Abstract:
:We have analysed two new genes, YBR1007 and YBR1015, discovered during the systematic sequencing of chromosome II of S. cerevisiae. YBR1007 shows strong similarities to amino-acid permeases, in particular the high-affinity proline permeases of S. cerevisiae and A. nidulans. The number and position of the predicted membrane-spanning domains suggest a conserved structure for these proteins, with 12 trans-membrane domains. YBR1015 shows strong similarities to serine carboxypeptidases; all three residues of the "catalytic triad" typical of this family of enzymes are conserved in the YBR1015 protein. In a preliminary functional analysis we have created a null allele of the YBR1015 gene, and shown that it is not essential for cellular viability.
journal_name
Curr Genetjournal_title
Current geneticsauthors
Nasr F,Bécam AM,Grzybowska E,Zagulski M,Slonimski PP,Herbert CJdoi
10.1007/BF00326297subject
Has Abstractpub_date
1994-07-01 00:00:00pages
1-7issue
1eissn
0172-8083issn
1432-0983journal_volume
26pub_type
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