Carbamazepine and its epoxide: an open study of efficacy and side effects after carbamazepine dose increment in refractory partial epilepsy.

abstract：:The major goal of immunosuppressive development is improved selectivity of the drug's inhibitory action against T and B cell-mediated as opposed to nonspecific granulocyte-, monocyte-, and macrophage-mediated resistance. This enterprise demands increased knowledge of alloantigen-induced stimulation, signal transductio...

journal_title：Therapeutic drug monitoring

authors： Kahan BD

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND:Dolutegravir (DTG) is an integrase strand transfer inhibitor, which is a newly approved antiretroviral drug used for the treatment of HIV-infected naive and experienced individuals. Many aspects of DTG pharmacology remain to be studied. Our aim was to develop and fully validate a robust analytical method for...

journal_title：Therapeutic drug monitoring

authors： Wang X,Penchala SD,Amara A,Else L,McClure M,Boffito M

更新日期：2016-06-01 00:00:00

abstract：:Ergotamine has been used for therapeutic purposes since the 1950s, usually to treat vascular headache. It is highly toxic and in large, repeated doses can produce all the symptoms of ergot poisoning. A selective and sensitive method, based on liquid chromatography-tandem mass spectrometry (LC-MS2), has been developed ...

journal_title：Therapeutic drug monitoring

authors： Favretto D,Frison G,Vogliardi S,Ferrara SD

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Analysis of residual gene expression of the nuclear factor of activated T cell (NFAT)-regulated genes has been developed as a pharmacodynamic biomarker to monitor therapy with calcineurin inhibitors. The availability of commercial primer sets (Search-LC) and the well-established assay protocol makes this bio...

journal_title：Therapeutic drug monitoring

authors： Abdel-Kahaar E,Giese T,Sommerer C,Rieger H,Shipkova M,Wieland E

更新日期：2016-12-01 00:00:00

abstract：:The objective of this study was to conduct an assessment of patient and parental preferences and an economic analysis of hospital costs in sampling blood and saliva for therapeutic drug monitoring (TDM). Costs and preferences were evaluated in the course of a study, which compared anticonvulsant concentrations in bloo...

journal_title：Therapeutic drug monitoring

authors： Gorodischer R,Burtin P,Hwang P,Levine M,Koren G

更新日期：1994-10-01 00:00:00

abstract：:Results of phenobarbital analyses are presented for 14 patients with chronic renal failure, and compared using gas-liquid chromatography (GLC), enzyme immunoassay (EIA), and fluorescence polarization immunoassay (FPIA). Correlation of FPIA with GLC and EIA was poor. ...

journal_title：Therapeutic drug monitoring

authors： Bridges RR,Jennison TA

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:Ribavirin exposure after the first dose (D0AUC0-4h) >1755 mcg·h·L is predictive of sustained virological response (SVR) in patients with hepatitis C treated with peginterferon and ribavirin. The aim of this study was to test the benefit of ribavirin early dose adjustment based on this target in naïve patient...

journal_title：Therapeutic drug monitoring

authors： Loustaud-Ratti V,Maynard M,Thevenon S,Pradat P,Rousseau A,Alain S,Deny P,Gagnieu MC,Tran A,Dao T,Silvain C,Lunel-Fabiani F,Picard N,Zublena I,Marquet P,Trepo C,RIBAJUSTE Group.

更新日期：2016-12-01 00:00:00

abstract：:A stabilized therapeutic drug monitoring procedure incorporating the novel Empore solid-phase extraction membrane (SPEM) for isolation of the antiarrhythmic drugs mexiletine (MEX) and flecainide (FLEC) from serum is described. Routinely, serum (0.5 ml), adjusted to pH 4.5, is passed through an octyl (C8) SPEM to extra...

journal_title：Therapeutic drug monitoring

authors： Lensmeyer GL,Wiebe DA,Doran TC

更新日期：1992-10-01 00:00:00

abstract：:Most recent cyclosporine (CsA) pharmacokinetic (PK) studies have focused on noncompartmental analysis. Because CsA undergoes significant first-pass elimination after oral dosing, the most appropriate compartment model may need to take this process into account for the construction of a valid population PK model for Sa...

journal_title：Therapeutic drug monitoring

authors： Ducharme MP,Verret L,Brouillette D,Sirois G

更新日期：1998-04-01 00:00:00

abstract：:Two hundred milligrams of valproic acid (VPA) was administered orally to seven healthy adults at 9:00 and 21:00 h for 5 consecutive days, including the morning dose on day 6. On the sixth day, blood samples were drawn at 0, 0.17, 0.33, 0.5, 0.75, 1, 1.5, 3, and 6 h after the morning dose. Binding of VPA to serum prote...

journal_title：Therapeutic drug monitoring

authors： Kodama Y,Koike Y,Kimoto H,Yasunaga F,Takeyama M,Teraoka I,Fujii I

更新日期：1992-02-01 00:00:00

abstract：:The study assessed the removal of mycophenolic acid (MPA) and its major glucuronide metabolite (MPAG) during continuous venovenous hemofiltration (CVVHF) and continuous venovenous hemodiafiltration (CVVHDF) in 4 heart transplant recipients treated for at least 6 days with mycophenolate mofetil (MMF) in addition to cyc...

journal_title：Therapeutic drug monitoring

authors： Cussonneau X,Bolon-Larger M,Prunet-Spano C,Bastien O,Boulieu R

更新日期：2008-02-01 00:00:00

abstract：:Previous studies have categorized duloxetine as a moderate inhibitor of CYP2D6. The aim of the present study was to investigate the potential interactions between duloxetine and the two CYP2D6 substrates risperidone and aripiprazole in psychiatric patients. Serum concentration data from patients treated with risperido...

journal_title：Therapeutic drug monitoring

authors： Hendset M,Molden E,Enoksen TB,Refsum H,Hermann M

更新日期：2010-12-01 00:00:00

abstract：:The purpose of this study was to construct a population pharmacokinetic (PK) metabolism (MB) model to describe ciprofloxacin (C) concentrations in plasma and vitreous and aqueous humors in 26 patients. Ciprofloxacin was given as a 3-day oral prophylactic treatment to 26 patients before vitrectomy. Plasma, vitreous, an...

journal_title：Therapeutic drug monitoring

authors： Di Marco MP,Chen J,Wainer IW,Ducharme MP

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:Anti-T lymphocyte globulin (ATLG) modulates the alloreactivity of T lymphocytes, reducing the risk of immunological posttransplant complications, in particular rejection and graft-versus-host disease, after allogeneic hematopoietic stem cell transplantation (HSCT). We developed and validated a new enzyme-lin...

journal_title：Therapeutic drug monitoring

authors： Montagna M,La Nasa G,Bernardo ME,Piras E,Avanzini MA,Regazzi M,Locatelli F

更新日期：2017-06-01 00:00:00

abstract：:A sensitive and specific direct-injection high-performance liquid chromatography-atmospheric pressure chemical ionization tandem mass-spectrometry (HPLC-APCI-MS-MS) method has been developed for the rapid identification and quantitation of seven tricyclic antidepressants-amitriptyline, nortriptyline, doxepin, dosulepi...

journal_title：Therapeutic drug monitoring

authors： Kollroser M,Schober C

更新日期：2002-08-01 00:00:00

abstract：:The plasma binding of phenytoin and the relationship between phenytoin concentrations in salivary and plasma ultrafiltrates were evaluated in pediatric epileptic patients aged 2-15 years. Paired samples of plasma and saliva were ultrafiltered through an Amicon YMT membrane. Phenytoin concentrations were measured by a ...

journal_title：Therapeutic drug monitoring

authors： Bachmann K,Forney RB Jr,Voeller K

更新日期：1983-01-01 00:00:00

abstract：:Whole blood steady-state trough concentrations of cyclosporine were measured by radioimmunoassay (RIA) and TDx assays employing monoclonal antibodies in 82 samples from 39 renal transplant patients. Intra- and interassay coefficients of variation for the new TDx technique averaged 3.2 and 5.4%, respectively. In the co...

journal_title：Therapeutic drug monitoring

authors： Klotz U

更新日期：1991-09-01 00:00:00

abstract：:An original, sensitive, and specific high-performance liquid chromatographic (HPLC) assay was developed for the quantitation of morphine and its two major metabolites, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G), in human plasma and cerebrospinal fluid (CSF) and in rat plasma, using hydromorphone as ...

journal_title：Therapeutic drug monitoring

authors： Wright AW,Watt JA,Kennedy M,Cramond T,Smith MT

更新日期：1994-04-01 00:00:00

abstract：:Plasma concentration-antidepressant response relationships for dothiepin, nordothiepin, dothiepin-S-oxide, and nordothiepin-S-oxide were investigated in 50 patients (33 women and 17 men), who had had a major depressive episode. Depression and anxiety were assessed at the start of therapy and after 2 and 4 weeks by mea...

journal_title：Therapeutic drug monitoring

authors： Ilett KF,Blythe TH,Hackett LP,Ong RT,Tannenbaum DA,Clarke TM

更新日期：1993-10-01 00:00:00

abstract：:We report a clinically relevant suspected interaction between acyclovir and the antiepileptic drugs phenytoin (PHT) and valproic acid (VPA). In a child receiving PHT and VPA therapy, a 6-day acyclovir treatment reduced PHT and VPA plasma concentrations to subtherapeutic values. This probably worsened both clinical sta...

journal_title：Therapeutic drug monitoring

authors： Parmeggiani A,Riva R,Posar A,Rossi PG

更新日期：1995-06-01 00:00:00

abstract：:Effects of carbamazepine coadministration on plasma concentrations of trazodone and its active metabolite, m-chlorophenylpiperazine (m-CPP) were studied in six depressed patients treated with trazodone. The daily dose of trazodone was 150 mg in three cases and 300 mg in three cases. Carbamazepine, 400 mg/day, was coad...

journal_title：Therapeutic drug monitoring

authors： Otani K,Ishida M,Kaneko S,Mihara K,Ohkubo T,Osanai T,Sugawara K

更新日期：1996-04-01 00:00:00

abstract：:The pharmacokinetic interaction between chloroquine (CQ) and imipramine was investigated in six healthy volunteers who received 300 mg of CQ, 50 mg of imipramine, and combined doses of both drugs in a randomized, crossover design. Blood and urine samples were collected at predetermined time intervals and were analyzed...

journal_title：Therapeutic drug monitoring

authors： Onyeji CO,Toriola TA,Ogunbona FA

更新日期：1993-02-01 00:00:00

abstract：:The ability of a pharmacokinetic/pharmacodynamic Bayesian forecasting computer program to predict prothrombin response to warfarin therapy was investigated. The performance of the program was evaluated retrospectively in an inpatient study population of 45 subjects. Predictions of prothrombin response at discharge, ba...

journal_title：Therapeutic drug monitoring

authors： Svec JM,Coleman RW,Mungall DR,Ludden TM

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Antiepileptic drug therapeutic regimens often need to be adjusted individually on the basis of serum assays. We aimed to develop a quantitative, fast, and sensitive liquid chromatography-tandem mass spectrometry method to simultaneously analyze carbamazepine, oxcarbazepine, and the 10-11 epoxide carbamazepin...

journal_title：Therapeutic drug monitoring

authors： Lionetto L,Casolla B,Cavallari M,Tisei P,Buttinelli C,Simmaco M

更新日期：2012-02-01 00:00:00

abstract：:For the evaluation and interpretation of pharmacokinetic data reliable quantitative determinations are a requirement that can only be met by well-characterized and fully validated analytical methods. To cope with these requirements a method is being established that is based on an integrated and automated fiber-optic ...

journal_title：Therapeutic drug monitoring

authors： Gygax D,Botta L,Ehrat M,Graf P,Lefèvre G,Oroszlan P,Pfister C

更新日期：1996-08-01 00:00:00

abstract：:The emergence of point-of-care assays enabling bedside testing such as the VerifyNow P2Y12 system might prove useful in clinical settings. The aim of this study was to evaluate the ability of the VerifyNow P2Y12 assay to estimate the inhibition of platelet aggregation provided by clopidogrel in the absence of baseline...

journal_title：Therapeutic drug monitoring

authors： Lordkipanidzé M,Pharand C,Nguyen TA,Schampaert E,Diodati JG

更新日期：2008-06-01 00:00:00

abstract：:The enantioselectivity of hydroxylation of nortriptyline (NT) to E-10-hydroxynortriptyline (E-10-OH-NT) was studied in human liver microsomes, intestinal homogenate, and patients treated with NT. The rate of formation of (-)-E-10-OH-NT was higher than that of (+)-E-10-OH-NT both in the liver microsomes and in the inte...

journal_title：Therapeutic drug monitoring

authors： Dahl ML,Nordin C,Bertilsson L

更新日期：1991-05-01 00:00:00

abstract：:The high incidence of psychiatric illness in the postpartum period and the increasing percentage of women who breastfeed has focused attention on the treatment of breastfeeding women with psychotropic medications and, additionally, the exposure of nursing infants to these medications. Consequently, there has been an i...

journal_title：Therapeutic drug monitoring

authors： Hostetter AL,Stowe ZN,Cox M,Ritchie JC

更新日期：2004-02-01 00:00:00

abstract：:A highly sensitive, specific method for determining chloramphenicol levels in human blood plasma and cerebrospinal fluid is described. The method uses high performance liquid chromatography for the analysis, requires minimal quantities of patient specimen, and thus is suitable for use in newborn and pediatric patients...

journal_title：Therapeutic drug monitoring

authors： Sood SP,Green VI,Bailey CL

更新日期：1987-09-01 00:00:00

abstract：:Concentration monitoring and dose individualization is required to optimize either tacrolimus or cyclosporin therapy. In this study, the validation of a simple, rapid high-performance liquid chromatography-tandem mass spectrometry method for the simultaneous measurement of tacrolimus and cyclosporin in whole blood is ...

journal_title：Therapeutic drug monitoring

authors： Salm P,Taylor PJ,Rooney F

更新日期：2008-06-01 00:00:00