Vaginal application of lactobacilli in the prophylaxis of recurrent lower urinary tract infection in women.

Abstract:

OBJECTIVE:To examine whether vaginal application of Lactobacillus casei v. rhamnosus reduces the reinfection rate in cystitis-prone women. DESIGN:A controlled, randomized, double-blind clinical trial. SETTING:Division for General Practice, University of Bergen, Norway. INTERVENTION:Vaginal application of lactobacilli twice weekly. SUBJECTS:47 women, aged 18-50 years, reporting three or more episodes of distal urinary symptoms during the previous 12 months, of which at least one episode had been medically verified as a lower UTI. MAIN OUTCOME MEASURE:The incidence rate of lower UTI during 6 months' follow-up. RESULTS:No difference in infection rate between the two groups; the incidence rate ratio between the treatment group and the placebo group was 1.41 (95% confidence interval 0.88-1.98). Lactobacilli were not found more frequently periurethrally in the treatment group than in the control group. CONCLUSION:It is still uncertain whether vaginal application of lactobacilli reduces the infection rate in cystitis-prone women.

authors

Baerheim A,Larsen E,Digranes A

doi

10.3109/02813439409029247

subject

Has Abstract

pub_date

1994-12-01 00:00:00

pages

239-43

issue

4

eissn

0281-3432

issn

1502-7724

journal_volume

12

pub_type

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