Six groups of the OXY beta-Lactamase evolved over millions of years in Klebsiella oxytoca.

abstract：:A number of compounds, as exemplified by verapamil and desipramine, have been shown to enhance the susceptibility of resistant malaria parasites to chloroquine. The mechanism by which these agents reverse resistance is still controversial but is though to involve alterations in drug transport causing an increase in st...

journal_title：Antimicrobial agents and chemotherapy

authors： Ndifor AM,Howells RE,Bray PG,Ngu JL,Ward SA

更新日期：1993-06-01 00:00:00

abstract：:Various steroids were tested for their effects upon gonococcal O2 consumption and glucose catabolism. The ability to inhibit gonococcal O2 uptake appeared to be related to the molecular configuration of the steroid. The presence of lipophilic groups enhanced inhibition, whereas the addition of hydrophilic groups marke...

journal_title：Antimicrobial agents and chemotherapy

authors： Lysko PG,Morse SA

更新日期：1980-08-01 00:00:00

abstract：:Here, we report the first autochthonous cases of infections caused by blaNDM-5 New Delhi metallo-β-lactamase-producing Escherichia coli strains recovered from urine and blood specimens of three patients from Algeria between January 2012 and February 2013. The three isolates belong to sequence type 2659 and they coexpr...

journal_title：Antimicrobial agents and chemotherapy

authors： Sassi A,Loucif L,Gupta SK,Dekhil M,Chettibi H,Rolain JM

更新日期：2014-09-01 00:00:00

abstract：:Five isoforms of protein mannosyltransferase (Pmt) O-mannosylate secretory proteins in Candida albicans. pmt mutants were differentially defective for biofilm formation on plastic in static and flow-through systems, and a Pmt inhibitor blocked early stages of biofilm formation. Conceptually, Pmt inhibition may prevent...

journal_title：Antimicrobial agents and chemotherapy

authors： Peltroche-Llacsahuanga H,Goyard S,d'Enfert C,Prill SK,Ernst JF

更新日期：2006-10-01 00:00:00

abstract：:In a crossover study, single doses of netilmicin and gentamicin were administered intramuscularly, each at 1.0 and 2.5 mg/kg. The serum concentrations, analyzed by a two-compartment open model with a first-order absorption, indicated that the pharmacokinetics of the drugs are essentially the same. Both drugs were rapi...

journal_title：Antimicrobial agents and chemotherapy

authors： Chung M,Costello R,Symchowicz S

更新日期：1980-02-01 00:00:00

abstract：:The penam nucleus can assume two conformations; these are designated open and closed. The synthetic (2,3)-alpha- and (2,3)-beta-methylenepenams can be regarded as analogs of the open and closed conformations, respectively. It has been shown that the beta-methylenepenams are essentially inactive, suggesting that the cl...

journal_title：Antimicrobial agents and chemotherapy

authors： Christenson JG,Pruess DL,Talbot MK,Keith DD

更新日期：1988-07-01 00:00:00

abstract：:MICs of a set of cephalosporins against a variety of gram-positive and gram-negative pathogens showed no strong correlations with the rate at which these inhibitors acylate or are deacylated by beta-lactam-sensitive DD-peptidases excreted by Streptomyces sp. strain R61 and Actinomadura sp. strain R39. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Boyd DB,Ott JL

更新日期：1986-05-01 00:00:00

abstract：:Azithromycin is an effective treatment for uncomplicated infections with Salmonella enterica serovar Typhi and serovar Paratyphi A (enteric fever), but there are no clinically validated MIC and disk zone size interpretative guidelines. We studied individual patient data from three randomized controlled trials (RCTs) o...

journal_title：Antimicrobial agents and chemotherapy

authors： Parry CM,Thieu NT,Dolecek C,Karkey A,Gupta R,Turner P,Dance D,Maude RR,Ha V,Tran CN,Thi PL,Be BP,Phi LT,Ngoc RN,Ghose A,Dongol S,Campbell JI,Thanh DP,Thanh TH,Moore CE,Sona S,Gaind R,Deb M,Anh HV,Van SN,

更新日期：2015-05-01 00:00:00

abstract：:In this study, susceptibilities were determined for AZD0914, a spiropyrimidinetrione DNA gyrase inhibitor, azithromycin, doxycycline, and levofloxacin against Mycoplasma and Ureaplasma species. The activity of AZD0914 was comparable to that of levofloxacin and doxycycline against Mycoplasma genitalium and Mycoplasma p...

journal_title：Antimicrobial agents and chemotherapy

authors： Waites KB,Crabb DM,Duffy LB,Huband MD

更新日期：2015-01-01 00:00:00

abstract：:We investigated the antistaphylococcal activity of daptomycin, vancomycin, oxacillin, gentamicin, and rifampin in human monocyte-derived macrophages. Compared with vancomycin and oxacillin, daptomycin had the most rapid and greatest antibacterial activity, but that of oxacillin was most sustained. The combination of d...

journal_title：Antimicrobial agents and chemotherapy

authors： Baltch AL,Ritz WJ,Bopp LH,Michelsen PB,Smith RP

更新日期：2007-04-01 00:00:00

abstract：:An antibody induced in rabbits against a gentamicin-bovine serum albumin conjugate cross-reacted with the chemically related aminoglycoside, sisomicin, facilitating the development of a sisomicin radioimmunoassay. Sisomicin was labeled with (125)I using an acylating agent [3-(4-hydroxyphenyl)propionic acid-N-hydroxy-s...

journal_title：Antimicrobial agents and chemotherapy

authors： Broughton A,Strong JE,Bodey GP

更新日期：1976-02-01 00:00:00

abstract：:Resistance to daptomycin in enterococcal clinical isolates remains rare but is being increasingly reported in the United States and worldwide. There are limited data on the genetic relatedness and microbiological and clinical characteristics of daptomycin-nonsusceptible enterococcal clinical isolates. In this study, w...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang G,Kamalakaran S,Dhand A,Huang W,Ojaimi C,Zhuge J,Yee LL,Mayigowda P,Surendraiah PK,Dimitrova N,Fallon JT

更新日期：2014-08-01 00:00:00

abstract：:Enviroxime, an inhibitor of rhinovirus replication, was studied in a double-blind, placebo-controlled trial with 99 volunteers. The efficacy of a nasal-spray formulation of enviroxime was tested as pretreatment or as postchallenge treatment for rhinovirus type 4 infection. In the regimens used, drug administration nei...

journal_title：Antimicrobial agents and chemotherapy

authors： Levandowski RA,Pachucki CT,Rubenis M,Jackson GG

更新日期：1982-12-01 00:00:00

abstract：:A fluoroquinolone (FQ) resistance rate of 5.9% is reported in 205 Mycobacterium tuberculosis isolates from patients presenting to field clinics in Karachi, Pakistan (2006 to 2009). FQ resistance among multidrug-resistant (MDR) strains was 11.1% (5/45), and it was 4.9% (5/103) in M. tuberculosis strains susceptible to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Rafiq Y,Jabeen K,Hasan R,Jafri S,Laiq R,Malik F,Mangi R,Channa A,Hasan Z

更新日期：2011-02-01 00:00:00

abstract：:We evaluated the in vitro activity of polymyxin B plus imipenem, meropenem, or tigecycline against six KPC-2-producing Enterobacteriaceae strains with high MICs for these antimicrobial agents. Polymyxin B with carbapenems, especially meropenem, were the most active combinations for Klebsiella pneumoniae and Enterobact...

journal_title：Antimicrobial agents and chemotherapy

authors： Barth N,Ribeiro VB,Zavascki AP

更新日期：2015-01-01 00:00:00

abstract：:Ga(3+) is a semimetal element that competes for the iron-binding sites of transporters and enzymes. We investigated the activity of gallium maltolate (GaM), an organic gallium salt with high solubility, against laboratory and clinical strains of methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resista...

journal_title：Antimicrobial agents and chemotherapy

authors： Baldoni D,Steinhuber A,Zimmerli W,Trampuz A

更新日期：2010-01-01 00:00:00

abstract：:The fungus Saprochaete capitata causes opportunistic human infections, mainly in immunocompromised patients with hematological malignancies. The best therapy for this severe infection is still unknown. We evaluated the in vitro killing activity and the in vivo efficacy of posaconazole at 5, 10, or 20 mg/kg twice a day...

journal_title：Antimicrobial agents and chemotherapy

authors： Thomson P,Guarro J,Mayayo E,Capilla J

更新日期：2015-12-01 00:00:00

abstract：:We determined the antibiotic susceptibilities of 1,785 enterococcal bloodstream isolates collected over 25 years. Antibiotic resistance emerged at a greater rate in Enterococcus faecium than in other enterococcal species, and E. faecium isolates became proportionally more common over time. Our findings confirm the pat...

journal_title：Antimicrobial agents and chemotherapy

authors： Murdoch DR,Mirrett S,Harrell LJ,Monahan JS,Reller LB

更新日期：2002-11-01 00:00:00

abstract：:Daptomycin is a lipopeptide antibiotic with activity against gram-positive bacteria, including Staphylococcus aureus. We defined the pharmacodynamic parameters that determine the activity of daptomycin for S. aureus using in vitro methods and the Craig (W. A. Craig, J. Redington, and S. C. Ebert, J. Antimicrob. Chemot...

journal_title：Antimicrobial agents and chemotherapy

authors： Louie A,Kaw P,Liu W,Jumbe N,Miller MH,Drusano GL

更新日期：2001-03-01 00:00:00

abstract：:RBx 11760, a bi-aryl oxazolidinone, was investigated for antibacterial activity against Gram-positive bacteria. The MIC90s of RBx 11760 and linezolid against Staphylococcus aureus were 2 and 4 mg/liter, against Staphylococcus epidermidis were 0.5 and 2 mg/liter, and against Enterococcus were 1 and 4 mg/liter, respecti...

journal_title：Antimicrobial agents and chemotherapy

authors： Barman TK,Kumar M,Mathur T,Chaira T,Ramkumar G,Kalia V,Rao M,Pandya M,Yadav AS,Das B,Upadhyay DJ,Hamidullah,Konwar R,Raj VS,Singh H

更新日期：2016-11-21 00:00:00

abstract：:We present a new strategy for predicting novel antibiotic mechanisms of action based on the analysis of whole-genome microarray data. We first built up a reference compendium of Bacillus subtilis expression profiles induced by 14 different antibiotics. This data set was expanded by adding expression profiles from muta...

journal_title：Antimicrobial agents and chemotherapy

authors： Freiberg C,Fischer HP,Brunner NA

更新日期：2005-02-01 00:00:00

abstract：:Ribonucleoside analog inhibitors (rNAI) target the hepatitis C virus (HCV) RNA-dependent RNA polymerase nonstructural protein 5B (NS5B) and cause RNA chain termination. Here, we expand our studies on β-d-2'-C-methyl-2,6-diaminopurine-ribonucleotide (DAPN) phosphoramidate prodrug 1 (PD1) as a novel investigational inhi...

journal_title：Antimicrobial agents and chemotherapy

authors： Ehteshami M,Tao S,Ozturk T,Zhou L,Cho JH,Zhang H,Amiralaei S,Shelton JR,Lu X,Khalil A,Domaoal RA,Stanton RA,Suesserman JE,Lin B,Lee SS,Amblard F,Whitaker T,Coats SJ,Schinazi RF

更新日期：2016-07-22 00:00:00

abstract：:The human pathogen Giardia lamblia is an anaerobic protozoan parasite that causes giardiasis, one of the most common diarrheal diseases worldwide. Although several drugs are available for the treatment of giardiasis, drug resistance has been reported and is likely to increase, and recurrent infections are common. The ...

journal_title：Antimicrobial agents and chemotherapy

authors： Chen CZ,Kulakova L,Southall N,Marugan JJ,Galkin A,Austin CP,Herzberg O,Zheng W

更新日期：2011-02-01 00:00:00

abstract：:We undertook a prospective, randomized open comparison of the broad-spectrum cephalosporins cefepime and ceftazidime in treatment of hospitalized subjects with skin or wound infections and complicated nosocomial urinary tract infections. Cefepime treatment (dosage, 2.0 g intravenously twice daily for 4 to 28 days) was...

journal_title：Antimicrobial agents and chemotherapy

authors： Gentry LO,Rodriguez-Gomez G

更新日期：1991-11-01 00:00:00

abstract：:Low-level vancomycin-resistant Staphylococcus aureus (vancomycin-intermediate S. aureus [VISA] and heterogenous VISA [hVISA]) is increasingly reported and leads to glycopeptide treatment failure. Various phenotypic features have been reported for these isolates, but the genetic changes leading to hVISA and VISA have y...

journal_title：Antimicrobial agents and chemotherapy

authors： Howden BP,Johnson PD,Ward PB,Stinear TP,Davies JK

更新日期：2006-09-01 00:00:00

abstract：:The activities of mecillinam and ampicillin, alone and in combination, were evaluated in mice infected with the LT-2 strain of Salmonella typhimurium. The minimal inhibitory concentrations of mecillinam and ampicillin for this strain were, respectively, 6.2 and 0.4 microgram/ml of culture medium. In vitro synergy was ...

journal_title：Antimicrobial agents and chemotherapy

authors： Butler T,Shuster CW,Dixon P

更新日期：1981-02-01 00:00:00

abstract：:The in vitro susceptibilities of 22 penicillinase-producing and 32 non-penicillinase-producing strains of Neisseria gonorrhoeae to 13 antimicrobial agents, including the new semisynthetic penicillins and cephalosporins, are reported. Ceftriaxone, ceftazidime, and cefotaxime were the most active agents tested; none of ...

journal_title：Antimicrobial agents and chemotherapy

authors： Coovadia YM,Ramsaroop U

更新日期：1984-11-01 00:00:00

abstract：:The susceptibilities of Streptococcus pneumoniae (1,476 strains) and untypeable Haemophilus influenzae (1,676 strains) to various oral beta-lactam, macrolide-azalide, and fluoroquinolone antimicrobial agents were determined by broth microdilution. Organisms were isolated from specimens obtained from outpatients in six...

journal_title：Antimicrobial agents and chemotherapy

authors： Jacobs MR,Bajaksouzian S,Zilles A,Lin G,Pankuch GA,Appelbaum PC

更新日期：1999-08-01 00:00:00

abstract：:The time course of plasma drug levels and urinary recovery for two lipopeptide antifungal antibiotics, L-671,329 and cilofungin, were measured in male rhesus monkeys (Macaca mulatta) and in female DBA/2 mice. The antibiotics were administered intravenously at 10 mg/kg of body weight in phosphate-buffered saline-26% po...

journal_title：Antimicrobial agents and chemotherapy

authors： Sundelof JG,Hajdu R,Cleare WJ,Onishi J,Kropp H

更新日期：1992-03-01 00:00:00

abstract：:The in vitro activity of the investigational siderophore cephalosporin, cefiderocol (formerly S-649266), was determined against a 2014-2016, 52-country, worldwide collection of clinical isolates of carbapenem-nonsusceptible Enterobacteriaceae (n = 1,022), multidrug-resistant (MDR) Acinetobacter baumannii (n = 368), MD...

journal_title：Antimicrobial agents and chemotherapy

authors： Hackel MA,Tsuji M,Yamano Y,Echols R,Karlowsky JA,Sahm DF

更新日期：2018-01-25 00:00:00