Abstract：
:The effects of radiation damage, tumour repopulation and cell sublethal damage repair and the possibility of extracting information about the model parameters describing them are investigated in this work. Previously published data on two different cultured cell lines were analysed with the help of a tumour control probability (TCP) model that describes tumour cell dynamics properly. Different versions of a TCP model representing the cases of full or partial cell recovery between fractions of radiation, accompanied by repopulation or no repopulation were used to fit the data and were ranked according to statistical criteria. The data analysis shows the importance of the linear-quadratic mechanism of cell damage for the description of the in vitro cell dynamics. In a previous work where in vivo data were analysed, the employment of the single hit model of cell kill and cell repopulation produced the best fit, while ignoring the quadratic term of cell damage in the current analysis leads to poor fits. It is also concluded that more experiments using different fractionation regimes producing diverse data are needed to help model analysis and better ranking of the models.
journal_name
Phys Med Bioljournal_title
Physics in medicine and biologyauthors
Stavrev P,Weldon M,Warkentin B,Stavreva N,Fallone BGdoi
10.1088/0031-9155/50/13/006subject
Has Abstractpub_date
2005-07-07 00:00:00pages
3053-61issue
13eissn
0031-9155issn
1361-6560pii
S0031-9155(05)94517-Xjournal_volume
50pub_type
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