Retrospective study of 151 patients with cutaneous leishmaniasis treated with meglumine antimoniate.

Abstract:

:We retrospectively analyzed a series of 151 cases of cutaneous leishmaniasis treated between 1967 and 1982. One-hundred-and-thirty-nine (92%) patients presented with active lesions and were treated with daily doses of meglumine antimoniate: 81 adults received a 5-ml vial IM and 58 children received 1 to 5 ml. Forty-five (32.4%) patients underwent continuous treatment with meglumine antimoniate for 25 to 116 days without rest intervals, and 94 (67.6%) intermittent treatment with 2 to 5 series of meglumine antimoniate. Intermittent series could include schedules of daily IM applications for 10 to 25 days each and intervals varying from 10 to 60 days. Antimony dose was calculated for 66 (47.5%) patients and ranged from 3.9 to 28.7 Sb5+/kg/day. Of these, 35 patients received > or =10 mg and 31 patients < 10 mg Sb5+/kg/day. Median time of healing was longer for lesions on the legs and feet -- 67.5 days versus 48.7 days (p < 0.001) for other sites. However, there were no significant differences in the median time of healing between adults and children, intermittent and continuous regimens or high and low antimony doses. Fifty-one patients were reassessed 5 to 14 years after treatment and showed no evidence of disease. These results support further investigation (clinical trials) on treatment using low doses of antimony.

journal_name

Rev Soc Bras Med Trop

authors

Schubach Ade O,Marzochi KB,Moreira JS,Schubach TM,Araújo ML,Vale AC,Passos SR,Marzochi MC

doi

10.1590/s0037-86822005000300001

subject

Has Abstract

pub_date

2005-05-01 00:00:00

pages

213-7

issue

3

eissn

0037-8682

issn

1678-9849

pii

S0037-86822005000300001

journal_volume

38

pub_type

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