[Anti-inflammatory effect of topical diclofenac sodium (Voltarène Ophta) after argon laser trabeculoplasty: preliminary results of a prospective double-blind method].

Abstract:

:Using the laser flare-cell meter (LFMC), we have previously determined the intensity and pattern of post-ALT ocular inflammation. Inflammation peak occurs 48 hours after ALT and clinically relevant inflammation is seen in 100% of pigmentary glaucomas (PIG), 75% of pseudoexfoliative glaucomas (PEXG) but only in 25% of primary open angle glaucomas (POAG). We also showed that topical diclofenac reduced inflammation in all 17 treated patients. Prostaglandins are thought to play a major role in ALT-inflammation and it is therefore logical to assume that NSAID are effective in that situation and will probably advantageously replace corticosteroids. In order to assess the anti-inflammatory effect of diclofenac drops (Voltaren Ophtha) we included a total of 37 PIG or PEXG (19 in the diclofenac and 18 in the placebo group) scheduled for ALT in prospective randomized placebo-controlled study. Visual acuity, tonometry, and LFCM flare measure were performed before, 3, 6 hours, 1, 2, 4, 7, 14 days after ALT. Topical diclofenac or placebo was given before and after ALT and then QID for a total of 4 days. Mean maximal flare increase was significantly less in the diclofenac group than in the placebo group (4.6 +/- 3.8 ph/msec v. 17.4 +/- 19 ph/msec; p less than 0.01). Flare increase compared to pre-ALT values was significant at 1 and 2 days after ALT in the placebo group only (p less than 0.02; p less than 0.05); no significant flare increase occurred in the diclofenac group.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Klin Monbl Augenheilkd

authors

Herbort CP,Mermoud A,Schnyder C,Pittet N

doi

10.1055/s-2008-1045765

subject

Has Abstract

pub_date

1992-05-01 00:00:00

pages

358-61

issue

5

eissn

0023-2165

issn

1439-3999

journal_volume

200

pub_type

临床试验,杂志文章,随机对照试验
  • [External trabeculecomy (ETE): an alternative? A retrospective comparison with goniotrepanation].

    abstract:PURPOSE:The purpose of this retrospective study is to compare the results of deep sclerectomy versus trabeculectomy for IOP reduction and the respective complication rates. METHODS:199 patients were treated by deep sclerectomy and 80 patients by trabeculectomy between 2000 and 2005. Retrospective results for IOP reduc...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1027599

    authors: Eschstruth P,Schmidt J

    更新日期:2008-12-01 00:00:00

  • [Zinc concentration in the aqueous humor (author's transl)].

    abstract::The zinc concentration in normal human aqueous humor was determined with the help of an atomic absorption spectrophotometer. The mean value was 0.359 ppm with a scatter range of 0.27 to 0.44 ppm. The spectrophotometer permits simultaneous determination of two metals, in this case zinc and copper. It was possible to de...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1057525

    authors: Gerhard JP,Calmé P,Kraeminger E

    更新日期:1980-04-01 00:00:00

  • [Expression of EphA2 in Metastatic and Non-Metastatic Primary Uveal Melanoma].

    abstract:BACKGROUND:Little is known about how the expression of Ephrin type-A receptor 2 (EphA2) influences cell-cell adhesion, migration, angiogenesis, and the formation of vasculogenic mimicry (VM) channels in uveal melanomas or how this may be related to the rate of metastasis. MATERIAL AND METHODS:Paraffin embedded section...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-0041-110956

    authors: Vukoja V,Brandenbusch T,Tura A,Nassar K,Rohrbach DJ,Lüke M,Grisanti S,Lüke J

    更新日期:2016-03-01 00:00:00

  • [Centering intraocular lenses with reference to capsular incision].

    abstract:BACKGROUND:Can the capsulotomy with small radial incisions compared to the continuous curvilinear capsulorhexis with perfect IOL centration still be recommended? This problem should be clarified under standard conditions. METHOD:On 100 patients both procedures were applied alternating with corneoscleral incision, phac...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1035520

    authors: Fetscher M,Müller-Jensen K

    更新日期:1994-04-01 00:00:00

  • [Analysis of Factors Influencing the Suitability of Donor Corneas in the LIONS Cornea Bank Saar-Lor-Lux, Trier/Westpfalz from 2006 to 2016].

    abstract:BACKGROUND AND PURPOSE:With the discrepancy between availability and demand for corneal donors, the purpose of our study was to identify significant factors influencing the suitability and affecting the main reasons for discarding organ-cultured corneas. We thus aimed to minimise the percentage of unsuitable corneas in...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/a-1141-3703

    authors: Kramp K,Suffo S,Laun D,Bischoff-Jung M,Huber M,Langenbucher A,Seitz B

    更新日期:2020-11-01 00:00:00

  • [Clinical and pathologic-anatomical results following the application of a mobile argon-laser beam in aphakic pupillary block glaucoma (author's transl)].

    abstract::In the last four years we have treated with the mobile argon-laser beam 25 cases of aphakic pupillary block glaucoma (p. b. g.). According to the time of manifestation of the p. b. g. the patients were divided into an "early" and a "late" group. In the "early" group (17 eyes) the glaucoma manifested itself 1--4 days a...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Theodossiadis G,Kouris-Bairaktari E,Velissaropoulos P

    更新日期:1979-08-01 00:00:00

  • [Effect of histological criteria (TpNM classification, degree of differentiation) on mortality of patients with retinoblastoma].

    abstract::153 patients suffering from retinoblastoma and treated between 1960 and 1980 were analysed retrospectively. Median follow-up was 11.2 years. 13 patients (8.5%) died from retinoblastoma. 3 patients died from a secondary osteosarcoma. The survival rates from patients with differentiated retinoblastomas did not differ fr...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1045753

    authors: Lommatzsch PK,Morgenstern B

    更新日期:1992-04-01 00:00:00

  • [Paediatric retinal detachment and hereditary vitreoretinal disorders].

    abstract::The number of retinal detachments in children is very low in comparison to the number in adults. One predisposing factor for development of paediatric retinal detachment is suffering from hereditary vitreoretinal degeneration (e.g., Stickler syndrome, Wagner syndrome, Kniest dysplasia, familial exudative vitreoretinop...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,评审

    doi:10.1055/s-0033-1350759

    authors: Meier P

    更新日期:2013-09-01 00:00:00

  • [Diminution of myopia following operation of macular hole-induced retinal detachment].

    abstract::This paper presents an assessment of the diminution of myopia in 25 eyes after surgery according to the technique of G. P. Theodossiadis for retinal detachment due to a macular hole. The procedure consists in the stretching and fixation of a silicone sponge at the posterior pole and dispenses entirely with either cryo...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1050806

    authors: Theodossiadis GP,Damanakis AG,Koutsandrea CN

    更新日期:1986-10-01 00:00:00

  • [Videography with the slit lamp].

    abstract:BACKGROUND:Many new diagnostic instruments have been introduced for imaging in ophthalmology, particularly for retinal diseases and diagnostics in glaucoma. The slit lamp, however, as the most important instrument in practical ophthalmological work, has been largely unchanged for decades. It will be shown that a video ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-0031-1281765

    authors: Gellrich MM

    更新日期:2011-12-01 00:00:00

  • [Computer tomography in unilateral exophthalmos caused by an osteomas of the orbital wall (author's transl)].

    abstract::A 67-year-old woman patient presented with protrusion of the right globe of unknown origin. Computer tomography revealed a probably benign space-occupying lesion (osteoma) originating in the orbital wing portion of the sphenoidal bone and extending to the orbital roof of the frontal bone. ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1057477

    authors: Kleifeld O

    更新日期:1980-03-01 00:00:00

  • [Idiopathic episcleral venous stasis with secondary open-angle glaucoma (Radius-Maumenee syndrome)].

    abstract:BACKGROUND:Dilated episcleral vessels may be observed in patients with orbital tumors, carotid-cavernous-sinus fistula and other orbital obstructive lesions. As an idiopathic phenomenon dilated episcleral vessels may be associated with secondary open-angle glaucoma. PATIENT:We report on a 59-year-old patient with a hi...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1035110

    authors: Groh MJ,Küchle M

    更新日期:1997-08-01 00:00:00

  • [Experimental findings with a fibrin tissue adhesive in conjunctival and skleral surgery in a rabbit model (author's transl)].

    abstract::The authors investigated the wound closure of conjunctival wounds with fibrin adhesive as compared to a suture technique in rabbits. Similarly, the fixation of a transplant of lyophilized dura mater on the sclera by fibrin adhesive was also compared with a suture technique. Both clinically and histologically, there we...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1057252

    authors: Härting F,Mellin KB

    更新日期:1981-07-01 00:00:00

  • [Medallion lenses, 500 implantations].

    abstract::A report is given on the implantation of 500 Medallion lenses, most of which were implanted after intracapsular cataract operation (88%) and were kept under observation for between 3 and 88 months (average 22 months). In 1.2% a severe keratopathy resulted from an operation that was too traumatic, from decentration of ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1054737

    authors: Fechner PU

    更新日期:1983-02-01 00:00:00

  • [Myopic implant of the posterior chamber using a flexible Collamer lens].

    abstract:BACKGROUND:The purpose of this study was to report results, effectiveness and safety of implanting a negative collagen/HEMA copolymer posterior chamber phakic intraocular lens in moderate to highly myopic eyes. MATERIAL AND METHODS:23 eyes from 12 patients with a mean preoperative spherical equivalent refraction of - ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2002-30666

    authors: Roy S,Tritten JJ

    更新日期:2002-04-01 00:00:00

  • [Eye involvement in cancer].

    abstract::Intraocular metastatic tumors are rare. They are seen in 10% of patients having died of a malignant tumor. Frequently metastatic tumors of the eye are not observed clinically because the may develop in the terminal stage of the disease. The most frequent primary tumor is carcinoma of the breast with 60% of all intraoc...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Vogel M

    更新日期:1997-04-01 00:00:00

  • [Traction detachment in Coats disease].

    abstract::Immunocytochemical examination of a subretinal membrane removed during vitrectomy from a patient suffering from Coats' disease revealed macrophages, fibronectin, and vimentin. Vimentin is considered to be a marker of mesenchymal cells. Fibronectin may represent a guide rail and scaffold for the cellular organization o...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1050247

    authors: Wiedemann P,Weller M,Heimann K

    更新日期:1988-08-01 00:00:00

  • [Diagnostic procedure in uveitis patients to determine general concomitant disorders].

    abstract::A thorough examination, planned jointly by an internist and an ophthalmologist, is advocated for patients with uveitis. Close cooperation with all medical subspecialties is mandatory in order to save the time and money of both the physician and the patient. One or more relevant concomitant diseases were diagnosed in 7...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1054563

    authors: Wulle KG,Reichel M

    更新日期:1984-07-01 00:00:00

  • [Disorders of binocular vision in amblyopic patients working at computer terminals].

    abstract::For the first time two cases are described with disturbances of binocular vision caused by subjective perception of positive scotomata in the amblyopic eye. The visual strain of working at a terminal leads to a slight increase in the squint angle; as a result, a paracentral scotoma may shift into the middle of the bin...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1054340

    authors: Stangler-Zuschrott E,Harrer S

    更新日期:1985-11-01 00:00:00

  • [A case of papillophlebitis].

    abstract::A case history of a young man with recurrent papillophlebitis. The fluorescein angiogram showed an extensive hyperfluorescence of the disk and surrounding retinal veins in the venous and late phase. The electro-ophthalmological findings were normal in both eyes, while computerized perimetry demonstrated an enlarged bl...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1055250

    authors: Wochesländer E,Bartl G

    更新日期:1982-11-01 00:00:00

  • [Damage caused by wearing contact lenses throughout the day].

    abstract::Seventy-eight contact lens patients issued with soft HEMA lenses were examined in order to establish reasons for intolerance. The examination was carried out in conjunction with a questionnaire designed to furnish information about the habits of the contact lens patients. Less than 50% of the patients had been advised...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1057272

    authors: Bernd HJ

    更新日期:1981-08-01 00:00:00

  • [Optimization of irradiation time in the treatment of malignant melanoma of the choroid with beta applicators (106Ru/106Rh)].

    abstract::Brachytherapy with 106Ru/106Rh necessitates protracted irradiation because the applicators have to be sutured to the sclera. Protracted radiotherapy causes more intensive damage in tumor cells with increased metabolism and a higher mitosis rate than in normal tissue. Beta irradiation of rabbit eyes with 0.258-0.231 Gy...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1050770

    authors: Lommatzsch PK,Weise B,Ballin R

    更新日期:1986-08-01 00:00:00

  • [Closure of the central artery of the retina in progressive scleroderma (author's transl)].

    abstract::In the present paper a case of generalized scleroderma with concomitant central arterial occlusion is reported. To our knowledge this coincidence of generalized scleroderma and central arterial occlusion has not been described so far. As fibrinoid necrosis and proliferative changes of the choroidal vessels occur with ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Berndt K,Hoffmann A

    更新日期:1977-10-01 00:00:00

  • [Alternate day squint (author's transl)].

    abstract::3 cases of cyclical convergent strabismus (48 hour rhythm) were investigated. In contrast to intermittant strabismus, cyclical strabismus is not fatigue dependant. An alteration in the rhythm of the cyclical esotropia was produced by wearing prisms, red glasses or occlusion for several days. This observation indicates...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Schmidt D,Mattheus S

    更新日期:1975-12-01 00:00:00

  • [Cryptophthalmos solum corneae].

    abstract::The authors report on an 11-month-old child in whom subcutaneous fatty tissue covered with normal skin was found instead of a cornea. Since the lid and conjunctiva were intact this developmental anomaly may be designated cryptophthalmos solum corneae. ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1046162

    authors: Alberth B,el Zein G

    更新日期:1990-04-01 00:00:00

  • [Experimental venous thrombosis: preretinal PO2 before and after photocoagulation].

    abstract::Experimental occlusion of a retinal vein leads to retinopathy in the affected drainage area. In some cases the formation of ischemic regions, where the retina is completely destroyed, is typical for the development of this retinopathy. Laser photocoagulation restores the physiological preretinal oxygen pressure in the...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1050970

    authors: Pournaras CJ,Ilic J,Gilodi N,Tsacopoulos M,Leuenberger MP

    更新日期:1985-06-01 00:00:00

  • [Correspondence alterations due to tenomyotomy (author's transl)].

    abstract::This report covers 310 patients with concomitant convergent strabismus and anomalous retinal correspondence. In 36 cases tenomyotomy alone was responsible for normalization of correspondence. This is best achieved in cases of bilateral converging strabismus without vertical divergence. ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Schellenbeck R,Schmidt I

    更新日期:1979-08-01 00:00:00

  • Spasm of accommodation in a patient with increased intracranial pressure and pineal cyst.

    abstract:BACKGROUND:In the setting of a normal neurological examination, accommodation spasm is frequently attributed to a non-organic etiology. Occasionally, organic disorders are associated. In particular, central lesions involving the dorsal midbrain and quadrigeminal plate have been described with disorders of accommodation...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2005-857976

    authors: Kawasaki A,Borruat FX

    更新日期:2005-03-01 00:00:00

  • [Nitrergic reactivity in endothelial cells of human uveal blood vessels].

    abstract:BACKGROUND:We investigated the presence of Nicotinamid-adenin-dinucleotid-phosphat (NADPH)-diaphorase activity in endothelial cells of the human uveal vessels, using a histochemical procedure which presumably localizes the reaction product nitric oxide. MATERIAL AND METHODS:11 donor eyes destined for corneal transplan...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1035414

    authors: Bergua A

    更新日期:1995-02-01 00:00:00

  • [Juvenile cataract associated with microcornea and glucosuria: a new syndrome].

    abstract:BACKGROUND:Predisposition is responsible for approximately 50% of age-related cataracts. Investigation of inherited forms of cataract provides the opportunity to identify the genes that may play a role in age-related cataract as well. PATIENTS AND METHODS:We describe the phenotype of a Swiss family with juvenile catar...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2007-962943

    authors: Vandekerckhove K,Lange AP,Herzog D,Schipper I

    更新日期:2007-04-01 00:00:00