Abstract：
:Various routes of immunotherapy (injection, intranasal, oral) using lyophilized, aqueous, glycerinated, and modified allergenic extracts have all produced blocking antibodies and symptomatic improvement. No single, empirical predetermined maintenance or optimal dose of allergenic extract right for every patient, can be predicted, nor can immunotherapy be administered to patients without possible adverse reactions. Patients are at a lesser risk of anaphylaxis when immunotherapy dosage is escalated to the optimal maintenance dose. The AU/mL (Amb a I) ragweed AgE, or weight/volume dose required to produce maximum IgG blocking antibody varies with each patient, indicating that not all patients require or tolerate the same optimal immunotherapeutic dose. Immunotherapy patient failures may be the result of inadequate treatment dose potency or failure to include relevant allergens. Allergen-specific IgG monitoring during immunotherapy can provide an objective method to identify allergens that could safely be escalated to a more potent immunotherapy dose.
journal_name
Otolaryngol Clin North Amjournal_title
Otolaryngologic clinics of North Americaauthors
Willoughby JWsubject
Has Abstractpub_date
1992-02-01 00:00:00pages
71-100issue
1eissn
0030-6665issn
1557-8259journal_volume
25pub_type
杂志文章,评审abstract：:Because of the complexity and variability in the expression of otitis media, its effects on auditory function are diverse. The various influences of otitis media on auditory function are described within this article, including acoustic reflex, audiometry, and tympanometry. ...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1991-08-01 00:00:00
abstract：:Chronic rhinosinusitis (CRS) is a prevalent condition that is heterogeneous in disease characteristics and multifactorial in cause. Although sinonasal mucosal inflammation in CRS is often either reversible or well-managed medically and surgically, a significant proportion of patients has a refractory form of CRS despi...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.otc.2016.08.009
更新日期：2017-02-01 00:00:00
abstract：:Contemporary surgical techniques for treating various pathologies affecting the middle ear address not only eradication of the underlying disease process but also restoration of normal auditory function. Trauma, neoplasms, inflammatory processes, and cholesteatomas can erode and alter normal middle ear components and ...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.otc.2006.08.010
更新日期：2006-12-01 00:00:00
abstract：:Polysomnography provides information on the physiological changes occurring in many different organ systems in relation to sleep stages and wakefulness. It allows qualitative and quantitative documentation of abnormalities of sleep and wakefulness, of sleep-wake transition, and of physiological function of other organ...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.otc.2007.04.003
更新日期：2007-08-01 00:00:00
abstract：:Telemedicine or the electronic transmission of medical data has become an even more important part of medical practice with developing technology. How to best use this technology to enhance and empower both physician and patient is the challenge. What is there, what is coming, and thoughts regarding how otolaryngologi...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章
doi：10.1016/s0030-6665(05)70051-7
更新日期：1998-04-01 00:00:00
abstract：:The nasal septum is a structure poorly understood and appreciated by the lay public and the nonotolaryngologist--head and neck surgeon alike. Deviation of the caudal portion of the nasal septum may result in nasal obstruction, a crooked nose, and columellar irregularities. The correction of a severely deviated caudal ...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.otc.2009.03.005
更新日期：2009-06-01 00:00:00
abstract：:An improved nomenclature framework is crucial to improve communication regarding voice problems and to advance the field of voice disorders. The subjective nature of the voice evaluation process does not lend itself readily to uniformity and most voice-disordered patients demonstrate multiple pathologic processes. In ...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s0030-6665(05)70262-0
更新日期：2000-10-01 00:00:00
abstract：:The management of base of tongue cancer has evolved steadily over time. Organ preservation with primary radiation therapy has produced excellent oncologic and functional outcomes. Concomitant chemotherapy has become important in patients with locoregionally advanced disease. Planned neck dissection after organ preserv...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.otc.2004.10.016
更新日期：2005-02-01 00:00:00
abstract：:The epidemiology, diagnostic features, differential diagnosis, and treatment of vestibular neuritis are reviewed. The authors present considerations for physical examination, imaging, and management in both the acute and chronic phases of this disease. The authors also present a dizziness questionnaire in the Appendix...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.otc.2011.01.007
更新日期：2011-04-01 00:00:00
abstract：:This article details the imaging modalities available for patients being considered for functional endoscopic sinus surgery. The pertinent radiologic anatomy is reviewed with an emphasis on normal variations. Imaging appearances of inflammatory sinus disease as well as postoperative appearances, including complication...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1995-06-01 00:00:00
abstract：:Endoscopy offers several distinct advantages over the operating microscope during neuro-otologic surgery that make it an excellent adjunctive tool to the microscope or independent modality during cranial base surgery. The high magnification gives excellent definition of perforating blood vessels, cranial nerves, and n...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s0030-6665(02)00015-4
更新日期：2002-04-01 00:00:00
abstract：:Endoscopic endonasal skull base surgical techniques, initially developed in adult patients, are being utilized with increasing frequency in pediatric patients to treat sinonasal and skull base lesions. This article reviews the current state of endoscopic endonasal approaches to the skull base to both treat disease and...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.otc.2014.09.007
更新日期：2015-02-01 00:00:00
abstract：:Active auditory implants, such as the Maxum, provide significantly improved hearing function compared to hearing aids in patients with moderate to severe hearing loss who are not reaching their cochlear hearing potential. The speech perception gap (SPG), defined as PB Max (phonetically balanced maximum) minus word rec...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.otc.2018.11.014
更新日期：2019-04-01 00:00:00
abstract：:Inner ear medical therapy has been gaining increasing popularity during the last 2 decades. Despite the increased use of this therapy,basic questions regarding this type of treatment have not been answered. The authors have used a variety of sustained-release devices in the laboratory to begin to answer some of these ...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.otc.2004.04.005
更新日期：2004-10-01 00:00:00
abstract：:Neuromuscular retraining is an effective method for rehabilitating facial musculature in patients with facial paralysis. This nonsurgical therapy has demonstrated improved functional outcomes and is an important adjunct to surgical treatment for restoring facial movement. Treatment begins with an intensive clinical ev...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1997-10-01 00:00:00
abstract：:It is evident from the foregoing that the evaluation of such a common complaint as nasal obstruction can be extremely complex. If a thorough history and examination are undertaken, however, only a small number of these investigations (if any) may be required. In each individual, it is always worth considering possible...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1992-08-01 00:00:00
abstract：:The standard treatment for patients with advanced laryngeal cancer remains total laryngectomy. Radiotherapy as a primary treatment modality is a reasonable alternative. Surgical salvage by total laryngectomy is an important part of the treatment plan when irradiation is used primarily to treat advanced laryngeal cance...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1997-02-01 00:00:00
abstract：:Despite recent, major steps forward in our understanding of tinnitus pathophysiology and improved research methodology, tinnitus remains a clear unmet clinical need. Here, the authors identify current active clinical and preclinical development programs of tinnitus drug candidates using publications, databases, and co...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.otc.2020.03.012
更新日期：2020-08-01 00:00:00
abstract：:Cystic fibrosis and the various conditions associated with ciliary dysmotility are well known to the otolaryngologist. Although the underlying pathophysiology and clinical courses of these diseases are quite different, they both involve chronic and acute infection in the paranasal sinuses. Some patients may suffer fro...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s0030-6665(05)70284-x
更新日期：2000-12-01 00:00:00
abstract：:Pharmacologic labyrinthectomy has become an alternative to surgery for treatment of severe Ménièr's disease. The use of systemic streptomycin has been replaced by intratympanal instillations of gentamicin that are administered once daily for a limited number of days. Gentamicin provides a high success rate for ablatio...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章
doi：
更新日期：1994-04-01 00:00:00
abstract：:Chronic rhinosinusitis (CRS) is a condition characterized by persistent inflammation due to intrinsic mucosal hypersensitivity or persistent infection. Proper medical treatment with antibiotic, leukotriene modifiers, oral corticosteroids, or even aspirin desensitization for the sinus inflammation can prevent the need ...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.otc.2010.02.013
更新日期：2010-06-01 00:00:00
abstract：:The Sewall-Boyden flap, as used to reconstruct a frontal recess after frontoethmoidectomy, is conceptually similar to the endoscopic Lothrop procedure for surgical access to the frontal sinus. The operative technique, indications, and philosophy are presented in this article. ...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s0030-6665(05)70303-0
更新日期：2001-02-01 00:00:00
abstract：:There are two undeniable attributes of radiotherapy: its value in controlling head and neck malignancies and the progressive damage it inflicts on all treated tissues. It is fortunate that over the past decade, we have developed techniques and treatments that counteract, at least in part, the negative effects of radio...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1995-10-01 00:00:00
abstract：:Over the years, a variety of empirical regimens have evolved using intratympanic gentamicin to treat the vertigo associated with Meniere's disease. Although these regimens have been effective, their application is not without risk. Many of the problems associated with intratympanic medications could be overcome with t...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1997-12-01 00:00:00
abstract：:Advances in pediatric otology have provided new tools to diagnose and manage complex otologic disease. Diffusion-weighted MRI provides the surgeon with a tool to detect recurrent or residual cholesteatoma that may obviate a second look surgery. Surgical trends move toward less invasive surgery. The literature provides...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.otc.2019.05.003
更新日期：2019-10-01 00:00:00
abstract：:Otolaryngology and ophthalmology have a long and congenial professional relationship in the development of their mutual specialties over many years. In the early years they were one professional society, but later split into their separate specialties. Some problems involve both specialties because of the shared commo...
journal_title：Otolaryngologic clinics of North America
pub_type： 历史文章,杂志文章
doi：10.1016/j.otc.2006.06.004
更新日期：2006-10-01 00:00:00
abstract：:Computed tomography (CT) and MRI have become an integral part of the evaluation of children with hearing loss. Abnormalities on CT or MRI are found in 20% to 50% of children with sensorineural hearing loss and correlate with the degree of hearing loss. CT and MRI have distinct advantages and disadvantages in imaging t...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.otc.2015.07.003
更新日期：2015-12-01 00:00:00
abstract：:Frontal recess dissection proposes many challenges to the surgeon. These challenges stem from its highly variable nature, small caliber, difficult visualization, and proximity to vital structures such as the skull base and orbit. As such, delicate mucosal-sparing dissection of the frontal recess with proper instrument...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.otc.2016.03.018
更新日期：2016-08-01 00:00:00
abstract：:Reflux is a significant contributor to cough in otolaryngology practice; cough is just one marker of its many negative effects on the upper aerodigestive tract. Reflux causes cough both by direct irritation/inflammation and by increasing sensitivities to other noxious agents. Detailed and diligent clinical evaluation,...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章
doi：10.1016/j.otc.2009.12.003
更新日期：2010-02-01 00:00:00
abstract：:The saddle nose and short nose deformities are challenging surgical problems characterized by significant architectural deficiencies of the nasal framework. These defects produce cosmetic and functional nasal problems. Reconstructive techniques and augmentation materials are reviewed. Case examples illustrate the auth...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章
doi：10.1016/s0030-6665(05)70117-1
更新日期：1999-02-01 00:00:00
