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A procedure for estimating the dose modifying effect of chemotherapy on radiation response.

Abstract：

:A procedure based on a logistic regression model was used to estimate the dose-modifying effect of chemotherapy on the response of normal tissues to radiation. The magnitude of this modifying effect is usually expressed as a dose-effect factor (DEF). Values > 1.0 indicate an enhancing effect of chemotherapy while values < 1.0 suggest a 'protective' effect. The DEF in the proposed procedure is expressed as a function of logistic regression coefficients, response levels and values of covariates in the model. The proposed procedure is advantageous as it allows consideration of both the response levels and the values of covariates in calculating the DEF. A plot of the DEF against the response or a covariate describes how the DEF varies with the response levels or a covariate describes how the DEF varies with the response levels or the covariate values. Confidence intervals of the DEF were obtained based on the normal approximation of the distribution of the estimated DEF and on a non-parametric Bootstrap method. An example is given to illustrate the proposed procedure.

journal_name

Int J Radiat Biol

journal_title

International journal of radiation biology

authors

Hao Y,Keane T

doi

10.1080/09553009414550821

subject

Has Abstract

pub_date

1994-06-01 00:00:00

pages

699-704

issue

6

eissn

0955-3002

issn

1362-3095

pii

80KHVFWWFD0PGVVL

journal_volume

65

pub_type

临床试验,杂志文章

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