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Gamma-knife radiosurgery for the treatment of ovarian cancer metastatic to the brain.

Abstract：

BACKGROUND:Central nervous system (CNS) metastases from an ovarian malignancy are uncommon. The long-term prognosis for these patients is poor, with studies reporting a mean survival of less than 12 months. CASES:We present three ovarian cancer patients who developed metastatic disease to the brain. All patients were heavily pre-treated prior to the development of CNS disease. Following detection of CNS disease, they all were treated with multi-modality therapy including gamma-knife radiosurgery (GKRS). At this time, one patient is alive at 26 months following treatment with GKRS. The second and third patients survived for 88 and 22 months respectively, before succumbing to their disease. CONCLUSION:Local control of ovarian cancer metastatic to the brain can be achieved in some patients with GKRS. Additional investigation into GKRS is warranted.

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

Brown JV 3rd,Goldstein BH,Duma CM,Rettenmaier MA,Micha JP

doi

10.1016/j.ygyno.2005.02.019

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

858-61

issue

3

eissn

0090-8258

issn

1095-6859

pii

S0090-8258(05)00129-0

journal_volume

97

pub_type

杂志文章

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