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A case of pediatric ovarian dysgerminoma associated with high serum levels and positive immunohistochemical staining of neuron-specific enolase.

Abstract：

:A 5-year-old girl presented with a painful abdominal mass. Abdominal magnetic resonance imaging (MRI) showed 3 separate masses. Tumor markers including lactate dehydrogenase (LDH), cancer antigen-125 (CA-125), beta-subunit of human chorionic gonadotropin (beta-hCG) and neuron-specific enolase (NSE) were elevated. At operation, the main tumor arose from the left ovary and was associated with torsion, whereas the other lesions were lymph node metastases. A salpingo-oophorectomy was performed. Histopathologic examination indicated that the tumor was a dysgerminoma. Immunohistochemicallly, the cells were positive for NSE and placental alkaline phosphatase (PALP) but were negative for CA-125, beta-hCG, S-100, glial fibrillary acidic protein, and vimentin. The elevated serum levels of tumor markers improved dramatically after the operation and chemotherapy.

journal_name

J Pediatr Surg

journal_title

Journal of pediatric surgery

authors

Tatekawa Y,Kemmotsu H,Mouri T,Joe K,Ohkawa H

doi

10.1016/j.jpedsurg.2004.05.023

subject

Has Abstract

pub_date

2004-09-01 00:00:00

pages

1437-9

issue

9

eissn

0022-3468

issn

1531-5037

pii

S0022346804003628

journal_volume

39

pub_type

杂志文章

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