Abstract:
:The purpose of these experiments was to determine whether or not acetylcholine modulated the electrophysiological effects of isoproterenol on canine cardiac Purkinje fibers. Conventional microelectrode techniques were used. Predictably, isoproterenol produced shortening of action potential duration; acetylcholine significantly blunted this effect of isoproterenol. Isoproterenol restored excitability to fibers exposed to 22 mM potassium solutions, and acetylcholine abolished this isoproterenol-restored excitability. Both of these antagonistic effects of acetylcholine were blocked by atropine. Acetylcholine alone did not affect action potential duration in polarized fibers or excitability in potassium-depolarized fibers. Furthermore, acetylcholine had no effect on the decrease in action potential duration induced by premature electrical stimulation or by acetylstrophanthidin administration, or on excitability of fibers exposed to a zero sodium, high calcium superfusant. These data demonstrate a direct cellular basis for cholinergic antagonism of the electrophysiological effects of beta-adrenergic stimulation of canine cardiac specialized intraventricular conducting tissue.
journal_name
Circ Resjournal_title
Circulation researchauthors
Bailey JC,Watanabe AM,Besch HR Jr,Lathrop DAdoi
10.1161/01.res.44.3.378subject
Has Abstractpub_date
1979-03-01 00:00:00pages
378-83issue
3eissn
0009-7330issn
1524-4571journal_volume
44pub_type
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更新日期:2019-09-13 00:00:00
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更新日期:2007-08-17 00:00:00
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更新日期:1987-04-01 00:00:00
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更新日期:2015-10-09 00:00:00
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更新日期:2010-02-19 00:00:00
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更新日期:2002-06-14 00:00:00
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更新日期:1999-08-06 00:00:00
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更新日期:1992-05-01 00:00:00