Neuroendoscopic findings in patients with intracranial germinomas correlating with diabetes insipidus.


OBJECT:Intracranial germinomas commonly occur in the pineal region, the floor of the third ventricle (hypothalamus), or both, and they are often associated with diabetes insipidus (DI). The authors conducted a study to correlate preoperative DI with the endoscopic and magnetic resonance (MR) imaging evidence of tumor on the third ventricle floor. METHODS:The authors reviewed hospital records, office charts, and MR imaging studies obtained in patients in whom a biopsy sampling procedure was performed with or without endoscopic third ventriculostomy (ETV) at Children's Hospital, Birmingham, Alabama between May 1998 and July 2002. Ten patients with the pathological diagnosis of pure germinoma were identified. Preoperative MR imaging findings and presenting symptoms were correlated with intraoperative neuroendoscopic findings. Seven patients presented with symptomatic hydrocephalus and underwent concomitant ETV. Six patients presented with DI and MR imaging evidence of involvement of the third ventricle floor. Two patients presented with DI and no initial MR imaging evidence of neoplastic involvement of the third ventricle floor; in both there was endoscopic evidence of neoplastic involvement of the floor of the third ventricle. In two children without DI, neither MR imaging nor endoscopic evidence of involvement of the third ventricle floor was observed. CONCLUSIONS:In the authors' experience with intracranial germinoma, endoscopic tumor biopsy sampling, and ETV provide an effective, safe, and minimally invasive means of obtaining diagnostic tissue and treating any concomitant hydrocephalus. The authors found that preoperative DI is an absolute predictor of neoplastic involvement of the hypothalamus regardless of MR imaging findings. Therefore, in the setting of DI and intracranial germinoma without neuroimaging evidence of hypothalamic involvement, germinomatous involvement of the hypothalamus should be assumed present, if not confirmed endoscopically at the time of biopsy sampling or third ventriculostomy, when devising adjuvant treatment plans for such patients.


J Neurosurg


Journal of neurosurgery


Wellons JC 3rd,Reddy AT,Tubbs RS,Abdullatif H,Oakes WJ,Blount JP,Grabb PA




Has Abstract


2004-05-01 00:00:00




5 Suppl Pediatrics








  • Inhibition of delayed arterial narrowing by the iron-chelating agent deferoxamine.

    abstract::The potential role of iron in cerebral vasospasm was examined in the rat femoral artery model by the perivascular application of deferoxamine, a ferric ion chelator and antioxidant. In 25 rats, platelet-rich plasma or fresh autologous whole blood containing deferoxamine at concentrations of 1, 5, 10, or 15 mg/ml was a...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Harada T,Mayberg MR

    更新日期:1992-11-01 00:00:00

  • Transluminal angioplasty for treatment of intracranial arterial vasospasm.

    abstract::Percutaneous transluminal angioplasty for treatment of intracerebral arterial vasospasm is now being performed in selected cases. Thirty-six vascular territories in 13 patients, ranging in age from 15 to 73 years, have been treated with a new silicone microballoon device. This balloon has allowed mechanical dilatation...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Higashida RT,Halbach VV,Cahan LD,Brant-Zawadzki M,Barnwell S,Dowd C,Hieshima GB

    更新日期:1989-11-01 00:00:00

  • Pyrogenic cytokine interleukin-6 expression by a chordoid meningioma in an adult with a systemic inflammatory syndrome. Case report and review of the literature.

    abstract::Chordoid meningioma is a rare meningothelial tumor characterized by chordoma-like histological features with lymphoplasmacellular infiltration. This tumor is often seen in children, but not in adults, with a systemic inflammatory syndrome (iron-resistant microcytic anemia and/or dysgammaglobulinemia) and very rarely w...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Denaro L,Di Rocco F,Gessi M,Lauriola L,Lauretti L,Pallini R,Fernandez E,Maira G

    更新日期:2005-09-01 00:00:00

  • Correlation between the efferent venous drainage of the tumor and peritumoral edema in intracranial meningiomas: superselective angiographic analysis of 25 cases.

    abstract:OBJECT:The extent of peritumoral brain edema (PTBE) associated with meningiomas can be highly variable. The authors studied the correlation between the development of efferent venous drainage from the tumor and the degree of PTBE that occurs in intracranial meningiomas. METHODS:Twenty-five patients with 27 intracrania...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Tanaka M,Imhof HG,Schucknecht B,Kollias S,Yonekawa Y,Valavanis A

    更新日期:2006-03-01 00:00:00

  • Chronic spinal subdural hematomas. Report of two cases.

    abstract::Two patients with chronic spinal subdural hematomas are described. Both had a fluctuating clinical course, not previously documented in the literature. Surgical evacuation resulted in almost complete recovery. The pathogenesis of spinal subdural hematoma is discussed and the pertinent literature is reviewed. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Khosla VK,Kak VK,Mathuriya SN

    更新日期:1985-10-01 00:00:00

  • A brachial plexopathy due to myositis ossificans. Case report and review of the literature.

    abstract::Myositis ossificans (MO) is a disorder characterized by the intramuscular proliferation of fibroblasts and osteoblasts, with subsequent deposition of bone and cartilage. A typical clinical presentation involves traumatic injury to a young adult, usually localized to the thigh, buttock, or upper arm, with resultant MO ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Reavey-Cantwell JF,Garonzik I,Viglione MP,McCarthy EF,Belzberg AJ

    更新日期:2001-09-01 00:00:00

  • Targeting the cranial nerve: microradiosurgery for trigeminal neuralgia with CISS and 3D-flash MR imaging sequences.

    abstract:OBJECT:The authors undertook a study to identify magnetic resonance (MR) imaging techniques that can be used reliably during gamma knife surgery (GKS) to identify the trigeminal nerve, surrounding vasculature, and areas of compression. METHODS:Preoperative visualization of the trigeminal nerve and surrounding vasculat...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Zerris VA,Noren GC,Shucart WA,Rogg J,Friehs GM

    更新日期:2005-01-01 00:00:00

  • Characterizing the heterogeneity in 5-aminolevulinic acid-induced fluorescence in glioblastoma.

    abstract:OBJECTIVE:5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX) fluorescence is an effective surgical adjunct for the intraoperative identification of tumor tissue during resection of high-grade gliomas. The use of 5-ALA-induced PpIX fluorescence in glioblastoma (GBM) has been shown to double the extent of gro...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Almiron Bonnin DA,Havrda MC,Lee MC,Evans L,Ran C,Qian DC,Harrington LX,Valdes PA,Cheng C,Amos CI,Harris BT,Paulsen KD,Roberts DW,Israel MA

    更新日期:2019-05-24 00:00:00

  • Acute posttraumatic spinal cord herniation. Case report and review of the literature.

    abstract::Transdural herniations of the spinal cord are rare, and those occurring acutely after a spinal cord injury (SCI) are particularly unusual. In this report, the authors present the case of acute posttraumatic spinal cord herniation in a patient who sustained severe polytraumatic injuries. The clinical manifestations wer...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审


    authors: Marquardt G,Weidauer S,Zanella FE,Seifert V

    更新日期:2001-04-01 00:00:00

  • Compartments in arteriovenous malformation nidi demonstrated with rotational three-dimensional digital subtraction angiography by using selective microcatheterization. Report of three cases.

    abstract::Although in several histological studies of arteriovenous malformation (AVM) nidi the presence of compartments has been documented, no clinical study has been published. The present study was conducted to determine the presence of nidus compartments in clinical cases by using a new radiographic method. Two patients wi...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Kakizawa Y,Nagashima H,Oya F,Ito K,Tanaka Y,Hongo K,Kobayashi S

    更新日期:2002-04-01 00:00:00

  • Combined surgical and endovascular treatment of a spontaneous diploic arteriovenous fistula. Case report.

    abstract::The authors report on the case of a 28-year-old woman presenting with an intraosseous arteriovenous fistula (AVF) located in the left parietal bone. The fistula was formed by direct arteriovenous shunts connecting branches of the left middle meningeal and superficial temporal arteries with a parietal diploic vein. Dra...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Burger IM,Tamargo RJ,Broussard J,Gailloud P

    更新日期:2005-07-01 00:00:00

  • Primary myxoma of the parafalcine meninges. Case report.

    abstract::The authors report on an unusual case of a primary intracranial myxoma in a 39-year-old woman. The patient presented with headache and generalized seizure. Magnetic resonance imaging revealed a large right frontal tumor resembling a parasagittal meningioma. A gross-total resection was performed, and histological revie...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Powers CJ,Pizzi CC,Cummings TJ,Friedman AH

    更新日期:2006-03-01 00:00:00

  • Choroid plexus carcinoma presenting as an intraparenchymal mass.

    abstract::A 6-year-old girl with a history of a nondisplaced skull fracture diagnosed with computerized tomography (CT) scanning 3 years previously presented with a 6-week history of headaches and decreased use of her right side. On admission CT scans, a large cystic mass was identified in the left frontal lobe region of the br...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审


    authors: Carter AB,Price DL Jr,Tucci KA,Lewis GK,Mewborne J,Singh HK

    更新日期:2001-12-01 00:00:00

  • Operative management of selected brachial plexus lesions.

    abstract::A 12-year operative experience with 171 consecutive patients with severe brachial plexus lesions who had at least 1 1/2 years of follow-up review is analyzed. Selection for and timing of operation was helped by categorization of each individual plexus element as "completely" or "incompletely" injured and as "in contin...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Kline DG,Judice DJ

    更新日期:1983-05-01 00:00:00

  • Proteasome inhibition with bortezomib induces cell death in GBM stem-like cells and temozolomide-resistant glioma cell lines, but stimulates GBM stem-like cells' VEGF production and angiogenesis.

    abstract:OBJECT:Recurrent malignant gliomas have inherent resistance to traditional chemotherapy. Novel therapies target specific molecular mechanisms involved in abnormal signaling and resistance to apoptosis. The proteasome is a key regulator of multiple cellular functions, and its inhibition in malignant astrocytic lines cau...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Bota DA,Alexandru D,Keir ST,Bigner D,Vredenburgh J,Friedman HS

    更新日期:2013-12-01 00:00:00

  • Valproate therapy for prevention of posttraumatic seizures: a randomized trial.

    abstract:OBJECT:Seizures frequently accompany moderate to severe traumatic brain injury. Phenytoin and carbamazepine are effective in preventing early, but not late, posttraumatic seizures. In this study the authors compare the safety and effectiveness of valproate with those of short-term phenytoin for prevention of seizures f...

    journal_title:Journal of neurosurgery

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Temkin NR,Dikmen SS,Anderson GD,Wilensky AJ,Holmes MD,Cohen W,Newell DW,Nelson P,Awan A,Winn HR

    更新日期:1999-10-01 00:00:00

  • Reliability of left and right indicators in CT scanning of the head. Case report.

    abstract::A case is described in which incorrect preliminary programming of a computerized tomography (CT) machine caused transposition of the left- and right-side indicators in a CT scan, which led to craniotomy on the normal side. The possible mechanism for this is incorrect pre-scan programming of the CT scanner with respect...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Luessenhop AJ,Schellinger D

    更新日期:1987-08-01 00:00:00

  • A graft-versus-tumor effect in a patient with ependymoma who received an allogenic bone marrow transplant for therapy-related leukemia. Case report.

    abstract::Graft-versus-leukemia effect is an immune-mediated antitumor phenomenon associated with allogenic bone marrow transplants (BMTs) for hematological malignancies, and recent findings have indicated that a similar effect could occur in some solid tumors such as breast cancers. The authors report on a 42-year-old man with...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Tanaka M,Shibui S,Kobayashi Y,Nomura K,Nakanishi Y

    更新日期:2002-08-01 00:00:00

  • Mercury water and cauterizing stones: Nicolas André and tic douloureux.

    abstract::In his 1756 text, Observations pratiques sur les maladies de l'urèthre et sur plusiers faits convulsifs, Nicolas André coined the term "tic douloureux." He believed that this pain originated from compression of facial sensory peripheral nerves. Using scientific observation and experimentation to confirm this hypothesi...

    journal_title:Journal of neurosurgery

    pub_type: 传,历史文章,杂志文章


    authors: Brown JA,Coursaget C,Preul MC,Sangvai D

    更新日期:1999-05-01 00:00:00

  • Sixteen-year single-surgeon experience with coil embolization for ruptured intracranial aneurysms: recurrence rates and incidence of late rebleeding. Clinical article.

    abstract:OBJECT:Over a 16-year period, 570 patients presenting with acute aneurysmal subarachnoid hemorrhage were successfully treated using endosaccular coil embolization within 30 days of hemorrhage by a single surgeon. Patients were followed to assess the stability of aneurysm occlusion and its longer-term efficacy in protec...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Plowman RS,Clarke A,Clarke M,Byrne JV

    更新日期:2011-03-01 00:00:00

  • Risks associated with preoperative anemia and perioperative blood transfusion in open surgery for intracranial aneurysms.

    abstract:OBJECT:Preoperative anemia may be treated with a blood transfusion. Both are associated with adverse outcomes in various surgical procedures, but this has not been clearly elucidated in surgery for cerebral aneurysms. In this study the authors assessed the association of preoperative anemia and perioperative blood tran...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,多中心研究


    authors: Seicean A,Alan N,Seicean S,Neuhauser D,Selman WR,Bambakidis NC

    更新日期:2015-07-01 00:00:00

  • Rebound phenomenon complicating cerebral dehydration with glycerol. Case report.

    abstract::A patient with glioblastoma multiforme of the brain was treated with both intravenous and oral glycerol as well as intravenous mannitol in an attempt to reduce increased intracranial pressure. After an initial lowering of the cerebrospinal fluid (CSF) pressure to near normal values during continuous glycerol administr...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Guisado R,Tourtellotte WW,Arieff AI,Tomiyasu U,Mishra SK,Schotz MC

    更新日期:1975-02-01 00:00:00

  • The effect of a PP2A inhibitor on the nuclear receptor corepressor pathway in glioma.

    abstract:OBJECT:Nuclear receptor corepressor (N-CoR) forms a complex that maintains neural stem cells in an undifferentiated state through transcriptional repression. Recently, it has been shown that N-CoR is overexpressed in glioblastoma multiforme (GBM) tumor stem cells and has a putative role in maintaining these cells in an...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Lu J,Zhuang Z,Song DK,Mehta GU,Ikejiri B,Mushlin H,Park DM,Lonser RR

    更新日期:2010-08-01 00:00:00

  • Phase II study of ifosfamide, carboplatin, and etoposide in patients with a first recurrence of glioblastoma multiforme.

    abstract:OBJECT:The prognosis of recurrent glioblastoma multiforme (GBM) remains unsatisfactory. The authors conducted a Phase II study of ifosfamide, carboplatin, and etoposide (ICE) for a first recurrence of GBM to determine whether it prolonged a patient's good-quality life. METHODS:This trial was an open-label, single-cent...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Aoki T,Mizutani T,Nojima K,Takagi T,Okumura R,Yuba Y,Ueba T,Takahashi JA,Miyatake S,Nozaki K,Taki W,Matsutani M

    更新日期:2010-01-01 00:00:00

  • Intracerebral microdialysis in severe brain trauma: the importance of catheter location.

    abstract:OBJECT:Intracerebral microdialysis has attracted increasing interest as a monitoring technique during neurological/neurosurgical intensive care. The purpose of this study was to compare cerebral energy metabolism, an indicator of secondary excitotoxic injury and cell membrane degradation close to focal traumatic lesion...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Engström M,Polito A,Reinstrup P,Romner B,Ryding E,Ungerstedt U,Nordström CH

    更新日期:2005-03-01 00:00:00

  • Monosomy 22 in rhabdoid or atypical tumors of the brain.

    abstract::Cytogenetic studies of three rare childhood brain tumors were performed. Two children presented with pure rhabdoid tumors. The third child had a tumor composed of a mixture of rhabdoid elements with neuroepithelial, epithelial, and mesenchymal tissue - an atypical teratoid tumor. All three tumors demonstrated monosomy...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Biegel JA,Rorke LB,Packer RJ,Emanuel BS

    更新日期:1990-11-01 00:00:00

  • Delayed cyst formation after stereotactic radiosurgery for brain arteriovenous malformations.

    abstract:OBJECTIVE:Stereotactic radiosurgery (SRS) is a commonly employed treatment modality for brain arteriovenous malformations (AVMs). However, due to the low frequency of delayed cyst formation after AVM SRS, as well as the prolonged time interval between treatment and its occurrence, the characteristics of post-SRS cyst f...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Pomeraniec IJ,Ding D,Starke RM,Liu KC,Mrachek EK,Lopes MB,Sheehan JP

    更新日期:2018-10-01 00:00:00

  • Voxel-based lesion mapping of meningioma: a comprehensive lesion location mapping of 260 lesions.

    abstract::OBJECTIVE In the present study the authors aimed to determine preferred locations of meningiomas by avoiding descriptive analysis and instead using voxel-based lesion mapping and 3D image-rendering techniques. METHODS Magnetic resonance images obtained in 248 treatment-naïve meningioma patients with 260 lesions were r...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Hirayama R,Kinoshita M,Arita H,Kagawa N,Kishima H,Hashimoto N,Fujimoto Y,Yoshimine T

    更新日期:2018-06-01 00:00:00

  • Rate of cerebral energy consumption in concussive head injury in the rat.

    abstract::The metabolic rate was determined in the rat brain during the immediate concussive response to standardized impact accelerations of 7 and 9 m/sec velocity. In one series, the metabolic state was determined in freeze-clamped cortical and brain-stem tissue 20 seconds after the impact. The metabolic rate was calculated f...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Nilsson B,Nordström CH

    更新日期:1977-08-01 00:00:00

  • Identical embryopathogenesis for exencephaly and myeloschisis: an experimental study.

    abstract::Extensive histological and immunohistochemical studies were performed to elucidate the histopathogenesis of exencephaly induced in chick embryo as an experimental model. The findings were compared with those identified in a chick myeloschisis experimental model and in human autopsy cases. The experimental model of exe...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Oi S,Kokunai T,Okuda Y,Sasaki M,Matsumoto S

    更新日期:1990-03-01 00:00:00