Abstract:
BACKGROUND:Older people with elevated blood pressure (BP) often have metabolic syndrome, a clustering of central obesity, insulin resistance, dyslipidemia, and hypertension. Exercise reduces many of these risk factors. This study examined whether the benefits of exercise on cardiovascular and metabolic disease risk factors are mediated by exercise-induced changes in fitness or body composition. METHODS:Randomized controlled trial, comprising 6 months of exercise training, conducted between July 1999 and November 2003. Participants included men and women (n =115) aged 55 to 75 years with untreated systolic blood pressure (SBP) of 130 to 159 or diastolic blood pressure of (DPB) 85 to 99 mm Hg. Fitness measures included BP, lipids, lipoproteins, insulin, and glucose; peak oxygen uptake and muscle strength; and body composition measured by anthropometry, dual-energy x-ray absorptiometry, and magnetic resonance imaging. RESULTS:A total of 51 men and 53 women completed the trial. Exercise significantly increased aerobic and muscle fitness, lean mass, and high-density lipoprotein cholesterol and reduced total and abdominal fat. DBP was reduced more among exercisers. There were no associations among changes in fitness with risk factors. Reductions in total body and abdominal fat and increases in leanness, largely independent of weight loss, were associated with improved SBP, DBP, total cholesterol, very low-density lipoprotein cholesterol, triglycerides, lipoprotein(a), and insulin sensitivity. At baseline, 42.3% of participants had metabolic syndrome. At 6 months, nine exercisers (17.7%) and eight controls (15.1%) no longer had metabolic syndrome, whereas four controls (7.6%) and no exercisers developed it (p =0.06). CONCLUSIONS:Although exercise improved fitness, the reductions in total and abdominal fatness and increase in leanness were more strongly associated with favorable changes in risk factors for cardiovascular disease and diabetes, including those that constitute metabolic syndrome.
journal_name
Am J Prev Medjournal_title
American journal of preventive medicineauthors
Stewart KJ,Bacher AC,Turner K,Lim JG,Hees PS,Shapiro EP,Tayback M,Ouyang Pdoi
10.1016/j.amepre.2004.09.006subject
Has Abstractpub_date
2005-01-01 00:00:00pages
9-18issue
1eissn
0749-3797issn
1873-2607pii
S0749-3797(04)00245-4journal_volume
28pub_type
临床试验,杂志文章,随机对照试验abstract:INTRODUCTION:Hepatocellular carcinoma disproportionately affects minorities. Southern states have high proportions of black populations and prevalence of known risk factors. Further research is needed to understand the role of southern geography in hepatocellular carcinoma disparities. This paper examined racial dispar...
journal_title:American journal of preventive medicine
pub_type: 杂志文章
doi:10.1016/j.amepre.2018.05.030
更新日期:2018-11-01 00:00:00
abstract:INTRODUCTION:In an effort to reduce methicillin-resistant Staphylococcus aureus (MRSA) transmission through universal screening and isolation, the Department of Veterans Affairs (VA) launched the National MRSA Prevention Initiative in October 2007. The objective of this analysis was to quantify the budget impact and co...
journal_title:American journal of preventive medicine
pub_type: 杂志文章
doi:10.1016/j.amepre.2015.10.016
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:To determine the age-specific prevalence of Lyme disease and whether preventive behaviors on Nantucket Island correlate with Lyme disease, we surveyed island residents. METHODS:A survey with questions on Lyme disease symptoms, history, and preventive behaviors was mailed to all residents. Respondents were s...
journal_title:American journal of preventive medicine
pub_type: 杂志文章
doi:10.1016/s0749-3797(00)00315-9
更新日期:2001-04-01 00:00:00
abstract::We designed a randomized clinical trial to examine effectiveness of a follow-up educational mailing to improve referral completion following a workplace cholesterol screening program. Of 836 employees who participated in a cholesterol screening program at Blue Cross and Blue Shield of Maryland, 313 (37%) had a total c...
journal_title:American journal of preventive medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1991-11-01 00:00:00
abstract:CONTEXT:Community-based participatory research (CBPR) has been promoted as an approach to understanding complex health problems not amenable to research conducted solely by outside investigators. Although broad dissemination of research results is a key element of the CBPR approach, existing dissemination efforts have ...
journal_title:American journal of preventive medicine
pub_type: 杂志文章,评审
doi:10.1016/j.amepre.2010.05.021
更新日期:2010-10-01 00:00:00
abstract:INTRODUCTION:Colorectal cancer (CRC) is the second leading cause of cancer mortality in the U.S.; however, if the population aged 50 years or older received routine screening, approximately 60% of these deaths could be eliminated. This study investigates whether adults, aged 50-75 years, with one of three disabilities ...
journal_title:American journal of preventive medicine
pub_type: 杂志文章
doi:10.1016/j.amepre.2017.01.005
更新日期:2017-06-01 00:00:00
abstract:INTRODUCTION:Several authors have explored the effect of individual risk factors on vaccination inequity in Indian infants. This study explores the combined impact of >1 risk factor on the probability of full vaccination. METHODS:The proportion of fully vaccinated infants (aged 1-2 years) was calculated from the Natio...
journal_title:American journal of preventive medicine
pub_type: 杂志文章
doi:10.1016/j.amepre.2020.10.001
更新日期:2021-01-01 00:00:00
abstract:CONTEXT:The effectiveness of personalized-feedback interventions to reduce problem drinking has been evaluated in several RCTs and systematic reviews. A meta-analysis was performed to examine the overall effectiveness of brief, single-session personalized-feedback interventions without therapeutic guidance. EVIDENCE A...
journal_title:American journal of preventive medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.amepre.2008.10.016
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:Child maltreatment has been linked to multiple negative health outcomes and many leading causes of death. Statewide population-based evaluations are needed to identify high-risk populations early in life for targeted interventions. PURPOSE:To assess the utility of combining Pregnancy Risk Assessment Monitor...
journal_title:American journal of preventive medicine
pub_type: 杂志文章
doi:10.1016/j.amepre.2011.02.022
更新日期:2011-06-01 00:00:00
abstract:INTRODUCTION:Justice-involved adolescents are at high risk for sexually transmitted infections; one primary reason is co-occurring substance use. This study investigates the additive benefit of including alcohol and cannabis use content in a theory-based sexual risk reduction intervention, delivered using group-based m...
journal_title:American journal of preventive medicine
pub_type: 杂志文章
doi:10.1016/j.amepre.2020.07.009
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Fecal occult blood testing (FOBT) programs cost-effectively reduce colon cancer mortality. To improve the rate of colon cancer screening with FOBT, we tested the effect of mailing FOBT cards timed to appointments on the rates of completion of FOBT. DESIGN:Controlled trial. SETTING/PARTICIPANTS:A total of 1...
journal_title:American journal of preventive medicine
pub_type: 临床试验,杂志文章
doi:10.1016/j.amepre.2004.02.009
更新日期:2004-06-01 00:00:00
abstract:INTRODUCTION:Cost sharing can deter the use of health services and act as a potential contributor to racial/ethnic disparities in cancer. The Affordable Care Act required most health plans to cover, without cost sharing, preventive services, including colorectal cancer screening. Population-based data were used to esti...
journal_title:American journal of preventive medicine
pub_type: 杂志文章
doi:10.1016/j.amepre.2019.09.002
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Physical inactivity is a risk factor for obesity, cardiovascular disease, hypertension, and other chronic diseases that are increasingly prevalent in the U.S. and worldwide. Time at work represents a major portion of the day for employed people. PURPOSE:To determine how employment status (full-time, part-ti...
journal_title:American journal of preventive medicine
pub_type: 杂志文章
doi:10.1016/j.amepre.2011.03.019
更新日期:2011-08-01 00:00:00
abstract:INTRODUCTION:Healthcare organizations are transitioning from fee-for-service, volume-based care toward value-based care and the Triple Aim. Physicians have critical roles as leaders and practitioners in this emerging field of population health management; however, the competencies required of these physicians are not w...
journal_title:American journal of preventive medicine
pub_type: 杂志文章
doi:10.1016/j.amepre.2020.06.016
更新日期:2021-02-01 00:00:00
abstract::Editors' Note: We invited a sample of AJPM's Editorial Board, supplement guest editors, and longtime colleagues and contributors to share their experiences and impressions of the impact of AJPM on their respective domains. We were particularly fond of Ken Powell's analogy to being "tenders of the planted seed"--as pla...
journal_title:American journal of preventive medicine
pub_type: 历史文章,信件
doi:10.1016/j.amepre.2013.09.006
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Mortality differentials by level and intensity of physical activity have been widely documented. A comprehensive review of scientific evidence of the health benefits of physical activity led the USDHHS to issue new Federal Guidelines for physical activity in 2008. Reductions in mortality risk associated with...
journal_title:American journal of preventive medicine
pub_type: 杂志文章
doi:10.1016/j.amepre.2010.12.029
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:Recognition of health disparities among underserved individuals, whose demographic, geographic, or economic characteristics impede access to health-related services, has led to calls for the development of medical school curricula that address care for the underserved, but reports of the development and eval...
journal_title:American journal of preventive medicine
pub_type: 杂志文章
doi:10.1016/j.amepre.2006.06.024
更新日期:2006-10-01 00:00:00
abstract::Medical systems and associative communities are two distinctive social tools. To promote health, tools of community are more significant than system tools. Medical systems were created to serve many needs efficiently and to produce standardized procedures and outcome. Clients are a necessary component of a medical sys...
journal_title:American journal of preventive medicine
pub_type: 杂志文章
doi:
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to estimate, using meta-analysis, pooled odds ratios for the effects of smoking on five pregnancy complications: placenta previa, abruptio placenta, ectopic pregnancy, preterm premature rupture of the membrane (PPROM), and pre-eclampsia. METHODS:Published articles were identifi...
journal_title:American journal of preventive medicine
pub_type: 杂志文章,meta分析
doi:10.1016/s0749-3797(98)00089-0
更新日期:1999-04-01 00:00:00
abstract:INTRODUCTION:Although some view the ownership of firearms as a deterrent to crime, the relationship between population-level firearm ownership rates and violent criminal perpetration is unclear. The purpose of this study is to test the association between state-level firearm ownership and violent crime. METHODS:State-...
journal_title:American journal of preventive medicine
pub_type: 杂志文章
doi:10.1016/j.amepre.2015.02.008
更新日期:2015-08-01 00:00:00
abstract:CONTEXT:The study systematically reviewed articles on the association between tobacco smoking and periodontitis, as it has been hypothesized that smoking affects the course of periodontitis through impairment of immunological and vascular mechanisms. EVIDENCE ACQUISITION:Searches of articles indexed in PubMed, Scopus,...
journal_title:American journal of preventive medicine
pub_type: 杂志文章,meta分析
doi:10.1016/j.amepre.2018.02.014
更新日期:2018-06-01 00:00:00
abstract::Factor analysis, combined with an evaluation of item difficulty and discrimination, can provide useful insights in questionnaire development. In 1993, as part of a study to develop a questionnaire to assess performance of the core functions of public health at a community level, 370 local health departments (LHDs) in ...
journal_title:American journal of preventive medicine
pub_type: 杂志文章
doi:
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND:The Michigan Maternal and Infant Health Program (MIHP) is a population-based home-visitation program providing care coordination, referrals, and visits based on a plan of care. MIHP is available to all Medicaid-eligible pregnant women and infants aged ≤1 year in Michigan. PURPOSE:To assess the effects of MI...
journal_title:American journal of preventive medicine
pub_type: 杂志文章
doi:10.1016/j.amepre.2013.05.005
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:In 2012, CDC launched the first federally funded national mass media antismoking campaign. The Tips From Former Smokers (Tips) campaign resulted in a 12% relative increase in population-level quit attempts. PURPOSE:Cost-effectiveness analysis was conducted in 2013 to evaluate Tips from a funding agency's pe...
journal_title:American journal of preventive medicine
pub_type: 杂志文章
doi:10.1016/j.amepre.2014.10.011
更新日期:2015-03-01 00:00:00
abstract:INTRODUCTION:This study aims to quantify out-of-pocket spending associated with respiratory hospitalizations for conditions similar to those caused by coronavirus disease 2019 and to compare out-of-pocket spending differences among those enrolled in consumer-directed health plans and in traditional, low-deductible plan...
journal_title:American journal of preventive medicine
pub_type: 杂志文章
doi:10.1016/j.amepre.2020.05.008
更新日期:2020-09-01 00:00:00
abstract:CONTEXT:The risk of chronic kidney disease (CKD) in the U.S. is higher in individuals with low SES than in those with high SES. However, differences in these risks between African Americans and whites are unclear. EVIDENCE ACQUISITION:Studies published through August 30, 2016 in Medline and EMBASE were searched. From ...
journal_title:American journal of preventive medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.amepre.2017.06.036
更新日期:2017-11-01 00:00:00
abstract::This paper defines the appropriation and resource allocation structure of federal government programs that deliver vaccines to the public through state and local governments, with a special focus on the Centers for Disease Control and Prevention (CDC) Section 317 program. The paper places these programs in the context...
journal_title:American journal of preventive medicine
pub_type: 杂志文章
doi:10.1016/s0749-3797(00)00206-3
更新日期:2000-10-01 00:00:00
abstract::Modifying identified risk factors for cardiovascular disease should change an individual's risk. Educational interventions might change behavior to modify some risk factors. To evaluate this possibility, we evaluated the health and fitness status of freshman medical students at the University of Utah (n = 89) in 1983 ...
journal_title:American journal of preventive medicine
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Underage alcohol use is a major contributor to morbidity and mortality in adolescents and young adults. This study examined drinking levels and ensuing problems among college students and factors associated with binge drinking. METHOD:The Harvard School of Public Health College Alcohol Study conducted a sel...
journal_title:American journal of preventive medicine
pub_type: 杂志文章
doi:10.1016/s0749-3797(00)00163-x
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:The proportion of tuberculosis (TB) cases diagnosed among residents of correctional facilities in Arizona increased from 2.7% in 1993 to 8.0% in 2000, while the national average remained at approximately 4%. The purpose of this study was to determine the proportion of TB cases in Maricopa County, Arizona wit...
journal_title:American journal of preventive medicine
pub_type: 杂志文章
doi:10.1016/j.amepre.2004.10.006
更新日期:2005-02-01 00:00:00