The 6-derivative of beta-cyclodextrin with succinic acid: a new chiral selector for CD-EKC.

Abstract:

:6-O-Succinil-beta-cyclodextrin (CDsuc6) was synthesized with very good yield by one pot synthesis and characterized by NMR spectroscopy and ESI-MS. It was used as a chiral selector in capillary electrophoresis to resolve catecholamine racemates, namely norepinephrine, epinephrine, terbutaline and norphenilephrine. The CE experiments at pH 5.6 show very promising selector ability by 6-O-succinil-beta-cyclodextrin for the chiral recognition of all the catecholamines tested, while at pH 9.2, only racemic terbutaline was successfully separated.

journal_name

J Pharm Biomed Anal

authors

Cucinotta V,Giuffrida A,Maccarrone G,Messina M,Puglisi A,Torrisi A,Vecchio G

doi

10.1016/j.jpba.2004.08.023

subject

Has Abstract

pub_date

2005-04-29 00:00:00

pages

1009-14

issue

5

eissn

0731-7085

issn

1873-264X

pii

S0731-7085(04)00404-2

journal_volume

37

pub_type

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