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Relationship between serum adiponectin concentration, pulse wave velocity and nonalcoholic fatty liver disease.

Abstract：

OBJECTIVES:We aimed to investigate the relationship between nonalcoholic fatty liver disease (NAFLD), serum adiponectin concentration and brachial-ankle pulse wave velocity (baPWV) as a risk marker for atherosclerosis. METHODS:A total of 213 nonalcoholic subjects (67 males, 146 females) participated in this study. Division of subjects into the NAFLD group or the normal group was based on the existence of fatty liver detected by sonography. RESULTS:Serum adiponectin levels in the NAFLD group were significantly lower than those in the normal group. After adjusting for age, body-mass index (BMI) and the homeostasis model of assessment (HOMA), there was a significant negative correlation between NAFLD and serum adiponectin level only in females (r = -0.22, P = 0.008). Multiple logistic regression analysis showed a tendency of inverse correlation between NAFLD and serum adiponectin level in females (P = 0.055). After adjustment for age, BMI and HOMA value, serum adiponectin levels were inversely correlated with serum alanine aminotransferase (ALT) and gamma-glutamyltranspeptidase (GGT) levels (r = -0.199 (P = 0.004) and r = -0.282 (P < 0.001)). On the other hand, baPWV in the NAFLD group was also significantly higher than that in the normal group in females (P = 0.005). Individual levels of serum ALT, aspatate aminotransferase (AST), alkaline phosphatase (ALP) and GGT were positively correlated with baPWV after adjusting for age, sex, BMI, HOMA and systolic blood pressure (P < 0.05). CONCLUSION:Serum adiponectin level and baPWV were significantly associated with NAFLD and various liver enzymes, especially in females.

journal_name

Eur J Endocrinol

journal_title

European journal of endocrinology

authors

Kim SG,Kim HY,Seo JA,Lee KW,Oh JH,Kim NH,Choi KM,Baik SH,Choi DS

doi

10.1530/eje.1.01842

subject

Has Abstract

pub_date

2005-02-01 00:00:00

pages

225-31

issue

2

eissn

0804-4643

issn

1479-683X

pii

152/2/225

journal_volume

152

pub_type

杂志文章

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