Clock genes, oscillators, and cellular networks in the suprachiasmatic nuclei.

Abstract:

:The mammalian SCN contains a biological clock that drives remarkably precise circadian rhythms in vivo and in vitro. Recent advances have revealed molecular and cellular mechanisms required for the generation of these daily rhythms and their synchronization between SCN neurons and to the environmental light cycle. This review of the evidence for a cell-autonomous circadian pacemaker within specialized neurons of the SCN focuses on 6 genes implicated within the pace making mechanism, an additional 4 genes implicated in pathways from the pacemaker, and the intercellular and intracellular mechanisms that synchronize SCN neurons to each other and to solar time.

journal_name

J Biol Rhythms

authors

Hastings MH,Herzog ED

doi

10.1177/0748730404268786

subject

Has Abstract

pub_date

2004-10-01 00:00:00

pages

400-13

issue

5

eissn

0748-7304

issn

1552-4531

pii

19/5/400

journal_volume

19

pub_type

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