheller MS




Has Abstract


1994-10-01 00:00:00












  • Clearance of valproic acid from cerebrospinal fluid in anesthetized rabbit.

    abstract::Clearance of valproic acid from brain tissue is believed to occur via a carrier-mediated system(s). The present study was designed to determine whether clearance was capacity-limited (saturable) and whether it occurred primarily at the choroid plexus. Ten rabbits were anesthetized with halothane and surgically prepare...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章


    authors: Artru AA,Adkinson KD,Powers KM,Shen DD

    更新日期:1994-07-01 00:00:00

  • Perioperative Management of Direct Oral Anticoagulants in Intracranial Surgery.

    abstract::The use of direct oral anticoagulants is increasing rapidly, because of perceived benefits over older agents, such as predictable pharmacokinetics and a reduced risk of bleeding. Elderly patients, who are more likely to be prescribed these drugs, are also presenting for neurosurgical procedures more often. The combina...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章


    authors: Porter J,Dinsmore J

    更新日期:2020-10-01 00:00:00

  • Cerebral ischemia after venous air embolism in the absence of intracardiac defects.

    abstract::Cerebral air embolism occurred in a patient undergoing posterior fossa surgery performed in the sitting position for acoustic neuroma removal. The patient experienced two episodes of venous air embolism, as evidenced by precordial Doppler, end-tidal carbon dioxide reduction, and oxygen desaturation. In both cases, air...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章


    authors: Tommasino C,Rizzardi R,Beretta L,Venturino M,Piccoli S

    更新日期:1996-01-01 00:00:00

  • Dual effects of ketamine: neurotoxicity versus neuroprotection in anesthesia for the developing brain.

    abstract::Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, is widely used in pediatric anesthesia. Recently, a series of animal studies have shown that ketamine may have neurotoxic effects on the developing brain and that these effects can later cause neurofunctional impairment. However, other studies have also sho...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章,评审


    authors: Yan J,Jiang H

    更新日期:2014-04-01 00:00:00

  • Neonatal Sevoflurane Exposure Induces Adulthood Fear-induced Learning Disability and Decreases Glutamatergic Neurons in the Basolateral Amygdala.

    abstract:BACKGROUND:Neonatal mice exposed to sevoflurane show certain cognitive and behavioral impairments in adulthood. However, the mechanisms underlying long-term cognitive deficits induced by sevoflurane exposure remain unknown. The present study was performed to investigate whether there is differential neuronal activation...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章


    authors: Satomoto M,Sun Z,Adachi YU,Makita K

    更新日期:2018-01-01 00:00:00

  • Ion distributions in brain during ischemia.

    abstract::The function of the central nervous system-and other organs-depends upon preservation of ionic gradients across cell membranes. In nervous tissue, the ion gradients are especially important since generation of action potentials and synaptic processes relies on transfer of ions across the plasma membrane. This report d...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章


    authors: Hansen AJ,Lundbaek JA

    更新日期:1989-12-01 00:00:00

  • Effect of Albumin in Combination With Mannitol on Whole-blood Coagulation In Vitro Assessed by Thromboelastometry.

    abstract:BACKGROUND:Albumin and mannitol may interfere with hemostasis, but their coinfluence is unclear. We aimed to determine the effects of albumin alone and in combination with mannitol or Ringer acetate (RAC) on hemostasis in crossover in vitro study. MATERIALS AND METHODS:From citrated fresh whole blood withdrawn from 10...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章


    authors: Lillemäe K,Laine AT,Schramko A,Niemi TT

    更新日期:2018-07-01 00:00:00

  • Dexamethasone PONV prophylaxis alters the hypothalamic-pituitary-adrenal axis after transsphenoidal pituitary surgery.

    abstract:BACKGROUND:Postoperative nausea and vomiting (PONV) is common after general anesthesia and are reported by approximately 20% to 25% of all patients and up to 39% of patients undergoing neurosurgical procedures. The most common standard prophylaxis is a single application of 4 mg of dexamethasone before initiating anest...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章


    authors: Burkhardt T,Rotermund R,Schmidt NO,Kiefmann R,Flitsch J

    更新日期:2014-07-01 00:00:00

  • A comparison of equivolume, equiosmolar solutions of hypertonic saline and mannitol for brain relaxation in patients undergoing elective intracranial tumor surgery: a randomized clinical trial.

    abstract:BACKGROUND:Hyperosmolar solutions have been used in neurosurgery to modify brain bulk and prevent neurological deterioration. The purpose of the study was to compare the effects of equivolume, equiosmolar solutions of mannitol and hypertonic saline (HTS) on brain relaxation and postoperative complications in patients u...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章,随机对照试验


    authors: Dostal P,Dostalova V,Schreiberova J,Tyll T,Habalova J,Cerny V,Rehak S,Cesak T

    更新日期:2015-01-01 00:00:00

  • Lund concept for the management of traumatic brain injury: a physiological principle awaiting stronger evidence.

    abstract::The "Lund concept" involving a "volume-targeted" strategy for intracranial pressure control originated in the University of Lund, Sweden, more than 20 years ago and has remained controversial ever since. It is based on the premise that the blood-brain barrier is disrupted after traumatic brain injury and cerebral auto...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章,评审


    authors: Sharma D,Vavilala MS

    更新日期:2011-10-01 00:00:00

  • Assessing risk factors for postoperative nausea and vomiting: a retrospective study in patients undergoing retromastoid craniectomy with microvascular decompression of cranial nerves.

    abstract::We have observed that patients, after retromastoid craniectomy (RMC) with microvascular decompression (MVD) of cranial nerves, frequently experienced postoperative nausea and vomiting (PONV). The authors conducted this study to track the incidence of PONV and to identify potential factors for PONV after RMC with MVD. ...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章


    authors: Meng L,Quinlan JJ

    更新日期:2006-10-01 00:00:00

  • Prostaglandin E1 but not corticosteroid increases nerve root blood flow velocity after lumbar diskectomy in surgical patients.

    abstract::The purpose of this study was to clarify whether prostaglandin E1 (PGE(1)) or corticosteroid could increase blood flow in the nerve root because neurologic symptoms in spinal stenosis may be based on the vascular insufficiency in the nerve root. Fifty-seven patients undergoing lumbar diskectomy were randomly assigned ...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Fukusaki M,Miyako M,Miyoshi H,Takada M,Terao Y,Konishi H,Sumikawa K

    更新日期:2003-04-01 00:00:00

  • Home-based Cognitive Prehabilitation in Older Surgical Patients: A Feasibility Study.

    abstract:BACKGROUND:Cognitive training is beneficial in various clinical settings, although its perioperative feasibility and impact remain unknown. The objective of this pilot study was to determine the feasibility of home-based cognitive prehabilitation before major surgery in older adults. MATERIALS AND METHODS:Sixty-one pa...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章,随机对照试验


    authors: Vlisides PE,Das AR,Thompson AM,Kunkler B,Zierau M,Cantley MJ,McKinney AM,Giordani B

    更新日期:2019-04-01 00:00:00

  • Effectiveness of an intravascular cooling method compared with a conventional cooling technique in neurologic patients.

    abstract::Fever is common among neurologic patients and is usually treated by antipyretic drugs and external cooling. An alternative method for temperature management may be an intravascular approach. The aim of the study was to compare the effectiveness and the therapeutic costs of this new method with conventional treatment i...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章,随机对照试验


    authors: Hinz J,Rosmus M,Popov A,Moerer O,Frerichs I,Quintel M

    更新日期:2007-04-01 00:00:00

  • Do recently developed techniques for skull base surgery increase the risk of difficult airway management? Assessment of pseudoankylosis of the mandible following surgical manipulation of the temporalis muscle.

    abstract::We report our experience with anesthetic care for six patients with pseudoankylosis of the mandible following neurosurgical procedures, four of whom required fiberoptically guided intubation for anesthesia. We suggest that the development of operative approaches and reconstruction techniques in skull base surgery may ...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 临床试验,杂志文章


    authors: Kawaguchi M,Sakamoto T,Ohnishi H,Karasawa J,Furuya H

    更新日期:1995-07-01 00:00:00

  • Comparison of the Effects of Propofol and Sevoflurane Combined With Remifentanil on Transcranial Electric Motor-evoked and Somatosensory-evoked Potential Monitoring During Brainstem Surgery.

    abstract:BACKGROUND:We compared the effect of propofol and sevoflurane combined with remifentanil under comparable bispectral index (BIS) levels on transcranial electric motor-evoked potentials (TceMEPs) and somatosensory-evoked potentials (SSEPs) during brainstem surgery. MATERIALS AND METHODS:A total of 40 consecutive patien...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章,随机对照试验


    authors: Hernández-Palazón J,Izura V,Fuentes-García D,Piqueras-Pérez C,Doménech-Asensi P,Falcón-Araña L

    更新日期:2015-10-01 00:00:00

  • The effects of neuromuscular blockade on operating conditions during general anesthesia for spinal surgery.

    abstract:BACKGROUND:Muscle relaxants are prescribed routinely for patients undergoing general anesthesia, but the requirement for paralysis in spinal surgery is unclear. This study compared the operating conditions of general anesthesia with and without a muscle relaxant on spinal surgery patients. METHODS:Eighty-six adults wh...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章,随机对照试验


    authors: Li YL,Liu YL,Xu CM,Lv XH,Wan ZH

    更新日期:2014-01-01 00:00:00

  • Effects of Prone Position and Positive End-Expiratory Pressure on Noninvasive Estimators of ICP: A Pilot Study.

    abstract:BACKGROUND:Prone positioning and positive end-expiratory pressure can improve pulmonary gas exchange and respiratory mechanics. However, they may be associated with the development of intracranial hypertension. Intracranial pressure (ICP) can be noninvasively estimated from the sonographic measurement of the optic nerv...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章


    authors: Robba C,Bragazzi NL,Bertuccio A,Cardim D,Donnelly J,Sekhon M,Lavinio A,Duane D,Burnstein R,Matta B,Bacigaluppi S,Lattuada M,Czosnyka M

    更新日期:2017-07-01 00:00:00

  • Safety Outcomes Following Spine and Cranial Neurosurgery: Evidence From the National Surgical Quality Improvement Program.

    abstract:BACKGROUND:The American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) was used to establish predictors for 30-day postoperative complications following spine and cranial neurosurgery. MATERIALS AND METHODS:The ACS-NSQIP participant use files were queried for neurosurgical cases between ...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章


    authors: Rock AK,Opalak CF,Workman KG,Broaddus WC

    更新日期:2018-10-01 00:00:00

  • Plaque Characteristics on CT Angiography Do Not Improve the Ability to Predict Hemodynamic Instability During and After Carotid Angioplasty and Stenting.

    abstract:BACKGROUND:Hemodynamic instability is commonly seen during carotid angioplasty and stenting. Although prophylactic treatment with anticholinergics is beneficial, selected use in high-risk patients is desirable. This study examines whether plaque characteristics on computed tomography angiography in addition to demograp...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章


    authors: Jensen SK,Eesa M,Walker A,Archer DP,Davis MJ

    更新日期:2020-05-05 00:00:00

  • Succinylcholine-induced increases in CSF pressure are not affected by PaCO2 or mean arterial pressure in dogs.

    abstract::The effects of PaCO2 and mean arterial pressure (MAP) on succinylcholine-induced changes in cerebrospinal fluid (CSF) pressure were examined in 31 dogs anesthetized with halothane (0.7% end-expired) and nitrous oxide (66% inspired) in oxygen. Group 1 (n = 9) received succinylcholine (1.5 mg/kg i.v.) without control of...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章


    authors: Artru AA

    更新日期:1990-03-01 00:00:00

  • Intra-arterial 133Xe measurements suggest a dose-dependent increase in cerebral blood flow during intracarotid infusion of adenosine in nonhuman primates.

    abstract::Intra-arterial vasodilators, such as papaverine, have been used to treat cerebrovascular insufficiency. The short biologic half-life, and the vasodilating and neuroprotective properties of adenosine could be useful during the treatment of cerebral ischemia. However, in human subjects a proposed intracarotid dose of 1 ...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章


    authors: Joshi S,Mangla S,Wang M,Sciacca RR,Young WL

    更新日期:2002-04-01 00:00:00

  • Brain edema after human cerebral hemorrhage: a magnetic resonance imaging volumetric analysis.

    abstract::Although perihematoma brain edema can significantly modify neurologic outcome after intracerebral hemorrhage (ICH), our knowledge of its natural history is incomplete. We report on the correlation between hematoma (HV) and edema volumes (EV) in 14 patients with ICH during the first week after the ictus using MRI volum...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章


    authors: Carhuapoma JR,Hanley DF,Banerjee M,Beauchamp NJ

    更新日期:2003-07-01 00:00:00

  • Evaluation of the optimal preemptive dose of gabapentin for postoperative pain relief after lumbar diskectomy: a randomized, double-blind, placebo-controlled study.

    abstract::We evaluated the optimal preemptive dose of gabapentin for postoperative pain relief after single-level lumbar diskectomy and its effect on fentanyl consumption during the initial 24 hours in a randomized, double-blinded, placebo-controlled study in 100 patients with American Society of Anesthesiologists physical stat...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Pandey CK,Navkar DV,Giri PJ,Raza M,Behari S,Singh RB,Singh U,Singh PK

    更新日期:2005-04-01 00:00:00

  • Epidemiology and Resource Utilization of Simple Febrile Seizure-associated Hospitalizations in the United States, 2003-2012.

    abstract:BACKGROUND:Simple febrile seizure (SFS) affects 2% to 4% of children under 6 years of age. The purpose of this study is to examine the epidemiologic patterns and resource utilization of SFS-associated hospitalizations in children aged younger than 6 years of age in the United States. MATERIALS AND METHODS:This study i...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章


    authors: Huang YY,Li G,Sun LS

    更新日期:2019-01-01 00:00:00

  • A case of shock subsequent to treatment of intracranial hypertension by mannitol injection combined with hyperventilation.

    abstract::This report describes a sudden decrease in blood pressure after conservative treatment of acute intracranial hypertension. A 63-year-old woman with acute hydrocephalus after undergoing clipping of an aneurysm of the right supracerebellar artery developed increased intracranial pressure, necessitating surgical manageme...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章


    authors: Inoue S,Ninaga H,Kawaguchi M,Furuya H

    更新日期:1998-04-01 00:00:00

  • Sevoflurane (0.4 MAC) does not influence cerebral compliance in healthy individuals.

    abstract::The use of sevoflurane is favored for its rapid onset and offset of anesthesia as well as good intraoperative titratability of the anesthetic. With regard to neuroanesthesia, the reported effects of sevoflurane on cerebral hemodynamics and cerebrospinal fluid dynamics are inconsistent. We used phase-contrast magnetic ...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 临床试验,杂志文章


    authors: Kolbitsch C,Lorenz HI,Hörmann C,Schocke M,Felber S,Zschiegner F,Pfeiffer PK,Benzer A

    更新日期:2000-10-01 00:00:00

  • Cerebral monitoring during cardiopulmonary bypass in children.

    abstract::Although cerebral monitoring during CPB remains primarily investigational, recent data support its clinical utility. In particular, it is cerebral metabolic monitoring that provides meaningful information in terms of preparing the brain for dhCPB and dhCA. Cerebral blood flow or cerebral blood flow velocity monitoring...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章,评审


    authors: Kern FH,Schell RM,Greeley WJ

    更新日期:1993-07-01 00:00:00

  • Repair of two unruptured intracranial aneurysms in the presence of coarctation of the aorta-anesthetic implications and management.

    abstract::A case of two incidental familial intracranial aneurysms associated with asymptomatic coarctation of the aorta is reported. Priority was assigned to aneurysm surgery, which was accomplished by means of two distinct procedures, both requiring moderate, deliberate hypotension. Invasive monitoring always included radial ...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章


    authors: Orsi P,Rosa G,Liberatori G,Lunardi PP,Ferrante L

    更新日期:1993-01-01 00:00:00

  • Hemodynamic Instability and Cardiovascular Events After Traumatic Brain Injury Predict Outcome After Artifact Removal With Deep Belief Network Analysis.

    abstract:BACKGROUND:Hemodynamic instability and cardiovascular events heavily affect the prognosis of traumatic brain injury. Physiological signals are monitored to detect these events. However, the signals are often riddled with faulty readings, which jeopardize the reliability of the clinical parameters obtained from the sign...

    journal_title:Journal of neurosurgical anesthesiology

    pub_type: 杂志文章


    authors: Kim H,Lee SB,Son Y,Czosnyka M,Kim DJ

    更新日期:2018-10-01 00:00:00