The separated enantiomers of 2'-deoxy-3'-thiacytidine (BCH 189) both inhibit human immunodeficiency virus replication in vitro.

Abstract:

:Racemic 2'-deoxy-3'-thiacytidine (BCH 189) is a dideoxycytidine analog having a sulfur atom in place of the 3' carbon. The enantiomers of BCH 189 have been resolved and found to be equipotent in antiviral activity against human immunodeficiency virus types 1 and 2. However, the (-)-enantiomer (3TC) is considerably less cytotoxic than the (+)-enantiomer.

authors

Coates JA,Cammack N,Jenkinson HJ,Mutton IM,Pearson BA,Storer R,Cameron JM,Penn CR

doi

10.1128/aac.36.1.202

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

202-5

issue

1

eissn

0066-4804

issn

1098-6596

journal_volume

36

pub_type

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