当前位置： SCI文献检索 > AMERICAN HEART JOURNAL期刊下所有文献 > Reduction of hospital mortality rate of acute myocardial infarction with glucose-insulin-potassium infusion.

Reduction of hospital mortality rate of acute myocardial infarction with glucose-insulin-potassium infusion.

Abstract：

:Free fatty acids (FFA), the predominant myocardial energy substrate, are present in increased quantities immediately following acute myocardial infarction (AMI) and may cause deleterious alterations in cardiac rhythm, oxygen consumption, and mechanical performance. In an attempt to suppress FFA and simultaneously increase the availability of carbohydrate as a myocardial substrate, 70 patients with unequivocal AMI were administered a right atrial infusion of glucose-insulin-potassium (GIK) (300 gm. of glucose, 50 U. of regular insulin, and 80 mEq. of KC1 per liter of H2O) at a constant rate of 0.5 to 2.0 ml. per kilogram per hour for 48 hours. A dramatic fall in FFA (944 +/- 57 to 289 +/- 16 muEq per liter, p less than 0.0005) occurred during GIK infusion, and FFA rebounded to 420 +/- 39 muEq per liter (p less than 0.005) when GIK was discontinued. The hospital mortality rate in the 70 GIK recipients was compared to that of 64 untreated patients (controls) from the same coronary-care unit during the previous year. GIK and control groups had similar severity of infarction as assessed by prognostic scales of Killip, Peel, and Norris, respectively. The hospital mortality rate was reduced in the GIK recipients compared to the control group (11/70 vs. 19/64, p less than 0.05). In patients without history of prior myocardial infarction, the mortality rate was reduced four-fold in GIK recipients compared to controls (6 vs. 24 per cent, p less than 0.05). Complications of GIK infusion were infrequent and included chiefly hyperglycemia and hyperkalemia, both of which dictated meticulous monitoring of serum chemistries. The data suggest that suppression of plasma FFA with GIK infusion may be associated with a significant reduction in the hospital mortality rate of acute myocardial infarction.

journal_name

Am Heart J

journal_title

American heart journal

authors

Rogers WJ,Stanley AW Jr,Breinig JB,Prather JW,McDaniel HG,Moraski RE,Mantle JA,Russell RO Jr,Rackley CE

doi

10.1016/s0002-8703(76)80043-9

subject

Has Abstract

pub_date

1976-10-01 00:00:00

pages

441-54

issue

4

eissn

0002-8703

issn

1097-6744

pii

S0002-8703(76)80043-9

journal_volume

92

pub_type

临床试验,杂志文章

相关文献

AMERICAN HEART JOURNAL文献大全
  • Reversibility of bronchospasm in airway obstruction.

    abstract：:In a double-blind, randomized crossover study of 12 patients suffering from chronic bronchitis, the comparative influence of equipotent doses of pindolol (5 mg) and metoprolol (100 mg) on the bronchodilatory potential of inhaled fenoterol (0.4 mg), a beta 2-agonist, was investigated by means of body plethysmography. N...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0002-8703(82)90138-7

    authors： von Wichert P

    更新日期：1982-08-01 00:00:00

  • Prevalence and significance of reversible radionuclide ischemic perfusion defects in symptomatic aortic valve disease patients with or without concomitant coronary disease.

    abstract：:To determine the prevalence and significance of exercise-induced localized perfusion defects in symptomatic patients with aortic valve disease, thallium-201 rest and exercise studies were performed in a consecutive series of 29 such patients prior to left heart catheterization with coronary arteriography. Eight patien...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(82)90535-x

    authors： Pfisterer M,Müller-Brand J,Bründler H,Cueni T

    更新日期：1982-01-01 00:00:00

  • Glomerular capillary pressure and hypertension.

    abstract：:In patients with essential hypertension, glomerular filtration rate remains normal or elevated, whereas renal blood flow tends to be lower, which results in an increased filtration fraction. The afferent (preglomerular) arteriolar resistance determines the fraction of the pressure that is transmitted to the glomerular...

    journal_title：American heart journal

    pub_type： 杂志文章,评审

    doi：10.1016/0002-8703(91)90945-e

    authors： Larochelle P

    更新日期：1991-10-01 00:00:00

  • Protective effect of the CYP2C19 *17 polymorphism with increased activation of clopidogrel on cardiovascular events.

    abstract：BACKGROUND:The prodrug clopidogrel requires activation by cytochrome P-450 (CYP) enzymes for its antiplatelet effect. The genes encoding enzymes for clopidogrel activation are polymorphic, leading to reduced or increased function, depending on the respective genotype. Reduced-function alleles have been associated with ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2010.06.039

    authors： Tiroch KA,Sibbing D,Koch W,Roosen-Runge T,Mehilli J,Schömig A,Kastrati A

    更新日期：2010-09-01 00:00:00

  • Adverse reactions to methyldopa with particular reference to hypotension.

    abstract：:Of 26,294 consecutive patients monitored in a comprehensive drug surveillance program, 1067 (4 per cent) received methyldopa for treatment of hypertension. Adverse reactions attributed to methyldopa were reported in 149 patients (14 per cent), the most frequent being hypotension. Life-threatening adverse effects were ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(78)90192-8

    authors： Lawson DH,Gloss D,Jick H

    更新日期：1978-11-01 00:00:00

  • The acute effects of flecainide in the swine heart failing from incessant supraventricular tachycardia.

    abstract：:The acute hemodynamic and electrophysiologic effects of flecainide in tachycardia-induced ventricular dysfunction were investigated using an animal model. Seven swine were initially (CON) evaluated by echocardiography and then by right heart catheterization and provocative electrical ventricular stimulation both befor...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(91)90018-d

    authors： Trippel DL,Harold ME,Spinale FG,Buckles DS,Gillette PC

    更新日期：1991-06-01 00:00:00

  • Acute coronary occlusion occurring after successful percutaneous transluminal coronary angioplasty: temporal relationship to discontinuation of anticoagulation.

    abstract：:The incidence and prognosis of acute coronary reocclusion occurring after patients had left the catheterization laboratory following a successful percutaneous transluminal coronary angioplasty (PTCA) procedure and the temporal relation of this event to the discontinuation of systemic heparin administration were analyz...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(88)90326-2

    authors： Gabliani G,Deligonul U,Kern MJ,Vandormael M

    更新日期：1988-09-01 00:00:00

  • Undiagnosed diabetes is prevalent in younger adults and associated with a higher risk cardiometabolic profile compared to diagnosed diabetes.

    abstract：BACKGROUND:A substantial percentage of patients have undiagnosed diabetes. We investigated the demographic characteristics and cardiometabolic profiles of subjects with undiagnosed diabetes. METHODS:A cross-sectional study with nationally representative samples of 25490 subjects aged ≥ 20 years from the KHNANES 2008 t...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ahj.2015.07.024

    authors： Lee YH,Armstrong EJ,Kim G,Oh J,Kang SM,Lee BW,Ahn CW,Cha BS,Lee HC,Mantzoros CS,Kang ES

    更新日期：2015-10-01 00:00:00

  • Aggravated renal dysfunction during intensive therapy for advanced chronic heart failure.

    abstract：BACKGROUND:Chronic heart failure is associated with impaired renal function, which may worsen during therapy. The incidence, predictors, and consequences of aggravated renal dysfunction (ARD) in patients undergoing intensive therapy for advanced chronic heart failure are unknown. METHODS:We reviewed the experience of ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(99)70113-4

    authors： Weinfeld MS,Chertow GM,Stevenson LW

    更新日期：1999-08-01 00:00:00

  • Interposed abdominal compression as an adjunct to cardiopulmonary resuscitation.

    abstract：:The addition of IAC to otherwise standard CPR provides for the application of external pressure over the abdomen in counterpoint to the rhythm of chest compression. Interposed abdominal compression is a simple manual technique that can supplement the use of adrenergic drugs to increase both coronary perfusion pressure...

    journal_title：American heart journal

    pub_type： 杂志文章,评审

    doi：10.1016/0002-8703(94)90132-5

    authors： Babbs CF,Sack JB,Kern KB

    更新日期：1994-02-01 00:00:00

  • Direct intramyocardial percutaneous delivery of autologous bone marrow in patients with refractory myocardial angina.

    abstract：BACKGROUND:Intramyocardial injection of autologous bone marrow (ABM) may induce angiogenesis. We tested the safety and feasibility of catheter-based direct percutaneous intramyocardial delivery of ABM in patients with refractory angina pectoris. METHODS:Ten patients (9 men, 67 +/- 8 years) with refractory angina (Cana...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2005.04.033

    authors： Briguori C,Reimers B,Sarais C,Napodano M,Pascotto P,Azzarello G,Bregni M,Porcellini A,Vinante O,Zanco P,Peschle C,Condorelli G,Colombo A

    更新日期：2006-03-01 00:00:00

  • Safety, feasibility, and prognostic implications of pharmacologic stress echocardiography in 1482 patients evaluated in an ambulatory setting.

    abstract：BACKGROUND:The outpatient prognostic assessment of coronary artery disease (CAD) by exercise electrocardiography has limitations, including the feasibility of the test and its low positive predictive value in several clinical conditions. In the current study we investigated the safety, feasibility, and prognostic value...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1067/mhj.2001.113997

    authors： Cortigiani L,Picano E,Coletta C,Chiarella F,Mathias W,Gandolfo N,De Alcantara M,Mazzoni V,Gensini GF,Landi P,Echo Persantine International Cooperative (EPIC) Study Group.,Echo Dobutamine International Cooperative (EDIC) Study Group

    更新日期：2001-04-01 00:00:00

  • Onset and extent of platelet inhibition by clopidogrel loading in patients undergoing elective coronary stenting: the Plavix Reduction Of New Thrombus Occurrence (PRONTO) trial.

    abstract：BACKGROUND:Despite the common practice of clopidogrel loading for coronary stenting, the time dependence and degree of platelet inhibition after this therapy are not well defined. We sought to establish an optimal clopidogrel dosing regimen for sustained platelet inhibition in stented patients. METHODS AND RESULTS:Pla...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1067/mhj.2003.109

    authors： Gurbel PA,Cummings CC,Bell CR,Alford AB,Meister AF,Serebruany VL,Plavix Reduction Of New Thrombus Occurrence (PRONTO) trial.

    更新日期：2003-02-01 00:00:00

  • Accelerated treatment of endocarditis-The POET II trial: Rationale and design of a randomized controlled trial.

    abstract：BACKGROUND:The optimal antibiotic treatment length for infective endocarditis (IE) is uncertain. International guidelines recommend treatment duration of up to 6 weeks for patients with left-sided IE but are primarily based on historical data and expert opinion. Efficacies of modern therapies, fast recovery seen in man...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2020.05.012

    authors： Østergaard L,Pries-Heje MM,Hasselbalch RB,Rasmussen M,Åkesson P,Horvath R,Povlsen J,Gill S,Bruun NE,Müllertz K,Tuxen CD,Ihlemann N,Helweg-Larsen J,Moser C,Fosbøl EL,Bundgaard H,Iversen K

    更新日期：2020-09-01 00:00:00

  • Correlation between the signal-averaged electrocardiogram and electrophysiologic study findings in patients with coronary artery disease and sustained ventricular tachycardia.

    abstract：:Ventricular late potentials at the end of the surface QRS, detected on the signal-averaged electrocardiogram (SAECG) have been shown to be markers for spontaneous and/or inducible ventricular tachycardia (VT) in patients with coronary artery disease (CAD). We examined the correlations between electrophysiologic study ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(88)90884-8

    authors： Borbola J,Ezri MD,Denes P

    更新日期：1988-04-01 00:00:00

  • Percutaneous coronary intervention outcomes in US hospitals with varying structural characteristics: analysis of the NCDR®.

    abstract：BACKGROUND:In the United States, there continues to be debate about whether certain types of hospitals deliver improved patient outcomes. We sought to assess the association between hospital organizational characteristics and in-hospital outcomes for percutaneous coronary intervention (PCI). METHODS:Retrospective anal...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ahj.2011.10.010

    authors： Cram P,House JA,Messenger JC,Piana RN,Horwitz PA,Spertus JA

    更新日期：2012-02-01 00:00:00

  • Anticoagulant therapy and outcomes in patients with prior or acute heart failure and acute coronary syndromes: Insights from the APixaban for PRevention of Acute ISchemic Events 2 trial.

    abstract：BACKGROUND:Clinical outcomes and the effects of oral anticoagulants among patients with acute coronary syndrome (ACS) and either a history of or acute heart failure (HF) are largely unknown. We aimed to assess the relationship between prior HF or acute HF complicating an index ACS event and subsequent clinical outcomes...

    journal_title：American heart journal

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ahj.2014.12.022

    authors： Cornel JH,Lopes RD,James S,Stevens SR,Neely ML,Liaw D,Miller J,Mohan P,Amerena J,Raev D,Huo Y,Urina-Triana M,Gallegos Cazorla A,Vinereanu D,Fridrich V,Harrington RA,Wallentin L,Alexander JH,APPRAISE-2 Study Group.

    更新日期：2015-04-01 00:00:00

  • Implementation of a Brazilian Cardioprotective Nutritional (BALANCE) Program for improvement on quality of diet and secondary prevention of cardiovascular events: A randomized, multicenter trial.

    abstract：BACKGROUND:Appropriate dietary recommendations represent a key part of secondary prevention in cardiovascular disease (CVD). We evaluated the effectiveness of the implementation of a nutritional program on quality of diet, cardiovascular events, and death in patients with established CVD. METHODS:In this open-label, m...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ahj.2019.06.010

    authors： Weber B,Bersch-Ferreira ÂC,Torreglosa CR,Marcadenti A,Lara ES,da Silva JT,Costa RP,Santos RHN,Berwanger O,Bosquetti R,Pagano R,Mota LGS,de Oliveira JD,Soares RM,Galante AP,da Silva SA,Zampieri FG,Kovacs C,Amparo FC,

    更新日期：2019-09-01 00:00:00

  • Effect of center catheterization volume on risk of catastrophic adverse event after cardiac catheterization in children.

    abstract：BACKGROUND:Procedural volume has been shown to be associated with outcome in cardiac catheterization and intervention in adults. The impact of center-level factors (such as volume) and their interaction with subject- and procedure-level factors on outcome after cardiac catheterization in children is not well described....

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ahj.2015.02.018

    authors： O'Byrne ML,Glatz AC,Shinohara RT,Jayaram N,Gillespie MJ,Dori Y,Rome JJ,Kawut S

    更新日期：2015-06-01 00:00:00

  • Intraventricular thrombosis in polycythemia vera: A cause of intractable cardiac failure.

    abstract：:The occurrence of thrombotic events is central to the course of polycythemia vera. Myocardial, cerebral, peripheral, and pulmonary infarctions are frequent and are consequences of throbmoses in small and medium caliber arteries. Thrombosis in large caliber arteries is a rare event. Thrombosis within the chambers of th...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(80)90667-5

    authors： Ali M,Fayemi AO,Malcolm D,Braun EV

    更新日期：1980-10-01 00:00:00

  • A comparison of the acute hypotensive effects of two different doses of nifedipine.

    abstract：:To determine whether a dose of 5 mg of nifedipine would be useful in the treatment of hypertensive emergencies, we compared the acute hypotensive effects of two different doses of nifedipine, 5 mg and 10 mg, in patients with severe hypertension. In this prospective, randomized, double-blind study, 30 consecutive black...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0002-8703(92)90283-2

    authors： Maharaj B,van der Byl K

    更新日期：1992-09-01 00:00:00

  • Effects of warfarin on markers of hypercoagulability in patients with heart failure.

    abstract：:Heart failure is associated with a hypercoagulable state. A single-center, randomized, double-blind, placebo-controlled trial was performed to test the hypothesis that warfarin will modify a hypercoagulable state in heart failure. This study included 76 patients with heart failure. At baseline, patients had evidence f...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0002-8703(97)70103-0

    authors： Jafri SM,Mammen EF,Masura J,Goldstein S

    更新日期：1997-07-01 00:00:00

  • Ventricular septal defect: selection of patients and timing for surgery.

    abstract：:Eighty-seven patients with isolated ventricular septal defect (VSD) operated on in the first 5 years of life, that had a mean interval of 10 months between diagnostic catheterization and surgery, were studied retrospectively. The size of the VSD was correlated with diagnostic catheterization data and comparative analy...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(77)80170-1

    authors： Yasui H,Yoshitoshi M,Miyamoto AT,Kato H,Takeda Y

    更新日期：1977-01-01 00:00:00

  • Socioeconomic status, ethnic origin, and risk factors for coronary heart disease in children.

    abstract：:The associations between socioeconomic status, ethnic origin, and risk factors for CHD were studied in 2,591 white and black children from two socioeconomically dissimilar populations in the New York City area. The study subjects were selected from all fourth graders in 44 elementary schools. Blood pressure, plasma li...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(87)90724-1

    authors： Walter HJ,Hofman A

    更新日期：1987-03-01 00:00:00

  • Perindopril and β-blocker for the prevention of cardiac events and mortality in stable coronary artery disease patients: A EUropean trial on Reduction Of cardiac events with Perindopril in stable coronary Artery disease (EUROPA) subanalysis.

    abstract：BACKGROUND:β-Blockers relieve angina/ischemia in stable coronary artery disease (CAD), and angiotensin-converting enzyme inhibitors prevent CAD outcomes. In EUROPA, the angiotensin-converting enzyme inhibitor perindopril reduced cardiovascular outcomes in low-risk stable CAD patients over 4.2 years. This post hoc analy...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ahj.2015.08.018

    authors： Bertrand ME,Ferrari R,Remme WJ,Simoons ML,Fox KM

    更新日期：2015-12-01 00:00:00

  • Loss of bone marrow-derived vascular progenitor cells leads to inflammation and atherosclerosis.

    abstract：BACKGROUND:Aging represents the most powerful risk for the development of atherosclerosis and atherosclerotic thromboembolic complications. Yet, the mechanism by which aging affects the arterial wall and its deterioration has remained essentially uncharacterized. FINDINGS:Chronic injuries to the arterial wall contribu...

    journal_title：American heart journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.ahj.2003.09.002

    authors： Goldschmidt-Clermont PJ

    更新日期：2003-10-01 00:00:00

  • Prediction of survival in progressive systemic sclerosis by multivariate analysis of clinical features.

    abstract：:The records of 64 patients with progressive systemic sclerosis (PSS) were reviewed. More than 100 items from the patient's history, physical examination, and laboratory tests were encoded. A two-tailed Gehan's test was used to evaluate the effect of each variable on patient survival. Variables significant at the 0.05 ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(85)90525-3

    authors： Wynn J,Fineberg N,Matzer L,Cortada X,Armstrong W,Dillon JC,Kinney EL

    更新日期：1985-07-01 00:00:00

  • Prognostic value of C-reactive protein and cardiac troponin I in primary percutaneous interventions for ST-elevation myocardial infarction.

    abstract：BACKGROUND:The rise in cardiac troponin I after ST-elevation myocardial infarction treated by primary percutaneous coronary interventions (PCIs) is predictive of infarct size and left ventricular ejection fraction (LVEF). However, the comparative value of C-reactive protein (CRP) and troponin I for infarct size evaluat...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2006.07.016

    authors： Ohlmann P,Jaquemin L,Morel O,El Behlgiti R,Faure A,Michotey MO,Beranger N,Roul G,Schneider F,Bareiss P,Monassier JP

    更新日期：2006-12-01 00:00:00

  • Repeat stenting for the prevention of the early lumen loss phenomenon in patients with in-stent restenosis. Angiographic and intravascular ultrasound findings of a randomized study.

    abstract：BACKGROUND:Early lumen loss (ELL) may be detected in patients undergoing coronary interventions for in-stent restenosis. This phenomenon may contribute to recurrences. This prospective, randomized study was designed to determine if repeat stent implantation may prevent ELL in patients with in-stent restenosis. METHODS...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.ahj.2004.06.022

    authors： Alfonso F,García P,Fleites H,Pimentel G,Sabaté M,Hernández R,Escaned J,Bañuelos C,Pérez-Vizcayno MJ,Moreno R,Macaya C

    更新日期：2005-02-01 00:00:00

  • Coffee consumption and mortality after acute myocardial infarction: the Stockholm Heart Epidemiology Program.

    abstract：BACKGROUND:Cohort studies have suggested little effect of coffee consumption on risk of acute myocardial infarction. The effect of coffee consumption on prognosis after myocardial infarction is uncertain. METHODS:In a population-based inception cohort study, we followed 1,369 patients hospitalized with a confirmed fir...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2008.11.009

    authors： Mukamal KJ,Hallqvist J,Hammar N,Ljung R,Gémes K,Ahlbom A,Ahnve S,Janszky I

    更新日期：2009-03-01 00:00:00