Distribution of clindamycin in cortical bone during direct local infusion of the canine tibia.


:The distribution of clindamycin in tibial cortical bone, administered via direct local infusion with an implantable pump, is described. Clindamycin concentrations in cortical bone were measured after 3, 7, and 21 days of intraosseous infusion. The tibia were divided into four quadrants relative to the outflow infusion catheter site located in the medial aspect of the mid-diaphysis. A gradient of 5-30 mm from the infusion site was documented in all four quadrants (proximal lateral, proximal medial, distal lateral, and distal medial). At all sampling times, clindamycin concentrations in all quadrants exceeded the minimum inhibitory concentrations for gram-positive aerobic bacteria, including Staphylococcus aureus and S. epidermidis, and both the gram-positive and gram-negative anaerobes, including Peptostreptococcus species and Bacteroides species. The data suggest that gravitational forces affect the diffusion of the clindamycin because concentrations in both distal quadrants were greater than in corresponding proximal quadrants.


J Orthop Trauma


Budsberg SC,Brown J




Has Abstract


1994-10-01 00:00:00












  • Comparison of Outcomes of Intertrochanteric Fracture Fixation Using Percutaneous Compression Plate Between Stable and Unstable Fractures in the Elderly.

    abstract:OBJECTIVES:To evaluate the outcomes of treatment with a percutaneous compression plate (PCCP) in stable and unstable intertrochanteric hip fractures. DESIGN:Clinical prospective nonrandomized cohort study. SETTING:San Cecilio University Hospital, Granada (Spain). A tertiary-care hospital. PATIENTS:Patients older tha...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Carvajal-Pedrosa C,Gómez-Sánchez RC,Hernández-Cortés P

    更新日期:2016-06-01 00:00:00

  • Stiffness of knee-spanning external fixation systems for traumatic knee dislocations: a biomechanical study.

    abstract:OBJECTIVE:The purpose of this study was to compare the relative stiffness of four common external fixation (XF) configurations used to span and stabilize the knee after knee dislocation. METHODS:Synthetic composite femora and tibiae connected with cords were used to simulate a knee. Four configurations of external fix...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Mercer D,Firoozbakhsh K,Prevost M,Mulkey P,DeCoster TA,Schenck R

    更新日期:2010-11-01 00:00:00

  • The "swashbuckler": a modified anterior approach for fractures of the distal femur.

    abstract::A modified anterior approach to the distal femur is presented. The approach allows surgical exposure of the entire articular surface of the distal femur. The quadriceps muscle bellies are spared during the approach. The skin incision used will not interfere with subsequent total knee arthroplasty, if posttraumatic art...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Starr AJ,Jones AL,Reinert CM

    更新日期:1999-02-01 00:00:00

  • Operating room efficiency: benefits of an orthopaedic traumatologist at a level II trauma center.

    abstract:OBJECTIVES:Fellowship-trained orthopaedic traumatologists are presumably taught skill sets leading to "best practice" outcomes and more efficient use of hospital resources. This should result in more favorable economic opportunities when compared with general orthopaedic surgeons (GOSs) providing similar clinical servi...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Althausen PL,Kauk JR,Shannon S,Lu M,O'Mara TJ,Bray TJ

    更新日期:2014-05-01 00:00:00

  • Biomechanical Assessment of Locking Plate Fixation of Comminuted Proximal Olecranon Fractures.

    abstract:OBJECTIVES:To determine if mean ultimate strength or failure mechanism differed between comminuted olecranon fractures created at the proximal 25% or 50% of the trochlear notch and fixed with precontoured posterior locking plates (PLPs). METHODS:Comminuted osteotomies were created in 10 matched pairs of cadaveric uppe...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Fantry A,Sobel A,Capito N,Hodax JD,Pidgeon T,Koruprolu S,Rich R,Fava JL,Green A,Paxton S

    更新日期:2018-11-01 00:00:00

  • Patellar fixation protected with a load-sharing cable: a mechanical and clinical study.

    abstract::The stability of patellar fracture fixation protected with a load-sharing cable was studied in cadavers. A transverse patellar osteotomy was produced and stabilized with standard patellar fixation with or without a figure-of-eight cable that extends from the proximal pole of the patella to the tibial tubercle. Standar...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Perry CR,McCarthy JA,Kain CC,Pearson RL

    更新日期:1988-01-01 00:00:00

  • The surgical treatment of isolated mason type 2 fractures of the radial head in adults: comparison between radial head resection and open reduction and internal fixation.

    abstract:OBJECTIVES:To compare the outcomes of two different surgical treatments for the management of isolated closed Mason Type 2 radial head fractures. DESIGN:Retrospective study. The Student t test and McPearson chi-square test were used to evaluate whether there was a significance difference between the groups. PATIENTS:...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Zarattini G,Galli S,Marchese M,Mascio LD,Pazzaglia UE

    更新日期:2012-04-01 00:00:00

  • Prospective comparison of contrast-enhanced computed tomography versus magnetic resonance venography in the detection of occult deep pelvic vein thrombosis in patients with pelvic and acetabular fractures.

    abstract:OBJECTIVE:To determine the rate of pelvic vein thrombosis following acetabular or pelvic fracture identified by enhanced computed tomography venography or magnetic resonance venography. DESIGN:Prospective evaluation of computed tomography venography and magnetic resonance venography in patients with pelvic and acetabu...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Stover MD,Morgan SJ,Bosse MJ,Sims SH,Howard BJ,Stackhouse D,Weresh MJ,Kellam JF

    更新日期:2002-10-01 00:00:00

  • Pathomorphologic characteristics of posttraumatic acetabular dysplasia.

    abstract:OBJECTIVES:The pathomorphology of posttraumatic acetabular dysplasia differs fundamentally from the classic developmental dysplasia of the adolescent. The aim of this report is to qualify and quantify the pathomorphologic characteristics of the posttraumatic acetabular dysplasia and to define the requirements for adequ...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Dora C,Zurbach J,Hersche O,Ganz R

    更新日期:2000-09-01 00:00:00

  • Management of severe musculoskeletal injuries of the upper extremity.

    abstract::Limb salvage was successful in 25 patients treated for severe grade III upper extremity injuries. In a retrospective review of 20 men and five women, follow-up time averaged 26 months. These high-energy injuries were characterized by massive soft-tissue injury, highly comminuted fractures, and significant neurovascula...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Levin LS,Goldner RD,Urbaniak JR,Nunley JA,Hardaker WT Jr

    更新日期:1990-01-01 00:00:00

  • Regeneration of segmental diaphyseal defects in sheep tibiae using resorbable polymeric membranes: a preliminary study.

    abstract:OBJECTIVE:To investigate whether a long bone cortex of well-defined thickness can be regenerated by using an anatomically designed membranous resorbable "tube-in-tube" implant and to establish the functions of membranes in the healing of segmental diaphyseal bone defects larger than the "critical size." DESIGN:Bone he...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Gugala Z,Gogolewski S

    更新日期:1999-03-01 00:00:00

  • Randomized, prospective comparison of plate versus intramedullary nail fixation for distal tibia shaft fractures.

    abstract:OBJECTIVES:Malalignment has been frequently reported after intramedullary stabilization of distal tibia fractures. Nails have also been associated with knee pain in several studies. Historically, plate fixation has resulted in increased risks of infection and nonunion. Our purposes were to compare plate and nail stabil...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章,随机对照试验


    authors: Vallier HA,Cureton BA,Patterson BM

    更新日期:2011-12-01 00:00:00

  • The Community Orthopaedic Surgeon Taking Trauma Call: Lateral Humeral Condyle Fracture Pearls and Pitfalls.

    abstract::Lateral condyle fractures are second only to supracondylar humeral fractures when it comes to pediatric elbow fractures. Whether minimally displaced or substantially displaced, these growth plate fractures may present significant treatment challenges. These include nonunion, malunion, avascular necrosis, and growth di...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章,评审


    authors: Ho CA,Mehlman CT

    更新日期:2019-08-01 00:00:00

  • Unexpected high complication rate following internal fixation of unstable proximal humerus fractures with an angled blade plate.

    abstract:OBJECTIVES:The increasing number of fractures of the proximal humerus, especially in the elderly, carries with it the unsolved problem of the optimal treatment for the displaced or unstable fractures. The authors' goal was to analyze whether fixation with a bent valgus angled blade plate could improve the outcomes repo...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Meier RA,Messmer P,Regazzoni P,Rothfischer W,Gross T

    更新日期:2006-04-01 00:00:00

  • A comparison between the effects of acetaminophen and celecoxib on bone fracture healing in rats.

    abstract:OBJECTIVES:This study compared the acute treatment effects of systemic analgesics with (celecoxib) and without anti-inflammatory activity (acetaminophen) on bone fracture healing. STUDY DESIGN:Longitudinal time study of fracture healing in rats. METHODS:Closed, mid diaphyseal femur fractures were produced in female S...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Bergenstock M,Min W,Simon AM,Sabatino C,O'Connor JP

    更新日期:2005-11-01 00:00:00

  • Spinal canal decompression in traumatic thoracolumbar burst fractures: posterior distraction rods versus transpedicular screw fixation.

    abstract::Although the benefit of spinal canal decompression of traumatic thoracolumbar burst fractures is controversial, it remains a desirable procedure, as many reports describe improved neurologic outcome with spinal canal reconstruction. The optimal type of posterior instrumentation for reconstructing the spinal canal is u...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Doerr TE,Montesano PX,Burkus JK,Benson DR

    更新日期:1991-01-01 00:00:00

  • Comparison of the 95-degree angled blade plate and the locking condylar plate for the treatment of distal femoral fractures.

    abstract:OBJECTIVES:In the distal femur, locked plating is efficacious when coronal fractures preclude the use of a conventional fixed-angle device. However, minimal comparative data exist for supracondylar fracture patterns, which could be treated with other devices. The purpose of this study was to compare the 95-degree angle...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Vallier HA,Immler W

    更新日期:2012-06-01 00:00:00

  • Extensile Fasciotomy for Compartment Syndrome of the Forearm and Hand.

    abstract:PURPOSE:The purpose of this video is to demonstrate the technique of an extensile fasciotomy of the forearm and hand. METHODS:A patient presented to our hospital with a rapidly progressing infection of the right upper extremity and clinical signs and symptoms of compartment syndrome. The patient was immediately taken ...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Turkula SC,Fuller DA

    更新日期:2017-08-01 00:00:00

  • Surgeons and their patients disagree regarding cosmetic and overall outcomes after surgery for high-energy lower extremity trauma.

    abstract:OBJECTIVES:To determine whether surgeons' and patients' perceptions of outcomes after high-energy lower-extremity trauma are similar and to identify factors associated with disagreement. DESIGN:Prospective study. SETTING:Eight level 1 trauma centers. PATIENTS:Four hundred sixty-three patients treated for limb-threat...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章,多中心研究


    authors: O'Toole RV,Castillo RC,Pollak AN,MacKenzie EJ,Bosse MJ,LEAP Study Group.

    更新日期:2009-11-01 00:00:00

  • Do Safe Radiographic Sacral Screw Pathways Exist in a Pediatric Patient Population and Do They Change With Age?

    abstract:OBJECTIVES:Iliosacral screw pathways in the first (S1) and second (S2) sacral segments are commonly used for adult pelvic ring stabilization. We hypothesize that radiographically "safe" pathways exist in pediatric patients. SETTING:Academic level I Trauma Center. PATIENTS:All patients between ages 2 and 16 years with...

    journal_title:Journal of orthopaedic trauma

    pub_type: 临床试验,杂志文章


    authors: Burn M,Gary JL,Holzman M,Heydemann JA,Munz JW,Galpin M,Ambrose CG,Achor TS,Kumaravel M

    更新日期:2016-01-01 00:00:00

  • Ipsilateral combination Monteggia and Galeazzi injuries in an adult patient: a case report.

    abstract::Monteggia fractures represent approximately 1 to 2 percent of forearm fractures, whereas Galeazzi fractures represent 3 to 6 percent. The combination of these injuries in the same extremity is an exceedingly rare occurrence. We report a case of ipsilateral combination Monteggia and Galeazzi fractures in an adult patie...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Clare DJ,Corley FG,Wirth MA

    更新日期:2002-02-01 00:00:00

  • Deep venous thrombosis complicating rupture of the medial head of the gastrocnemius muscle.

    abstract::Rupture of the medial head of the gastrocnemius muscle ("tennis leg") is an affliction generally associated with athletic activity. The diagnosis is made by careful history and physical examination. Although its findings are characteristic, previous reports have documented misdiagnosis of this lesion as thrombophlebit...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Slawski DP

    更新日期:1994-01-01 00:00:00

  • Acute vascular injury associated with fracture of the distal radius: a report of 6 cases.

    abstract:OBJECTIVES:To highlight the potential for vascular injury with fracture of the distal radius. DESIGN:Retrospective case series. SETTING:The practices of several orthopaedic hand surgeons. PATIENTS/PARTICIPANTS:Six patients with arterial injury as a consequence of fracture of the distal radius: 2 partial lacerations ...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: de Witte PB,Lozano-Calderon S,Harness N,Watchmaker G,Green MS,Ring D

    更新日期:2008-10-01 00:00:00

  • Bone Marrow Aspirate Concentrate in Animal Long Bone Healing: An Analysis of Basic Science Evidence.

    abstract:OBJECTIVES:Long bone fractures that fail to heal or show a delay in healing can lead to increased morbidity. Bone marrow aspirate concentrate (BMAC) containing bone mesenchymal stem cells (BMSCs) has been suggested as an autologous biologic adjunct to aid long bone healing. The purpose of this study was to systematical...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章,评审


    authors: Gianakos A,Ni A,Zambrana L,Kennedy JG,Lane JM

    更新日期:2016-01-01 00:00:00

  • Definitive Management of Distal Tibia and Simple Plafond Fractures With Circular External Fixation.

    abstract::Obtaining optimal results in the treatment of extraarticular distal tibia fractures can be challenging. Plate and screw and intramedullary fixation have proven to be effective treatments, but are associated with significant complication rates when used for open fractures and patient with severe medical comorbidities. ...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Quinnan SM

    更新日期:2016-11-01 00:00:00

  • Intraarticular calcaneus fractures: a biomechanical comparison or two fixation methods.

    abstract:OBJECTIVE:To compare the strength of fixation obtained using two unicortical 4.0 mm diameter cancellous screws versus two bicortical 3.5 mm diameter cortical screws in the fixation of intra-articular calcaneus fractures. DESIGN:In eight paired fresh frozen cadaver feet, the subtalar joint complex, consisting of the ta...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Bailey EJ,Waggoner SM,Albert MJ,Hutton WC

    更新日期:1997-01-01 00:00:00

  • No effect of low-intensity ultrasound on healing time of intramedullary fixed tibial fractures.

    abstract:OBJECTIVE:To determine whether stimulation with low-intensity ultrasound will reduce the radiologic healing time of fresh tibial shaft fractures fixed with a reamed and statically locked intramedullary rod. DESIGN:Prospective, randomized, double blinded, and placebo controlled. PATIENTS AND METHODS:Thirty-two adult p...

    journal_title:Journal of orthopaedic trauma

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Emami A,Petrén-Mallmin M,Larsson S

    更新日期:1999-05-01 00:00:00

  • Valgus osteotomy of the proximal femur with sliding hip screw for the treatment of femoral neck nonunions: the technique, a case series, and literature review.

    abstract::Femoral neck nonunions are a difficult complication in the treatment of femoral neck fractures and have traditionally been managed using an intertrochanteric valgus osteotomy and blade plate. We propose an alternative method, a proximal femoral valgus osteotomy using a sliding hip screw instead of a blade plate. This ...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章,评审


    authors: Schoenfeld AJ,Vrabec GA

    更新日期:2006-07-01 00:00:00

  • Ultrasound-Guided Nerve Blocks as Analgesia for Nonoperative Management of Distal Radius Fractures-Two Consecutive Randomized Controlled Trials.

    abstract:OBJECTIVES:To investigate whether a conventional fracture hematoma block (FHB) or an ultrasound-guided peripheral nerve block has more superior analgesic effect during nonoperative management of distal radius fractures in an emergency department setting. Two peripheral nerve block types were investigated, one at the le...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章,随机对照试验


    authors: Siebelt M,Hartholt KA,van Winden DFM,Boot F,Papathanasiou D,Verdouw BC,de Vries MR,Mathijssen NM,Kraan GA

    更新日期:2019-04-01 00:00:00

  • Biomechanics of Ender rods, compression screw, and Zickel nail in the fixation of stable subtrochanteric femur osteotomies.

    abstract::Compression screws, Ender rods, and Zickel nails were evaluated mechanically to determine their resulting stability in the fixation of experimental subtrochanteric femur osteotomies. Twenty-five pairs of human cadaver femurs were used. Experimental osteotomies were created and a random member of each pair was fixed wi...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Wainer RA,Wright PH,Gilbert JA,Taylor DF

    更新日期:1990-01-01 00:00:00