Recent updates in the clinical use of platinum compounds for the treatment of gynecologic cancers.

Abstract:

:Platinum compounds have long played a role in the treatment of gynecologic cancers. Single-agent cisplatin and carboplatin have shown activity in endometrial cancer, and more recent studies have begun to investigate a variety of new platinum-based combinations. In cervical cancer, chemotherapy is used primarily to treat advanced or recurrent disease. Agents with proven single-agent activity in this setting include cisplatin, ifosfamide, and doxorubicin, and a number of cisplatin-based combination therapies are under clinical investigation. A variety of cisplatin-based combinations have also been used in ovarian cancer chemotherapy, with more recent studies investigating the substitution of carboplatin or oxaliplatin for cisplatin and the addition of paclitaxel. This review will examine recent clinical data on the use of platinum-based chemotherapies for the treatment of these gynecologic cancers.

journal_name

Semin Oncol

journal_title

Seminars in oncology

authors

Muggia FM

doi

10.1053/j.seminoncol.2004.11.007

subject

Has Abstract

pub_date

2004-12-01 00:00:00

pages

17-24

issue

6 Suppl 14

eissn

0093-7754

issn

1532-8708

pii

S0093775404005202

journal_volume

31

pub_type

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