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The effect of methimazole on the immune system is unlikely to operate directly on T lymphocytes.

Abstract：

:It has been shown that the antithyroid drug methimazole (MMI) may affect B cells and possibly accessory cell function. In the present study we investigated in detail the effects of MMI on T cell in vitro proliferation. The following variables were evaluated: T cell proliferation following stimulation with phytohemagglutinin (PHA), and anti-CD3 or anti-CD2 monoclonal antibodies; interleukin-2 (IL-2) and gamma-interferon (gamma-IFN) production by PHA-stimulated T cells in bulk culture and by T cell clones; PHA-induced IL-2 receptor expression; LPS-induced interleukin-1 production by accessory cells. The results obtained failed to demonstrate any effect of MMI on T cells in vitro proliferation, whatever the activation pathway considered. In addition, IL-2 and gamma-IFN productions were substantially unaffected by the drug, as well as IL-1 production by accessory cells. However, a slight reduction of PHA-induced IL-2 receptor expression was observed. Although the hypothesis of an effect of MMI on some specialized T cell functions cannot be ruled out, it is likely that the supposed "immunosuppressive" effect of the drug does not concern primarily the T lymphocyte.

journal_name

J Endocrinol Invest

journal_title

Journal of endocrinological investigation

authors

Bagnasco M,Venuti D,Ciprandi G,Pesce G,Paolieri F,Canonica GW

doi

10.1007/BF03348606

subject

Has Abstract

pub_date

1990-06-01 00:00:00

pages

493-9

issue

6

eissn

0391-4097

issn

1720-8386

journal_volume

13

pub_type

杂志文章

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