Abstract:
OBJECTIVES:We sought to evaluate the feasibility and validity of a new method to quantify the hyperemic response of the forearms that can be incorporated into a rest myocardial perfusion protocol. BACKGROUND:Evaluation of the hyperemic response could provide useful clinical information in the detection and risk stratification of atherosclerotic vascular disease. METHODS:Patients with proven coronary artery disease (CAD) (n = 46) were compared with low-risk subjects without such evidence (n = 47). A regular dose of Myoview was injected after 5 min of right arm ischemia. Three dimensionless parametric ratios (right/left) were derived from the analysis of activity-time curves of the hyperemic right forearm and that of the contralateral left forearm. RESULTS:The maximal ingress upslope ratio was 40% lower in the CAD group (3.0 +/- 0.2 vs. 4.2 +/- 0.3, p < 0.0005), and the integral to peak ratio was also lower (23 +/- 4 vs. 52 +/- 11, p < 0.01), whereas the peak activity ratio was nonsignificantly lower (3.0 +/- 0.3 vs. 3.8 +/- 0.3, p = 0.07). Using a value of 3.55 for the maximal upslope ratio, this approach could predict the presence of CAD with a sensitivity of 0.70 and a specificity of 0.60. CONCLUSIONS:This simple and noninvasive method is feasible and can discriminate between patients with known CAD and those at low risk of atherosclerosis. Refinements of this approach and its inclusion in larger clinical trials are needed to determine whether it could provide additional value to myocardial scintigraphic imaging.
journal_name
J Am Coll Cardioljournal_title
Journal of the American College of Cardiologyauthors
Dupuis J,Arsenault A,Meloche B,Harel F,Staniloae C,Grégoire Jdoi
10.1016/j.jacc.2004.02.064subject
Has Abstractpub_date
2004-10-06 00:00:00pages
1473-7issue
7eissn
0735-1097issn
1558-3597pii
S0735-1097(04)01450-0journal_volume
44pub_type
杂志文章abstract:OBJECTIVES:The purpose of this study was to define the incidence and characterization of cardiovascular cause of sudden death in the young. BACKGROUND:The epidemiology of sudden cardiac death (SCD) in young adults is based on small studies and uncontrolled observations. Identifying causes of sudden death in this popul...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/j.jacc.2011.01.049
更新日期:2011-09-13 00:00:00
abstract:OBJECTIVES:The purpose of the study is to identify the predictors of clinical outcome (mortality and survival without repeat septal reduction procedures) of alcohol septal ablation for the treatment of patients with hypertrophic obstructive cardiomyopathy. BACKGROUND:Alcohol septal ablation is used for treatment of me...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jacc.2011.06.073
更新日期:2011-11-22 00:00:00
abstract:OBJECTIVES:This study sought to investigate whether pulse pressure (PP) is associated with endothelium-dependent vasodilation in a group of never-treated hypertensives. BACKGROUND:Pulse pressure represents a well-established independent predictor for cardiovascular morbidity and mortality. Forearm endothelial dysfunct...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/s0735-1097(03)00295-x
更新日期:2003-05-21 00:00:00
abstract:OBJECTIVES:The goal of this study was to identify genes upregulated in the heart in human patients with hypertrophic cardiomyopathy (HCM). BACKGROUND:Hypertrophic cardiomyopathy is a genetic disease caused by mutations in contractile sarcomeric proteins. The molecular basis of diverse clinical and pathologic phenotype...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/s0735-1097(01)01509-1
更新日期:2001-10-01 00:00:00
abstract:OBJECTIVES:The goal of this research was to determine the incremental cost and cost-effectiveness of embolic protection in patients undergoing percutaneous revascularization (PCI) of diseased saphenous vein bypass grafts (SVGs). BACKGROUND:Distal protection using the GuardWire balloon occlusion device has been shown t...
journal_title:Journal of the American College of Cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.jacc.2004.05.086
更新日期:2004-11-02 00:00:00
abstract:OBJECTIVES:We sought to study the safety, feasibility and efficacy of selective suction and pressure-regulated retroinfusion to protect against myocardial ischemia in patients undergoing normal risk and high risk balloon angioplasty. BACKGROUND:In a pig model of acute myocardial ischemia it was previously shown that u...
journal_title:Journal of the American College of Cardiology
pub_type: 临床试验,杂志文章
doi:10.1016/s0735-1097(98)00135-1
更新日期:1998-06-01 00:00:00
abstract:OBJECTIVES:The goal of this study was to report a variety of atrial tachycardia that might be caused by an unusual electrophysiologic substrate. BACKGROUND:The mechanism of atrial tachycardias is attributed to re-entry, abnormal automaticity or triggered activity, based on their electropharmacological responses. A rat...
journal_title:Journal of the American College of Cardiology
pub_type: 临床试验,杂志文章
doi:10.1016/s0735-1097(00)00906-2
更新日期:2000-11-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to determine the prevalence and characteristics of ambulatory myocardial ischemia in patients with diabetes mellitus and to delineate the relation between the presence and severity of autonomic nervous system dysfunction and the incidence and time of onset of myocardial ischemia. B...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/0735-1097(94)90855-9
更新日期:1994-10-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the effects of bariatric surgery on small artery function and the mechanisms underlying this. BACKGROUND:In lean healthy humans, perivascular adipose tissue (PVAT) exerts an anticontractile effect on adjacent small arteries, but this is lost in obesity-associated con...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/j.jacc.2013.04.027
更新日期:2013-07-09 00:00:00
abstract:OBJECTIVES:This study sought to test the effect on thrombus score of the "rescue" utilization of the glycoprotein IIb/IIIa antagonist abciximab given to patients in whom intracoronary thrombus has developed as a complication after percutaneous transluminal coronary angioplasty (PTCA) and to determine its clinical utili...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/s0735-1097(97)00395-1
更新日期:1997-12-01 00:00:00
abstract::Immediate and short-term cardiovascular effects of a new angiotensin-converting enzyme inhibitor, fosinopril, were assessed in 10 patients with mild to moderate essential hypertension. Administration of a 10 mg oral dose of fosinopril reduced mean arterial pressure (p less than 0.001) as a result of a 24% fall in tota...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/0735-1097(91)90852-z
更新日期:1991-04-01 00:00:00
abstract::Ventricular arrhythmia (VA) in structurally normal hearts can be broadly considered under non-life-threatening monomorphic and life-threatening polymorphic rhythms. Monomorphic VA is classified on the basis of site of origin in the heart, and the most common areas are the ventricular outflow tracts and left ventricula...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.jacc.2012.01.036
更新日期:2012-05-15 00:00:00
abstract:OBJECTIVES:This study evaluated technetium-99m (Tc-99m) teboroxime kinetics in postischemic and partially necrotic myocardium with complete and low flow reperfusion using an isolated perfused rat heart model. BACKGROUND:Technetium-99m teboroxime has been proposed for use in the early diagnosis of reperfusion after thr...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/0735-1097(96)00159-3
更新日期:1996-08-01 00:00:00
abstract::This study was performed 1) to determine the ability of dobutamine stress echocardiography to detect stenoses in individual coronary arteries by utilizing a new model of coronary artery distribution; 2) to evaluate its ability to detect coronary artery stenosis with a minimal lumen diameter less than 1 mm; and 3) to c...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/0735-1097(92)90324-g
更新日期:1992-05-01 00:00:00
abstract::The accuracy of a computer system that was developed for the analysis of ST segment changes recorded on Holter ambulatory electrocardiographic monitoring tapes was compared with conventional visual scrutiny, beat by beat analog printouts and a commercial J point trend system. The program calculates and plots multiple ...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/s0735-1097(84)80209-0
更新日期:1984-08-01 00:00:00
abstract::A patient is presented with partial absence of the right pulmonary artery, left coronary artery to bronchial artery fistula and systemic arterial desaturation with a patent foramen ovale. The various aspects of the syndrome are discussed and the rationale for nonoperative closure of the foramen is described. ...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/s0735-1097(83)80177-6
更新日期:1983-08-01 00:00:00
abstract::To examine whether cardiopulmonary receptors participate in the reflex control of coronary vascular resistance, systemic and coronary hemodynamics were assessed before and during -10 mm Hg lower body negative pressure in eight normal subjects and eight hypertensive patients with left ventricular hypertrophy. In both s...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/s0735-1097(98)90050-x
更新日期:1988-05-01 00:00:00
abstract:BACKGROUND:Short-term exposure to ambient air pollution has been linked to occurrence of myocardial infarction (MI); however, only a limited number of studies investigated its association with death from MI, and the results remain inconsistent. OBJECTIVES:This study sought to investigate the association of short-term ...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/j.jacc.2020.11.033
更新日期:2021-01-26 00:00:00
abstract:OBJECTIVES:This study was undertaken to determine the extent to which cardiovascular specialists are involved with and affected by managed care and to ascertain their attitudes toward it. This survey also served as the follow-up to an initial study on the subject performed by the American College of Cardiology in 1993....
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/S0735-1097(96)00455-X
更新日期:1996-12-01 00:00:00
abstract:BACKGROUND:In patients referred for radiofrequency catheter ablation (RFCA) of ventricular tachycardia (VT) in the setting of structural heart disease, early post-procedural mortality (EM) has not been previously investigated. OBJECTIVES:The purpose of this study was to evaluate EM after catheter ablation of scar-rela...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jacc.2017.02.044
更新日期:2017-05-02 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the relation between coronary atherosclerotic plaque injury and activation of the coagulation cascade. BACKGROUND:Thrombus formation after atherosclerotic plaque disruption has been implicated in the pathogenesis of atherosclerosis, unstable angina and myocardial inf...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/0735-1097(94)90144-9
更新日期:1994-11-15 00:00:00
abstract:OBJECTIVES:This study sought to measure the impact of pre-hospital (PH) electrocardiography (ECG) on scene-to-hospital time for patients with chest pain of cardiac origin and those with ST-segment elevation myocardial infarction (STEMI). BACKGROUND:Pre-hospital ECG decreases door-to balloon (D2B) time for STEMI patien...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/j.jacc.2012.03.071
更新日期:2012-08-28 00:00:00
abstract:BACKGROUND:Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds low-density lipoprotein receptor (LDLR), preventing its recycling. PCSK9 is a risk predictor and a biotarget in atherosclerosis progression. OBJECTIVES:The aim of this study was to determine whether the PCSK9-LDLR axis could predict risk in patient...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jacc.2017.08.057
更新日期:2017-10-24 00:00:00
abstract::Long-term variation in the frequency of myocardial ischemia during daily activity in patients with coronary artery disease who do not experience symptomatic changes has not been documented. Because at one point in time, the magnitude of such ischemia is strongly related to the ischemic threshold measured during exerci...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/s0735-1097(10)80261-x
更新日期:1992-03-01 00:00:00
abstract:OBJECTIVES:We compared the effects of triple-site versus dual-site biventricular stimulation in candidates for cardiac resynchronization therapy. BACKGROUND:Conventional biventricular stimulation with a single right ventricular (RV) and a single left ventricular (LV) lead is associated with persistence of cardiac dyss...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.jacc.2007.11.074
更新日期:2008-04-15 00:00:00
abstract:OBJECTIVES:We sought to determine the importance of nitric oxide (NO) production in maintaining coronary blood flow during exercise in hearts with collateral-dependent myocardium. BACKGROUND:Coronary collateral vessels demonstrate endothelium-mediated NO-dependent vasodilation in response to agonists such as acetylcho...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/s0735-1097(97)00437-3
更新日期:1998-01-01 00:00:00
abstract::Cardiovascular disease is the leading cause of mortality in the world, and the increasing burden is largely a consequence of modifiable behavioral risk factors that interact with genomics and the environment. Continuous cardiovascular health promotion and disease prevention throughout the lifespan is critical, and the...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.jacc.2016.01.036
更新日期:2016-04-12 00:00:00
abstract:OBJECTIVES:This study reevaluated the anatomy of the areas anterior and posterior to the atrioventricular (AV) septal structures, previously said to represent anterior and posterior septal areas. BACKGROUND:In descriptions of the locations of accessory AV pathways within the AV junctions, four regions have been recogn...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/0735-1097(94)90179-1
更新日期:1994-12-01 00:00:00
abstract:OBJECTIVES:This study tested whether genetic variation in the CETP gene is consistent with a protective effect of cholesteryl ester transfer protein (CETP) inhibition on risk of ischemic events and on total mortality, without the adverse effects reported for torcetrapib. BACKGROUND:Torcetrapib, an inhibitor of CETP, i...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/j.jacc.2012.07.045
更新日期:2012-11-13 00:00:00
abstract:OBJECTIVES:This study was designed to establish the direct vascular effects of apelin in vivo in man. BACKGROUND:Apelin is the endogenous ligand for the previously orphaned G-protein-coupled receptor, APJ. This novel pathway is widely expressed in the cardiovascular system and is emerging as an important mediator of c...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/j.jacc.2008.06.013
更新日期:2008-09-09 00:00:00