Cleavage of DNA by N-phosphoryl histidine.

Abstract:

:DNA cleavage by N-(O,O-diisopropyl)phosphoryl histidine(DIPP-His) is investigated by a submarine agarose electrophoresis technique. It was found that DIPP-His could cleave supercoiled DNAs and lambda DNA without the participation of divalent metal ions, while the histidine itself and N-(O,O-diisopropyl)phosphoryl alanine had no such function. Supercoiled pUC8 and pBR322 DNAs are cleaved to linear DNA and eventually fragments; lambda DNA is cleaved directly to fragments. Two mechanistic pathways are proposed for the cleavage reaction.

authors

Li Y,Sha YW,Ma Y,Zhao Y

doi

10.1006/bbrc.1995.2210

subject

Has Abstract

pub_date

1995-08-24 00:00:00

pages

875-80

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006291X85722103

journal_volume

213

pub_type

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