[Mitochondrial DNA deletions in newborn brain samples].

Abstract:

INTRODUCTION:Mitochondrial DNA deletion affecting 4977 base pairs (mtDNA4977) thought to be the most common somatic mutation in man was analysed in samples taken from various parts of the brains at autopsy in order to analyse the supposition whether this mitochondrial damage may play a role in the causation of neurological dysfunction in childhood. METHODS:DNA was isolated from the samples of 15 newborns and 8 adults taken during autopsy. mtDNA4977 deletion was determined by polymerase chain reaction. RESULTS:mtDNA4977 could be demonstrated not only in adults but also in every newborn sample. Estimation of the amount of mtDNA4977 indicated that the level of mtDNA4977 was smaller in the newborn samples than in the elderly's. CONCLUSION:Results suggest that mtDNA4977, contrary to the generally accepted opinion stating that it is acquired during life span, may already be present in the beginning of life. However, the possibility can not be excluded that mutations in the extreme sensitive mtDNA against oxidative damage might be generated by perinatal hypoxia and intensive care. Such a causative role of mtDNA mutations may be an important additional factor in explaining the pathomechanism of cerebral palsy and mental retardation frequently observed in surviving children.

journal_name

Orv Hetil

journal_title

Orvosi hetilap

authors

Nádasi E,Melegh B,Seress L,Kosztolányi G

subject

Has Abstract

pub_date

2004-06-20 00:00:00

pages

1321-5

issue

25

eissn

0030-6002

issn

1788-6120

journal_volume

145

pub_type

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