Intravenous amitriptyline in pediatrics.

Abstract:

:Oral amitriptyline has been used as an analgesic in a wide range of pain settings. Despite long-term availability of a parenteral form, the few reports about this formulation have been limited to pharmacokinetic studies in normal volunteers, trials in depressed patients, and analyses of electroencephalogram (EEG) activation. We retrospectively reviewed our experience using intravenous (IV) amitriptyline at Children's Hospital, Boston and at Children's Hospital at Stanford. Eight children (aged 5-16.6 years), who were unable to tolerate medications by the oral route, received IV amitriptyline for a variety of indications, including neuropathic pain, depression, sleep disturbance, and as an adjuvant agent for opioid analgesia. One patient experienced an extrapyramidal reaction temporally related to the administration of IV amitriptyline, which was successfully managed with diphenhydramine. Further prospective, controlled studies are needed to further assess the safety, efficacy and tolerability of this novel use of amitriptyline.

journal_name

J Pain Symptom Manage

authors

Collins JJ,Kerner J,Sentivany S,Berde CB

doi

10.1016/0885-3924(95)00062-4

subject

Has Abstract

pub_date

1995-08-01 00:00:00

pages

471-5

issue

6

eissn

0885-3924

issn

1873-6513

pii

0885392495000624

journal_volume

10

pub_type

杂志文章
  • The Family Caregiving Crisis Meets an Actual Pandemic.

    abstract::The coronavirus disease 2019 (COVID-19) pandemic presents unique challenges to those who work with the seriously ill population, including both health care providers and the family caregivers providing unpaid care. We rely on this lay workforce as health care routinely transitions care to the home, and now more than e...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章

    doi:10.1016/j.jpainsymman.2020.04.006

    authors: Kent EE,Ornstein KA,Dionne-Odom JN

    更新日期:2020-07-01 00:00:00

  • Clinicians' Views of Educational Interventions for Carers of Patients With Breathlessness Due to Advanced Disease: Findings From an Online Survey.

    abstract:CONTEXT:Carers' needs in advanced disease, and specifically in relation to breathlessness, are well evidenced. Publications on educational interventions for carers of patients with advanced disease that focus on symptoms are scarce and absent for breathlessness. OBJECTIVES:To establish current education provided by cl...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章

    doi:10.1016/j.jpainsymman.2016.08.015

    authors: Ewing G,Penfold C,Benson JA,Mahadeva R,Howson S,Burkin J,Booth S,Lovick R,Gilligan D,Todd C,Farquhar M

    更新日期:2017-02-01 00:00:00

  • ASCPRO recommendations for the assessment of fatigue as an outcome in clinical trials.

    abstract:CONTEXT:Development of pharmacological and behavioral interventions for cancer-related fatigue (CRF) requires adequate measures of this symptom. A guidance document from the Food and Drug Administration offers criteria for the formulation and evaluation of patient-reported outcome measures used in clinical trials to su...

    journal_title:Journal of pain and symptom management

    pub_type: 指南,杂志文章,评审

    doi:10.1016/j.jpainsymman.2010.02.006

    authors: Barsevick AM,Cleeland CS,Manning DC,O'Mara AM,Reeve BB,Scott JA,Sloan JA,ASCPRO (Assessing Symptoms of Cancer Using Patient-Reported Outcomes).

    更新日期:2010-06-01 00:00:00

  • Online Module Builds Skills for Internal Medicine Interns in Responding to Emotions During Complex Serious Illness Conversations.

    abstract:CONTEXT:Responding to emotion cues is an essential skill for communicating with patients and families, but many health care trainees have difficulty applying this skill within the context of a complex conversation. OBJECTIVES:We created an original online module to facilitate deliberate practice of a three-skill frame...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章

    doi:10.1016/j.jpainsymman.2020.02.002

    authors: Gibbon LM,Hurd CJ,Merel SE

    更新日期:2020-06-01 00:00:00

  • HIV/AIDS symptom management in Southern Africa.

    abstract::We describe self-reported strategies used by persons living with HIV/AIDS in Botswana, Lesotho, South Africa, and Swaziland to manage common HIV-related symptoms. A questionnaire asked participants to list three to six symptoms they had recently experienced, the care strategies they had used to make them better, where...

    journal_title:Journal of pain and symptom management

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/j.jpainsymman.2004.05.007

    authors: Sukati NA,Mndebele SC,Makoa ET,Ramukumba TS,Makoae LN,Seboni NM,Human S,Holzemer WL

    更新日期:2005-02-01 00:00:00

  • Myoclonic spasms following intrathecal diamorphine.

    abstract::The use of intrathecal diamorphine via an implanted portal system is described for pain control in a patient suffering from vertebral metastatic disease. The complication of myoclonic spasms affecting the lower half of the body occurred after 14 days, when increasing the bolus dose to 40 mg. The spasms lasted for 3 hr...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章

    doi:10.1016/0885-3924(93)90192-x

    authors: Cartwright PD,Hesse C,Jackson AO

    更新日期:1993-10-01 00:00:00

  • Oral glycopyrrolate alleviates drooling in a patient with tongue cancer.

    abstract::Although sialorrhea and drooling are uncommon symptoms in cancer patients, they can cause considerable discomfort, inconvenience and social embarrassment. In this article we describe a patient with tongue cancer who was successfully treated with oral glycopyrrolate 0.4 mg 3 times daily. Glycopyrrolate is a quaternary ...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章

    doi:10.1016/s0885-3924(99)00080-9

    authors: Olsen AK,Sjøgren P

    更新日期:1999-10-01 00:00:00

  • Caregiver Expectations: Predictors of a Worse Than Expected Caregiving Experience at the End of Life.

    abstract:CONTEXT:The gap between informal caregivers' expectations of caregiving at the end of life and their actual caregiving experience has important affective and behavioral consequences. OBJECTIVES:This study analyzes for the first time the characteristics of those caregivers who report a worse or much worse than expected...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章

    doi:10.1016/j.jpainsymman.2015.04.017

    authors: Burns EJ,Quinn SJ,Abernethy AP,Currow DC

    更新日期:2015-10-01 00:00:00

  • Comparing Symptom Ratings by Staff and Family Carers in Residents Dying in Long-Term Care Facilities in Three European Countries, Results From a PACE Survey.

    abstract:CONTEXT:Symptom management is essential in the end-of-life care of long-term care facility residents. OBJECTIVES:To study discrepancies and possible associated factors in staff and family carers' symptom assessment scores for residents in the last week of life. METHODS:A postmortem survey in Belgium, The Netherlands,...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章

    doi:10.1016/j.jpainsymman.2020.03.002

    authors: Tanghe M,Van Den Noortgate N,Deliens L,Smets T,Onwuteaka-Philipsen B,Finne-Soveri H,Van den Block L,Piers R,PACE.

    更新日期:2020-08-01 00:00:00

  • Validation of single-item linear analog scale assessment of quality of life in neuro-oncology patients.

    abstract::Assessment of patient quality of life (QOL) requires balancing the details provided by multi-item assessments with the reduced burden of single-item assessments. In this project, we investigated the psychometric properties of single-item Linear Analog Scale Assessments (LASAs) for patients with newly diagnosed high-gr...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章

    doi:10.1016/j.jpainsymman.2007.01.016

    authors: Locke DE,Decker PA,Sloan JA,Brown PD,Malec JF,Clark MM,Rummans TA,Ballman KV,Schaefer PL,Buckner JC

    更新日期:2007-12-01 00:00:00

  • Palliative sedation: a review of the research literature.

    abstract::The overall aim of this paper is to systematically review the following important aspects of palliative sedation: prevalence, indications, survival, medication, food and fluid intake, decision making, attitudes of physicians, family experiences, and efficacy and safety. A thorough search of different databases was con...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章,评审

    doi:10.1016/j.jpainsymman.2007.10.004

    authors: Claessens P,Menten J,Schotsmans P,Broeckaert B

    更新日期:2008-09-01 00:00:00

  • The opioid contract in the management of chronic pain.

    abstract::Although the "opioid contract" is widely used in the administration of chronic opioid therapy, its use has not been well defined and there are few guidelines for developing or revising such tools. We reviewed opioid contracts from 39 major academic pain centers and analyzed every statement for its core meaning. These ...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章,多中心研究

    doi:10.1016/s0885-3924(99)00035-4

    authors: Fishman SM,Bandman TB,Edwards A,Borsook D

    更新日期:1999-07-01 00:00:00

  • Deep Natural Language Processing Identifies Variation in Care Preference Documentation.

    abstract:CONTEXT:Documentation of care preferences within 48 hours of admission to an intensive care unit (ICU) is a National Quality Forum-endorsed quality metric for older adults. Care preferences are poorly captured by administrative data. OBJECTIVES:Using deep natural language processing, our aim was to determine the rate ...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章

    doi:10.1016/j.jpainsymman.2019.12.374

    authors: Udelsman BV,Moseley ET,Sudore RL,Keating NL,Lindvall C

    更新日期:2020-06-01 00:00:00

  • Chronic pain management in older adults: special considerations.

    abstract::The rising prevalence of neuropathic pain and the multifaceted sequelae of pain particularly within older adults are part of the increasing challenges in providing good geriatric pain management. Aging can lead to a higher sensitivity to pain within older adults, whereas physiological changes modify the absorption, bi...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章,评审

    doi:10.1016/j.jpainsymman.2009.05.002

    authors: Fine PG

    更新日期:2009-08-01 00:00:00

  • Iontophoretic vincristine in the treatment of postherpetic neuralgia: a double-blind, randomized, controlled trial.

    abstract::The effect of iontophoretic administration of vincristine in the treatment of postherpetic neuralgia (PHN) was investigated in a prospective, double-blind, placebo-controlled trial. Twenty patients with intercostal or lumbar PHN for more than 6 months that was unresponsive to conventional medical therapy were randomiz...

    journal_title:Journal of pain and symptom management

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0885-3924(98)00121-3

    authors: Dowd NP,Day F,Timon D,Cunningham AJ,Brown L

    更新日期:1999-03-01 00:00:00

  • Temporal Trends Between 2010 and 2015 in Intensity of Care at End-of-Life for Patients With Chronic Illness: Influence of Age Under vs. Over 65 Years.

    abstract:CONTEXT:Recent analyses of Medicare data show decreases over time in intensity of end-of-life care. Few studies exist regarding trends in intensity of end-of-life care for those under 65 years of age. OBJECTIVES:To examine recent temporal trends in place of death, and both hospital and intensive care unit (ICU) utiliz...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章

    doi:10.1016/j.jpainsymman.2017.08.032

    authors: Sathitratanacheewin S,Engelberg RA,Downey L,Lee RY,Fausto JA,Starks H,Dunlap B,Sibley J,Lober W,Loggers ET,Khandelwal N,Curtis JR

    更新日期:2018-01-01 00:00:00

  • Multicenter study of pain and its management in patients with advanced cancer in Korea.

    abstract::The aim of this study was to evaluate the prevalence, severity, and management of pain in Korean patients with advanced cancer, and to identify the predictors of inadequate management of cancer pain in Korea. From 8 university hospitals, 655 patients with advanced cancer were surveyed. Information concerning analgesic...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章,多中心研究

    doi:10.1016/s0885-3924(03)00103-9

    authors: Yun YH,Heo DS,Lee IG,Jeong HS,Kim HJ,Kim SY,Kim YH,Ro YJ,Yoon SS,Lee KH,Huh BY

    更新日期:2003-05-01 00:00:00

  • Patient-Clinician Communication About End-of-Life Care in Patients With Advanced Chronic Organ Failure During One Year.

    abstract:CONTEXT:Patient-clinician communication is an important prerequisite to delivering high-quality end-of-life care. However, discussions about end-of-life care are uncommon in patients with advanced chronic organ failure. OBJECTIVES:The aim was to examine the quality of end-of-life care communication during one year fol...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.jpainsymman.2014.12.008

    authors: Houben CH,Spruit MA,Schols JM,Wouters EF,Janssen DJ

    更新日期:2015-06-01 00:00:00

  • Personalized Pain Goal as an Outcome Measure in Routine Cancer Pain Assessment.

    abstract:BACKGROUND:There is currently no universally accepted outcome measure in cancer pain management. The personalized pain goal (PPG) has been shown to be a relevant outcome measure. We examined its use in routine outpatient practice and compared it with the clinically important difference (CID, ≥2 points or 30%), a pain o...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章

    doi:10.1016/j.jpainsymman.2018.03.004

    authors: Arthur J,Tanco K,Park M,Haider A,Maligi C,Dalal S,Naqvi SMA,Liu D,Bruera E

    更新日期:2018-07-01 00:00:00

  • Role of nitric oxide in the physiopathology of pain.

    abstract::Many painful disorders, including joint dysfunctions such as rheumatoid arthritis (RA) or temporomandibular joint disorders (TMD), are associated with hyperthermia of the overlying skin. The same is true of certain intractable chronic pain conditions, such as chronic orofacial pain, which may be associated with TMD. W...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章,评审

    doi:10.1016/s0885-3924(97)00178-4

    authors: Anbar M,Gratt BM

    更新日期:1997-10-01 00:00:00

  • Prevalence of symptoms among patients with advanced cancer: an international collaborative study. Symptom Prevalence Group.

    abstract::The aims of this study were (a) to estimate the prevalence of pain and eight other common symptoms in a large population of patients with advanced cancer from different palliative care centers, and (b) to assess the differences in prevalence of the symptoms by primary site. In 1990-1991, the prevalence of eight major ...

    journal_title:Journal of pain and symptom management

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/0885-3924(96)00042-5

    authors: Vainio A,Auvinen A

    更新日期:1996-07-01 00:00:00

  • Prevalence of pain in Italian hospitals: results of a regional cross-sectional survey.

    abstract::The aims of this study were to quantify the prevalence of pain among hospitalized Italian patients and to describe the potential determinants of pain in this population. All patients older than 18 years and hospitalized for at least 24 hours in one of the 30 public hospitals of the Liguria region (n = 4709) were eligi...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章

    doi:10.1016/s0885-3924(01)00405-5

    authors: Costantini M,Viterbori P,Flego G

    更新日期:2002-03-01 00:00:00

  • Improving Advance Care Planning in Outpatients With Decompensated Cirrhosis: A Pilot Study.

    abstract:BACKGROUND:Despite significant morbidity and mortality among patients with decompensated cirrhosis, reported rates of advance directive (AD) completion and goals of care discussions (GCDs) between patients and providers are very low. We aimed to improve these rates by implementing a hepatologist-led advance care planni...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章

    doi:10.1016/j.jpainsymman.2019.12.355

    authors: Patel A,Kogekar N,Agarwal R,Cohen C,Esteban JP,Pourmand K,Tsai E,Harty A,Pelham-Braithwaite A,Perumalswami P,Dieterich D,Schiano T

    更新日期:2020-04-01 00:00:00

  • Combined administration of opioids with selected drugs to manage pain and other cancer symptoms: initial safety screening for compatibility.

    abstract::Cancer patients suffer multiple symptoms and require numerous drug therapies. Parenteral administration of multiple medications from a single container can simplify drug regimens for patient self-administration. This simplification reduces drug preparation costs and risk of infection. Therapeutic options are limited b...

    journal_title:Journal of pain and symptom management

    pub_type: 临床试验,杂志文章

    doi:10.1016/0885-3924(96)00127-3

    authors: Chandler SW,Trissel LA,Weinstein SM

    更新日期:1996-09-01 00:00:00

  • Optimizing opioid treatment of postoperative pain.

    abstract::The problem of undertreatment of acute postoperative pain has been documented in many studies. This article reviews this evidence and defines the problem of undertreatment as a group of attitudes about pain treatment that originate with deficiencies in knowledge and skills and lead to the development of inappropriate ...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章

    doi:

    authors: Edwards WT

    更新日期:1990-02-01 00:00:00

  • Palliative care development: the Nepal model.

    abstract::Over the last few years, Nepali and international colleagues have been collaborating in the development of palliative care services in Nepal. The program continues to move forward amid the considerable social and political difficulties facing Nepal. Although a number of individuals and organizations have been involved...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章,评审

    doi:10.1016/j.jpainsymman.2007.02.009

    authors: Brown S,Black F,Vaidya P,Shrestha S,Ennals D,LeBaron VT

    更新日期:2007-05-01 00:00:00

  • Meaninglessness in terminally ill cancer patients: a validation study and nurse education intervention trial.

    abstract::Recent empirical studies revealed that fostering patients' perception of meaning in their life is an essential task for palliative care clinicians. However, few studies have reported the effects of training programs for nurses specifically aimed at improving skills to relieve the meaninglessness of terminally ill canc...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章

    doi:10.1016/j.jpainsymman.2006.10.021

    authors: Morita T,Murata H,Hirai K,Tamura K,Kataoka J,Ohnishi H,Akizuki N,Kurihara Y,Akechi T,Uchitomi Y,Japanese Spiritual Care Task Force.

    更新日期:2007-08-01 00:00:00

  • Prioritizing Chinese Medicine Clinical Research Questions in Cancer Palliative Care: International Delphi Survey.

    abstract:CONTEXT:Chinese medicine modalities, including acupuncture and Chinese herbal medicine (CHM), have been used as palliative interventions among cancer patients. More research should be conducted to confirm their effectiveness. OBJECTIVES:The objective of this study was to prioritize Chinese medicine clinical research q...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章

    doi:10.1016/j.jpainsymman.2019.08.002

    authors: Wong CHL,Wu IXY,Balneaves LG,Lo RSK,Witt CM,Wu JCY,Leung TH,Chung VCH

    更新日期:2019-12-01 00:00:00

  • Validation of the Chinese version of the EORTC colorectal cancer-specific quality-of-life questionnaire module (QLQ-CR38).

    abstract::The European Organization for Research and Treatment of Cancer colorectal cancer (CRC)-specific quality-of-life questionnaire module (QLQ-CR38) assesses health-related quality of life in patients with CRC. We studied its psychometric properties and clinical validity in Hong Kong Chinese patients with CRC. The 38 items...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章

    doi:10.1016/j.jpainsymman.2007.03.013

    authors: Law CC,Tak Lam WW,Fu YT,Wong KH,Sprangers MA,Fielding R

    更新日期:2008-02-01 00:00:00

  • The impact of body mass index dynamics on survival of patients with advanced pancreatic cancer receiving chemotherapy.

    abstract:CONTEXT:High body mass index (BMI) is linked to an increased risk of developing pancreatic cancer (PC). However, in patients with advanced PC (APC), especially those receiving palliative chemotherapy, the impact of BMI on survival has not been investigated fully. OBJECTIVES:To assess changes in BMI during the course o...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章

    doi:10.1016/j.jpainsymman.2013.08.017

    authors: Choi Y,Kim TY,Lee KH,Han SW,Oh DY,Im SA,Kim TY,Bang YJ

    更新日期:2014-07-01 00:00:00