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A case of laryngeal posttransplantation lymphoproliferative disease.

Abstract：

:The development of posttransplant lymphoproliferative disease (PTLD) is strongly linked to infection with the Epstein-Barr virus (EBV), immunosuppression-state, the type of allograft, and EBV-seronegativity. A 18-month-old girl who had undergone living donor liver transplantation using the left lateral segment from her father was treated with tacrolimus and corticosteroid as an immunosuppressant regimen. She was readmitted 3 months after the transplant to evaluate the etiology of dyspnea and abdominal fullness as well as a decreased urine volume. She was diagnosed as an anastomotic stenosis of the hepatic vein for which she underwent balloon angioplasty. The treatment was repeated at postoperative month 5, 8, and 11. As postoperative 6 months, the result of the serological EBV-CA (IgG/IgM) was positive. In postoperative month 10, the EBV PCR serologic test become positive, and a laryngeal biopsy revealed PTLD. She was treated with acyclovir and gangyclovir as well as reduced immunosuppression. We report herein a rare case of laryngeal PTLD in a patient who had undergone living donor liver transplant with paternal allograft.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Lee HH,Lee DS,Park JH,Lee KW,Kim SJ,Joh JW,Seo JM,Kwon GY,Choe YH,Lee SK

doi

10.1016/j.transproceed.2004.08.077

subject

Has Abstract

pub_date

2004-10-01 00:00:00

pages

2305-6

issue

8

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(04)00947-9

journal_volume

36

pub_type

杂志文章

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