当前位置： SCI文献检索 > TRANSPLANTATION PROCEEDINGS期刊下所有文献 > CTLA4-Fas ligand gene transfer mediated by adenovirus induce long-time survival of murine cardiac allografts.

CTLA4-Fas ligand gene transfer mediated by adenovirus induce long-time survival of murine cardiac allografts.

Abstract：

BACKGROUND:Fas ligand gene transfer to induce peripheral allograft tolerance in animal models has shown controversial results. The immunosuppression effects mediated by engineered FasL depend on whether alloreactive T cells are selectively deleted. In the present study, we tested the feasibility of a strategy to induce long-time survival by fusing CTLA4-FasL gene transfer in vivo. METHODS:Cardiac allografts from DA(RT-1(a)) rats were transplanted heterotopically into the abdomens of LEW(RT-1(1)) rats. Plaque units (5x10(9)) of either AdCTLA4-FasL, AdCTLA4Ig, or AdEGFP were administered via the portal vein immediately after cardiac transplantation. The frequencies of helper T lymphocyte precursors (HTLp) and cytotoxic T lymphocyte precursors (CTLp) were determined by a combined single limiting dilution assay on days 5 and 20 after transplantation. RESULTS:Cardiac allograft survival was significantly prolonged by either AdCTLA4-FasL or AdCTLA4Ig treatment(mean survival times [MST] of 71.0 +/- 3.7 and 45.7 +/- 2.4, respectively, n = 6) compared with untreated hosts or animals treated with AdEGFP(MST of 5.7 +/- 0.5 and 5.2 +/- 0.4, respectively, n = 6). In addition, treatment with AdCTLA4-FasL led to significantly prolonged allograft survival compared with AdCTLA4Ig treatment. Furthermore, the frequencies of HTLp and CTLp on day 20 among rats treated with AdCTLA4-FasL was lower than those on day 5, whereas frequencies of HTLp and CTLp on day 20 were similar with those on day 5 in the other groups. CONCLUSION:These results suggest that administration of an adenovirus encoding fusion CTLA4-FasL gene to rat recipients effectively decreased the size of alloreactive T cells and induced long-term survival of cardiac allografts.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Feng YG,Jin YZ,Zhang QY,Hao J,Wang GM,Xie SS

doi

10.1016/j.transproceed.2005.03.022

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

2379-81

issue

5

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(05)00259-9

journal_volume

37

pub_type

杂志文章

相关文献

TRANSPLANTATION PROCEEDINGS文献大全
  • Prognostic value of model for end-stage liver disease scores in patients with fulminant hepatic failure.

    abstract：BACKGROUND:This study was undertaken to investigate risk factors of mortality in patients with fulminant hepatic failure (FHF). METHODS:Fifty-three patients with FHF treated from January 2006 to April 2011 were allocated to a spontaneous survival group (group 1), a death without liver transplantation (LT) group (group...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2013.08.036

    authors： Lee HS,Choi GH,Joo DJ,Kim MS,Kim SI,Han KH,Ahn SH,Kim DY,Park JY,Choi JS

    更新日期：2013-10-01 00:00:00

  • Comparison of two techniques of arterial anastomosis during adult cadaveric liver transplantation.

    abstract：:Arterial complications are a major source of morbidity and mortality after orthotopic liver transplantation (OLT). The incidence of hepatic artery thrombosis (HAT) ranges from 1.6% to 8%, with a mortality rate that ranges from 11% to 35%. We have described herein a technique of arterial anastomosis aiming to perform t...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2007.05.008

    authors： Lorenzin D,Adani GL,Comuzzi C,Sainz-Barriga M,Benzoni E,Bresadola V,Risaliti A,Baccarani U,De Anna D

    更新日期：2007-07-01 00:00:00

  • Techniques to Ameliorate the Impact of Second Warm Ischemic Time on Kidney Transplantation Outcomes.

    abstract：:Anastomosing the renal artery and vein in transplant recipients without a cooling mechanism exposes the kidney to temperatures exceeding the metabolic threshold (15°C to 18°C), at which the protective effects of renal hypothermia are lost. This anastomotic time, or second warm ischemic time, can be deleterious to graf...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,评审

    doi：10.1016/j.transproceed.2018.09.003

    authors： Hameed AM,Yuen L,Pang T,Rogers N,Hawthorne WJ,Pleass HC

    更新日期：2018-12-01 00:00:00

  • Model for End-Stage Liver Disease (MELD) score does not predict outcomes of hepatitis B-induced acute-on-chronic liver failure in transplant recipients.

    abstract：BACKGROUND:Acute-on-chronic liver failure (ACLF) is a severe clinical entity and liver transplantation is the only definitive therapy to salvage these patients. However, the timing of liver transplant for these patients remains unclear. METHODS:Seventy-eight patients undergoing liver transplantation because of hepatit...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2014.07.075

    authors： Duan BW,Lu SC,Wu JS,Guo QL,Zeng DB,Jiang T,Kong DG,Ding J

    更新日期：2014-12-01 00:00:00

  • Split liver transplantation: where? when? how?

    abstract：:Donor scarcity is among the greatest concerns in the transplantation community. Dividing a liver graft theoretically offers a double benefit for candidates on the waiting list. Split liver transplantation entails a higher logistic and technical complexity that is extensively compensated, not only with an increase in t...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,评审

    doi：10.1016/j.transproceed.2012.05.002

    authors： Abradelo M,Sanabria R,Caso O,Álvaro E,Moreno E,Jiménez C

    更新日期：2012-07-01 00:00:00

  • Wilson Disease With Giant Splenic Artery Aneurysms Caused by Fibromuscular Dysplasia During Living Donor Liver Transplantation: A Case Report.

    abstract：:Liver cirrhosis can cause splenic artery aneurysms (SAA) that pose a threat to patients undergoing liver transplantation. However, liver transplantation with multiple visceral artery aneurysms including giant SAA caused by arterial fragility has never been reported. We describe a 36-year-old man with decompensated liv...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2019.06.005

    authors： Sakamoto K,Ogawa K,Tamura K,Ueno Y,Inoue H,Nakamura T,Watanabe J,Takai A,Tohyama T,Senba H,Yoshida O,Abe M,Hiasa Y,Kitazawa R,Kitazawa S,Takada Y

    更新日期：2019-11-01 00:00:00

  • Impact of Donor-Recipient Age Difference on Graft Function and Survival After Deceased Donor Kidney Transplantation.

    abstract：BACKGROUND:Donor-recipient age difference (DRAD) is one of the reasons why patients on kidney waiting lists refuse to receive the offered organ. However, its impact on deceased donor kidney transplantation (DDKT) outcomes is still controversial. METHODS:One hundred fifty-three kidney transplant recipients (KTRs) who r...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2020.02.163

    authors： Kim GH,Lim JH,Park TH,Choi JY,Jung HY,Cho JH,Park SH,Kim YL,Kim HK,Huh S,Kim CD

    更新日期：2020-12-01 00:00:00

  • Successful kidney transplantation in a patient with multiple endocrine neoplasia type 2A syndrome: case study.

    abstract：:We present the case of a 37-year-old patient diagnosed with multiple endocrine neoplasia type 2A (MEN 2A) syndrome, as confirmed by genetic tests, who underwent the transplantation of a kidney from a cadaveric donor. MEN 2A, a hereditary autosomal dominant syndrome, is caused by the mutation of the RET proto-oncogene....

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2011.08.018

    authors： Rudzki S,Matuszek M,Bicki J,Furmaga J,Pilat J,Gieryng J

    更新日期：2011-10-01 00:00:00

  • Prophylaxis of recurrent hepatitis B virus by vaccination after liver transplant: preliminary results.

    abstract：:Liver transplantation for chronic HBV-induced cirrhosis is associated with a high rate of recurrence and poor long-term survival. Prolonged and combined prophylaxis with hepatitis B immunoglobulin (HBIg) and lamivudine has been demonstrated to prevent HBV recurrence, but its lifelong administration is highly expensive...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/s0041-1345(03)00633-x

    authors： Albeniz Arbizu E,Barcena Marugan R,Oton Nieto E,Carrera Alonso E,Garcia Gonzalez M,Moreno Garcia J,de Vicente Lopez E,Nuño Vazquez-Garza J,Martin Davila P

    更新日期：2003-08-01 00:00:00

  • Impact of optimal heart failure medical therapy on heart transplant listing.

    abstract：:The data assessing the prognostic value of peak exercise oxygen consumption (VO2) in heart failure (HF) patients is largely derived from cross-sectional studies in which medical therapy was not maximized in all eligible patients and no clear explanation was given as to why such was the case. To assess the relative pro...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.02.099

    authors： Geisberg C,Goring J,Listerman J,Nading MA,Huang RL,Butler J

    更新日期：2006-06-01 00:00:00

  • Intrathymic inoculation of donor HLA class I-derived peptide generates donor-specific CD4+CD25+ regulatory T cells.

    abstract：:CD4(+)CD25(+) regulatory T cells are selected in the thymus to control autoreactive thymic escapees preventing autoimmunity that cannot be achieved by negative selection or deletion alone, thus playing an important role in the maintenance of immunological homeostasis. Not only significant in preventing autoimmunity, C...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2004.12.046

    authors： Tamura S,Beck Y,Ando Y,Tahara H

    更新日期：2005-01-01 00:00:00

  • The role of invariant NKT cells in liver transplant tolerance in rats.

    abstract：OBJECTIVE:The aim of this study was to investigate the role of invariant natural killer T (iNKT) cells in liver transplant tolerance in rats. METHODS:Animals were randomly divided into 3 groups. The α-galactosylceramide (α-GalCer) group underwent injection through the caudal vein; the saline group received the same do...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2012.01.082

    authors： Liu Y,Luan X,Li J,He Y,Li M

    更新日期：2012-05-01 00:00:00

  • The outcome of induction therapy with monoclonal antibodies in kidney transplantation among Iranian patients: a prospective study.

    abstract：INTRODUCTION:The administration of interlukin-2 receptor antagonists for induction therapy has reduced the incidence of acute rejection episodes in kidney transplantation. Although some studies have investigated the efficacy of these monoclonal antibodies, there is little experience among Iranian kidney transplant reci...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.transproceed.2009.06.180

    authors： Naderi GH,Mehraban D,Ganji MR,Jafarpouriani M,Latif AH

    更新日期：2009-09-01 00:00:00

  • Early hepatic artery thrombosis after liver transplantation: diagnosis and treatment.

    abstract：BACKGROUND:Hepatic artery thrombosis (HAT) occurs in 3% to 9% of all liver transplantations with acute graft failure as a possible sequel. METHODS:Eleven episodes of HAT were identified among 256 orthotropic liver transplantations (whole, LDCT, split) performed on 253 patients between April 1993 and July 2006. HAT was...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2007.02.017

    authors： Nikeghbalian S,Kazemi K,Davari HR,Salahi H,Bahador A,Jalaeian H,Khosravi MB,Ghaffari S,Lahsaee M,Alizadeh M,Rasekhi AR,Nejatollahi SM,Malek-Hosseini SA

    更新日期：2007-05-01 00:00:00

  • New Antivirals for Hepatitis C Infection Among Infected Kidney Transplant Recipients: A Case Report.

    abstract：:The most common hepatopathy in end-stage renal disease is chronic hepatitis C virus (HCV) infection, which decreases allograft and patient survival in kidney transplants. Until last year we did not have treatments free of interferon, which was contraindicated after renal transplantation owing to the risk of allograft ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2015.09.047

    authors： Suarez-Benjumea A,Gonzalez-Corvillo C,Bernal-Blanco G,Pascasio-Acevedo JM,Gonzalez-Roncero F,Perez-Valdivia MA,Suñer-Poblet M,Gentil-Govantes MA

    更新日期：2015-11-01 00:00:00

  • Outcome of Desensitization Therapy in Immunologically High-Risk Kidney Transplantation: Single-Center Experience.

    abstract：AIM:Sensitization to HLA antigens creates an immunologic barrier, linked to an increased risk of antibody-mediated rejection and poorer graft survival, that remains a persistent and often impenetrable deterrent to transplantation. Desensitization can improve transplantation rates in broadly sensitized kidney transplant...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2019.04.068

    authors： Sinangil A,Ucar ZA,Koc Y,Barlas S,Abouzahir S,Ecder ST,Akin EB

    更新日期：2019-09-01 00:00:00

  • Implantation of the liver during reperfusion of the heart in combined heart-liver transplantation: own experience and review of the literature.

    abstract：BACKGROUND:There are only a few reports about combined heart-liver transplantations. The surgical techniques differ widely, ranging from sequential implantation of the organs to simultaneous transplantations. We report our experience with simultaneous, combined heart-liver transplantations without using a veno-venous b...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,评审

    doi：10.1016/j.transproceed.2011.04.010

    authors： Rauchfuss F,Breuer M,Dittmar Y,Heise M,Bossert T,Hekmat K,Settmacher U

    更新日期：2011-09-01 00:00:00

  • Teenagers in Rural Areas Faced With Organ Donation and Transplantation.

    abstract：INTRODUCTION:In rural areas it is common to find unfavorable attitudes toward organ donation, and therefore it is important to find out the attitude and profile of new generations for improving predisposition to organ donation in these areas. Our objective was to analyze the attitude toward organ donation and the relat...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2017.09.054

    authors： Febrero B,Almela J,Ríos A,Ros I,Pérez-Sánchez B,Martínez-Alarcón L,Ruiz-Carreño P,Ferreras D,Ramírez P,Parrilla P

    更新日期：2018-03-01 00:00:00

  • Acute Antibody-Mediated Rejection as Cause of Late Liver Allograft Failure: A Case Report.

    abstract：BACKGROUND:Despite now being an infrequent complication in liver transplantation (LT) recipients, acute liver failure is still associated with high mortality. CASE REPORT:Here we report a case of acute liver failure 11 months after AB0-compatible LT in a hepatitis C-positive 50-year-old male recipient caused by late a...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2015.10.036

    authors： Vellalta G,Dopazo C,Bilbao I,Castells L,Sapisochin G,Lázaro JL,Montero Á,Salcedo MT,Caralt M,Charco R

    更新日期：2015-12-01 00:00:00

  • Human islet viability and function is maintained during high-density shipment in silicone rubber membrane vessels.

    abstract：BACKGROUND:The shipment of human islets (IE) from processing centers to distant laboratories is beneficial for both research and clinical applications. The maintenance of islet viability and function in transit is critically important. Gas-permeable silicone rubber membrane (SRM) vessels reduce the risk of hypoxia-indu...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2014.06.002

    authors： Kitzmann JP,Pepper AR,Gala-Lopez B,Pawlick R,Kin T,O'Gorman D,Mueller KR,Gruessner AC,Avgoustiniatos ES,Karatzas T,Szot GL,Posselt AM,Stock PG,Wilson JR,Shapiro AM,Papas KK

    更新日期：2014-07-01 00:00:00

  • Posttransplant diabetes mellitus: incidence and risk factors.

    abstract：UNLABELLED:Posttransplant diabetes mellitus (PTDM) is common post transplantation and is associated with tacrolimus (TAC) and steroid therapy. The aim of the present study was to analyze the incidences of PTDM and associated risk factors. METHODS:We selected renal transplant recipients treated with TAC, mycophenolate ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2008.03.018

    authors： Mazali FC,Lalli CA,Alves-Filho G,Mazzali M

    更新日期：2008-04-01 00:00:00

  • Changes in Tumor Markers and Their Implications in Selecting Liver Transplantation for Patients With Hepatocellular Carcinoma.

    abstract：BACKGROUND AND AIM:It has been suggested that tumor markers can provide additional information over tumor size and number-based liver transplantation (LT) criteria. We aimed to assess if changes in tumor markers are associated with the risk of tumor recurrence after LT for hepatocellular carcinoma (HCC) who received lo...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2020.01.037

    authors： Song BG,Sinn DH,Kang W,Gwak GY,Paik YH,Choi MS,Lee JH,Koh KC,Paik SW,Kim JM,Joh JW,Choi GS

    更新日期：2020-04-01 00:00:00

  • C2 monitoring of cyclosporine in stable renal transplant patients results in lower costs and improved renal function.

    abstract：INTRODUCTION:C2 (2-hour post-absorption levels) monitoring of cyclosporine (CsA) seems to reduce the rate of acute rejection episodes (ARE) without increasing nephrotoxicity during the first months after transplant. There are a few reports on the impact of adopting this strategy in patients with stable renal transplant...

    journal_title：Transplantation proceedings

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.transproceed.2004.09.016

    authors： Domínguez J,Fuenzalida D,Norambuena R,Pais E,Cortes Monroy G,Llanos R

    更新日期：2005-04-01 00:00:00

  • Preliminary Study of Bone Marrow-Derived Mesenchymal Stem Cells Pretreatment With Erythropoietin in Preventing Acute Rejection After Rat Renal Transplantation.

    abstract：:Renal transplantation is currently the most effective treatment for end-stage kidney diseases, and acute allograft rejection is well treated with high dose prednisolone and immunosuppressive agents, but long-term use of immunosuppressants will be detrimental to the long-term survival of the transplanted kidney and wil...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2018.04.063

    authors： Zhang Y,Zhou S,Hu JM,Chen H,Liu D,Li M,Guo Y,Fan LP,Li LY,Liu YG,Zhao M

    更新日期：2018-12-01 00:00:00

  • Structural and Functional Adaptation of the Remnant Kidney After Living Kidney Donation: Long-Term Follow-up.

    abstract：OBJECTIVE:Several adjustments occur after nephrectomy (NT) in the donor's remnant kidney. We investigated kidney donors 10 years after NT and compared several parameters before and after transplantation. METHODS:A total of 42 kidney donors of the University of Luebeck's Transplant Center were scheduled for a 10-year f...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2017.07.007

    authors： Meier M,Winterhoff J,Fricke L,Lehnert H,Nitschke M

    更新日期：2017-11-01 00:00:00

  • Holmium Intraductal Laser Lithotripsy of Biliary Stones in Liver Grafts.

    abstract：BACKGROUND:Biliary stones after liver transplantation (LT) rarely occur but a focus on those complications and their treatment is needed. PATIENTS AND METHODS:In total, 390 adult patients who underwent an LT from July 2004 to July 2014 entered the study. Biliary complications and notably biliary stones after LT were i...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2015.12.052

    authors： Maggi U,Paone G,Lauro R,Fornoni G,Chierici A,Nencioni M,Caruso A,Rossi G

    更新日期：2016-03-01 00:00:00

  • Continuous low-dose human atrial natriuretic peptide promotes diuresis in oliguric patients after living donor liver transplantation.

    abstract：:Human atrial natriuretic peptide (ANP) is beneficial for the prophylaxis of acute renal failure (ARF) after liver transplantation (OLT). We evaluated renal function in OLT patients with or without ARF, describing cases unresponsive to loop diuretics successfully treated with continuous low-dose ANP infusion without he...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.10.130

    authors： Sato K,Sekiguchi S,Kawagishi N,Akamatsu Y,Enomoto Y,Takeda I,Fukushima D,Fujimori K,Sato A,Satomi S

    更新日期：2006-12-01 00:00:00

  • Homocysteine-lowering therapy and carotid intima-media thickness in renal transplant recipients.

    abstract：:The aim of this study was to document, in hyperhomocysteinemic renal transplant recipients, the effect of vitamin supplementation on carotid intima-media thickness (cIMT). Fifty-six hyperhomocysteinemic stable renal transplant recipients were randomly assigned to either vitamin supplementation (group A) or placebo tre...

    journal_title：Transplantation proceedings

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.transproceed.2005.06.101

    authors： Marcucci R,Zanazzi M,Bertoni E,Rosati A,Fedi S,Lenti M,Prisco D,Castellani S,Abbate R,Salvadori M

    更新日期：2005-07-01 00:00:00

  • Severe bone marrow failure due to valganciclovir overdose after renal transplantation from cadaveric donors: four consecutive cases.

    abstract：:Valganciclovir is an l-valyl ester pro-drug of ganciclovir that was initially used to treat cytomegalovirus (CMV)-associated retinitis in patients with human immunodeficiency virus. Currently, it is also indicated for the prevention of CMV disease in solid-organ transplantation. It is primarily eliminated via the kidn...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2009.02.093

    authors： Ar MC,Ozbalak M,Tuzuner N,Bekoz H,Ozer O,Ugurlu K,Tabak F,Ferhanoglu B

    更新日期：2009-06-01 00:00:00

  • The influence of brain death on liver in rats.

    abstract：OBJECTIVE:Donor brain death produces functional and morphological changes in peripheral organs. We examined the influence of brain death on liver function. METHODS:Fifty rats were randomly divided into three groups: controls (C), sham-operated (E1), and brain-dead (E2). All rats underwent tracheotomy with assisted res...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2004.07.008

    authors： Zhang SJ,Chen S

    更新日期：2004-09-01 00:00:00