Nuclear localization signals, but not putative leucine zipper motifs, are essential for nuclear transport of hepatitis delta antigen.

abstract：:The vaccinia virus F10 protein is one of two virally encoded protein kinases. A phenotypic analysis of infections involving a tetracycline-inducible recombinant (vDeltaiF10) indicated that F10 is involved in the early stages of virion morphogenesis, as previously reported for the mutants ts28 and ts15. The proteins en...

journal_title：Journal of virology

authors： Punjabi A,Traktman P

更新日期：2005-02-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) glycoprotein B (gB), encoded by the UL55 open reading frame, is an essential envelope glycoprotein involved in cell attachment and entry. Previously, we identified residue serine 900 (Ser900) as a unique site of reversible casein kinase 2 phosphorylation in the cytoplasmic domain of HCMV g...

journal_title：Journal of virology

authors： Jarvis MA,Jones TR,Drummond DD,Smith PP,Britt WJ,Nelson JA,Baldick CJ

更新日期：2004-01-01 00:00:00

abstract：:Recombinant viruses possessing reporter proteins have been generated for virus research. In the case of the family Flaviviridae, we recently generated recombinant viruses, including the hepatitis C virus of the genus Hepacivirus, Japanese encephalitis virus (JEV) of the genus Flavivirus, and bovine viral diarrhea viru...

journal_title：Journal of virology

authors： Tamura T,Igarashi M,Enkhbold B,Suzuki T,Okamatsu M,Ono C,Mori H,Izumi T,Sato A,Fauzyah Y,Okamoto T,Sakoda Y,Fukuhara T,Matsuura Y

更新日期：2019-10-29 00:00:00

abstract：:Genomic replication of the negative-strand RNA viruses is dependent upon protein synthesis. To examine the requirement for protein synthesis in replication, we developed an in vitro system that supports the genome replication of defective interfering particles of the negative-strand rhabdovirus vesicular stomatitis vi...

journal_title：Journal of virology

authors： Patton JT,Davis NL,Wertz GW

更新日期：1984-02-01 00:00:00

abstract：:SF162 is a primary (PR), non-syncytium-inducing, macrophagetropic human immunodeficiency virus type 1 (HIV-1) clade B isolate which is resistant to antibody-mediated neutralization. Deletion of the first or second hypervariable envelope gp120 region (V1 or V2 loop, respectively) of this virus does not abrogate its abi...

journal_title：Journal of virology

authors： Stamatatos L,Cheng-Mayer C

更新日期：1998-10-01 00:00:00

abstract：:The utility of the present generation of adenovirus (Ad) vectors for gene therapy applications could be improved by restricting native viral tropism to selected cell types. In order to achieve modification of Ad tropism, we proposed to exploit a minor component of viral capsid, protein IX (pIX), for genetic incorporat...

journal_title：Journal of virology

authors： Dmitriev IP,Kashentseva EA,Curiel DT

更新日期：2002-07-01 00:00:00

abstract：:The interferon response elicited by Salmonella typhimurium mutants in mice is not dependent on the presence of a complete cell wall lipopolysaccharide. In fact, a mutant (G30/C21) which has lost all the polysaccharide side chains and sugars of the O antigen and contains only 2-keto-3-deoxyoctonate and lipid is indisti...

journal_title：Journal of virology

authors： Youngner JS,Feingold DS

更新日期：1967-12-01 00:00:00

abstract：:One unique feature of the shrimp white spot syndrome virus (WSSV) genome is the presence of a giant open reading frame (ORF) of 18,234 nucleotides that encodes a long polypeptide of 6,077 amino acids with a hitherto unknown function. In the present study, by applying proteomic methodology to analyze the sodium dodecyl...

journal_title：Journal of virology

authors： Leu JH,Tsai JM,Wang HC,Wang AH,Wang CH,Kou GH,Lo CF

更新日期：2005-01-01 00:00:00

abstract：:In this study we report the complete sequence and genome organization of the serotype I feline coronavirus (FCoV) strain Black. Furthermore, a reverse genetic system was established for this FCoV strain by cloning a full-length cDNA copy into vaccinia virus. This clone served as basis for the generation of recombinant...

journal_title：Journal of virology

authors： Tekes G,Hofmann-Lehmann R,Stallkamp I,Thiel V,Thiel HJ

更新日期：2008-02-01 00:00:00

abstract：:Natural evolution in primate lentiviral reverse transcriptase (RT) appears to have been constrained by the necessity to maintain function within an asymmetric protein composed of two identical primary amino acid sequences (66 kDa), of which one is cleaved (51 kDa). In this study, a detailed phylogenetic analysis now s...

journal_title：Journal of virology

authors： Tebit DM,Lobritz M,Lalonde M,Immonen T,Singh K,Sarafianos S,Herchenröder O,Kräusslich HG,Arts EJ

更新日期：2010-10-01 00:00:00

abstract：:The herpes simplex virus type 1 (HSV-1) alpha protein ICP27 regulates the transition between the delayed-early and late phases of the viral infection. Previous genetic analyses have suggested that the important functional domains of ICP27 map to its carboxyl-terminal half. One striking feature of the primary sequence ...

journal_title：Journal of virology

authors： Rice SA,Lam V,Knipe DM

更新日期：1993-04-01 00:00:00

abstract：:A polymorphism in the gene encoding CCR2 is associated with a delay in progression to AIDS in human immunodeficiency virus (HIV)-infected individuals. The polymorphism, CCR2-64I, changes valine 64 of CCR2 to isoleucine. However, it is not clear whether the effect on AIDS progression results from the amino acid change ...

journal_title：Journal of virology

authors： Mariani R,Wong S,Mulder LC,Wilkinson DA,Reinhart AL,LaRosa G,Nibbs R,O'Brien TR,Michael NL,Connor RI,Macdonald M,Busch M,Koup RA,Landau NR

更新日期：1999-03-01 00:00:00

abstract：:Polyoma virus particles were purified by equilibrium centrifugation in CsCl. Particles from three regions of the density gradient were examined for infectivity, for their ability to induce expanded pools of deoxyribonucleic acid (DNA) precursors, and for their ability to stimulate the synthesis of DNA. The most infect...

journal_title：Journal of virology

authors： Skoog L,Nordenskjöld BA,Lindberg U

更新日期：1970-07-01 00:00:00

abstract：:For the identification of RNA-binding proteins that specifically interact with potato spindle tuber viroid (PSTVd), we subjected a tomato cDNA expression library prepared from viroid-infected leaves to an RNA ligand screening procedure. We repeatedly identified cDNA clones that expressed a protein of 602 amino acids. ...

journal_title：Journal of virology

authors： Martínez de Alba AE,Sägesser R,Tabler M,Tsagris M

更新日期：2003-09-01 00:00:00

abstract：:The E6 oncoproteins encoded by the cancer-associated human papillomaviruses (HPVs) can associate with and promote the degradation of wild-type p53 in vitro. To gain further insight into this process, the ability of HPV-16 E6 to complex with and promote the degradation of mutant forms of p53 was studied. A correlation ...

journal_title：Journal of virology

authors： Scheffner M,Takahashi T,Huibregtse JM,Minna JD,Howley PM

更新日期：1992-08-01 00:00:00

abstract：:Replication-defective vaccine vectors based on vesicular stomatitis virus (VSV) lacking its envelope glycoprotein gene (G) are highly effective in animal models. However, such ΔG vectors are difficult to grow because they require complementation with the VSV G protein. In addition, the complementing G protein induces ...

journal_title：Journal of virology

authors： Chattopadhyay A,Rose JK

更新日期：2011-03-01 00:00:00

abstract：:West Nile virus (WNV) is a neurotropic flavivirus and the leading cause of mosquito-borne encephalitis in the United States. Recent studies in humans have found that dysfunctional T cell responses strongly correlate with development of severe WNV neuroinvasive disease. However, the contributions of human dendritic cel...

journal_title：Journal of virology

authors： Zimmerman MG,Bowen JR,McDonald CE,Pulendran B,Suthar MS

更新日期：2019-11-13 00:00:00

abstract：UNLABELLED:Kaposi's sarcoma-associated herpesvirus (KSHV, also called human herpesvirus 8) is linked to the development of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD). KSHV expresses several proteins that modulate host cell signaling pathways. One of these proteins...

journal_title：Journal of virology

authors： Giffin L,Yan F,Ben Major M,Damania B

更新日期：2014-08-01 00:00:00

abstract：:In this study, we show that human cytomegalovirus DNA synthesis is inhibited in infected confluent human embryonic lung cells treated with the DNA-intercalative topoisomerase II inhibitor 4-9'-(acridinylamino)methanesulfon-m-anisidide (m-AMSA). Similar inhibitory effects were observed with VM-26, a nonintercalative to...

journal_title：Journal of virology

authors： Benson JD,Huang ES

更新日期：1988-12-01 00:00:00

abstract：UNLABELLED:Gammaherpesviruses establish persistent, systemic infections and cause cancers. Murid herpesvirus 4 (MuHV-4) provides a unique window into the early events of host colonization. It spreads via lymph nodes. While dendritic cells (DC) pass MuHV-4 to lymph node B cells, subcapsular sinus macrophages (SSM), whic...

journal_title：Journal of virology

authors： Lawler C,Tan CS,Simas JP,Stevenson PG

更新日期：2016-09-29 00:00:00

abstract：:In addition to PTAP L domains, primate lentiviruses carry Alix-binding motifs that include the recently described type 3 SREKPYKEVTEDLLHLNSLF sequence. We examined the requirements for the type 3 sequence motif in simian immunodeficiency virus SIV(smE543) and identified the (499)LNSLF(503) sequence as a key functional...

journal_title：Journal of virology

authors： Bello NF,Wu F,Sette P,Dussupt V,Hirsch VM,Bouamr F

更新日期：2011-11-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) specifically incorporates the host cell peptidyl-prolyl isomerase cyclophilin A into virions via contacts with the capsid (CA) domain of the Gag polyprotein Pr55gag. The immunosuppressant drug cyclosporin A and the nonimmunosuppressive cyclosporin A analog SDZ NIM 811 bind t...

journal_title：Journal of virology

authors： Dorfman T,Göttlinger HG

更新日期：1996-09-01 00:00:00

abstract：:The Kresse strain of porcine parvovirus (PPV) was cloned into pUC19, and independent infectious clones were sequenced. The PPV Kresse and NADL-2 strains, which have different pathogenicities, shared an identical genomic organization and a high degree of sequence identity. Partial genomes (1.5 or 1.6 kb) of 15 field is...

journal_title：Journal of virology

authors： Bergeron J,Hébert B,Tijssen P

更新日期：1996-04-01 00:00:00

abstract：:When residues 17 and 18 in nef of simian immunodeficiency virus strain SIVmac239 were changed from RQ to YE, the resultant virus was able to replicate in peripheral blood mononuclear cell cultures without prior lymphocyte activation and without the addition of exogenous interleukin-2, caused extensive lymphocyte activ...

journal_title：Journal of virology

authors： Du Z,Ilyinskii PO,Sasseville VG,Newstein M,Lackner AA,Desrosiers RC

更新日期：1996-06-01 00:00:00

abstract：:The temperature-sensitive and attenuated phenotypes of the Sabin type 1 vaccine strain of poliovirus result from numerous point mutations which occurred in the virulent Mahoney virus parent. One of these mutations is located in a 3D polymerase (3Dpol) codon (U-6203-->C, Tyr-73-->His) and is involved in attenuation in ...

journal_title：Journal of virology

authors： Georgescu MM,Tardy-Panit M,Guillot S,Crainic R,Delpeyroux F

更新日期：1995-09-01 00:00:00

abstract：:Passive transfer of neutralizing antibodies is effective in protecting rhesus macaques against simian/human immunodeficiency virus (SHIV) challenge. In addition to neutralization, effector functions of the crystallizable fragment (Fc) of antibodies are involved in antibody-mediated protection against a number of virus...

journal_title：Journal of virology

authors： Moldt B,Schultz N,Dunlop DC,Alpert MD,Harvey JD,Evans DT,Poignard P,Hessell AJ,Burton DR

更新日期：2011-10-01 00:00:00

abstract：:Apoptosis of infected cells is critically involved in antiviral defense. Apoptosis, however, may also support the release and spread of viruses. Although the elimination of infected hepatocytes is required to combat hepatitis B virus (HBV) infection, it is still unknown which consequences hepatocyte apoptosis has for ...

journal_title：Journal of virology

authors： Arzberger S,Hösel M,Protzer U

更新日期：2010-11-01 00:00:00

abstract：:Severe acute respiratory syndrome (SARS) is a highly contagious and life threatening disease, with a fatality rate of almost 10%. The etiologic agent is a novel coronavirus, severe acute respiratory syndrome coronavirus (SARS-CoV), with animal reservoirs found in bats and other wild animals and thus the possibility of...

journal_title：Journal of virology

authors： Oh HL,Chia A,Chang CX,Leong HN,Ling KL,Grotenbreg GM,Gehring AJ,Tan YJ,Bertoletti A

更新日期：2011-10-01 00:00:00

abstract：:The 2009 H1N1 influenza pandemic provided an opportunity to study human virus-specific T cell responses after infection with a novel influenza virus against which limited humoral immunity existed in the population. Here we describe the magnitude, kinetics, and nature of the virus-specific T cell response using intrace...

journal_title：Journal of virology

authors： Hillaire ML,van Trierum SE,Bodewes R,van Baalen CA,van Binnendijk RS,Koopmans MP,Fouchier RA,Osterhaus AD,Rimmelzwaan GF

更新日期：2011-11-01 00:00:00

abstract：:Sequences and structures within the terminal genomic regions of plus-strand RNA viruses are targets for the binding of host proteins that modulate functions such as translation, RNA replication, and encapsidation. Using murine norovirus 1 (MNV-1), we describe the presence of long-range RNA-RNA interactions that were s...

journal_title：Journal of virology

authors： López-Manríquez E,Vashist S,Ureña L,Goodfellow I,Chavez P,Mora-Heredia JE,Cancio-Lonches C,Garrido E,Gutiérrez-Escolano AL

更新日期：2013-11-01 00:00:00