DCS liquid-based system is more effective than conventional smears to diagnosis of cervical lesions: study in high-risk population with biopsy-based confirmation.

Abstract:

OBJECTIVE:To compare the performances of Papanicolaou test (PapTest) and of a new liquid-based cytology method, DNA-Citoliq System (DCS), in a high-risk population, with histology confirmation. METHODS:Paired specimens of exfoliated cervical cells were collected under split-sample protocol. All patients were submitted to colposcopy and a biopsy taken when any atypical transformation zone was seen. Sensitivity, specificity, positive and negative predictive values, and overall accuracy of both conventional and DCS methods were computed in relation to histology. RESULTS:A total of 1095 patients were analyzed by two cytology methods and, in 425 (38.8%), histologically. There were significantly more adequate samples with DCS (98.63%) than with conventional (89.6%) smears (P < 0.001). ASCUS was diagnosed significantly more with DCS than with conventional Pap (P < 0.001). Conventional Pap misclassified as normal 55.4% (158/285) of cases with either LSIL or HSIL or cancer at histology, whereas DCS misclassified 31.2% (89/285) of cases (P < 0.001). DCS had a significantly higher sensitivity (70% and 91.3%) than the conventional Pap (49.8% and 72.8%) to detect both LSIL+ and HSIL+ at histology, respectively. On the other hand, specificity of conventional smear (88.2% and 85.2%) was significantly higher than DCS (75.4% and 70.9%) considering both LSIL+ and HSIL+ at histology, respectively. CONCLUSIONS:This study confirms the superiority of the liquid-based cytology system DCS to detect cervical lesions. The rate of adequate DSC slides was significantly higher than with conventional cytology.

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

Longatto Filho A,Pereira SM,Di Loreto C,Utagawa ML,Makabe S,Sakamoto Maeda MY,Marques JA,Santoro CL,Castelo A

doi

10.1016/j.ygyno.2005.01.013

subject

Has Abstract

pub_date

2005-05-01 00:00:00

pages

497-500

issue

2

eissn

0090-8258

issn

1095-6859

pii

S0090-8258(05)00041-7

journal_volume

97

pub_type

杂志文章
  • Immunization with adenoviral vectors carrying recombinant IL-12 and E7 enhanced the antitumor immunity to human papillomavirus 16-associated tumor.

    abstract:OBJECTIVE:Human papillomavirus (HPV) infection play a significant role in cervical carcinogenesis, and HPV oncoprotein E7 has important functions in the formation and maintenance of cervical cancers. Interleukin-12 (IL-12) has been reported to induce cellular immune responses, and has also been demonstrated to suppress...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2005.01.046

    authors: Jin HS,Park EK,Lee JM,NamKoong SE,Kim DG,Lee YJ,Jun HJ,Han BD,Bae SM,Ahn WS

    更新日期:2005-05-01 00:00:00

  • "Microinvasive" adenocarcinoma of the cervix implanting in an episiotomy scar.

    abstract::Episiotomy scar tumor implantation arising from a cervical carcinoma is rare. This report details a patient who developed an episiotomy implant from a "microinvasive" adenocarcinoma of the cervix 5 months following vaginal delivery. The implant behaved as a primary focus for metastases to the inguinal lymph nodes. Des...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1995.0025

    authors: Van den Broek NR,Lopes AD,Ansink A,Monaghan JM

    更新日期:1995-11-01 00:00:00

  • Polymorphisms in genes hydroxysteroid-dehydrogenase-17b type 2 and type 4 and endometrial cancer risk.

    abstract:OBJECTIVE:Hydroxysteroid-dehydrogenase-17b (HSD17b) genes control the last step in estrogen biosynthesis. The isoenzymes HSD17b2 and HSD17b4 in the uterus preferentially catalyze the conversion of estradiol, the most potent and active form of estrogen, to estrone, the inactive form of estrogen. Endometrial adenocarcino...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2010.11.014

    authors: Karageorgi S,McGrath M,Lee IM,Buring J,Kraft P,De Vivo I

    更新日期:2011-04-01 00:00:00

  • A phase II study of etoposide, cisplatin, and doxorubicin chemotherapy in mixed müllerian tumors (MMT) of the uterus.

    abstract::Mixed Müllerian tumors (MMT) of the uterus are aggressive entities that result in a very poor prognosis even for patients in whom the disease is limited to the uterus. This phase II trial was undertaken in an attempt to improve overall survival as well as progression-free survival of these patients. Forty-two consecut...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章

    doi:10.1006/gyno.1995.1065

    authors: Resnik E,Chambers SK,Carcangiu ML,Kohorn EI,Schwartz PE,Chambers JT

    更新日期:1995-03-01 00:00:00

  • Spatial analysis of adherence to treatment guidelines for advanced-stage ovarian cancer and the impact of race and socioeconomic status.

    abstract:OBJECTIVE:To determine the impact of geographic location on advanced-stage ovarian cancer care adherence to the National Comprehensive Cancer Network (NCCN) guidelines in relation to race and socioeconomic status (SES). METHODS:Patients diagnosed with stage IIIC/IV epithelial ovarian cancer (1/1/96-12/31/06) were iden...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2014.03.561

    authors: Bristow RE,Chang J,Ziogas A,Anton-Culver H,Vieira VM

    更新日期:2014-07-01 00:00:00

  • Supervised clustering of immunohistochemical markers to distinguish atypical endometrial hyperplasia from grade 1 endometrial cancer.

    abstract:OBJECTIVES:Differentiation between grade-1 endometrial cancer (EC) and atypical endometrial hyperplasia (AEH) is crucial to determine optimal surgical management. However, discrepancies exist between preoperative diagnosis of AEH and final histology. Our aim was to establish clusters of immunohistochemical markers to d...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2014.02.018

    authors: Laas E,Ballester M,Cortez A,Gonin J,Daraï E,Graesslin O

    更新日期:2014-05-01 00:00:00

  • Prognostic significance and predictors of the neutrophil-to-lymphocyte ratio in ovarian cancer.

    abstract:OBJECTIVE:To investigate the neutrophil-to-lymphocyte ratio (NLR) from peripheral blood, a general measure of inflammation, in ovarian cancer. METHODS:White cell counts and CA125 levels before treatment, tumor features, and questionnaire data on 519 women with ovarian cancer at two Boston hospitals were recorded. Coun...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2014.01.026

    authors: Williams KA,Labidi-Galy SI,Terry KL,Vitonis AF,Welch WR,Goodman A,Cramer DW

    更新日期:2014-03-01 00:00:00

  • Does the interval from primary surgery to chemotherapy influence progression-free survival in ovarian cancer?

    abstract:OBJECTIVES:The objective of this study was to determine whether the length of the interval from primary surgery to commencement of chemotherapy has any direct effect on progression-free survival in ovarian cancer. METHODS:The progression-free survival of 472 patients enrolled in four trials who had all received platin...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.2002.6750

    authors: Flynn PM,Paul J,Cruickshank DJ,Scottish Gynaecological Cancer Trials Group.

    更新日期:2002-09-01 00:00:00

  • Comparison of different commercial methods for HPV detection in follow-up cytology after ASCUS/LSIL, prediction of CIN2-3 in follow up biopsies and spontaneous regression of CIN2-3.

    abstract:OBJECTIVE:Different Human Papilloma Virus (HPV) tests are currently used. An integrated comparison of the Amplicor, Cobas4800, PreTect HPV-Proofer and APTIMA HPV tests has not been done. METHODS:We compared the high-risk HPV detection power of these HPV tests in 528 consecutive population-based follow-up Liquid-Based ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2011.07.024

    authors: Ovestad IT,Vennestrøm U,Andersen L,Gudlaugsson E,Munk AC,Malpica A,Feng W,Voorhorst F,Janssen EA,Baak JP

    更新日期:2011-11-01 00:00:00

  • How to make a hospital-based wound center financially viable: the Georgetown University Hospital model.

    abstract::As the medical need and expenditure for chronic wound care have increased markedly over the past decade, wound centers have grown exponentially throughout the country. They can be community-based or hospital-based, and in either case, can be run by the facility or by a national chain. The wound center's viability is d...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2008.07.044

    authors: Attinger CE,Hoang H,Steinberg J,Couch K,Hubley K,Winger L,Kugler M

    更新日期:2008-11-01 00:00:00

  • Molecular characterization of adenocarcinoma of the cervix.

    abstract::In an attempt to characterize the molecular alterations of cervical adenocarcinoma, we analyzed 32 paraffin-embedded specimens for the presence of K-ras mutations, p53 overexpression, p16 and Rb protein expression, and the presence of HPV 16 and 18 DNA. Overall 25/32 (78%) of the tumors displayed an abnormality in at ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1996.4580

    authors: Parker MF,Arroyo GF,Geradts J,Sabichi AL,Park RC,Taylor RR,Birrer MJ

    更新日期:1997-02-01 00:00:00

  • The prognostic significance of peritoneal seeding and size of postsurgical residual in patients with stage III epithelial ovarian cancer treated with surgery, chemotherapy, and high-dose radiotherapy.

    abstract:OBJECTIVE:The aim of this study was to retrospectively analyze the prognostic importance of age, histologic type and grade, ascites, lymph node status, size and type of postoperative residual disease, and radiation dose on disease-specific (DSS) and progression-free survival (PFS) in stage III epithelial ovarian cancer...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1999.5477

    authors: Kapp KS,Kapp DS,Poschauko J,Stücklschweiger GF,Hackl A,Pickel H,Petru E,Winter R

    更新日期:1999-09-01 00:00:00

  • Carcinoma of the cervix with extensive endometrial and myometrial involvement.

    abstract::Verrucous carcinoma is a rare variant of epidermoid carcinoma with distinct clinical and histopathologic features. To date, 31 cases have been reported in the cervix. They are typically slow-growing, locally invasive tumors with low potential for lymphatic metastasis and appear to be radioresistant. We report a case w...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审

    doi:10.1016/0090-8258(90)90185-n

    authors: de Jesus M,Tang W,Sadjadi M,Belmonte AH,Poon TP

    更新日期:1990-02-01 00:00:00

  • Sexual function following hysterectomy for endometrial cancer: A five-year follow up investigation.

    abstract:OBJECTIVES:We sought to determine a baseline and five-year follow up sexual function score in women undergoing hysterectomy for endometrial cancer. METHODS:A cross-section of endometrial cancer patients receiving care from 2006 to 2010 was identified. Patients were surveyed during academic year 2011 using the Pelvic O...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2018.10.025

    authors: Buckingham L,Haggerty A,Graul A,Morgan M,Burger R,Ko E,Andy U,Giuntoli R

    更新日期:2019-01-01 00:00:00

  • Prognostic significance of hysteroscopic imaging in endometrioid endometrial adenocarcinoma.

    abstract:OBJECTIVE:The aim of this study was to relate hysteroscopic features of endometrioid endometrial adenocarcinoma to stage, grade and overall survival. METHODS:Sixty women with endometrioid adenocarcinoma underwent laparotomy and staging according to current FIGO classification. Before surgery hysteroscopy was performed...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.2001.6173

    authors: Garuti G,De Giorgi O,Sambruni I,Cellani F,Luerti M

    更新日期:2001-06-01 00:00:00

  • Skull metastasis in primary vulvar adenocarcinoma of the Bartholin's gland: a case report.

    abstract:BACKGROUND:Metastatic bone involvement in vulvar squamous carcinoma is very rare. Here, we present a case of primary adenocarcinoma of the Bartholin's gland giving rise to isolated skull metastasis. CASE:A 74-year-old woman was referred with a diagnosis of primary vulvar adenocarcinoma of the right labium minus. A rig...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2005.04.019

    authors: Ferrandina G,Testa AC,Zannoni GF,Poerio A,Scambia G

    更新日期:2005-08-01 00:00:00

  • Failure of hexamethylmelamine as salvage therapy in ovarian epithelial adenocarcinoma resistant to combination chemotherapy.

    abstract::Favorable responses to hexamethylmelamine (HMM) have been documented in untreated as well as in alkylating agent-resistant ovarian epithelial adenocarcinoma (OvCa). Platinum-based combination therapy for OvCa has been used since 1976. Eighteen patients with OvCa were treated with HMM as salvage therapy between Februar...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(84)90076-3

    authors: Stehman FB,Ehrlich CE,Callangan MF

    更新日期:1984-02-01 00:00:00

  • Mutational analysis of the BRCA1 tumor suppressor gene in endometrial carcinoma.

    abstract:OBJECTIVE:To investigate whether alteration of BRCA1 tumor suppressor gene occurs in sporadic endometrial carcinomas. METHODS:Genomic DNAs were prepared from 33 consecutively collected endometrial carcinoma tissues for BRCA1 mutational analysis. To screen for BRCA1 mutation, polymerase chain reaction (PCR) amplificati...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1997.4800

    authors: Liu FS,Ho ES,Shih RT,Shih A

    更新日期:1997-09-01 00:00:00

  • Risk-stratification of endometrial carcinomas revisited: a combined preoperative and intraoperative scoring system for a reliable prediction of an advanced disease.

    abstract:OBJECTIVE:The aim of this study is to develop a risk-scoring system for predicting lymph node and distant metastasis in endometrial carcinoma. METHODS:A total of 1166 patients, treated at a single institution between 1-2007 and 12-2013, were included in the study. The association of stage IIIC-IV disease with demograp...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2015.01.545

    authors: Tuomi T,Pasanen A,Luomaranta A,Leminen A,Bützow R,Loukovaara M

    更新日期:2015-04-01 00:00:00

  • Management of malignant, mixed mesodermal tumors of the uterus.

    abstract::Forty-two patients with malignant, mixed mesodermal tumors of the uterus were identified by retrospective chart review. Only 2 patients were premenopausal at the time of diagnosis. Six of the patients had previously received pelvic radiotherapy. Surgical/pathologic findings were inconsistent with clinical staging in 1...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/s0090-8258(89)80041-1

    authors: Podczaski ES,Woomert CA,Stevens CW Jr,Manetta A,Larson JE,Zaino RJ,Mortel R

    更新日期:1989-02-01 00:00:00

  • Placental site trophoblastic tumor: A study of 55 cases and review of the literature emphasizing factors of prognostic significance.

    abstract:OBJECTIVE:The placental site trophoblastic tumor is a rare form of gestational trophoblastic disease. Fifteen percent of reported cases have been fatal, but predicting behavior in individual patients has been challenging. METHODS:The clinical, gross and histopathological features of 55 cases and 180 cases in the liter...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2005.08.058

    authors: Baergen RN,Rutgers JL,Young RH,Osann K,Scully RE

    更新日期:2006-03-01 00:00:00

  • Metabolic monitoring of advanced uterine cervical cancer neoadjuvant chemotherapy by using [F-18]-Fluorodeoxyglucose positron emission tomography: preliminary results in three patients.

    abstract:OBJECTIVE:The aim of this report is to describe the potential clinical utility of tracer [F-18]-Fluorodeoxyglucose (FDG) uptake, quantitated as a standardized uptake value (SUV) by positron emission tomography (PET), to evaluate treatment response to neoadjuvant chemotherapy (NAC) in advanced uterine cervical cancer. ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2004.08.037

    authors: Yoshida Y,Kurokawa T,Kawahara K,Yagihara A,Tsuchida T,Okazawa H,Fujibayashi Y,Yonekura Y,Kotsuji F

    更新日期:2004-12-01 00:00:00

  • Endometrial adenocarcinoma arising in a secretory endometrium.

    abstract::Endometrial adenocarcinoma in young women below the age of 45 years and in a functioning endometrium is rare. We present the case of a 41-year-old woman, who without clinical risk factors, was found to have a focal well-differentiated endometrial adenocarcinoma in the background of a histologically secretory endometri...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1993.1122

    authors: Pai UL,Razi A,Selim MA,Petrelli M

    更新日期:1993-05-01 00:00:00

  • Participation of the general gynecologist in surgical staging of endometrial cancer: analysis of cost and perioperative outcomes.

    abstract:OBJECTIVE:To compare the cost and perioperative outcomes of endometrial cancer staging when the procedure is performed by a gynecologic oncologist alone or when a general gynecologist participates in the procedure. METHODS:A retrospective analysis was performed on a series of women with clinical stage I endometrial ca...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2006.05.019

    authors: Hoekstra A,Singh DK,Garb M,Arekapudi S,Rademaker A,Lurain JR

    更新日期:2006-12-01 00:00:00

  • Prevalence of antibodies to herpes simplex virus and frequency of HLA antigens in patients with preinvasive and invasive cervical cancer.

    abstract::Previous herpes simplex virus type 2 (HSV-2) infections are known to predispose women for the development of cervical cancer, but causal relationship between the virus and the cancer has never been proven. Forty-six patients with cervical carcinoma (13 with preinvasive lesions and 33 with various stages of invasive di...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(84)90047-7

    authors: Vass-Sørensen M,Abeler V,Berle E,Pedersen B,Davy M,Thorsby E,Norrild B

    更新日期:1984-07-01 00:00:00

  • Role of an early second-look laparotomy in ovarian cancer.

    abstract::Of a group of 68 patients treated with standard polychemotherapy (CAP-5), 52 were evaluated by an early second-look laparotomy, preferably after three cycles of treatment. Of 21 patients with initial tumor residuals smaller than 2 cm, only 5 had residual tumor, and of 31 patients with tumor larger than 2 cm, 27 had re...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(89)90055-3

    authors: van Lith JM,Bouma J,Aalders JG,Boonstra H,Sleijfer DT,Willemse PH

    更新日期:1989-11-01 00:00:00

  • A phase II trial of docetaxel and bevacizumab in recurrent ovarian cancer within 12 months of prior platinum-based chemotherapy.

    abstract:OBJECTIVES:The efficacy and safety of bevacizumab and docetaxel were evaluated in women who developed recurrent epithelial ovarian, fallopian, or peritoneal cancer within 12 months of platinum-based therapy. METHODS:Patients received docetaxel (40 mg/m(2)) on days 1 and 8 and bevacizumab (15 mg/kg) on day 1 of a 21-da...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2013.04.049

    authors: Wenham RM,Lapolla J,Lin HY,Apte SM,Lancaster JM,Judson PL,Gonzalez-Bosquet J,Herschberger A,Havrilesky LJ,Secord AA

    更新日期:2013-07-01 00:00:00

  • Photodynamic therapy using topically applied dihematoporphyrin ether in the treatment of cervical intraepithelial neoplasia.

    abstract:OBJECTIVE:To perform a phase I study of topically applied dihematoporphyrin ether (DHE) in the photodynamic treatment (PDT) of cervical intraepithelial neoplasia (CIN) using fixed DHE doses and application schedules, and a variable dose of 630 nm red light delivered by an argon-pumped dye laser. METHODS:Between Februa...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章

    doi:10.1006/gyno.1996.4463

    authors: Monk BJ,Brewer C,VanNostrand K,Berns MW,McCullough JL,Tadir Y,Manetta A

    更新日期:1997-01-01 00:00:00

  • Change in clinical management of sentinel lymph node location in early stage cervical cancer: the role of SPECT/CT.

    abstract:OBJECTIVE:The aim of this study was to investigate the feasibility of the sentinel lymph node (SLN) identification with SPECT/CT lymphoscintigraphy imaging in the early stage invasive cervical cancer in patients undergoing radical hysterectomy and pelvic lymphadenectomy. METHODS:Between March 2007 and June 2009, a pro...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2010.12.336

    authors: Díaz-Feijoo B,Pérez-Benavente MA,Cabrera-Diaz S,Gil-Moreno A,Roca I,Franco-Camps S,Fernández MS,García-Jiménez A,Xercavins J,Martínez-Palones JM

    更新日期:2011-03-01 00:00:00

  • Impact of antibiotic treatment during platinum chemotherapy on survival and recurrence in women with advanced epithelial ovarian cancer.

    abstract:OBJECTIVE(S):To determine whether antibiotic treatment (ABX) during platinum chemotherapy (PC) for epithelial ovarian cancer (EOC) impacts progression-free survival (PFS) and overall survival (OS). STUDY DESIGN:Retrospective single institution cohort study in women with newly diagnosed stage III/IV EOC (n = 424) who u...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2020.09.010

    authors: Chambers LM,Kuznicki M,Yao M,Chichura A,Gruner M,Reizes O,Debernardo R,Rose PG,Michener C,Vargas R

    更新日期:2020-12-01 00:00:00