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Effect of nitroblue tetrazolium on NO synthase and motor function of opossum esophagus.

Abstract：

:Nitric oxide mediates neuromuscular events in the opossum esophagus. The NADPH diaphorase stain is used to localize nitric oxide synthase-containing enteric neurons. Cells stain by the NADPH diaphorase technique because they reduce nitroblue tetrazolium to the visible formazan. The effects of nitroblue tetrazolium on neuromuscular function and nitric oxide synthase of esophageal muscle were studied. The NADPH diaphorase stain was performed. Nitroblue tetrazolium inhibited lower esophageal sphincter relaxation, abolished the latency gradient of the off response, and inhibited nitric oxide synthase. The NADPH diaphorase technique stained myenteric plexus nerve cell bodies and nerve processes. Nitroblue tetrazolium is not a nonspecific muscle or nerve toxin, as nerve-mediated cholinergic responses, responses to exogenous nitric oxide, and responses to myogenic stimulation were maintained after nitroblue tetrazolium abolished the off response and lower esophageal sphincter relaxation. Nitroblue tetrazolium inhibits nitric oxide-mediated events and nitric oxide synthase. It stains neurons in the esophageal myenteric plexus.

journal_name

Dig Dis Sci

journal_title

Digestive diseases and sciences

authors

Conklin JL,O'Meara BW,Murray JA,Fang SY,Clark ED,Christensen J

doi

10.1007/BF02063243

subject

Has Abstract

pub_date

1995-11-01 00:00:00

pages

2390-7

issue

11

eissn

0163-2116

issn

1573-2568

journal_volume

40

pub_type

杂志文章

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