Neurodegenerative disease in infants with multiple congenital malformations--report of two cases.

abstract：INTRODUCTION:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary, progressive ischemic disease of small vessels of the brain characterized by migraine with aura (MA), recurrent subcortical ischemic episodes, cognitive decline and psychiatric disorders. CA...

journal_title：Folia neuropathologica

authors： Dorszewska J,Kowalska M,Grzegorski T,Dziewulska D,Karmelita-Katulska K,Barciszewska AM,Prendecki M,Gorczyński W,Kozubski W

更新日期：2020-01-01 00:00:00

abstract：:Increased pineal calcifications and decreased pineal melatonin biosynthesis, both age related, support the notion of a pineal bio-organic timing mechanism. The role of calcification in the pathogenesis of pineal gland dysfunction remains unknown but the available data document that calcification is an organized, regul...

journal_title：Folia neuropathologica

authors： Maślińska D,Laure-Kamionowska M,Deręgowski K,Maśliński S

更新日期：2010-01-01 00:00:00

abstract：:Cortical biopsies of 13 patients with clinical diagnosis of congenital hydrocephalus, Arnold-Chiari malformation and hydrocephalus, and postmeningitis hydrocephalus were examined by transmission electron microscopy to study the damage of endothelial cells, basement membrane, astrocytic end-feet layer, and perivascular...

journal_title：Folia neuropathologica

authors： Castejón OJ

更新日期：2009-01-01 00:00:00

abstract：:The importance of chemokines seems to extend far beyond their well-known role as mediators of an inflammatory response. The most interesting hypothesis is that these molecules may influence the migration of progenitor cells during development. Primary sensory neurones have been shown to migrate towards RANTES in vitro...

journal_title：Folia neuropathologica

authors： Geppert AM

更新日期：2003-01-01 00:00:00

abstract：:The visual cortex undergoes age related changes that have been studied mainly in rats Maccaca Mulata, and human beings. Despite the fact that there is no extensive neuronal loss in aged brains, a lot of important pathological changes are found in the morphology of the neurons. The present study describes the morpholog...

journal_title：Folia neuropathologica

authors： Mavroudis I,Petrides F,Manani M,Theocharides C,Ciobica A,Padurariu M,Kiourexidou M,Njau S,Costa V,Baloyannis S

更新日期：2012-01-01 00:00:00

abstract：:Cerebellar cortical biopsies of the peritumoural region of seven patients with cerebellar haemangioma, mesencephalic meningioma, cerebellopontine astrocytoma, cerebellopontine meningioma, and medulloblastoma of cerebellar vermis were examined by means of conventional transmission electron microscopy. Granule cells sho...

journal_title：Folia neuropathologica

authors： Castejón OJ

更新日期：2016-01-01 00:00:00

abstract：:Forty human primary brain tumors: twelve protoplasmic, six gemistocytic, four fibrillary and ten anaplastic astrocytomas, eight glioblastomas were submitted for immunohistochemical and histochemical characterization of microglia in tumor tissue and in its surroundings. The following antibodies were used: GFAP, ferriti...

journal_title：Folia neuropathologica

authors： Wierzba-Bobrowicz T,Kuchna I,Matyja E

更新日期：1994-01-01 00:00:00

abstract：:We demonstrate an unusually intensive accumulation of prion protein (PrP) on neuronal membranes in hamsters infected with the Echigo-1 panencephalopathic strain of Creutzfeldt-Jakob disease. This stands in strong contrast with the poor vacuolation in this model. Several distinct patterns of PrP(TSE) deposit were obser...

journal_title：Folia neuropathologica

authors： Liberski PP,Hainfellner JA,Sikorska B,Mori S,Budka H

更新日期：2004-01-01 00:00:00

abstract：:Cerebral ischemia injury seriously endangers human health and its molecular mechanism is still not fully understood. microRNA-223 (miR-223) has been reported to be involved in many physiological functions but the specific role of miRNA-223 in ischemic neuronal injury is still unclear. An oxygen-glucose deprivation and...

journal_title：Folia neuropathologica

authors： Feng SJ,Zhang XQ,Li JT,Dai XM,Zhao F

更新日期：2018-01-01 00:00:00

abstract：INTRODUCTION:Activated microglia produce neurotoxic factors, including pro-inflammatory cytokines and nitric oxide (NO), in response to neuronal destruction. Therapeutic suppression of microglial release of these factors by various approaches including hypothermia is considered to be neuroprotective after severe brain ...

journal_title：Folia neuropathologica

authors： Matsui T,Kida H,Iha T,Obara T,Nomura S,Fujimiya T,Suzuki M

更新日期：2014-01-01 00:00:00

abstract：:Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare transmissible disease caused by accumulation of pathological prion protein in the CNS. sCJD typically affects patients in their sixties. The median disease duration in sCJD (6 months) is shorter than in variant Creutzfeldt-Jakob disease (vCJD) (14 months). The clinic...

journal_title：Folia neuropathologica

authors： Krasnianski A,Meissner B,Heinemann U,Zerr I

更新日期：2004-01-01 00:00:00

abstract：:We have determined the cellular concentration of thyroxine (T4) and triiodothyronine (T3) and the activities of two brain iodothyronine deiodinases, type II (5'-D2) and type III (5-D3), in two types of tissues --tumour (26) and non-tumour (5), derived either from human gliomas with various histological malignancies or...

journal_title：Folia neuropathologica

authors： Nauman P,Bonicki W,Michalik R,Warzecha A,Czernicki Z

更新日期：2004-01-01 00:00:00

abstract：:Electron microscopic immunocytochemical evaluation of localization and distribution of endothelins 1, 2 and 3 in the CA1 hippocampal sector in rats submitted to 10 min global cerebral ischemia was performed. The studies were done in different postischemic periods (10 min, 3, 6, 12 and 24 h) with postembedding immuno-g...

journal_title：Folia neuropathologica

authors： Gajkowska B,Mossakowski MJ

更新日期：1995-01-01 00:00:00

abstract：:Granular cell astrocytoma (GCA) is an uncommon type of granular cell tumours (GCTs) in the central nervous system. Granular cells in these tumours are of enigmatic origin. We report a case of cerebral GCA in a 59-year-old man who suffered from diabetes and Addison-Biermer disease. The tumour was localized in the left ...

journal_title：Folia neuropathologica

authors： Wierzba-Bobrowicz T,Lewandowska E,Matyja E,Dziduszko J,Koszewski W,Stepień T,Błazejewska-Hyzorek B

更新日期：2008-01-01 00:00:00

abstract：:Glioblastoma, the most malignant astrocytic tumour, is associated with limited survival and thus rare metastases. We analysed a particularly interesting case - a 51-year-old male diagnosed within 2 years with primary and recurrent glioblastoma, isocitrate dehydrogenase (IDH)-wild type, as well as with numerous extra-c...

journal_title：Folia neuropathologica

authors： Janik K,Och W,Popeda M,Rosiak K,Peciak J,Rieske P,Kulbacki K,Szostak B,Parda A,Stoczynska-Fidelus E

更新日期：2019-01-01 00:00:00

abstract：:The present study examined the effect of DS exposure on median nerve development in rats during prenatal life. Pregnant female rats were divided into three groups: a control group, a saline group and a DS group. Offspring of these animals were divided into 2 subgroups: 4 weeks old and 20 weeks old. Nerve samples were ...

journal_title：Folia neuropathologica

authors： Ayrancı E,Altunkaynak BZ,Aktaş A,Rağbetli MÇ,Kaplan S

更新日期：2013-01-01 00:00:00

abstract：:A fetal, cryopreserved ventral mesencephalic rat tissue was transplanted into striatum of healthy adult rats. A stereotactic apparatus was used for transplantation of solid tissue blocks. The survival of transplanted dopaminergic cells in rat striatum was evaluated by means of histological and immunocytochemical metho...

journal_title：Folia neuropathologica

authors： Kosno-Kruszewska E,Wierzba-Bobrowicz T,Ilnicki K,Lechowicz W,Dymecki J

更新日期：1996-01-01 00:00:00

abstract：INTRODUCTION:Sporadic inclusion body myositis (sIBM) is one of the most common myopathies in patients above 50 years of age. Its progressive course finally leads to immobilisation, and no effective therapy exists. Its pathogenesis includes both degenerative and inflammatory processes, however, its direct causes remain ...

journal_title：Folia neuropathologica

authors： Kierdaszuk B,Berdynski M,Palczewski P,Golebiowski M,Zekanowski C,Kaminska AM

更新日期：2015-01-01 00:00:00

abstract：:Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) is an autosomal dominant neurodegenerative disorder caused by mutations in the MAPT gene which encodes the microtubule-associated protein tau. This hereditary tauopathy is a rare clinical syndrome, affecting approximately two hundred kindreds a...

journal_title：Folia neuropathologica

authors： Wszołek ZK,Słowiński J,Golan M,Dickson DW

更新日期：2005-01-01 00:00:00

abstract：:The authors present a rare case of C-6 vertebral involvement in a 12-year-old boy with histiocytosis X. The patient presented with limitation in movements of neck and upper extremities. Computed tomography (CT) and magnetic resonance (MRI) imaging were used in the preoperative workup. Surgery was performed via an ante...

journal_title：Folia neuropathologica

authors： Salehpour F,Tubbs RS,Zarrintan S,Meshkini A,Hadidchi S,Pourfathi H,Azhough R,Fakhrjou A,Goodrich JT,Khaki AA

更新日期：2007-01-01 00:00:00

abstract：:Metallothioneins take part in the homeostasis of the ions of the metals which are necessary for the proper metabolism of the organism (zinc, copper), in biosynthesis regulation of the zinc-containing proteins and also in the detoxication of metals from the tissues. They also protect the tissue from the effects of free...

journal_title：Folia neuropathologica

authors： Floriańczyk B,Osuchowski J,Kaczmarczyk R,Trojanowski T,Stryjecka-Zimmer M

更新日期：2003-01-01 00:00:00

abstract：:Early reviews identified over 20 risk factors associated with Alzheimer's disease (AD) including age, familial inheritance, exposure to aluminium, traumatic brain injury (TBI), and associated co-morbidities such as vascular disease and infection. In the light of recent evidence, this review reconsiders these risk fact...

journal_title：Folia neuropathologica

authors： A Armstrong R

更新日期：2019-01-01 00:00:00

abstract：:PPAX6 is an important transcription factor which plays an essential role in brain morphogenesis and eye development. It is related to migration of neuroblasts to the cerebral cortex and deep telencephalic nuclei, and the specification of cellular and regional identity. Disturbances of brain development in two sib fetu...

journal_title：Folia neuropathologica

authors： Schmidt-Sidor B,Szymańska K,Williamson K,van Heyningen V,Roszkowski T,Wierzba-Bobrowicz T,Zaremba J

更新日期：2009-01-01 00:00:00

abstract：:Metformin, a type 2 anti-diabetic drug and an activator of AMP-activated protein kinase (AMPK), has been shown to reduce infarct size and pathological changes affecting astroglia in animal models of ischemic stroke. In this study, we evaluated how metformin affects cell viability, apoptosis and determined the role of ...

journal_title：Folia neuropathologica

authors： Gabryel B,Liber S

更新日期：2018-01-01 00:00:00

abstract：:Neuronal and axonal degenerative changes in motor vagal neurons (DMNV) and sensory vagal neurons (nTS) in the medulla oblongata in newborns were studied. Material was taken from the autopsies of newborns, live and dead newborns, in different gestational weeks (aborted, immature, premature and mature). 46 cases were st...

journal_title：Folia neuropathologica

authors： Islami H,Shabani R,Shabani D,Dacaj R,Manxhuka S,Azemi M,Krasniqi S,Kurtishi I

更新日期：2011-01-01 00:00:00

abstract：:The Warburg micro syndrome (WARBM) is a genetically heterogeneous syndrome linked to at least 4 loci. At the clinical level, WARBM is characterized by microcephaly, microphthalmia, microcornea, congenital cataracts, corpus callosum hypoplasia, severe mental retardation, and hypogonadism. In some families additional cl...

journal_title：Folia neuropathologica

authors： Kabzińska D,Mierzewska H,Senderek J,Kochański A

更新日期：2016-01-01 00:00:00

abstract：:Myositis specific autoantibodies (MSA) are the most specific markers of idiopathic inflammatory myopathies (IIM). There is no evidence of presence MSA in patients with other neuromuscular or connective tissue diseases. We compared the frequency of MSA in two groups of IIM patients, one from Poland and one from North A...

journal_title：Folia neuropathologica

authors： Kowalska-Oledzka E,Stern LZ

更新日期：2000-01-01 00:00:00

abstract：:Introduction: Mixed dementia (MixD) refers to a combination of definite Alzheimer's disease (AD) and vascular encephalopathy. The existence of a "pure" type of vascular dementia (VaD) is controversial. There is a need to find magnetic resonance imaging (MRI) characteristics allowing the distinction between V...