Abstract:
:Since the discovery that clomipramine was effective in the treatment of obsessive-compulsive disorder (OCD), trials of several different medications for OCD have been published. The question of which agent, if any, is the medication of choice in OCD is of real clinical concern. Published clinical trials were collected using computerized search on MedLine and PsychLit. Trials that met predetermined criteria were included in a meta-analysis. Analyses of variance were used to compare the specific effect sizes of different medications in OCD. In placebo-controlled trials, serotonin reuptake inhibitor (SRI) type had a significant effect on medication effect size, with clomipramine more effective than fluoxetine. Although this finding did not alter when trials were restricted to those with large numbers of subjects (n > 50), the analysis was based on a very limited number of studies. The fact that so few placebo-controlled studies have been done in OCD compromises the findings of this meta-analysis. It would be premature to extrapolate the results to clinical practice, where clomipramine and certain selective SRIs are currently and justifiably used as first-line agents. Nevertheless, the current study supports previous work suggesting that increased serotonergic specificity is not necessarily correlated with greater efficacy in the treatment of OCD. Further head-to-head comparison studies are necessary to confirm or refute this preliminary impression.
journal_name
Int Clin Psychopharmacoljournal_title
International clinical psychopharmacologyauthors
Stein DJ,Spadaccini E,Hollander Edoi
10.1097/00004850-199503000-00002subject
Has Abstractpub_date
1995-03-01 00:00:00pages
11-8issue
1eissn
0268-1315issn
1473-5857journal_volume
10pub_type
杂志文章,meta分析abstract::Although life prevalence of substance use disorders among patients with schizophrenia is close to 50%, few studies have been carried out to date to identify an integrated pharmacological treatment for this comorbidity. So far, the most promising results, that we report here, have been obtained with clozapine. To a les...
journal_title:International clinical psychopharmacology
pub_type: 杂志文章,评审
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abstract::There is uncertainty with regard to the appropriate use of metformin for the prevention and management of second-generation antipsychotic-induced weight gain and metabolic abnormalities. We aim to systematically review the primary literature and to provide recommendations with regard to the use of metformin in psychia...
journal_title:International clinical psychopharmacology
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journal_title:International clinical psychopharmacology
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journal_title:International clinical psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:International clinical psychopharmacology
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journal_title:International clinical psychopharmacology
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journal_title:International clinical psychopharmacology
pub_type: 杂志文章,评审
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更新日期:2000-11-01 00:00:00
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journal_title:International clinical psychopharmacology
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pub_type: 杂志文章,多中心研究
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更新日期:2006-05-01 00:00:00
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journal_title:International clinical psychopharmacology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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journal_title:International clinical psychopharmacology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
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journal_title:International clinical psychopharmacology
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journal_title:International clinical psychopharmacology
pub_type: 临床试验,杂志文章
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journal_title:International clinical psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:International clinical psychopharmacology
pub_type:
doi:
更新日期:1996-06-01 00:00:00
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journal_title:International clinical psychopharmacology
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journal_title:International clinical psychopharmacology
pub_type: 杂志文章,评审
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journal_title:International clinical psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1989-07-01 00:00:00
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journal_title:International clinical psychopharmacology
pub_type: 杂志文章,评审
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更新日期:1996-12-01 00:00:00
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journal_title:International clinical psychopharmacology
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