Abstract:
:Patients with chronic heart failure (CHF) have a resting restrictive ventilatory defect. Any type of exercise requires patients with CHF to markedly increase their minute ventilation. Patients with chronic obstructive pulmonary disease (COPD) have airflow obstruction that leads to dynamic lung hyperinflation and reduced ventilatory response to exercise. Because exercise is associated with abnormally high minute ventilation in patients with CHF and with a limited minute ventilation increase in patients with COPD, functional capacity is severely impaired in patients with coexistent CHF and COPD. Optimal treatment of both conditions is a prerequisite to maximally improve functional capacity in patients with CHF and COPD. Unfortunately, beta-adrenergic blockade, the current cornerstone of CHF therapy, is frequently omitted in patients with CHF and COPD for fear of inducing bronchoconstriction. Furthermore, when prescribed, beta-adrenergic blockade is often attempted with a moderate dose of metoprolol tartrate, a beta-1-blocker that results in lesser clinical benefits than combined non-selective beta-blockade with carvedilol at the maximally recommended dose. Recent experience indicates that combined non-selective beta- and alpha-blockade with carvedilol is well tolerated in patients with COPD who do not have reversible airway obstruction. Alpha-adrenergic blockade may promote mild bronchodilation that offsets non-selective beta blockade-induced bronchoconstriction in patients with obstructive airway disease.
journal_name
J Am Coll Cardioljournal_title
Journal of the American College of Cardiologyauthors
Sirak TE,Jelic S,Le Jemtel THdoi
10.1016/j.jacc.2004.03.063subject
Has Abstractpub_date
2004-08-04 00:00:00pages
497-502issue
3eissn
0735-1097issn
1558-3597pii
S0735109704007971journal_volume
44pub_type
杂志文章,评审abstract::An international survey identified 40 patients less than 20 years old who underwent surgical implantation of an automatic implantable cardioverter-defibrillator (AICD). There was a history of aborted sudden cardiac death or sustained ventricular tachycardia in 92.5% of these patients. Twenty-two patients (55%) had str...
journal_title:Journal of the American College of Cardiology
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journal_title:Journal of the American College of Cardiology
pub_type: 临床试验,杂志文章
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journal_title:Journal of the American College of Cardiology
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更新日期:2011-07-19 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,评审
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更新日期:2014-07-22 00:00:00
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更新日期:2009-11-03 00:00:00
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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更新日期:1989-06-01 00:00:00
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更新日期:2003-08-06 00:00:00
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journal_title:Journal of the American College of Cardiology
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更新日期:2013-07-23 00:00:00
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更新日期:1995-11-15 00:00:00